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71. 发明申请

WO2010002254A1 MARKERS FOR DETECTION OF LEGIONELLA PNEUMOPHILA STRAINS 审中-公开
标题翻译：用于检测LEGIONELLA PNEUMOPHILA菌株的标记物
公开(公告)号：WO2010002254A1
公开(公告)日：2010-01-07
申请号：PCT/NL2009/050391
申请日：2009-07-01
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , VITENS N.V. , SCHUREN, Frank Henri Johan , ATSMA, Waatze Aize
发明人： SCHUREN, Frank Henri Johan , ATSMA, Waatze Aize
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y02A50/451
摘要： The invention relates to a method of detecting Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to one or morespecific sequence markers, as identified by SEQ ID NO:1 through SEQ ID NO:10 or homologues thereof or in an immunoassay with antibodies specifically recognizing the amino acid sequence of SEQ ID NO: 11 and/or 12. The invention further relates to a kit of parts comprising an array and reference materials for performing a method of the invention.
摘要翻译：本发明涉及通过将疑似含有军团菌的样品的基因组DNA与SEQ ID NO：1至SEQ ID NO：10所鉴定的或其同系物或免疫测定法鉴定的一种或多种特异性序列标记物进行杂交来检测嗜肺军团杆菌菌株的方法具有特异性识别SEQ ID NO：11和/或12的氨基酸序列的抗体。本发明还涉及包含用于实施本发明方法的阵列和参考材料的试剂盒。

72. 发明申请

WO2009154465A1 COUPLED CAVITY LASER DIODE FOR GENERATING CHAOTIC SIGNALS 审中-公开
标题翻译：用于产生气象信号的耦合孔径激光二极管
公开(公告)号：WO2009154465A1
公开(公告)日：2009-12-23
申请号：PCT/NL2009/050367
申请日：2009-06-19
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , YOUSEFI, Mirvais
发明人： YOUSEFI, Mirvais
IPC分类号： H01S5/065 , H01S5/10 , H01S5/125
CPC分类号： H01S5/1021 , H01S5/0617 , H01S5/0622 , H01S5/065 , H01S5/0656 , H01S5/0658 , H01S5/101 , H01S5/1032 , H01S5/1039 , H01S5/125 , Y10T29/49002
摘要： A chaotic light generator device comprises laser structures (10, 12) integrated on a common substrate (14). Each laser structure comprises a ridge (100, 120) of light amplifying material that forms a waveguide extending between at least partly reflective surfaces (19). Each laser structure comprises an injection electrode (102, 122) for injecting electric current into the ridge of light amplifying material. The laser structures are mutually coupled for exchanging light. A current feed circuit (20, 22) is coupled to the electrodes and configured to apply mutually different current densities to the electrodes of the laser structures. Choosing different lengths of the laser structures and suitable current densities, chaotic light emission is achieved suitable for telecommunication. Ultrashort pulses result from coupling of Eigenmodes with relaxation oscillations.
摘要翻译：混沌光发生器装置包括集成在公共衬底（14）上的激光结构（10,12）。每个激光器结构包括形成在至少部分反射表面（19）之间延伸的波导的光放大材料的脊（100,120）。每个激光器结构包括用于将电流注入到光放大材料的脊中的注入电极（102,122）。激光结构相互耦合用于交换光。电流馈电电路（20,22）耦合到电极并且被配置为向激光结构的电极施加相互不同的电流密度。选择不同长度的激光器结构和合适的电流密度，实现混沌发光适合电信。超短脉冲是由本征模与耦合振荡产生的。

73. 发明申请

WO2009151327A1 BLOCK CO-POLYPEPTIDE AND HYDROGELS MADE THEREOF 审中-公开
标题翻译：块状聚丙烯和水泥
公开(公告)号：WO2009151327A1
公开(公告)日：2009-12-17
申请号：PCT/NL2009/050327
申请日：2009-06-11
申请人： STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK , DE WOLF, Frederik Anton , WERTEN, Marc Willem Theodoor , MOERS, Antonius Petrus Hendricus Anna , WOLBERT, Emil Johan Harald , EGGINK, Gerrit
发明人： DE WOLF, Frederik Anton , WERTEN, Marc Willem Theodoor , MOERS, Antonius Petrus Hendricus Anna , WOLBERT, Emil Johan Harald , EGGINK, Gerrit
IPC分类号： C07K14/78
CPC分类号： C07K14/78
摘要： Disclosed is a block co-polypeptide comprising at least two blocks T and at least one block S, with blocks T and S alternating, wherein each T independently denotes a Trimerizing Block being a polypeptide block capable of forming a thermoreversible collagen-like triple helix structure, and whereineach S independently denotes a Spacer Block S being a polypeptide neither forming a collagen-like triple helix. The block co-polypeptide is capable of forming a gel, and is useful as an animal-free, biocompatible substitute for gelatin. Uniquely, the polypeptide allows the independent controlling of the melting temperature of the gel, the stiffness and crosslink density of the gel, the lower critical gel-forming concentration related to the length of the molecules, and unrelated (e.g. biological, physiological, pharmaceutical or signalling) functions of the molecule.
摘要翻译：公开了包含至少两个嵌段T和至少一个具有嵌段T和S交替的嵌段S的嵌段共 - 多肽，其中每个T独立地表示三聚体嵌段，其是能够形成热可逆性胶原样三螺旋结构的多肽嵌段并且其中S独立地表示间隔块S是不形成胶原样三螺旋的多肽。嵌段共 - 多肽能够形成凝胶，并且可用作明胶的无动物的生物相容性替代物。独特地，多肽允许独立控制凝胶的熔融温度，凝胶的刚度和交联密度，与分子长度相关的较低的临界凝胶形成浓度以及不相关的（例如生物，生理学，制药或信号）功能。

74. 发明申请

WO2009145632A1 AN INSTRUMENT FOR MINIMALLY INVASIVE SURGERY 审中-公开
标题翻译：最小手术手术仪器
公开(公告)号：WO2009145632A1
公开(公告)日：2009-12-03
申请号：PCT/NL2009/050299
申请日：2009-05-29
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , VLEUGELS HOLDING B.V. , VAN DEN DOOL, Teunis Cornelis , KRAMER, Geerten Frans Ijsbrand , TABAK, Erik , ODERWALD, Michiel Peter
发明人： VAN DEN DOOL, Teunis Cornelis , KRAMER, Geerten Frans Ijsbrand , TABAK, Erik , ODERWALD, Michiel Peter
IPC分类号： A61B17/00
CPC分类号： A61B17/29 , A61B2017/2939 , A61B2017/294 , A61B2090/065
摘要： The invention relates to an instrument, preferably for minimally invasive surgery,comprising a frame (27) having a proximal end and a distal end, a first working element (4) having a first origin located at the distal end and a second working element (5) having a second origin and being arranged at the distal end cooperating with the first working element, a force sensor for measuring a force exerted on at least one of the saidthe first and the second working elements, wherein the distal end of the frame comprises an opening (23) between the first origin and the second origin, the force sensor being arranged on the frame in a vicinity of the opening.
摘要翻译：本发明涉及一种优选用于微创手术的器械，包括具有近端和远端的框架（27），具有位于远端的第一原点的第一工作元件（4）和第二工作元件（ 5）具有第二原点并且布置在与第一工作元件配合的远端处;力传感器，用于测量施加在所述第一和第二工作元件中的至少一个上的力，其中框架的远端包括在第一原点和第二原点之间的开口（23），力传感器布置在开口附近的框架上。

75. 发明申请

WO2009145628A1 LIGHT DETECTION MODULE FOR STAR TRACKING 审中-公开
标题翻译：用于追踪灯的光检测模块
公开(公告)号：WO2009145628A1
公开(公告)日：2009-12-03
申请号：PCT/NL2009/050294
申请日：2009-05-27
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , DUIVENVOORDE, Tom , OUWERKERK, Bastiaan Robert
发明人： DUIVENVOORDE, Tom , OUWERKERK, Bastiaan Robert
IPC分类号： G01S3/86
CPC分类号： G01S3/7867 , G01S3/7861
摘要： Light detector module for star tracking, comprising at least two detectors (1,1'), each mounted at the bottom of a protection case (2,2'), the axes (3,3') of which protection cases being located within a common plane Pl and extending in a first angle area Al between a first inclination angle α to a second inclination angle β. The end of each protection case is truncated by mainly of at least nearby parallel truncation planes P2, P2' which are mainly perpendicular to said plane Pl and which, moreover, incline, for each protection case, under a third inclination angle γ being within said first angle area Al. preferably, the third inclination angle γ is between a second angle area A2, mainly extending around the value (α + β) / 2, e.g. between the value ((α + β) / 2) - 15°) and ((α + β) / 2) + 15°), or to provide module symmetry equal to (α + β) / 2. Preferably, the end of each protection case are truncated by nearby parallel truncation planes P2, P2', however, having a small positive deviation angle ε e.g. between 0 and 5°.
摘要翻译：用于星形跟踪的光检测器模块，包括至少两个检测器（1,1'），每个检测器（1,1'）安装在保护壳体（2,2'）的底部，保护壳体位于其内的轴线（3,3'）公共平面P1，并且在第一倾斜角度α到第二倾斜角度β之间的第一角度区域A1中延伸。每个保护壳的端部主要由主要垂直于所述平面P1的至少附近的平行截头平面P2，P2'截断，并且此外，对于每个保护壳体，在第三倾斜角度θ处倾斜。在所述第一角度区域A1内。优选地，第三倾斜角θ 在第二角度区域A2之间，主要围绕值（a +β）/ 2延伸，例如。（（a +ß）/ 2）-15°）和（（a +ß）/ 2）+ 15°之间），或提供等于（a +ß）/ 2的模块对称性。每个保护壳体由附近的平行截头平面P2，P2'截断，然而，具有小的正偏移角e，例如，介于0和5°之间。

76. 发明申请

WO2009142498A2 COUNTERMOUNT, TAPPING APPARATUS AND METHOD FOR REGULATING THE TEMPERATURE OF BEVERAGE 审中-公开
标题翻译：计数器，调节装置和调节饮料温度的方法
公开(公告)号：WO2009142498A2
公开(公告)日：2009-11-26
申请号：PCT/NL2009/050281
申请日：2009-05-22
申请人： HEINEKEN SUPPLY CHAIN B.V. , BAX, Bart Jan
发明人： BAX, Bart Jan
IPC分类号： F25D31/00 , B67D1/08
CPC分类号： F25D31/002 , B67D1/06 , B67D1/0864 , B67D1/0867 , B67D1/0872 , B67D1/0884 , B67D2210/00031 , B67D2210/00047 , B67D2210/00104
摘要： A countermount, provided with a jacket and a passage, wherein the jacket is provided with a supply and a discharge for a cooling fluid and the passage extends between an inlet and a tap, wherein within the passage a beverage line is provided which extends at least between the inlet and the tap, wherein between at least a part of a wall of the passage and the beverage line, a temperature regulating space and/or a temperature regulating element is provided.
摘要翻译：具有夹套和通道的对位装置，其中所述护套设置有用于冷却流体的供应和排出物，并且所述通道在入口和抽头之间延伸，其中在所述通道内提供至少延伸的饮料管线在入口和抽头之间，其中在通道的壁的至少一部分和饮料管线之间，设置有温度调节空间和/或温度调节元件。

77. 发明申请

WO2009142486A1 COOLING APPARATUS AND METHOD FOR COOLING HOLDERS 审中-公开
标题翻译：冷却装置和冷却夹具的方法
公开(公告)号：WO2009142486A1
公开(公告)日：2009-11-26
申请号：PCT/NL2009/050269
申请日：2009-05-20
申请人： HEINEKEN SUPPLY CHAIN B.V. , VOSS, Hans-Peter , BLOM, Patrick Johannes
发明人： VOSS, Hans-Peter , BLOM, Patrick Johannes
IPC分类号： F25D31/00
CPC分类号： F25D31/008 , F25D3/10
摘要： A cooling apparatus for holders such as glasses, provided with a gas source (2) in which gas under pressure is stored, a pipe (3) and a spray opening (4), wherein the pipe is included between the spray opening and the gas source, for passing gas under pressure from the gas source to the spray opening, wherein a cooling (30) is provided which extends along and/or around at least a part of the pipe.
摘要翻译：一种用于诸如玻璃的保持器的冷却装置，其设置有储存有压力气体的气体源（2），管道（3）和喷射开口（4），其中管道包括在喷雾口和气体源，用于将压力下的气体从气体源传递到喷雾开口，其中提供沿管和/或围绕管的至少一部分延伸的冷却（30）。

78. 发明申请

WO2009142474A1 GENETIC MARKERS PREDICTING AGE AT MENOPAUSE 审中-公开
标题翻译：遗传标记预测年龄在MENOPAUSE
公开(公告)号：WO2009142474A1
公开(公告)日：2009-11-26
申请号：PCT/NL2008/050308
申请日：2008-05-23
申请人： ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM , KING'S COLLEGE LONDON , UITTERLINDEN, Andreas Gerardus , STOLK, Lisette , SPECTOR, Timothy David , ZHAI, Guangju
发明人： UITTERLINDEN, Andreas Gerardus , STOLK, Lisette , SPECTOR, Timothy David , ZHAI, Guangju
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/156
摘要： The present relates to a method of predicting the age at natural menopause in a female individual comprising detecting at least one SNP in a gene selected from the group consisting of CLCA4, KALRN, TOPBPl, the gene for hypothetical protein FLJ16641, VCAN, MCTPl, BAI3, AGR2, LSM5, SEMA3E, CSMDl, CPA6, LINGO2, the gene for hypothetical protein C9orf85, EHMTl, ADARB2, DNA2L, MGMT, SPATA19, the gene for hypothetical protein LOC146167, MSI2, BRSKl, SUV4-20H2, HSPBl, and SCARF2.
摘要翻译：本发明涉及一种预测女性个体天然绝经年龄的方法，包括检测选自CLCA4，KALRN，TOPBP1，假想蛋白FLJ16641，VCAN，MCTP1，BAI3的基因中的至少一种SNP ，AGR2，LSM5，SEMA3E，CSMD1，CPA6，LINGO2，假定蛋白C9orf85，EHMT1，ADARB2，DNA2L，MGMT，SPATA19的基因，假定蛋白LOC146167，MSI2，BRSK1，SUV4-20H2，HSPB1和SCARF2的基因。

79. 发明申请

WO2009139626A1 INCREASED PRODUCTION OF HEALTH-PROMOTING COMPOUNDS IN PLANTS 审中-公开
标题翻译：增加生产健康促进化合物在植物
公开(公告)号：WO2009139626A1
公开(公告)日：2009-11-19
申请号：PCT/NL2009/050253
申请日：2009-05-13
申请人： EXPRESSIVE RESEARCH B.V. , DE BOER, Anne, Douwe , PASSARINHO, Paul, Alexandre
发明人： DE BOER, Anne, Douwe , PASSARINHO, Paul, Alexandre
IPC分类号： C12N15/82 , A01H5/00 , C12N15/54
CPC分类号： C12N15/8251 , C07K14/415 , C12N9/12 , C12N9/1205 , C12N15/8243 , C12N15/825
摘要： The present invention relates to a method to enhance the health-promoting capacity of a plant by increasing expression of a regulatory gene product, preferably wherein said regulatory gene product is a receptor kinase, more preferably a RKS receptor or a mutein thereof or a chimeric RKS receptor. Such a method comprises providing a plant with a nucleotide sequence encoding said RKS receptor, but alternatively also a sequence encoding a truncated RKS protein can be used. Said RKS gene can be chosen from the group consisting of RKS subgroup I (RKS1, RKS4, RKS5, RKS7, RKSIl, and RKS 14), more specifically RKS4 and truncated RKS4 and chimeric receptors comprising the extracellular domain of RKS 4. A further preferred embodiment is a method according to the invention wherein enhancing the health-promoting capacity of a plant comprises production in said plant of health-promoting substances selected from the group of polyphenols, glucosinolates, isoprenoids, and GABA and analogs, more preferably chosen from the group consisting of quercetin, kaempferol, sinapic acid, gallic acid, GABA and sinigrin. In another embodiment the invention is related to a method to produce a health-promoting substance in a plant by introducing into said plant a gene coding for a regulatory gene product, preferable a receptor kinase, more preferably an RKS gene. Further part of the invention is the use of an RKS gene for the production of health-promoting substances in a plant. Also part of the invention is a plant with an enhanced health-promoting capacity produced by the method according to the invention.
摘要翻译：本发明涉及通过增加调节基因产物的表达来增强植物的健康促进能力的方法，优选其中所述调节基因产物是受体激酶，更优选RKS受体或其突变蛋白或嵌合RKS 受体。这样的方法包括向植物提供编码所述RKS受体的核苷酸序列，但也可以使用编码截短的RKS蛋白的序列。所述RKS基因可以选自RKS亚组I（RKS1，RKS4，RKS5，RKS7，RKSI1和RKS14），更具体地说是RKS4和截短的RKS4以及包含RKS4细胞外结构域的嵌合受体。另外优选的实施方案是根据本发明的方法，其中增强植物的健康促进能力包括在所述植物中生产选自多酚，硫代葡萄糖苷，类异戊二烯和GABA的类似物的健康促进物质，更优选选自组由槲皮素，山奈酚，芥子酸，没食子酸，GABA和sinigrin组成。在另一个实施方案中，本发明涉及通过向所述植物中引入编码调节基因产物，优选受体激酶，更优选RKS基因的基因来在植物中产生健康促进物质的方法。本发明的另一部分是RKS基因在植物中生产健康促进物质的用途。本发明的另一部分是通过根据本发明的方法生产的具有增强的健康促进能力的植物。

80. 发明申请

WO2009134127A1 COMPOSITE MICROPHONE, MICROPHONE ASSEMBLY AND METHOD OF MANUFACTURING THOSE 审中-公开
标题翻译：复合麦克风，麦克风组件及其制造方法
公开(公告)号：WO2009134127A1
公开(公告)日：2009-11-05
申请号：PCT/NL2009/050224
申请日：2009-04-24
申请人： NEDERLANDSE ORGANISATOE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO , GELINCK, Gerwin Hermanus , SCHOO, Harmannus Franciscus Maria
发明人： GELINCK, Gerwin Hermanus , SCHOO, Harmannus Franciscus Maria
IPC分类号： H04R1/32 , H04R19/01 , H04R29/00 , H04R19/00 , H04R3/06 , H05K1/00
CPC分类号： H04R1/326 , H04R3/06 , H04R19/005 , H04R19/016 , H04R2201/401
摘要： A composite microphone comprises a flexible and stretchable substrate (22, 122, 250, 350, 450) with a grid of flexible and stretchable first and second conductors (31a,…,31e, 131a, 131g; 33a,…,33h, 133a, 133g). The first conductors (31a,…,31e, 131a, 131g) are arranged transverse to the second conductors (33a,…,33h, 133a, 133g). A plurality of acoustic sensors (40, 140) is each in connection with a respective pair of conductors in the grid.
摘要翻译：复合麦克风包括具有柔性和可拉伸的第一和第二导体（31a，31e，131a，131g; 33a，...，33a，133a，133g）的网格的柔性和可拉伸的基底（22,122,250,350,450）。第一导体（31a，31e，131a，131g）横向于第二导体（33a，...，33h，133a，133g）布置。多个声学传感器（40,140）各自与网格中相应的一对导体连接。

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