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61. 发明申请

US20040230044A1 MRI probes of membrane potential 失效
标题翻译：膜电位的MRI探针
公开(公告)号：US20040230044A1
公开(公告)日：2004-11-18
申请号：US10700712
申请日：2003-11-03
申请人： The Regents of the University of California
发明人： Angelique Louie , James Ross
IPC分类号： C07F005/00
CPC分类号： G01R33/5601 , A61K49/085 , A61K49/10 , A61K49/106 , A61K51/0446 , A61K51/0482 , A61K51/0497 , C07D491/10 , C07D491/107 , Y10T436/24
摘要： The invention provides methods and compositions for molecular resonance imaging of membrane potential. The compositions comprise an indicator moiety attached through an optional linker to a macrocycle component that binds a lanthanide. The indicator moiety changes conformation in response to alterations in membrane potential and alters the interaction of the bound lanthanide with water. This alteration produces a detectable change in MRI signal , notably the T1 value. A preferred indicator moiety is spiropyran as it exhibits membrane-potential driven interconversions between the closed-ring spiropyran conformer and the extended merocyanine conformer. A preferred macrocycle is DO3A, known to bind gadolinium and an established MRI contrast agent. The methods of the invention comprise in vivo and in vitro uses of compositions of the invention to obtain MRI images that provide information about membrane potential.
摘要翻译：本发明提供膜电位分子共振成像的方法和组合物。组合物包含通过任选的接头连接到结合镧系元素的大环组分的指示剂部分。指示剂部分响应于膜电位的变化而改变构象，并改变结合的镧系元素与水的相互作用。这种改变产生了可检测的MRI信号变化，特别是T1值。优选的指示剂部分是螺吡喃，因为它表现出闭环螺吡喃构象异构体与延伸的部花青同系异构体之间的膜电位驱动的相互转换。已知的优选的大环是DO3A，已知结合钆和已建立的MRI造影剂。本发明的方法包括体内和体外使用本发明的组合物以获得提供关于膜电位的信息的MRI图像。

62. 发明申请

US20040209822A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20040209822A1
公开(公告)日：2004-10-21
申请号：US10844699
申请日：2004-05-13
申请人： SmithKline Beecham p.l.c.
发明人： Andrew Faller , Anne-Geraldine Rousseau , David Timothy MacPherson , Peter Henry Milner
IPC分类号： A61K038/04 , C07F005/00
CPC分类号： C07C311/13 , C07C259/06 , C07D307/52
摘要： Compounds of the formula (I): 1 wherein: X1 is alkyl, sulphonyl or carboxy; X2 is hydrogen or alkyl; R1 is arylmethyl or heterocycylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated by s-CD23.
摘要翻译：式（I）的化合物：其中：X 1是烷基，磺酰基或羧基; X 2是氢或烷基; R 1是芳基甲基或杂环基甲基; R 2是烷基，烯基，环烷基或环烯基; 和R 3是氢，烷基，烯基，炔基或芳基; 可用于治疗由s-CD23介导的疾病。

63. 发明申请

US20040146895A1 Luminescent metal ion complexes 有权
标题翻译：发光金属离子络合物
公开(公告)号：US20040146895A1
公开(公告)日：2004-07-29
申请号：US10690806
申请日：2003-10-21
申请人： Biosearch Technologies, Inc.
发明人： Ronald M. Cook , Matt Lyttle , Mary Katherine Johansson
IPC分类号： C12Q001/68 , C07H021/04 , C07F005/00
CPC分类号： C07F15/0053 , C07B2200/11 , C09B56/00 , C09B57/10 , Y10T436/143333
摘要： The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.
摘要翻译：本发明提供用于广泛的生物和化学研究的发光金属离子络合物。本发明的发光金属离子络合物包含与载体分子共价结合的金属离子螯合组分。还提供了制造和使用发光金属离子络合物的方法。

64. 发明申请

US20040096393A1 Therapeutic and diagnostic compounds, compositions, and methods 失效
标题翻译：治疗和诊断化合物，组合物和方法
公开(公告)号：US20040096393A1
公开(公告)日：2004-05-20
申请号：US10615484
申请日：2003-07-08
发明人： Alan R. Fritzberg
IPC分类号： A61K051/00 , C07F005/00
CPC分类号： A61K51/0497
摘要： The invention provides a complex comprising a) a compound formula I: 1 wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a radionuclide. The complexes are useful as diagnostic agents and as therapeutic agents. The invention also provides methods and intermediates useful for preparing the complexes of the invention, as well as therapeutic and diagnostic methods.
摘要翻译：本发明提供了一种复合物，其包含a）式I化合物：其中R1，X和n具有说明书中描述的任何值，或其药学上可接受的盐; 和b）放射性核素。该复合物可用作诊断剂和治疗剂。本发明还提供了可用于制备本发明复合物的方法和中间体，以及治疗和诊断方法。

65. 发明申请

US20040092726A1 Novel rare earth metal cryptates which are not very sensitive to the fluorescence quenching 失效
标题翻译：新型稀土金属隐窝，对荧光猝灭不敏感
公开(公告)号：US20040092726A1
公开(公告)日：2004-05-13
申请号：US10311534
申请日：2002-12-16
发明人： Herve Autiero , Herve Bazin , Gerard Mathis
IPC分类号： C07F005/00 , A61K049/00
CPC分类号： G01N33/582 , C07D471/22 , G01N2458/40
摘要： The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates which are not very sensitive to this fluorescence quenching, said rare earth metal cryptates comprising at least one pyridine radical which is substituted one or more times or unsubstituted. The invention also relates to novel rare earth metal cryptates which are not very sensitive to the fluorescence quenching caused by the measuring medium.
摘要翻译：本发明涉及一种在荧光测定法中减少由测量介质引起的荧光猝灭的方法，该方法是通过向所述稀土金属隐蔽剂介质中引入对该荧光猝灭不是非常敏感的所述稀土金属沉淀物，所述稀土金属隐蔽剂包含至少一种吡啶基取代一次或多次或未取代。本发明还涉及对由测量介质引起的荧光淬灭不是很敏感的新型稀土金属隐蔽剂。

66. 发明申请

US20040081616A1 Pendant fatty acid imaging agents 失效
标题翻译：吊坠脂肪酸成像剂
公开(公告)号：US20040081616A1
公开(公告)日：2004-04-29
申请号：US10405094
申请日：2003-04-01
申请人： Biostream, Inc.
发明人： John W. Babich , Kevin P. Maresca
IPC分类号： A61K051/00 , C07F005/00
CPC分类号： A61K51/0478 , A61K51/0402 , A61K51/0487 , C07F13/005
摘要： The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.
摘要翻译：本公开提供用于诊断成像（特别是心血管系统）的侧链脂肪酸化合物以及由其构成的试剂盒。本公开还提供了对心肌具有高特异性的成像剂的给药方法。

67. 发明申请

US20030228262A1 Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same 失效
标题翻译：蝎子状的侧环大环配体，其配合物及其组合物及其使用方法
公开(公告)号：US20030228262A1
公开(公告)日：2003-12-11
申请号：US10318821
申请日：2002-12-13
申请人： The Government of the United States of America , represented by the Secretary Department of Health , and Human Services
发明人： Martin W. Brechbiel , Hyun-Soon Chong
IPC分类号： A61K049/00 , C07F005/00
CPC分类号： C07D255/02 , A61K49/0002 , A61K51/0482
摘要： Substituted 1,4,7-triazacyclononane-N,Nnull,Nnull-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
摘要翻译：具有侧供体氨基的取代的1,4,7-三氮杂环壬烷-N，N'，N“ - 三乙酸化合物，其金属络合物，其组合物，以及用于诊断成像和治疗细胞病症的方法。

68. 发明申请

US20030228254A1 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US20030228254A1
公开(公告)日：2003-12-11
申请号：US10370092
申请日：2003-02-21
申请人： AMERSHAM HEALTH AS
发明人： Jo Klaveness , Anne Naevestad , Alan Cuthbertson
IPC分类号： A61K051/00 , C07F013/00 , C07F005/00 , A61K049/00
CPC分类号： A61K49/0056 , A61K49/0021 , A61K49/0043 , A61K49/0052 , A61K49/0091 , A61K49/10 , A61K49/103 , A61K49/223 , A61K51/04 , A61K51/0453 , A61K51/0478 , A61K51/0497 , A61K51/1255
摘要： The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.
摘要翻译：本发明提供了式（I）的物质组合物：VLR，其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是连接体部分或键，R是在体内成像中可检测的部分的条件是V是血管紧张素或肽血管紧张素衍生物或类似物，然后VLR不是非金属放射性核素取代肽（例如125 I取代的血管紧张素II），而LV不仅仅是简单的具有与其侧链键合的螯合剂酰胺的肽。这种物质的组成可用于影像心血管疾病和病症。

69. 发明申请

US20030219377A1 Compounds and methods for diagnosing and treating amyloid-related conditions 审中-公开
标题翻译：用于诊断和治疗淀粉样蛋白相关病症的化合物和方法
公开(公告)号：US20030219377A1
公开(公告)日：2003-11-27
申请号：US10421126
申请日：2003-04-23
申请人： Pharmacia & Upjohn Company
发明人： Thomas J. Raub , Geri A. Sawada , Steven P. Tanis , Gregory J. Fici , Allen Edwin Buhl , Donald Bainbridge Carter , Tiziano Bandiera , Jacqueline Lansen , Cesare Pellerano , Luisa Savini
IPC分类号： A61K051/00 , C07F005/00 , C07D215/38
CPC分类号： C07D215/38 , A61K31/47 , A61K45/06 , A61K51/0455 , A61K2300/00 , A61K31/00
摘要： The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.
摘要翻译：本发明提供了用于诊断和治疗淀粉样蛋白相关病症的方法和对其有用的化合物。本发明提供了检测，成像，监测，诊断和治疗以淀粉样蛋白原纤维结合或聚集为特征的病症。更具体地，本发明涉及使用喹啉腙化合物来诊断和治疗淀粉样变性病症以及抗氧化剂。

70. 发明申请

US20030216248A1 Catalyst composition and method of polymerization 审中-公开
公开(公告)号：US20030216248A1
公开(公告)日：2003-11-20
申请号：US10413333
申请日：2003-04-14
发明人： John H. Oskam
IPC分类号： C07F015/00 , C07F005/00 , C08F004/06 , C08F004/42 , B01J031/00
CPC分类号： C08F10/00 , C07F7/00 , C07F7/003 , C08F4/65908 , C08F4/65912 , C08F110/02 , C08F110/14 , C08F210/02 , C08F210/16 , C08F4/64148 , C08F4/659 , C08F2500/04 , C08F210/14
摘要： This invention relates to a composition of matter comprising the catalyst compound comprising a transition metal complexed with a facially coordinating tridentate bisamide ligand. The invention is also directed to a catalyst system or a supported catalyst system comprising this compound and an activator and to a process for using the catalyst system or supported catalyst system in a process for polymerizing olefin(s).

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