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    • 72. 发明申请
    • Drug carrier and ultrasound apparatus
    • 药物载体和超声仪
    • US20070178047A1
    • 2007-08-02
    • US11653948
    • 2007-01-17
    • Kenichi Kawabata
    • Kenichi Kawabata
    • A61K49/22A61B8/00
    • A61K41/0014A61B8/481
    • A drug carrier and an ultrasound apparatus used in combination therewith for releasing a drug. The drug carrier undergoes a reversible phase change from liquid to gas upon ultrasound irradiation, so that the presence of the drug can be detected with a diagnostic apparatus without causing the spilling of the encased drug. The drug carrier includes a drug that is contained in a mixture of a poorly water-soluble substance having a boiling point of 37° C. or lower and a poorly water-soluble substance having a boiling point of higher than 37° C., which mixture is further encapsulated by a membrane of amphipathic substance.
    • 药物载体和与其组合使用的用于释放药物的超声装置。 药物载体在超声照射下经受从液体到气体的可逆相变,使得可以用诊断装置检测药物的存在而不会引起包封药物的溢出。 药物载体包括含有沸点为37℃以下的难溶于水的物质和沸点高于37℃的难溶于水的物质的混合物中的药物,其中 混合物被两亲物质的膜进一步包封。