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71. 发明申请

US20090110673A1 METHODS OF REDUCING CELL DEATH FOLLOWING HYPOXIA / REOXYGENATION 审中-公开
标题翻译：减少细胞死亡的方法与HYPOXIA / REOXYGENATION
公开(公告)号：US20090110673A1
公开(公告)日：2009-04-30
申请号：US12302140
申请日：2007-05-25
申请人： Terry L. Vanden Hoek , Zuo-Hui Shao , Chang-Qing Li , David G. Beiser , Lance Becker
发明人： Terry L. Vanden Hoek , Zuo-Hui Shao , Chang-Qing Li , David G. Beiser , Lance Becker
IPC分类号： A61K31/7084 , C12N5/06 , C12N9/99 , C12Q1/02 , A61K31/27 , A01N1/02 , A61K31/352 , A61K31/192
CPC分类号： A61K31/00 , A61K31/192 , A61K31/325 , A61K31/352 , A61K31/7084
摘要： Provided are methods of reducing cell death, attenuating a burst of reactive oxygen species, reducing cytotoxicity, reducing intracellular oxidant stress due species in a population of cells following hypoxia by reoxygenating the cells in the presence of a reversible electron transport chain inhibitor or under hypercarbic conditions. Also provided is a method to determine the effectiveness of a reversible electron transport chain inhibitor for reducing cell death in a population of cells.
摘要翻译：提供了减少细胞死亡的方法，减少活性氧的爆发，降低细胞毒性，通过在可逆电子传递链抑制剂的存在下再氧化细胞或在高胆固醇条件下，在缺氧后减少细胞内的细胞内氧化应激物质。还提供了确定可逆电子传递链抑制剂在细胞群中减少细胞死亡的有效性的方法。

72. 发明授权

US07376881B2 Encoder system, a decoder system, a coding/decoding apparatus, an encoding method and a decoding method 有权
标题翻译：编码器系统，解码器系统，编码/解码装置，编码方法和解码方法
公开(公告)号：US07376881B2
公开(公告)日：2008-05-20
申请号：US11132862
申请日：2005-05-19
申请人： Chang Qing Xu , Masayuki Tomisawa
发明人： Chang Qing Xu , Masayuki Tomisawa
IPC分类号： H04L1/18 , H03M13/03
CPC分类号： H03M13/3905 , H03M13/23 , H03M13/2957 , H03M13/41 , H03M13/6516
摘要： An encoder system for encoding a signal according to any number of FEC and/or channel codes comprises a shift register, an array of MOD/XOR stages, and a generator matrix stage for controlling the connections between the shift register and the MOD/XOR stages and altering these connections according to a coding format selected by an encoder selection stage. There is also disclosed a decoder system for decoding a signal encoded according to a number of FEC and/or channel codes comprising a decoding stage, and a generator matrix stage for configuring the decoding stage to a decoding code format to be applied an incoming encoded signal. A decoder selection stage is coupled to the generator matrix stage and selects the decoding code format to be used in the decoding process. The decoder selection stage instructs the generator matrix stage to configure the decoding stage according to the selected decoding code format. There is also disclosed a method for encoding and decoding.
摘要翻译：用于根据任何数量的FEC和/或信道码编码信号的编码器系统包括移位寄存器，MOD / XOR级的阵列和用于控制移位寄存器和MOD / XOR级之间的连接的发生器矩阵级以及根据由编码器选择级选择的编码格式来改变这些连接。还公开了一种解码器系统，用于对根据包含解码级的FEC和/或信道码的数量编码的信号进行解码，以及用于将解码级配置为应用输入编码信号的解码级的发生器矩阵级。解码器选择级耦合到发生器矩阵级，并选择要在解码过程中使用的解码码格式。解码器选择阶段指示发生器矩阵级根据选择的解码码格式配置解码级。还公开了一种编码和解码方法。

73. 发明申请

US20080004282A1 Compositions and methods for modulating gated ion channels 审中-公开
公开(公告)号：US20080004282A1
公开(公告)日：2008-01-03
申请号：US11786415
申请日：2007-04-10
申请人： Rahul Vohra , Zhonghong Gan , Chang-Qing Wei , Stephen Price , Hazel Dyke , Elsa Dechaux
发明人： Rahul Vohra , Zhonghong Gan , Chang-Qing Wei , Stephen Price , Hazel Dyke , Elsa Dechaux
IPC分类号： A61K31/50 , A61K31/47 , A61P1/00 , C07D217/00 , C07D401/02 , C12N5/00 , C07D401/10 , C07D217/14 , A61P13/00 , A61K31/4965
CPC分类号： C07D471/04 , C07D209/40
摘要： The present invention relates to compositions and methods to modulate the activity of gated ion channels.

74. 发明申请

US20060167222A1 Sh2 domain binding inhibitors 失效
标题翻译： Sh2结构域结合抑制剂
公开(公告)号：US20060167222A1
公开(公告)日：2006-07-27
申请号：US10517717
申请日：2003-06-26
申请人： Terrence Burke , Chang-Qing Wei , Zhen-DaN Shi , Yang Gao
发明人： Terrence Burke , Chang-Qing Wei , Zhen-DaN Shi , Yang Gao
IPC分类号： C07K5/12 , C07D245/02
CPC分类号： C07F9/6515 , C07K5/06026 , C07K5/06191
摘要： Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.
摘要翻译：公开了用于SH2结构域结合抑制的化合物，例如式（I）的化合物，其中R 1是亲脂体; R 2与苯环组合是苯基磷酸酯模拟基团或被保护的苯基磷酸酯模拟基团; R 3是氢，叠氮基，氨基，羧基烷基，烷氧基羰基烷基，氨基羰基烷基或烷基羰基氨基，其中R 3的烷基部分可以任选地被选自由卤素，羟基，羧基，氨基，氨基烷基，烷基，烷氧基和酮基组成; R 6是连接体; AA是氨基酸; n为1〜6; 或其盐。构象化合物提供与SH2结构域蛋白质增强的结合亲和力。还公开了用于抑制SH2结构域与磷蛋白结合的药物组合物和方法。

75. 发明授权

US07034990B2 Wavelength conversion element and method for using same 有权
标题翻译：波长转换元件及其使用方法
公开(公告)号：US07034990B2
公开(公告)日：2006-04-25
申请号：US10925011
申请日：2004-08-25
申请人： Takeshi Kamijoh , Chang-qing Xu
发明人： Takeshi Kamijoh , Chang-qing Xu
IPC分类号： G02F1/35 , G02F1/39
CPC分类号： G02F1/3536 , G02F2001/3548
摘要： A wavelength conversion element which can set the wavelength of a pump light to a wavelength longer or shorter than the wavelength of a plurality of signal lights and a wavelength of a plurality of conversion lights present in an optical communication band, and a method for using such a wavelength conversion element are provided. A first pump light with a wavelength λ1 of 1.51 μm, a second pump light with a wavelength λ2 of 1.57 μm, and a signal light with a wavelength of λS of 1.55 μm are multiplexed in a multiplexer and introduced as an incident light into an optical waveguide of a wavelength conversion element. In the optical waveguide, an SF light with a wavelength λSF of 0.77 μm is generated by the SFG of the first pump light with a wavelength λ1 of 1.51 μm and the second pump light with a wavelength λ2 of 1.57 μm, the signal light is wavelength converted as a DF light (wavelength 1.53 μm) by the DFG of the SF light and signal light, and this DF light is outputted as the converted light (wavelength λC=1.53 μm).
摘要翻译：一种波长转换元件，其可将泵浦光的波长设定为比多个信号光的波长长的或短于波长的光波长，以及存在于光通信带中的多个转换光的波长，以及使用该波长的方法提供波长转换元件。具有1.51μm波长λ<1> 1的第一泵浦光，波长为λ<2>1.5μm的第二泵浦光和波长为λ< 在多路复用器中复用1.55μm的子信号，并将其作为入射光引入到波长转换元件的光波导中。在光波导中，具有0.77μm波长λ SF 的SF光由波长λ1> 1.51的第一泵浦光的SFG产生，并且第二泵浦光的波长λ<2 1.57μm，信号光通过SF光和信号光的DFG被波长转换为DF光（波长1.53μm），该DF光为作为转换光（波长λC =1.53μm）输出。

76. 发明授权

US06959278B1 Systems and methods for implementing segmentation in speech recognition systems 失效
标题翻译：在语音识别系统中实现分割的系统和方法
公开(公告)号：US06959278B1
公开(公告)日：2005-10-25
申请号：US09826715
申请日：2001-04-05
申请人： Chang-Qing Shu , Han Shu
发明人： Chang-Qing Shu , Han Shu
IPC分类号： G10L15/00 , G10L15/02 , G10L15/04 , G10L15/14
CPC分类号： G10L15/142 , G10L15/04 , G10L2015/025
摘要： A speech recognition system (105) includes an acoustic front end (115) and a processing unit (125). The acoustic front end (115) receives frames of acoustic data and determines cepstral coefficients for each of the received frames. The processing unit (125) determines a number of peaks in the cepstral coefficients for each of the received frames of acoustic data and compares the peaks in the cepstral coefficients of a first one of the received frames with the peaks in the cepstral coefficients of at least a second one of the received frames. The processing unit (125) then segments the received frames of acoustic data based on the comparison.
摘要翻译：语音识别系统（105）包括声前端（115）和处理单元（125）。声学前端（115）接收声学数据帧，并确定每个接收帧的倒谱系数。处理单元（125）确定每个接收的声学数据帧的倒谱系数中的峰值数量，并将接收到的帧中的第一个的倒谱系数中的峰值与至少在倒频谱系数中的峰值进行比较接收的帧中的第二个。然后，处理单元（125）基于比较对所接收的声音数据帧进行分段。

77. 发明授权

US08327914B2 Feeding system for semi-solid metal injection 有权
标题翻译：半固体金属注射进料系统
公开(公告)号：US08327914B2
公开(公告)日：2012-12-11
申请号：US12786936
申请日：2010-05-25
申请人： Chang-Qing Zheng , Florentin Laplume
发明人： Chang-Qing Zheng , Florentin Laplume
IPC分类号： B22D17/04 , B22D23/00
CPC分类号： B22D17/007 , B22D17/2023
摘要： A semi-solid metal alloy injection feed system for reduced inclusion injection molding comprises a substantially closed injection chamber for containing a billet of semi-solid metal alloy, and thrusting the billet through the injection chamber into a mold, wherein the injection chamber has a first section defined by a wall with an inner contour for mating with a bearing surface for reciprocating motion of the bearing surface within the first section, along a center axis of the injection chamber; and the injection chamber has an outlet in fluid communication with the mold, the outlet provided at an opening in the injection chamber that is offset with respect to the center axis, and is disposed at an angle of 90° to 125° from the center axis. There is no neck or throttling between the chamber and the outlet. A butt end trap is preferably formed that requires inclusions that are principally on a bottom side of the injector to travel a relatively long ways to enter the outlet.
摘要翻译：用于减少夹杂物注射成型的半固体金属合金注射进料系统包括用于容纳半固体金属合金坯料的基本封闭的注射室，并将坯料通过注射室推入模具，其中注射室具有第一由具有用于与轴承表面配合的内部轮廓的壁限定，用于沿着所述注射室的中心轴线在所述第一部分内的所述支承表面的往复运动; 并且所述注射室具有与所述模具流体连通的出口，所述出口设置在所述注射室中的相对于所述中心轴线偏移的开口处，并且设置成与所述中心轴线成90°至125°的角度。室和出口之间没有颈部或节流。优选地形成对接端陷阱，其需要主要位于喷射器的底侧上的夹杂物以相对较长的方式行进以进入出口。

78. 发明申请

US20110186260A1 Thixotropic Injector with Improved Annular Trap 失效
标题翻译：具有改进的环形陷阱的触变注射器
公开(公告)号：US20110186260A1
公开(公告)日：2011-08-04
申请号：US12786824
申请日：2010-05-25
申请人： Chang-Qing Zheng , Dany Drolet
发明人： Chang-Qing Zheng , Dany Drolet
IPC分类号： B22D17/00 , B22D27/08 , B22D17/30
CPC分类号： B22D17/203 , B22D17/007 , B22D35/04 , B22D43/00
摘要： By blocking an angular extent of an annular skimming trap used for semi-solid injection, a notable reduction in lenticular defects and porosity are observed. The blocking can be performed by a ring having dimensions to completely occlude a prior art annular skimming trap throughout the angular extent, and providing complete and/or partial flow across the ring throughout the rest of the angular extent. Preferably an outlet to the ring trap includes a chamfered edge and/or a deflector for encouraging flow of the contaminated semi-solid material into the trap.
摘要翻译：通过阻挡用于半固体注射的环形撇取阱的角度范围，观察到透镜状缺陷和孔隙度的显着减少。可以通过具有尺寸的环来执行阻挡，所述环具有在整个角度范围内完全闭塞现有技术的环形撇渣阱，并且在角度范围的整个其余部分中提供穿过环的完整和/或部分流动。优选地，环形诱捕器的出口包括倒角边缘和/或偏转器，用于促使污染的半固体材料流入陷阱。

79. 发明申请

US20100145677A1 System and Method for Making a User Dependent Language Model 审中-公开
标题翻译：制作用户依赖语言模型的系统和方法
公开(公告)号：US20100145677A1
公开(公告)日：2010-06-10
申请号：US12396933
申请日：2009-03-03
申请人： Chang-Qing Shu
发明人： Chang-Qing Shu
IPC分类号： G06F17/27 , G06F17/30
CPC分类号： G06F16/313
摘要： A language model for a speech recognition engine is made based on user-viewed data files. The data files are reviewed and texts are extracted therefrom. The language model is generated based on the extracted texts. Transcriptions of previous user statements are not required. Different weighting factors can be applied to elements of the extracted texts based on the nature of the data files. The weighting factors are then considered during generation of the language model. A user dependent and application independent language model can be created prior to initial use of the speech recognition engine.
摘要翻译：语音识别引擎的语言模型基于用户观看的数据文件进行。审查数据文件并从中提取文本。语言模型基于提取的文本生成。以前的用户语句的转录不是必需的。基于数据文件的性质，可以将不同的加权因子应用于提取文本的元素。然后在语言模型的生成期间考虑加权因子。可以在语音识别引擎的初始使用之前创建用户依赖的和与应用无关的语言模型。

80. 发明授权

US07425537B2 SH2 domain binding inhibitors 失效
标题翻译： SH2结构域结合抑制剂
公开(公告)号：US07425537B2
公开(公告)日：2008-09-16
申请号：US10517717
申请日：2003-06-26
申请人： Terrence R Burke, Jr. , Chang-Qing Wei , Zhen-Dan Shi , Yang Gao
发明人： Terrence R Burke, Jr. , Chang-Qing Wei , Zhen-Dan Shi , Yang Gao
IPC分类号： A61K38/12 , C07K5/12 , C07K1/00
CPC分类号： C07F9/6515 , C07K5/06026 , C07K5/06191
摘要： Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.
摘要翻译：公开了用于SH2结构域结合抑制的化合物，例如式（I）的化合物，其中R 1是亲脂体; R 2与苯环组合是苯基磷酸酯模拟基团或被保护的苯基磷酸酯模拟基团; R 3是氢，叠氮基，氨基，羧基烷基，烷氧基羰基烷基，氨基羰基烷基或烷基羰基氨基，其中R 3的烷基部分可以任选地被选自由卤素，羟基，羧基，氨基，氨基烷基，烷基，烷氧基和酮基组成; R 6是连接体; AA是氨基酸; n为1〜6; 或其盐。构象化合物提供与SH2结构域蛋白质增强的结合亲和力。还公开了用于抑制SH2结构域与磷蛋白结合的药物组合物和方法。

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