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61. 发明授权

US08039246B2 Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal 有权
标题翻译：在哺乳动物中促进混合血液透析进入移植物或混合股动脉旁路移植物的内皮化的系统和方法
公开(公告)号：US08039246B2
公开(公告)日：2011-10-18
申请号：US12019533
申请日：2008-01-24
申请人： Michael Dancu
发明人： Michael Dancu
IPC分类号： A01N1/00 , A01N1/02 , C12M1/00 , C12M3/00
CPC分类号： G09B23/28 , G09B23/30 , Y10S623/915 , Y10S623/916 , Y10S623/921
摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.
摘要翻译：混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径样品架。方法的实施方案可以通过在有效促进内皮细胞形成的条件下将根据本发明的系统实施方案中放置混合血液透析入口移植物或混合股动脉旁路移植物来促进混合血液透析进入移植物或混合股动脉旁路移植物的内皮化在混合移植物的表面上的汇合单层。

62. 发明授权

US07759120B2 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US07759120B2
公开(公告)日：2010-07-20
申请号：US11515344
申请日：2006-09-01
申请人： Michael F. Wolf , Laurie A. Yunker , Paul V. Trescony
发明人： Michael F. Wolf , Laurie A. Yunker , Paul V. Trescony
IPC分类号： C12N11/08
CPC分类号： A61F2/062 , A61L27/16 , A61L27/3616 , A61L27/38 , A61L27/3808 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

63. 发明授权

US07611830B2 Device to lavage a blood vessel 有权
标题翻译：设备灌洗血管
公开(公告)号：US07611830B2
公开(公告)日：2009-11-03
申请号：US10257176
申请日：2001-04-10
申请人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
发明人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0247 , A61K9/0009 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/727 , A61K35/44 , A61K38/063 , A61K38/58 , Y10S623/916 , A61K2300/00
摘要： The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. The present invention also provides a device for perfusing tissues and organs with the solutions of the present invention.
摘要翻译：本发明提供了离体和原位保存组织和器官的组合物和方法。此外，本发明提供了可用于制备本发明的溶液的试剂盒。本发明还提供了用本发明的溶液灌注组织和器官的装置。

64. 发明申请

US20070110740A1 Composition and methods for tissue preservation 有权
标题翻译：组织保存的组成和方法
公开(公告)号：US20070110740A1
公开(公告)日：2007-05-17
申请号：US11510068
申请日：2006-08-25
申请人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
发明人： Hemant Thatte , Kunda Biswas , Shukri Khuri , Thomas Michel
IPC分类号： A61K38/48 , A61K31/727 , A61K31/375 , A61K38/05 , A61K31/198
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0247 , A61K9/0009 , A61K31/198 , A61K31/375 , A61K31/70 , A61K31/727 , A61K35/44 , A61K38/063 , A61K38/58 , Y10S623/916 , A61K2300/00
摘要： The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention.
摘要翻译：本发明提供了离体和原位保存组织和器官的组合物和方法。此外，本发明提供了可用于制备本发明的溶液的试剂盒。

65. 发明申请

US20060286664A1 Bioreactor for the Manufacture of Tissue Engineered Blood Vessels 有权
标题翻译：用于制造组织工程血管的生物反应器
公开(公告)号：US20060286664A1
公开(公告)日：2006-12-21
申请号：US11467519
申请日：2006-08-25
申请人： Todd McAllister , Nicolas L`Heureux
发明人： Todd McAllister , Nicolas L`Heureux
IPC分类号： C12M3/00
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention relates to bioreactors having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling for the manufacture of a tissue engineered blood vessel (TEBV). The TEBV is made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding.
摘要翻译：本发明涉及具有封闭室的生物反应器，片材生长模块，可滚动心轴和用于将片材保持在心轴上以用于制造组织工程化血管（TEBV）的夹具的夹具。 TEBV由经过培养的成纤维细胞片制成，该成纤维细胞片卷成多层容器，其具有足够的破裂强度以抵抗生理血压而不包括平滑肌细胞或合成脚手架。

66. 发明申请

US20060223047A1 System and method to simulate hemodynamics 有权
公开(公告)号：US20060223047A1
公开(公告)日：2006-10-05
申请号：US11440152
申请日：2006-05-25
申请人： Michael Dancu , John Tarbell
发明人： Michael Dancu , John Tarbell
IPC分类号： A01N1/02 , C12M1/36 , C12M3/00
CPC分类号： G09B23/28 , Y10S623/916 , Y10S623/917 , Y10S623/921
摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

67. 发明申请

US20060155164A1 Ex vivo remodeling of excised blood vessels for vascular grafts 审中-公开
公开(公告)号：US20060155164A1
公开(公告)日：2006-07-13
申请号：US11273888
申请日：2005-11-14
申请人： Valerie Clerin , Rebecca Gusic , Keith Gooch
发明人： Valerie Clerin , Rebecca Gusic , Keith Gooch
IPC分类号： A61F2/04
CPC分类号： A61L27/3695 , A61F2/062 , A61L27/3625 , A61L27/3691 , C12N5/0691 , Y10S623/916
摘要： The present invention provides an ex vivo vascular remodeling methods and system by which an excised, small diameter blood vessel can be harvested and expanded to provide viable vascular grafts, as demonstrated at the physical and molecular levels, and as optimized in vivo. The tissue-engineered vessels generated by the present invention closely resemble native vessels in terms of structure, histologically, including endothelial coverage and intricate structural components such as the internal elastic lamina, viability (as measured with the MTT assay and TUNEL analysis), and function (vasoactivity, mechanical and biomechanical properties). Thus, the resulting vascular grafts behave in a manner similar to native arteries in terms of mechanical integrity, and provide clinically relevant patency rates when implanted in vivo. Moreover, the ex vivo methods and system permit the precise control of the mechanical environment involving the excised vessel, while at the same time permitting carefully monitoring of the resulting growth/remodeling, thereby opening new avenues of research regarding the mechanical stimuli responsible for specific aspects of remodeling in vivo.

68. 发明申请

US20040147018A1 Bioartificial primarily vascularized tissue matrix, and bioartificial primarily vascularized tissue, method for the production and use of the same 失效
标题翻译：生物人造主要血管化组织基质和生物人造主要血管化组织，生产和使用方法相同
公开(公告)号：US20040147018A1
公开(公告)日：2004-07-29
申请号：US10467878
申请日：2004-03-11
发明人： Axel Haverich , Heike Mertsching
IPC分类号： C12N005/08
CPC分类号： A61L27/3683 , A61L27/3625 , A61L27/3629 , A61L27/38 , Y10S623/916
摘要： The invention relates to a bioartificial primarily vascularized tissue matrix, a bioartificial primarily vascularized tissue, a method for the production thereof and the use of the same. Said tissue matrix and bioartificial primarily vascularized tissue are obtained by preparing the necessary natural tissue, conserving at least one vessel.
摘要翻译：本发明涉及生物人造主要血管化组织基质，生物人造主要血管化组织，其生产方法及其用途。所述组织基质和生物人造主要血管化组织通过制备必需的天然组织获得，保存至少一个血管。

69. 发明授权

US5908449A Blood contact surfaces using extracellular matrix synthesized in vitro 失效
标题翻译：血液接触面使用体外合成的细胞外基质
公开(公告)号：US5908449A
公开(公告)日：1999-06-01
申请号：US627640
申请日：1996-04-04
申请人： William Carl Bruchman , Paul Christopher Begovac
发明人： William Carl Bruchman , Paul Christopher Begovac
IPC分类号： A61L27/00 , A61F2/06 , A61L27/50 , A61L33/00
CPC分类号： A61L27/507 , Y10S623/916
摘要： This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial matrix layer, which serves as the blood interface of the device, is analogous to the subendothelial matrix layer beneath the endothelium of native vascular surfaces. The device consists of a permanent synthetic base material, preferably porous expanded polytetrafluoroethylene, on which this biologic layer of subendothelial matrix is grown in situ. The biologic layer is produced using in vitro tissue culture methods whereby living cells synthesize and deposit extracellular matrix components, after which the cells are killed and/or removed and the subendothelial matrix layer preserved before implantation. A key aspect of this invention is that no living cells are present in the final configuration, so that the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.
摘要翻译：本发明涉及通过添加细胞外内皮下基质的保留层而改进的血液接触装置，例如基本上不引起血管假体的血液假体。用作装置血液界面的保留的内皮下基质层类似于天然血管表面内皮下面的内皮下基质层。该装置由永久性合成基础材料，优选多孔膨胀聚四氟乙烯组成，该生物层内皮下基质在其上原位生长。使用体外组织培养方法产生生物层，其中活细胞合成并沉积细胞外基质组分，之后细胞被杀死和/或去除，并且内皮下基质层在植入前保留。本发明的关键方面是在最终配置中不存在活细胞，使得受体免疫应答的可能性最小化。本发明导致对于需要直径为6mm或更小的动脉旁路特别有用的血管假体。

70. 发明授权

US5480434A Method and device for connecting biological duct to a prosthesis 失效
标题翻译：将生物管道连接到假体的方法和装置
公开(公告)号：US5480434A
公开(公告)日：1996-01-02
申请号：US91818
申请日：1993-07-13
申请人： Eugene C. Eckstein , Norman L. Block
发明人： Eugene C. Eckstein , Norman L. Block
IPC分类号： A61B17/11 , A61F2/04
CPC分类号： A61B17/11 , A61F2/042 , A61F2002/048 , Y10S623/916
摘要： An anastomotic method for connecting a biological duct, such as the ureter, to a man-made device. The method involves connecting the duct to the prosthesis via an intermediate tissue so there is no direct connection between the ureter and the prosthesis. The method includes securing the resected duct to a remote living tissue, such as the peritoneum or omentum, and then securing that tissue to the prosthesis so that the duct drains into the prosthesis.
摘要翻译：用于将诸如输尿管的生物导管连接到人造装置的吻合方法。该方法包括通过中间组织将管道连接到假体，使得输尿管和假体之间没有直接连接。该方法包括将切除的管道固定到诸如腹膜或网膜的远程生物组织，然后将该组织固定到假体，使得管道排入假体。

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