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61. 发明申请

WO1996028090A1 A METHOD OF MAGNETIC RESONANCE FOCUSED SURGICAL AND THERAPEUTIC ULTRASOUND 审中-公开
标题翻译：磁共振注射外科手术和治疗超声的方法
公开(公告)号：WO1996028090A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003054
申请日：1996-03-06
申请人： IMARX PHARMACEUTICAL CORP.
发明人： IMARX PHARMACEUTICAL CORP. , UNGER, Evan, C.
IPC分类号： A61B05/055
CPC分类号： G01R33/5601 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6911 , A61K47/6913 , A61K47/6925 , A61K49/103 , A61K49/16 , A61K49/1806 , A61K49/1839 , A61K49/1863 , A61K49/1866 , A61K49/1878 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , B82Y5/00 , G01R33/56308
摘要： A novel method of magnetic resonance focused surgical ultrasound by administering to a patient a magnetic resonance imaging (MRI) contrast medium comprising gas filled vesicles, then scanning the patient with MRI techniques, and then applying ultrasound to effect surgery. These methods may also use an MRI contrast medium comprising gaseous precursor filled vesicles which undergo a phase transition from a liquid to gas in vivo after administration. Additionally, the MRI contrast medium may comprise a therapeutic compound.
摘要翻译：通过向患者施用包含充满气体的囊泡的磁共振成像（MRI）造影剂，然后用MRI技术扫描患者，然后施加超声波以进行手术，来实现磁共振聚焦手术超声的新方法。这些方法还可以使用包含气体前体填充的囊泡的MRI造影剂，其在给药后在体内经历从液体到气体的相变。另外，MRI造影剂可以包含治疗化合物。

62. 发明申请

WO1996022731A1 CALCIUM/OXYANION-CONTAINING PARTICLES FOR USE IN MEDICAL DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于医学诊断成像的含钙/含氧化颗粒
公开(公告)号：WO1996022731A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000873
申请日：1996-01-24
申请人： MALLINCKRODT MEDICAL, INC.
发明人： MALLINCKRODT MEDICAL, INC. , NOSCO, Dennis , NEMA, Sandeep , KLIBANOV, Alexander, L. , ADZAMLI, Kofi
IPC分类号： A61B05/055
CPC分类号： B82Y5/00 , A61K49/0428 , A61K49/183 , A61K49/22 , Y10T436/24
摘要： The present invention provides new and structurally diverse particulates for use in magnetic resonance imaging and X-ray contrast imaging of body organs and tissues having the following general formula: CanMmXrYs, wherein M is a paramagnetic ion or stoichiometric mixture of metal ions having a valence of 2+ or 3+; X is a simple anion; Y is a tetrahedral oxyanion, or mixtures thereof; m is an integer greater than or equal to 1; n is an integer greater than or equal to 1; r and s are integers and are adjusted as needed to provide charge neutrality; and further comprising a polyalkoxy compound. Methods for using and making particles of the invention are also disclosed.
摘要翻译：本发明提供用于磁共振成像和身体器官和组织的X射线对比成像的新的和结构上不同的微粒，具有以下通式：CanMmXrYs，其中M是顺磁离子或化学计量的具有化合价 2+或3+; X是简单的阴离子; Y是四面体氧阴离子，或其混合物; m是大于或等于1的整数; n是大于或等于1的整数; r和s是整数，并根据需要进行调整以提供电荷中性; 并且还包含聚烷氧基化合物。还公开了使用和制造本发明颗粒的方法。

63. 发明申请

WO1996010359A1 CHELATE COMPLEX WITH HIGH CONSPICUITY FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的高粘度复合材料
公开(公告)号：WO1996010359A1
公开(公告)日：1996-04-11
申请号：PCT/US1995012693
申请日：1995-10-03
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , LEXA, Frank, L. , KACHUR, Alexander, V. , ROSENQUIST, Alan, C.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： A61B05/055
CPC分类号： A61K49/146 , A61K49/085 , A61K49/16
摘要： Constrast agents having improved contrast characteristics for use in imaging and non-imaging technologies are provided. Methods of synthesis and administration for the contrast agents are disclosed. A kit suitable for commercial sale is also provided.
摘要翻译：提供具有用于成像和非成像技术的具有改进的对比度特性的调整剂。公开了造影剂的合成和给药方法。还提供适合商业销售的套件。

64. 发明申请

WO1995034242A1 MAGNETIC RESONANCE IMAGING METHOD WITH PULSE SEQUENCE OPTIMISATION AND DEVICE FOR SUCH METHOD 审中-公开
标题翻译：具有脉冲序列优化的磁共振成像方法及其方法
公开(公告)号：WO1995034242A1
公开(公告)日：1995-12-21
申请号：PCT/IB1994000154
申请日：1994-06-14
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , VAN DER MEULEN, Peter , BRUIJNS, Jan
IPC分类号： A61B05/055
CPC分类号： G01R33/54 , G01R33/4833 , G01R33/543
摘要： A method for magnetic resonance imaging is described in which imaging sequences, consisting of RF- and gradient magnetic field pulses (RF, Gx, Gy, Gz) are optimised with respect to a relevant parameter (SAR, signal-to-noise, etc.) prior to applying the RF- and gradient pulse sequence to the object or patient (7) to be imaged. This reduces the amount of different sequences to a limited number of basic sequences from which an operator has to choose and allows adaptation of the sequence to the particular image to be obtained.
摘要翻译：描述了一种用于磁共振成像的方法，其中由相关参数（SAR，信噪比等）优化由RF和梯度磁场脉冲（RF，Gx，Gy，Gz）组成的成像序列），然后将RF-和梯度脉冲序列施加到待成像的对象或患者（7）上。这将不同序列的量减少到有限数量的基本序列，操作者必须从该序列中选择并允许将序列适配到要获得的特定图像。

65. 发明申请

WO1995027438A1 MAGNETIC RESONANCE IMAGING USING HYPERPOLARIZED NOBLE GASES 审中-公开
标题翻译：使用超高压NOBLE气体的磁共振成像
公开(公告)号：WO1995027438A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004175
申请日：1995-04-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY OFFICE OF RESEARCH AND PROJECT ADMINISTRATION
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY OFFICE OF RESEARCH AND PROJECT ADMINISTRATION , BALAMORE, Dilip , CATES, Gordon, D., Jr. , DRIEHUYS, Bastiaan , HAPPER, William , SAAM, Brian , WISHNIA, Arnold , ALBERT, Mitchell, S.
IPC分类号： A61B05/055
CPC分类号： G01R33/5601 , A61K49/1806 , A61K49/1815 , G01R33/282 , Y10T436/24
摘要： A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.
摘要翻译：通过核磁共振光谱法对惰性气体的空间分布进行成像的方法包括通过NMR光谱法检测至少一种惰性气体的空间分布，并产生稀有气体的所述空间分布的表示。稀有气体选自具有核自旋的惰性气体同位素，优选氙129和/或氦-3。惰性气体至少是热或平衡极化的，并且优选是超极化的，最优选通过在碱金属存在下的光学（激光）泵送或通过亚稳定性交换进行超极化。惰性气体空间分布的表示的产生包括空间分布的至少一个维度，优选2或3维度。惰性气体可以根据本发明在化学或生物系统中成像，优选在人或动物受试者或器官系统或组织中成像。此外，用于核磁共振成像至少一种稀有气体的空间分布的装置包括用于通过NMR光谱法成像惰性气体的装置，以及用于提供和/或存储可成像量的惰性气体，优选超极化氙129和/ 或氦-3。此外，医疗组合物包括有效体内麻醉和NMR成像功能的医学上可接受的双功能气体，包括至少一种惰性气体，优选超极化氙129和/或氦-3。

66. 发明申请

WO1995027437A1 MICROFLUIDIZATION OF CALCIUM/OXYANION-CONTAINING PARTICLES 审中-公开
标题翻译：含钙/含氧化物颗粒的微流化
公开(公告)号：WO1995027437A1
公开(公告)日：1995-10-19
申请号：PCT/US1994003276
申请日：1994-04-11
申请人： MALLINCKRODT MEDICAL, INC.
发明人： MALLINCKRODT MEDICAL, INC. , MEEH, Linda , CACHERIS, William, P.
IPC分类号： A61B05/055
CPC分类号： A61K49/225 , A61B90/39 , A61B2090/3925 , A61B2090/3954 , A61K33/32 , A61K49/1842
摘要： Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (
摘要翻译：使用微流化器制备固体磷灰石颗粒的方法，用于诸如磁共振成像，X射线和超声的医学诊断成像。合成所需的磷灰石颗粒，通过微流化器，并纯化以除去用于合成颗粒的过量碱，盐和其它材料。微流化器引起两个高压流在精确限定的微通道中以超高速度相互作用。制剂的微流化导致小（<5μm）和均匀的颗粒形成。涂层和净化（特别是通过切向流过滤），颗粒改善了颗粒的稳定性。

67. 发明申请

WO1995020352A1 MRI SYSTEM WITH TIME VARYING GRADIENT 审中-公开
标题翻译：具有时间变化梯级的MRI系统
公开(公告)号：WO1995020352A1
公开(公告)日：1995-08-03
申请号：PCT/US1995000791
申请日：1995-01-20
申请人： GENERAL ELECTRIC COMPANY
发明人： GENERAL ELECTRIC COMPANY , GLUSICK, Robert, Edward
IPC分类号： A61B05/055
CPC分类号： G01R33/561 , G01R33/446
摘要： An NMR system acquires data during the application of a readout gradient that varies in amplitude. The NMR signal is sampled uniformly in time and is mapped to NMR data which is sampled uniformly in k-space by a digital filter. Sets of stored filter coefficients adapt the digital filter to different readout gradient waveforms and different fields of view and image resolution.
摘要翻译： NMR系统在应用幅度变化的读出梯度时获取数据。 NMR信号在时间上均匀采样，并映射到通过数字滤波器在k空间中均匀采样的NMR数据。存储的滤波器系数的集合使数字滤波器适应不同的读出梯度波形和不同的视场和图像分辨率。

68. 发明申请

WO1995009564A1 COMPOSITIONS AND METHODS FOR MAGNETIC RESONANCE IMAGING, X-RAY IMAGING AND RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于磁共振成像，X射线成像和放射线测量的组合物和方法
公开(公告)号：WO1995009564A1
公开(公告)日：1995-04-13
申请号：PCT/US1994010999
申请日：1994-09-30
申请人： MALLINCKRODT MEDICAL, INC.
发明人： MALLINCKRODT MEDICAL, INC. , BEATY, Julie, A. , COOPER, Stephen , DUNN, T., Jeffrey
IPC分类号： A61B05/055
CPC分类号： G01R33/5601 , A61K49/0002 , A61K49/04 , A61K49/0447 , A61K49/189 , A61K51/1268 , B82Y5/00 , C07C229/16 , C07C2604/00 , C07K7/23
摘要： The present invention provides methods and compositions for improved magnetic resonance imaging and spectroscopy. The compositions are of the general formula: Cn-Lx-Gy, wherein n is about 60 to about 1,000; L is a bifunctional linker; x is from about 0 to about 12; G is a chelator; and Y is from about 0 to about 12. Also disclosed are diagnostic compositions and methods of performing diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the compositions of the invention and then exposing the warm-blooded animal to an imaging procedure.
摘要翻译：本发明提供用于改进磁共振成像和光谱学的方法和组合物。组合物具有以下通式：Cn-Lx-Gy，其中n为约60至约1,000; L是双官能接头; x为约0至约12; G是螯合剂; 并且Y为约0至约12.还公开了执行诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的本发明组合物，然后将温血动物暴露于成像程序。

69. 发明申请

WO1995008293A2 BREAST LOCALIZER 审中-公开
标题翻译：乳品本地化
公开(公告)号：WO1995008293A2
公开(公告)日：1995-03-30
申请号：PCT/US1994010651
申请日：1994-09-19
申请人： HUSSMAN, Karl, L.
IPC分类号： A61B05/055
CPC分类号： G01R33/58 , A61B17/3403 , A61B90/10 , A61B90/11 , A61B90/17 , A61B2017/00911 , A61B2017/3411 , A61B2090/3954 , G01R33/285

70. 发明申请

WO1995007653A1 SECOND SPHERE COMPLEXES AS RELAXATION AGENTS FOR IMAGE ENHANCEMENT IN MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：第二球形复合材料作为放大图像增强磁化谐振成像
公开(公告)号：WO1995007653A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010380
申请日：1994-09-14
申请人： THE UNIVERSITY OF TOLEDO
发明人： THE UNIVERSITY OF TOLEDO , DAVIES, Julian, A.
IPC分类号： A61B05/055
CPC分类号： G01R33/5601 , A61K49/06 , C07C309/42 , Y10S514/836 , Y10T436/24
摘要： A second sphere contrast enhancing agent for medical resonance imaging comprises a paramagnetic metal ion having catecholate ligands coordinated thereto and having water molecules hydrogen bonded to the catecholate ligands.
摘要翻译：用于医学共振成像的第二球形对比增强剂包括具有与其配位的儿茶酚酸盐配体并具有与儿茶酚酸盐配体键合的水分子的顺磁性金属离子。

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