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71. 发明专利

CA2669260C DIFFERENTIAL GENE EXPRESSION IN PHYSIOLOGICAL AND PATHOLOGICAL ANGIOGENESIS 未知
公开(公告)号：CA2669260C
公开(公告)日：2019-01-15
申请号：CA2669260
申请日：2007-06-28
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： ST CROIX BRAD , SEAMAN STEVEN
IPC分类号： A61K47/68 , A61P35/00 , C07K16/28 , C07K16/40 , C12Q1/68 , G01N33/48
摘要： Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat 10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII.alpha.1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.

72. 发明专利

SG10201806098QA PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES 未知
公开(公告)号：SG10201806098QA
公开(公告)日：2018-08-30
申请号：SG10201806098Q
申请日：2007-02-12
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： LINDSTROM STEPHEN , LOFTIN LAMORRIS
摘要： PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed. (Figure I) - -

73. 发明专利

NZ714757A Use of il-15 to increase thymic output and to treat lymphopenia 未知
公开(公告)号：NZ714757A
公开(公告)日：2018-07-27
申请号：NZ71475710
申请日：2010-08-13
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： BERGAMASCHI CRISTINA , PAVLAKIS GEORGE N , VALENTIN ANTONIO , FELBER BARBARA K
IPC分类号： A61K38/20 , A61K48/00 , A61P37/04 , C07K19/00
摘要： Discloses a ploynucleotides sequence encoding an IL-15 receptor alpha (IL-15Rα)-Fc fusion protein comprising a soluble IL-15Ra that lacks the transmembrane anchor portion fused an immunoglobulin constant region.

74. 发明专利

AU2010292069B2 Improved Pseudomonas Exotoxin A with reduced immunogenicity 未知
公开(公告)号：AU2010292069B2
公开(公告)日：2015-08-13
申请号：AU2010292069
申请日：2010-09-10
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： PASTAN IRA H , BEERS RICHARD , ONDA MASANORI
IPC分类号： C07K14/21 , A61K47/48
摘要： The present invention provides improved

75. 发明专利

PL2197903T3 DELECJE W DOMENIE II EGZOTOKSYNY A PSUEDOMONAS ZMNIEJSZAJĄCE TOKSYCZNOŚĆ NIESPECYFICZNĄ 未知
公开(公告)号：PL2197903T3
公开(公告)日：2015-03-31
申请号：PL08799197
申请日：2008-09-04
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： PASTAN IRA H , WELDON JOHN , FITZGERALD DAVID
IPC分类号： C07K14/21 , A61K38/16 , C07K19/00 , C12N15/11 , C12N15/62

77. 发明专利

AU2008321253B2 Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer 未知
公开(公告)号：AU2008321253B2
公开(公告)日：2014-01-16
申请号：AU2008321253
申请日：2008-10-21
申请人： MASARYK MEMORIAL CANCER INST , US GOV HEALTH & HUMAN SERVICES , THE UNIV OF DUNDEE
发明人： BOURDON JEAN-CHRISTOPHE , FUJITA KAORI , HARRIS CURTIS C , VOJTESEK BORIVOJ , HORIKAWA IZUMI , LANE DAVID P
IPC分类号： A61K31/7105 , A61K31/711 , A61K31/713 , A61P35/00 , C12N15/113
摘要： The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.

78. 发明专利

AU2007319576B2 Prevention of tissue ischemia, related methods and compositions 未知
公开(公告)号：AU2007319576B2
公开(公告)日：2014-01-16
申请号：AU2007319576
申请日：2007-10-05
申请人： US GOV HEALTH & HUMAN SERVICES , UNIV WASHINGTON
发明人： FRAZIER WILLIAM A , ROBERTS DAVID D , ISENBERG JEFFREY S
IPC分类号： C07K14/43 , C07K14/78 , G01N33/68
摘要： Provided herein are compositions and methods for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and/or blocking TSP1 and/or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. This in turn reduces or prevents tissue necrosis and death. The therapeutics identified herein allow for precise regulation of blood flow to tissues and organs which need it, while substantially avoiding systemic complications. Methods and compositions described herein can be used to increase tissue survival under conditions of trauma and surgery, as well as conditions of chronic vascular disease. Also disclosed are methods for the treatment of elderly subjects using agents that affect TSP1 and CD47 and thereby affect tissue perfusion. Additionally, provided herein are compositions and methods for influencing blood coagulation, allowing for controlled increased or decreased blood clotting. Additionally, provided herein are compositions and methods for decreasing blood flow, as in the case of cancer through mimicking the effects of TSP1 and CD47 on blood vessel diameter and blood flow.

79. 发明专利

AU2009212747B2 Engineered antibody constant domain molecules 未知
公开(公告)号：AU2009212747B2
公开(公告)日：2013-11-07
申请号：AU2009212747
申请日：2009-01-30
申请人： US GOV HEALTH & HUMAN SERVICES
发明人： DIMITROV DIMITER S
IPC分类号： C07K16/00 , C07K16/10 , C07K19/00
摘要： Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, exhibit little to no toxicity and are capable of binding antigen.

80. 发明专利

AU2008262252B2 Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells 未知
公开(公告)号：AU2008262252B2
公开(公告)日：2013-09-12
申请号：AU2008262252
申请日：2008-06-09
申请人： US GOV HEALTH & HUMAN SERVICES , UNIV OHIO STATE RES FOUND
发明人： YAMASHITA TARO , WANG XIN WEI , CROCE CARLO M , JI JUNFANG
IPC分类号： C12Q1/68
摘要： The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.

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