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71. 发明授权

US10781439B2 Extraction of cfDNA from biological samples 有权
公开(公告)号：US10781439B2
公开(公告)日：2020-09-22
申请号：US15473672
申请日：2017-03-30
申请人： Covaris, Inc.
发明人： Hamid Khoja , Hans-Ulrich Thomann , James A. Laugharn, Jr.
IPC分类号： C12N15/10 , C12N13/00
摘要： Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.

72. 发明授权

US10473566B2 Blood sampling, storage and treatment apparatus 有权
公开(公告)号：US10473566B2
公开(公告)日：2019-11-12
申请号：US15287828
申请日：2016-10-07
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr. , Hans-Ulrich Thomann
IPC分类号： G01N1/40 , B01L3/00 , A61B5/15
摘要： Systems and methods for collecting blood and other liquid samples. A sample holder may include a cap and porous element arranged to receive a blood or other liquid sample. The porous element may be stored in a sealed container, e.g., immediately after blood sample collection, and the sample dried while sealed in the container.

73. 发明授权

US10280395B2 Acoustic energy treatment using phase change couplant 有权
公开(公告)号：US10280395B2
公开(公告)日：2019-05-07
申请号：US14970969
申请日：2015-12-16
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr.
IPC分类号： C12N13/00 , C12N1/00 , C12N1/06 , C12M1/33 , C12M1/00
摘要： Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The phase change couplant may be solid before and after treatment, but liquid during treatment to improve acoustic energy transmission charactersitics.

74. 发明授权

US10168258B2 Sample holder for acoustic treatment 有权
公开(公告)号：US10168258B2
公开(公告)日：2019-01-01
申请号：US15480556
申请日：2017-04-06
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr.
IPC分类号： G01N1/28 , G01N1/40
摘要： A sample holder and method for separating components of a viscous sample, such as a sputum sample, in a vessel having a porous element. Liquid may be flowed through the vessel during acoustic energy treatment, which may disrupt the viscous sample. Smaller components of the sample may pass through the porous element with liquid introduced into the vessel. Larger components, such a microbes, may be captured by the porous element and may remain intact and viable for subsequent analysis. The porous element may be removable from the vessel to recover the microbes.

75. 发明申请

US20180037883A1 METHODS AND APPARATUSES FOR PROCESSING BLOOD AND OTHER BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20180037883A1
公开(公告)日：2018-02-08
申请号：US15730088
申请日：2017-10-11
申请人： Covaris, Inc.
发明人： James A. LAUGHARN, JR. , Austin PURDY
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q1/686 , C12Q2523/303 , G01N1/34 , C12Q2523/301 , C12Q2525/204 , C12Q2527/101 , C12Q2531/113 , C12Q2565/607
摘要： Systems and methods for the high yield extraction and recovery of higher quality target molecule(s) (e.g., DNA, RNA, protein, lipids, metabolites) from blood spots. High quality DNA recovered from dried blood spots can be an input source for high throughput analytical methods, such as for polymerase chain reaction (e.g., qPCR) and/or next generation sequencing (NGS). In various embodiments, at least 20.0 nanograms of nucleic acid (e.g., DNA, RNA), or at least 8.0 milligrams of protein, may be extracted and recovered per an amount of dried blood corresponding to approximately 5 microliters of fresh blood. In some embodiments, a majority (e.g., greater than 50%, greater than 60%, up to 95-100%) of the nucleic acid that is extracted and recovered from the blood spot via focused acoustics may be of a quality suitable for amplification via PCR or NGS.

76. 发明授权

US09776149B2 Compositions and methods for preparing nanoformulations and systems for nano-delivery using focused acoustics 有权
公开(公告)号：US09776149B2
公开(公告)日：2017-10-03
申请号：US13724796
申请日：2012-12-21
申请人： Covaris, Inc.
发明人： Carl Beckett , James A. Laugharn, Jr. , Srikanth Kakumanu
IPC分类号： B01J2/18 , B01F11/02 , B01F3/08
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.

77. 发明申请

US20170102299A1 BLOOD SAMPLING, STORAGE AND TREATMENT APPARATUS 审中-公开
公开(公告)号：US20170102299A1
公开(公告)日：2017-04-13
申请号：US15287828
申请日：2016-10-07
申请人： Covaris, Inc.
发明人： James A. LAUGHARN, JR. , Hans-Ulrich THOMANN
IPC分类号： G01N1/40 , A61B5/15 , B01L3/00
摘要： Systems and methods for collecting blood and other liquid samples. A sample holder may include a cap and porous element arranged to receive a blood or other liquid sample. The porous element may be stored in a sealed container, e.g., immediately after blood sample collection, and the sample dried while sealed in the container.

78. 发明授权

US09606031B2 Systems and methods for transfer and processing of biological samples 有权
公开(公告)号：US09606031B2
公开(公告)日：2017-03-28
申请号：US14338976
申请日：2014-07-23
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr. , Guillaume Durin , Jonathan Sampson , Austin Purdy
IPC分类号： A61B10/00 , G01N1/30 , G01N1/02 , G01N1/31 , G01N1/40
CPC分类号： G01N1/30 , G01N1/02 , G01N1/31 , G01N2001/028 , G01N2001/4094
摘要： Systems and methods are described for transfer of tissue samples from a substrate to a vessel, for subsequent processing (e.g., focused acoustic treatment) within the vessel. A transfer apparatus, having a transfer end and a handle end, may be used to collect a sample material from the substrate. When the sample material is collected from the substrate, the transfer end may be placed within a vessel for treatment of the sample material while the transfer end is also located within the vessel. In some embodiments, the transfer end may be decoupled or otherwise separated from the handle end so that only the transfer end portion of the transfer apparatus is located within the vessel during treatment.

79. 发明申请

US20160186126A1 ACOUSTIC ENERGY TREATMENT USING PHASE CHANGE COUPLANT 审中-公开
标题翻译：使用相位变化耦合的声学能量治疗
公开(公告)号：US20160186126A1
公开(公告)日：2016-06-30
申请号：US14970969
申请日：2015-12-16
申请人： Covaris, Inc.
发明人： James A. Laugharn, JR.
IPC分类号： C12N1/06 , C12N13/00
CPC分类号： C12N1/066 , C12M45/02 , C12M47/06 , C12N13/00
摘要： Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The phase change couplant may be solid before and after treatment, but liquid during treatment to improve acoustic energy transmission charactersitics.
摘要翻译：用于通过使用至少相邻于样品容器的相变耦合剂将声能传递到样品进行处理的方法和装置。相变耦合剂在处理前后可能是固体，而在处理过程中液体可以改善声能传播特性。

80. 发明授权

US09335237B2 Systems and methods for acoustically processing tissues samples 有权
标题翻译：用于声学处理组织样品的系统和方法
公开(公告)号：US09335237B2
公开(公告)日：2016-05-10
申请号：US13911197
申请日：2013-06-06
申请人： Covaris, Inc.
发明人： James A. Laugharn, Jr.
IPC分类号： G01N33/00 , G01N1/28 , G01N1/40
CPC分类号： G01N1/286 , G01N1/2813 , G01N2001/4094
摘要： Systems and methods for processing tissue samples using acoustic energy. The tissue sample may be collected and placed on a substrate (e.g., microscope slide), or other sample holder. A transfer substrate may be positioned on the other side of the sample opposite the substrate. A microscope incorporated with the acoustic treatment system may be used to view, identify and select a portion of the sample to be transferred from the initial substrate to the transfer substrate. The selected portion of the sample is exposed to focused acoustic energy while disposed between the two substrates. The focused acoustic energy has characteristics (e.g., high frequency, small focal zone) that may be effective to transfer the selected portion of the sample from the initial substrate to the transfer substrate. Such transfer may occur with little to no damage to the sample, for example, at low temperature isothermal conditions and/or little to no cavitation of or around the sample.
摘要翻译：用声能处理组织样本的系统和方法。可以收集组织样品并将其放置在基底（例如显微镜载片）或其他样品保持器上。转移衬底可以位于与衬底相对的样品的另一侧上。结合有声学处理系统的显微镜可以用于观察，识别和选择要从初始衬底转移到转移衬底的样品的一部分。样品的所选部分暴露于聚焦的声能同时设置在两个基底之间。聚焦的声能具有特征（例如，高频率，小焦点区域），其可以有效地将样品的选定部分从初始衬底转移到转移衬底。这种转移可能对样品几乎没有损坏，例如在低温等温条件下和/或样品的周围或周围很少甚至没有气穴。

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