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61. 发明授权

US06197808B1 Methods for treating hyperplasia 有权
标题翻译：治疗增生的方法
公开(公告)号：US06197808B1
公开(公告)日：2001-03-06
申请号：US09418890
申请日：1999-10-15
申请人： Shu Jun Cheng , De Chang Wang , Yukihiko Hara , Insu P. Lee , Woong Shick Ahn
发明人： Shu Jun Cheng , De Chang Wang , Yukihiko Hara , Insu P. Lee , Woong Shick Ahn
IPC分类号： A61K3135
CPC分类号： A61K31/353 , A61K31/352
摘要： A method for a treatment of hyperplasia caused by papilloma virus, such as Condyloma acuminata, which comprises concomitantly topically and orally administering at least one tea catechin. Tea catechins do not involve the risk of side-effects and may be easily administered by the patients themselves.
摘要翻译：一种用于治疗由乳头状瘤病毒引起的增生的方法，例如尖锐湿疣，其包括同时局部和口服施用至少一种茶儿茶素。茶儿茶素不涉及副作用的风险，并且可以容易地由患者自身施用。

62. 发明授权

US06194450B1 Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof 失效
标题翻译：多芳族杂环化合物及其组合物
公开(公告)号：US06194450B1
公开(公告)日：2001-02-27
申请号：US09121188
申请日：1998-07-23
申请人： Bruno Charpentier , Philippe Diaz , Philippe Nedoncelle
发明人： Bruno Charpentier , Philippe Diaz , Philippe Nedoncelle
IPC分类号： A61K3135
CPC分类号： A61Q19/00 , A61K8/498 , A61K8/671 , A61Q5/00 , A61Q7/00 , A61Q17/04 , A61Q19/08 , C07D311/58
摘要： Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): in which Z is a divalent radical selected from among —O—, —S— or —Nr′— and Ar is either a radical having the following structural formula (II): or a radical having the following structural formula (III): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
摘要翻译：新的药物/化妆活性多芳族杂环化合物具有结构式（I）：其中Z是选自-O - ， - S-或-Nr - 的二价基团，Ar是具有以下结构式的基团（II）：或具有以下结构式（III）的基团：并且可用于治疗各种疾病状态，无论是人类还是兽医，例如皮肤病学，风湿性，呼吸道，心血管和眼科疾病，以及对于哺乳动物皮肤和毛发状况/病症的治疗。

63. 发明授权

US06184218B2 Composition and methods employing it for the treatment of 5-HT-mediated disorders 失效
标题翻译：使用它来治疗5-HT介导的病症的组合物和方法
公开(公告)号：US06184218B2
公开(公告)日：2001-02-06
申请号：US09349590
申请日：1999-07-09
申请人： John Evenden , Seth-Olov Thorberg
发明人： John Evenden , Seth-Olov Thorberg
IPC分类号： A61K3135
CPC分类号： A61K31/35 , A61K31/445 , A61K31/55 , A61K31/34 , A61K31/135 , A61K2300/00
摘要： The invention relates to a composition comprising a first component (a) which is (R)-3N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate and a second component (b) which is 1-[3-(dimethylamino)propyl]-1-(p-fluorophenyl)-5-phthalancarbonitrile, as the racemate or an enantiomer thereof, in the form of the free base, or a pharmaceutically acceptable salt and/or solvate thereof The invention further concerns the preparation of the composition, pharmaceutical formulations containing said composition, and a method of treatment of affective disorders such as mood disorders and anxiety disorders with said composition, as well as a kit containing said composition.
摘要翻译：本发明涉及包含（R）-3N，N-二环丁基氨基-8-氟-3,4-二氢-2H-1-苯并吡喃-5-甲酰胺氢（2R，3R）的第一组分（a） - 酒石酸盐一水合物和第二组分（b），其为游离碱形式的1- [3-（二甲基氨基）丙基] -1-（对氟苯基）-5-邻苯二甲酰亚胺作为外消旋体或其对映异构体，或其药学上可接受的盐和/或溶剂化物。本发明还涉及组合物的制备，含有所述组合物的药物制剂，以及用所述组合物治疗情绪障碍（例如情绪障碍和焦虑症）的方法，以及包含所述组合物的试剂盒。

64. 发明授权

US06812245B2 Polycylic xanthones and their use 失效
标题翻译：多晶呫吨酮及其用途
公开(公告)号：US06812245B2
公开(公告)日：2004-11-02
申请号：US10312343
申请日：2003-06-09
申请人： Librada Maria Cañedo , Dolores Garcia Gravalos , Francisco Romero , Fernando Espliego , Julia Perez-Baz
发明人： Librada Maria Cañedo , Dolores Garcia Gravalos , Francisco Romero , Fernando Espliego , Julia Perez-Baz
IPC分类号： A61K3135
CPC分类号： C07D493/04 , C07H17/08 , C12P17/181 , C12R1/03
摘要： A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.
摘要翻译：基于与名为IB-00208的化合物的新型海洋微生物属于Actinomadura属植物菌株PO13-046的分离，已经认识到一类新的抗肿瘤化合物。式（I）或（II）的类别，其中R 1可以是氢，酰基，烷基，烯基，芳基，苄基，碱金属和/或糖，R 2和R 3可以是氢，烷基或一起R 2和R 3形成不饱和键。这些化合物表现出一些有趣的活性，一些取消细胞系和革兰氏阳性菌。

65. 发明授权

US06809113B2 Antagonists of MCP-1 function and methods of use thereof 失效
标题翻译： MCP-1功能的拮抗剂及其使用方法
公开(公告)号：US06809113B2
公开(公告)日：2004-10-26
申请号：US10087208
申请日：2002-02-27
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Yoshiro Ishiwata , Shoji Yokochi , Yukiharu Matsumoto , Takuji Kakigami , Hideaki Inagaki , Takahito Jomori , Kouji Matsushima
IPC分类号： A61K3135
CPC分类号： C07D401/12 , C07D215/48 , C07D241/42 , C07D265/36 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译：作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病，克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。

66. 发明授权

US06750248B2 Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof 失效
标题翻译：从植物制备雌激素制剂和分离的雌激素化合物的方法及其用途
公开(公告)号：US06750248B2
公开(公告)日：2004-06-15
申请号：US10289079
申请日：2002-11-05
申请人： Eu Leong Yong , Sook Peng Yap
发明人： Eu Leong Yong , Sook Peng Yap
IPC分类号： A61K3135
CPC分类号： C07D407/04 , C07D311/30
摘要： Methods for preparing an estrogenic preparation and isolating estrogenic compounds from a plant, such as an Epimedium plant, are provided. Also provided are estrogenic compounds from Epimedium plant that have been isolated and characterized, and methods for their use in modulating estrogen receptors and in treating conditions mediated by estrogen receptors, such as menopause and estrogen-dependent cancers. Also provided are preparations from Epimedium that are enriched for estrogenic compounds, and methods for their use in modulating estrogen receptors and preventing and treating conditions that are mediated by estrogen receptors.
摘要翻译：提供了制备雌激素制剂并从植物如淫羊藿植物中分离雌激素化合物的方法。还提供了已被分离和表征的来自淫羊藿植物的雌激素化合物，以及它们用于调节雌激素受体和治疗由雌激素受体介导的病症如绝经期和雌激素依赖性癌症的方法。还提供了富含雌激素化合物的淫羊藿的制剂，以及它们用于调节雌激素受体以及预防和治疗由雌激素受体介导的病症的方法。

67. 发明授权

US06743770B2 Nutritional supplement for the management of stress 失效
标题翻译：营养补充用于管理压力
公开(公告)号：US06743770B2
公开(公告)日：2004-06-01
申请号：US09783709
申请日：2001-02-14
申请人： Stacey J. Bell , Judith Shabert
发明人： Stacey J. Bell , Judith Shabert
IPC分类号： A61K3135
CPC分类号： A23L33/19 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2250/54252 , A23V2250/54242 , A23V2250/065 , A23V2250/194
摘要： A nutritional supplement to be incorporated into the diet of an individual under stress (e.g., chronic stress) is described, comprising a low-glycemic-index carbohydrate, alpha lactalbumin-enriched whey protein, fat, caffeine and a source of 5-hydroxytryptophan (5-HTP). The supplement provides active food-grade ingredients to improve the management of stress and symptoms associated therewith.
摘要翻译：描述了要纳入个体在压力下（例如慢性应激）的饮食中的营养补充剂，其包含低血糖指数碳水化合物，富含α乳清白蛋白的乳清蛋白，脂肪，咖啡因和5-羟色氨酸的来源（ 5-HTP）。该补充剂提供活性食品级成分以改善与其相关的压力和症状的管理。

68. 发明授权

US06740676B2 4-[(8-ETHYNYL, 8-VINYL OR 8-ETHYNYL-METHYL)-6-CHROMANOYL]-BENZOIC AND 2-[4-[(8-ETHYNYL, 8-VINYL OR 8-ETHYNYL-METHYL)-6-CHROMANOYL]-PHENYL]-ACETIC ACID, THEIR ESTERS AND SALTS HAVING CYTOCHROME P450RAI INHIBITORY ACTIVITY 失效
标题翻译： 4 - [（8-乙基，8-乙烯基或8-乙酰基 - 甲基）-6-氯苯基] - 苯基和2- [4 - [（8-乙酰基，8-乙烯基或8-乙酰基 - 甲基）色氨酸] - 苯甲酸，其酯和具有细胞色素P450RAI抑制活性的盐
公开(公告)号：US06740676B2
公开(公告)日：2004-05-25
申请号：US10100638
申请日：2002-03-19
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Yang-Dar Yuan , Roshantha S. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Yang-Dar Yuan , Roshantha S. Chandraratna
IPC分类号： A61K3135
CPC分类号： C07D311/58
摘要： Compounds of Formula 1: wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism's native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism's native retinoic acid.
摘要翻译：式1的化合物：其中变量在本说明书中定义为具有细胞色素P450RAI-1和P450RAI-2抑制活性，并且适用于具有可用类视黄醇治疗的病症的哺乳动物或由生物体天然视黄酸。含有本发明化合物的制剂也可以与类维生素A和/或维生素A共同施用，以增强或延长含有类维生素A，维生素A或有机体天然视黄酸的药物的作用。

69. 发明授权

US06737439B2 Aromatase inhibitors from Broussonetia papyrifera 失效
标题翻译：来自Broussonetia papyrifera的芳香酶抑制剂
公开(公告)号：US06737439B2
公开(公告)日：2004-05-18
申请号：US10205029
申请日：2002-07-25
申请人： Alan Douglas Kinghorn , John M. Pezzuto , Dongho Lee , Krishna P. L. Bhat
发明人： Alan Douglas Kinghorn , John M. Pezzuto , Dongho Lee , Krishna P. L. Bhat
IPC分类号： A61K3135
CPC分类号： A61K31/37 , A61K31/12 , A61K31/235 , A61K31/353
摘要： A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.
摘要翻译：公开了一种癌症治疗的组合物和方法。该组合物和方法利用了具有芳香酶抑制特性的苦参碱提取物或其中包含的化合物作为哺乳动物（包括人）中的活性癌症化学预防和治疗剂。

70. 发明授权

US06723747B2 Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents 失效
标题翻译：取代的6H-DiBenzo [c，h]色烯作为雌激素剂
公开(公告)号：US06723747B2
公开(公告)日：2004-04-20
申请号：US10317163
申请日：2002-12-11
申请人： Richard E. Mewshaw , Richard J. Edsall , Stephen T. Cohn , Heather A. Harris , James C. Keith, Jr. , Leo M. Albert
发明人： Richard E. Mewshaw , Richard J. Edsall , Stephen T. Cohn , Heather A. Harris , James C. Keith, Jr. , Leo M. Albert
IPC分类号： A61K3135
CPC分类号： C07D409/04 , C07D311/78
摘要： This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式I的雌激素受体调节剂，其具有其中R1，R2，R3，R4R5，R6和R7如说明书中所定义的结构，或其药学上可接受的盐。

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