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71. 发明申请

WO2019036479A1 SYSTEM, APPARATUS, AND METHODS FOR DISCRIMINATING OPTICAL SIGNALS 审中-公开
公开(公告)号：WO2019036479A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/046727
申请日：2018-08-14
申请人： SENSEONICS, INCORPORATED
发明人： JENKINS, Bill , TANKIEWICZ, Szymon
IPC分类号： G01J1/44 , G01J9/02 , G02B5/28 , G02B6/10 , H01J5/16 , H01L31/0216 , H03F3/08
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459
摘要： An analyte sensor incorporates one or more techniques for discriminating between different optical signals. In one embodiment, the sensor includes a photodetector that detects a narrow band optical signal. In another embodiment, the sensor includes a multilayer filter including an absorption filter, a reflection filter, and a transparent layer between the absorption and reflection filters. In another embodiment, the sensor employs an indicator that emits light for a period of time after an excitation source is turned off. In another embodiment, the sensor employs a first indicator that is excited by an excitation light source and a second indicator that is excited by light emitted by the first indicator. The second indicator emits light for a period after the excitation source is turned off. In another embodiment, excitation light is polarized by a first polarizer, and a second polarizer at a photodetector passes only light polarized by the first polarizer.

72. 发明申请

WO2018232350A1 SYSTEM AND METHOD FOR MEASURING AN AMOUNT OF BLOOD AND/OR CLOTTING IN A POCKET SURROUNDING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
公开(公告)号：WO2018232350A1
公开(公告)日：2018-12-20
申请号：PCT/US2018/037913
申请日：2018-06-15
申请人： SENSEONICS, INCORPORATED
发明人： CHAVAN, Abhi , MASCIOTTI, James
IPC分类号： A61B5/1459 , A61B5/026 , A61B5/0295 , A61B5/145 , A61B5/1455 , G01N21/59
摘要： A system and method for measuring an amount of blood and/or clotting in a pocket around an implantable device. The system may include a first light source configured to emit light over a first wavelength range. The system may include a first photodetector configured to output a first signal indicative of an amount of the first light received by the first photodetector. The system may include the implantable device and an external device. The implantable device may include one of the first light source and the first photodetector, and the external device may include the other of the first light source and the first photodetector. In some embodiments, the external device may include a controller configured to calculate the amount of blood/or clotting in the pocket around the implantable device using at least a measurement of the first signal.

73. 发明申请

WO2018183730A1 METHODS AND SYSTEMS FOR CORRECTING BLOOD ANALYTE MEASUREMENTS 审中-公开
公开(公告)号：WO2018183730A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025226
申请日：2018-03-29
申请人： SENSEONICS, INCORPORATED
发明人： CHEN, Xiaoxiao , DEHENNIS, Andrew
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/1459
摘要： A system, transceiver, and method for calculating and correcting levels (e.g., analyte levels) in a first medium (e.g., blood) using measurements from a second medium (e.g., interstitial fluid). In some embodiments, a transceiver may calculate an initial second medium level. The transceiver may calculate an initial second medium level rate of change ("ROC") using at least the initial second medium level and past second medium level(s). The transceiver may calculate a first medium level using at least the initial second medium level and the initial second medium level ROC. The transceiver may calculate a subsequent second medium level. The transceiver may calculate an updated second medium level ROC using at least the initial second medium level, the subsequent second medium level, and past second medium level(s). The transceiver may calculate a corrected first medium level using at least the initial second medium level and the updated second medium level ROC.

74. 发明申请

WO2017190143A1 REAL-TIME DENOISING AND PREDICTION FOR A CONTINUOUS GLUCOSE MONITORING SYSTEM 审中-公开
标题翻译：实时降噪和连续葡萄糖监测系统的预测
公开(公告)号：WO2017190143A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030440
申请日：2017-05-01
申请人： SENSEONICS, INCORPORATED
发明人： FACCIOLI, Simone , CHEN, Xiaoxiao , DEHENNIS, Andrew
IPC分类号： A61B5/00 , G01N33/48 , G06F11/30
摘要： An analyte monitoring system may include an analyte sensor and a transmitter. The analyte sensor may include an indicator element that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator element. The analyte sensor may be configured to generate one or more raw signals indicative of one or more analyte amounts or concentrations. The transmitter may be configured to receive from the analyte sensor one or more raw signals indicative of analyte concentration. The transmitter may be configured to denoise the raw signal using a real-time filtering technique with one or more time-varying parameters. The transmitter may be configured to predict ahead of time an analyte concentration based on one or more of the received one or more raw signals using one or more prediction models.
摘要翻译：分析物监测系统可以包括分析物传感器和发射器。分析物传感器可以包括指示器元件，该指示器元件基于接近指示器元件的分析物的量或浓度来展现一种或多种可检测性质。分析物传感器可以被配置为生成指示一个或多个分析物量或浓度的一个或多个原始信号。发射器可以被配置为从分析物传感器接收指示分析物浓度的一个或多个原始信号。发射机可以被配置为使用具有一个或多个时变参数的实时滤波技术来对原始信号进行去噪。发射器可以被配置为使用一个或多个预测模型基于一个或多个所接收的一个或多个原始信号提前预测分析物浓度。

75. 发明申请

WO2016014800A1 FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE 审中-公开
标题翻译：用于感应分析仪的荧光材料的制造
公开(公告)号：WO2016014800A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041739
申请日：2015-07-23
申请人： SENSEONICS, INCORPORATED
发明人： HUFFSTETLER, Philip , EMKEN, Jeremy , WHITEHURST, Todd
IPC分类号： C12M1/30 , C12M3/00
CPC分类号： G01N21/6428 , G01N21/77 , G01N31/22 , G01N33/544 , G01N33/582 , G01N2021/773 , G01N2021/7786
摘要： An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.
摘要翻译：分析物指示剂可以包括多孔基底，并且可以包括在分析物传感器中。分析物指示剂可在压缩存在的情况下保持其物理，化学和光学性质。多孔基底可以不透明度变化。分析物指示剂可以包括（i）在多孔基底上连接或聚合的聚合物单元和（ii）附着到聚合物单元上或与聚合物单元共聚的分析物感测元件。分析物感测元件可以包括一个或多个指示剂分子。分析物感测元件可以包括一个或多个指示剂聚合物链。分析物指示剂可以包括（i）在多孔基底上连接或聚合的指示剂聚合物链，和（ii）附着于指示剂聚合物链的指示剂分子。

76. 发明申请

WO2015021273A1 ANALYTE SENSOR TRANSCEIVER CONFIGURED TO PROVIDE TACTILE, VISUAL, AND / OR AURAL FEEDBACK 审中-公开
标题翻译：分析传感器收发器配置为提供触觉，视觉和/或AURAL反馈
公开(公告)号：WO2015021273A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050141
申请日：2014-08-07
申请人： SENSEONICS INCORPORATED
发明人： TANKIEWICZ, Szymon , EMKEN, Jeremy , DEHENNIS, Andrew , WHITEHURST, Todd
IPC分类号： A61B5/145
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/14532 , A61B5/7455 , A61B5/746
摘要： A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.
摘要翻译：用于与分析物传感器接口的收发器。收发器可以包括接口设备和通知设备。接口装置可以被配置为将功率信号传送到分析物传感器并且从分析物传感器接收数据信号。通知装置可以被配置为基于从分析物传感器接收的一个或多个数据信号来生成振动，听觉和视觉信号中的一个或多个。收发器的接口设备可以从分析物传感器接收分析物数据，并且收发器可以包括被配置为基于接收的分析物数据计算分析物浓度值的处理器。通知装置可以被配置为当所计算的分析物浓度值超过或低于阈值时产生听觉，视觉或振动报警中的一个或多个。

77. 发明申请

WO2015021269A1 A CO-PLANAR, NEAR FIELD COMMUNICATION TELEMETRY LINK FOR AN ANALYTE SENSOR 审中-公开
标题翻译：一个CO-PLANAR，用于分析仪传感器的近场通信电话链路
公开(公告)号：WO2015021269A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050136
申请日：2014-08-07
申请人： SENSEONICS, INCORPORATED
发明人： TANKIEWICZ, Szymon , SCHAEFER, Joshua , DEHENNIS, Andrew , WHITEHURST, Todd
IPC分类号： A61B5/145
CPC分类号： A61B5/0031 , A61B5/0004 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14556 , A61B5/1459
摘要： An inductive sensor system for remote powering and communication with an analyte sensor (e.g., a fully implantable analyte sensor). The system may include an analyte sensor and transceiver. The system may be ferrite-enhanced. The transceiver may implement a passive telemetry for communicating with the analyte sensor via an inductive magnetic link for both power and data transfer. The link may be a co-planar, near field communication telemetry link. The transceiver may include a reflection plate configured to focus flux lines linking the transceiver and the sensor uniformly beneath the transceiver. The transceiver may include an amplifier configured to amplify battery power and provide radio frequency (RF) power to a transceiver antenna.
摘要翻译：用于远程供电和与分析物传感器（例如，完全可植入的分析物传感器）通信的感应传感器系统。该系统可以包括分析物传感器和收发器。该系统可以是铁氧体增强的。收发器可以实现用于通过用于电力和数据传输的感应磁链路与分析物传感器通信的无源遥测。链路可以是共面的近场通信遥测链路。收发器可以包括反射板，该反射板被配置为将收发器和传感器均匀地聚集在收发器之下的磁通线。收发器可以包括被配置为放大电池功率并且向收发器天线提供射频（RF）功率的放大器。

78. 发明申请

WO2014144514A2 IMPROVED IMPLANTATION AND ANTENNA ORIENTATION OF AN IMPLANTABLE SENSOR 审中-公开
标题翻译：改进可植入传感器的植入和天线方向
公开(公告)号：WO2014144514A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028956
申请日：2014-03-14
申请人： SENSEONICS, INCORPORATED
发明人： TANKIEWICZ, Szymon , WHITEHURST, Todd
IPC分类号： B29C67/00
CPC分类号： A61B5/686 , A61B5/0015 , A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/1459 , H04B5/00 , H04B5/0043 , H04B5/0087
摘要： A sensor system including an implantable sensor and an external transceiver. Aspects of the sensor system may provide improved implantation and antenna orientation of the implanted sensor. The sensor may include a sensor antenna, the transceiver may include a transceiver antenna. In some embodiments, the sensor antenna and/or transceiver antenna may include a first set of coils oriented in a first plane and a second set of coils oriented in a second plane that is different than the first plane. In some embodiments, the sensor may have a geometry that will prevent or reduce movement and/or rotation of the implanted sensor. For instance, in some embodiments, the sensor may be enclosed in silicon that contains antenna coils and/or include wings, a fluid filled sack, a swelling material, an expansion material, and/or arms.
摘要翻译：包括可植入传感器和外部收发器的传感器系统。传感器系统的各方面可以提供植入传感器的改进的注入和天线取向。传感器可以包括传感器天线，收发器可以包括收发器天线。在一些实施例中，传感器天线和/或收发器天线可以包括定向在第一平面中的第一组线圈和定向成不同于第一平面的第二平面中的第二组线圈。在一些实施例中，传感器可以具有将防止或减少植入传感器的移动和/或旋转的几何形状。例如，在一些实施例中，传感器可以被封装在包含天线线圈和/或包括翅膀，流体填充袋，膨胀材料，膨胀材料和/或臂的硅中。

79. 发明申请

WO2013149129A1 PURIFICATION OF GLUCOSE CONCENTRATION SIGNAL IN AN IMPLANTABLE FLUORESCENCE BASED GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖浓度信号在基于可植入荧光的葡萄糖传感器中的纯化
公开(公告)号：WO2013149129A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034575
申请日：2013-03-29
申请人： SENSEONICS, INCORPORATED
发明人： COLVIN, Arthur, E. , WANG, Xiaolin , MDINGI, Colleen , DEHENNIS, Andrew
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14556 , A61B5/1459 , A61B5/7203
摘要： Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.
摘要翻译：公开了用于测定活体动物培养基中葡萄糖浓度的方法，传感器和系统。确定葡萄糖浓度可以包括将来自光源的激发光发射到指示剂分子，产生指示由光电检测器接收的光量的原始信号，纯化和归一化原始信号，以及将归一化信号转换为葡萄糖浓度。净化可以包括从原始信号中去除噪声（例如，偏移和/或失真）。净化和归一化可以涉及跟踪光源已经发射激发光的累积发射时间，并且跟踪从光学传感器植入以来经过的注入时间。净化和归一化可能涉及测量传感器的温度。净化，归一化和转化可以涉及使用在制造，体外测试和/或体内测试期间确定的参数。

80. 发明申请

WO2013119951A2 DIGITAL ASIC SENSOR PLATFORM 审中-公开
标题翻译：数字ASIC传感器平台
公开(公告)号：WO2013119951A2
公开(公告)日：2013-08-15
申请号：PCT/US2013/025346
申请日：2013-02-08
申请人： SENSEONICS, INCORPORATED
发明人： DEHENNIS, Andrew , COLVIN, Arthur, E.
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/1455 , A61B5/0031 , A61B5/076 , A61B5/1451 , A61B5/14532 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/1459 , A61B5/6861 , A61B5/7225
摘要： The present invention relates to an optical sensor that may be implanted within a living animal (e.g., a human) and may be used to measure the concentration of an analyte in a medium within the animal. The optical sensor may wirelessly receive and may be capable of bi-directional data communication. The optical sensor may include a semiconductor substrate in which various circuit components, one or more photodectors and/or a light source may be fabricated. The circuit components fabricated in the semiconductor substrate may include a comparator, an analog to digital converter, a temperature transducer, a measurement controller, a rectifier and/or a nonvolatile storage medium. The comparator may output a signal indicative of the difference between the outputs of first and second photodetectors. The measurement controller may receive digitized temperature, photodetector and/or comparator measurements and generate measurement information, which may be wirelessly transmitted from the optical sensor.
摘要翻译：本发明涉及一种可以植入活体动物（例如人）中的光学传感器，并可用于测量动物中介质中分析物的浓度。光学传感器可以无线地接收并且可能能够进行双向数据通信。光学传感器可以包括其中可以制造各种电路部件，一个或多个光电探测器和/或光源的半导体衬底。制造在半导体衬底中的电路部件可以包括比较器，模数转换器，温度传感器，测量控制器，整流器和/或非易失性存储介质。比较器可以输出指示第一和第二光电检测器的输出之间的差的信号。测量控制器可以接收数字化的温度，光电检测器和/或比较器测量并产生可以从光学传感器无线传输的测量信息。

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