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61. 发明申请

WO2014008282A2 DIAGNOSTIC APPARATUS 审中-公开
标题翻译：诊断设备
公开(公告)号：WO2014008282A2
公开(公告)日：2014-01-09
申请号：PCT/US2013/049112
申请日：2013-07-02
申请人： ADVANCED ANIMAL DIAGNOSTICS, INC.
发明人： BRESOLIN, Stefano , CALDERWOOD, David A. , HEINECK, Tobias M. , NEWCOMB, David , PAUL, Chris , POLLARD, Jasper N. , RODRIGUEZ, Rodolfo R. , YOUNG, Demetris
IPC分类号： G06T7/00 , G02B21/00 , G06F1/20 , G02B21/26
CPC分类号： G01N33/5094 , G01N2800/365 , G02B21/00 , G02B21/0016 , G02B21/26 , G06F1/20 , G06T7/0012
摘要： An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof.
摘要翻译：一种自动显微镜设备包括具有外壁的外壳; 可选地但优选地，所述外壳中的内壁被配置为在所述外壳中形成第一隔室和分离的第二隔室; （优选在第一隔室中）的显微镜组件; （优选地在第二隔室中）的微处理器以及（可选地但是优选地）安装在壳体外壁上，优选邻近第二隔室的散热器，其中微处理器热耦合到所述散热器并与显微镜可操作地相关联部件。还描述了使用其的系统和方法及其组成部分。

62. 发明申请

WO2010120178A1 METHODS OF MEASURING NATURAL IMMUNITY IN MILK 审中-公开
标题翻译：测量自然免疫力的方法
公开(公告)号：WO2010120178A1
公开(公告)日：2010-10-21
申请号：PCT/NL2010/050201
申请日：2010-04-16
申请人： CRV Holding B.V. , Ploegaert, Tosca, Catharina, Wilhelmina , Tijhaar, Edwin, Johannus , Parmentier, Hendrik, Karel , Savelkoul, Hubertus, Franciscus, Jozef , van Arendonk, Johannus, Antonius, Maria
发明人： Ploegaert, Tosca, Catharina, Wilhelmina , Tijhaar, Edwin, Johannus , Parmentier, Hendrik, Karel , Savelkoul, Hubertus, Franciscus, Jozef , van Arendonk, Johannus, Antonius, Maria
IPC分类号： G01N33/68 , G01N33/72
CPC分类号： G01N33/6854 , G01N33/72 , G01N2333/4722 , G01N2400/50 , G01N2469/20 , G01N2800/365
摘要： The invention relates to the field of animal breeding, in particular to a method of predicting an animal's natural immunity, as well as a method for obtaining a group of animals which has a predicted level of natural immunity. Also, the invention relates to a method of predicting an animal's resistance or susceptibility to mastitis. Also described is a method for obtaining from a population of animals a group of animals which has a predicted level of female fertility, longevity, NR56, calving interval, somatic cell score, udder health, vitality.
摘要翻译：本发明涉及动物育种领域，特别涉及预测动物天然免疫的方法，以及获得具有预测的天然免疫水平的一组动物的方法。此外，本发明涉及预测动物对乳腺炎的抵抗力或易感性的方法。还描述了一种从动物群体获得具有预测女性生育能力，寿命，NR56，产犊间隔，体细胞评分，乳房健康，活力等级的动物群体的方法。

63. 发明申请

WO2014038524A1 乳癌の判定方法审中-公开
标题翻译：确定乳腺癌的方法
公开(公告)号：WO2014038524A1
公开(公告)日：2014-03-13
申请号：PCT/JP2013/073594
申请日：2013-09-03
申请人：和光純薬工業株式会社 , 国立大学法人大阪大学
发明人：松浦　脩治 , 松浦　成昭 , 黒野　定 , 金子　有香
IPC分类号： G01N33/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/527 , C12Q1/28 , C12Q1/30 , G01N33/57415 , G01N2800/365 , G01N2800/52
摘要：　本発明は、カルボキシペプチダーゼＮサブユニット２、細胞外マトリックスタンパク質１、血清アミロイドＰ成分、ネブリン、補体成分C8α鎖、アポリポタンパク質Ｌ１、フラビンレダクターゼ、カタラーゼ、炭酸脱水酵素２（カルボニックアンヒドラーゼ２）、アポリポタンパク質C-I、核膜孔糖タンパク質２１０、スーパーオキシドジスムターゼ[Cu-Zn]（超酸化物不均化酵素[Cu-Zn]）、ビスホスホグリセリン酸ムターゼ、炭酸脱水酵素１（カルボニックアンヒドラーゼ１）、及びペルオキシレドキシン２からなる群から選択される乳癌マーカー、試料中の該乳癌マーカーを検出し、その結果に基づいて判定する乳癌の判定方法、並びにそのために用いられるキット、に関する。
摘要翻译：本发明涉及：选自羧肽酶N亚基2，细胞外基质蛋白1，血清淀粉样蛋白P成分，神经蛋白，补体成分C8α链，载脂蛋白L1，黄素还原酶，过氧化氢酶，碳酸的乳腺癌标志物脱水酶2，载脂蛋白CI，核孔糖蛋白210，超氧化物歧化酶[Cu-Zn]，双磷酸甘油酸变位酶，碳酸酐酶1和过氧氧化还原酶2; 一种确定乳腺癌的方法，其包括根据检测结果检测样品中的乳腺癌标志物并确定乳腺癌; 以及用于该方法的试剂盒。

64. 发明申请

WO2013016512A1 METHODS AND KITS FOR DETECTING MASTITIS 审中-公开
标题翻译：检测主体的方法和工具
公开(公告)号：WO2013016512A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048296
申请日：2012-07-26
申请人： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , MADURA, Kiran
发明人： MADURA, Kiran
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12Q1/6888 , G01N33/573 , G01N2800/365
摘要： Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein. Components and reagents for use in the kits and assays are also disclosed.
摘要翻译：公开了用于确定一种或多种动物是否具有乳腺炎和监测动物以及它们产生的乳的质量的方法和试剂盒。公开的试剂盒和测试测定用于测定蛋白酶体及其蛋白质的量，蛋白酶体酶的活性，蛋白酶体的结合和调节蛋白的量以及泛素化蛋白的量。还公开了用于试剂盒和试验的组分和试剂。

65. 发明申请

WO2012074559A2 TREATMENT OF NON-PROLIFERATIVE CYSTIC DISEASE 审中-公开
标题翻译：非增殖性疾病的治疗
公开(公告)号：WO2012074559A2
公开(公告)日：2012-06-07
申请号：PCT/US2011001954
申请日：2011-12-02
申请人： UNIV NEW YORK , KLEINBERG DAVID L
发明人： KLEINBERG DAVID L
IPC分类号： A61K39/395 , A61K38/31 , A61P35/00 , C12Q1/02 , G01N33/573
CPC分类号： G01N33/5011 , A61K38/12 , A61K38/16 , A61K38/31 , G01N33/5088 , G01N33/57415 , G01N2800/365
摘要： The present invention relates generally to the treatment of non-proliferative cystic disease of the breast. More particularly, the present invention relates generally to the treatment of non-proliferative cystic disease of the breast in BRCA1 mutant carriers. Accordingly, the invention relates to the use and application of compounds or agents, including somatostatin analogs, that inhibit insulin-like growth factor I (IGF-I) or insulin-like growth factor I receptor signaling for the treatment of non-proliferative cystic disease of the breast. The invention further relates to the use and application of these compounds or agents for the treatment of non-proliferative cystic disease of the breast in BRCA1 patients. The invention also relates to use of somatostatin analog SOM230 in treatment of non-proliferative cystic disease of the breast and more particularly, to use of somatostatin analog SOM230 in treatment of BRCA1 associated non-proliferative cystic disease.
摘要翻译：本发明一般涉及乳腺非增生性囊性疾病的治疗。更具体地说，本发明一般涉及BRCA1突变体携带者乳腺非增殖性囊性疾病的治疗。因此，本发明涉及抑制胰岛素样生长因子I（IGF-I）或胰岛素样生长因子I受体信号传导治疗非增殖性囊性疾病的化合物或试剂（包括生长抑素类似物）的用途和应用的乳房本发明还涉及这些化合物或药剂在BRCA1患者中用于治疗乳腺非增殖性囊性疾病的用途和应用。本发明还涉及生长抑素类似物SOM230在治疗乳腺非增殖性囊性疾病中的用途，更具体地说，涉及使用生长抑素类似物SOM230来治疗BRCA1相关的非增殖性囊性疾病。

66. 发明申请

WO2009137113A2 PEPTIDES, ANTIBODIES, AND USES THEREOF FOR IDENTIFYING AND TARGETING PROVASOPRESSIN-EXPRESSING CANCER CELLS 审中-公开
标题翻译：肽，抗体及其用于鉴定和靶向预防癌症的癌细胞的用途
公开(公告)号：WO2009137113A2
公开(公告)日：2009-11-12
申请号：PCT/US2009002938
申请日：2009-05-11
申请人： WOOMERA THERAPEUTICS INC , NORTH WILLIAM G , PANG ROY
发明人： NORTH WILLIAM G , PANG ROY
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K47/6851 , A61K47/6857 , A61K49/0002 , A61K49/085 , A61K49/16 , A61K51/1045 , A61K51/1054 , A61K2039/505 , C07K14/575 , C07K16/3023 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57415 , G01N33/57423 , G01N33/57438 , G01N33/6893 , G01N2333/575 , G01N2800/365
摘要： This application provides peptides, antibodies, and antigen-binding portions thereof, for identifying and targeting provasopressin-expressing cancer cells. Also provided are methods of using said compositions, for example to image cancer cells in vivo and in biological samples. Also provided are methods of using said compositions for treating patients suffering from a provasopressin-associated cancers, including breast cancer and small cell lung cancer.
摘要翻译：该应用提供肽，抗体及其抗原结合部分，用于鉴定和靶向表达加强素的癌细胞。还提供了使用所述组合物的方法，例如在体内和生物样品中成像癌细胞。还提供了使用所述组合物治疗患有与加压素相关的癌症（包括乳腺癌和小细胞肺癌）的患者的方法。

67. 发明授权

EP2901163B1 METHOD FOR DETECTING LYSYL OXIDASE-LIKE 2 PROTEIN (LOXL2) AND BREAST CANCER 有权
公开(公告)号：EP2901163B1
公开(公告)日：2018-11-28
申请号：EP13840525.3
申请日：2013-09-30
申请人： Case Western Reserve University
发明人： LIU, Chung, Chiun , ZHANG, Yuan , JANYASUPAB, Metini , LIU, Cheng-Wei , DUDIK, Laurie
IPC分类号： G01N33/68 , G01N33/574 , C12Q1/26
CPC分类号： G01N27/3277 , A61B5/150755 , A61B10/007 , C12Q1/26 , G01N27/3278 , G01N33/57415 , G01N2333/90638 , G01N2800/365 , G01N2800/7028
摘要： A detection system for determining lysyl oxidase-like 2 protein (LOXL2) levels in a bodily sample, includes at least one reaction solution for generating H2O2 upon combination with LOXL2 in the bodily sample, the reaction solution including lysine that can be oxidatively deaminated by LOXL2 to generate α-aminoadipic-δ-semialdehyde (allysine) and hydrogen peroxide (H2O2).

68. 发明授权

EP2630487B1 METHOD FOR DETERMINING A DEGREE OF MASTITIS INFECTION 有权
标题翻译：用于确定感染乳腺炎的度数
公开(公告)号：EP2630487B1
公开(公告)日：2016-08-17
申请号：EP10768012.6
申请日：2010-10-18
申请人： FOSS Analytical A/S
发明人： HOLM, Claus
IPC分类号： G01N33/50 , G01N33/569 , C12Q1/06 , G01N33/58
CPC分类号： C12Q1/06 , G01N33/5047 , G01N33/5091 , G01N33/582 , G01N2800/365

69. 发明公开

EP2870499A4 DIAGNOSTIC APPARATUS 有权
公开(公告)号：EP2870499A4
公开(公告)日：2015-12-30
申请号：EP13813619
申请日：2013-07-02
申请人： ADVANCED ANIMAL DIAGNOSTICS INC
发明人： BRESOLIN STEFANO , CALDERWOOD DAVID A , HEINECK TOBIAS M , NEWCOMB DAVID , PAUL CHRIS , POLLARD JASPER N , RODRIGUEZ RODOLFO R , YOUNG DEMETRIS
IPC分类号： B01L9/00 , G01N21/64 , G01N33/543 , G01N33/569 , G02B21/26 , G02B21/34
CPC分类号： G01N33/5094 , G01N2800/365 , G02B21/00 , G02B21/0016 , G02B21/26 , G06F1/20 , G06T7/0012
摘要： An automated microscope apparatus, comprises an outer housing having an external wall; optionally but preferably an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing; a microscope assembly in said housing, preferably in said first compartment; and a microprocessor in said housing, preferably in said second compartment; and optionally but preferably a heat sink mounted on said housing external wall, preferably adjacent said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.

70. 发明公开

EP2901163A4 SYSTEM AND METHOD FOR DETECTING LYSYL OXIDASE-LIKE 2 PROTEIN (LOXL2) AND BREAST CANCER 审中-公开
标题翻译：检测类似2蛋白（LOXL2）和乳腺癌的LYSYLOXIDASE的系统和方法
公开(公告)号：EP2901163A4
公开(公告)日：2015-08-05
申请号：EP13840525
申请日：2013-09-30
申请人： UNIV CASE WESTERN RESERVE
发明人： LIU CHUNG CHIUN , ZHANG YUAN , JANYASUPAB METINI , LIU CHENG-WEI , DUDIK LAURIE
IPC分类号： G01N33/68 , C12Q1/26 , G01N33/574
CPC分类号： G01N27/3277 , A61B5/150755 , A61B10/007 , C12Q1/26 , G01N27/3278 , G01N33/57415 , G01N2333/90638 , G01N2800/365 , G01N2800/7028
摘要： A detection system for determining lysyl oxidase-like 2 protein (LOXL2) levels in a bodily sample, includes at least one reaction solution for generating H2O2 upon combination with LOXL2 in the bodily sample, the reaction solution including lysine that can be oxidatively deaminated by LOXL2 to generate α-aminoadipic-δ-semialdehyde (allysine) and hydrogen peroxide (H2O2).

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