专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US07387880B2 Method for monitoring resting and activated platelets in unfixed blood samples 失效
标题翻译：监测未固定血液样本中静息和活化血小板的方法
公开(公告)号：US07387880B2
公开(公告)日：2008-06-17
申请号：US11075024
申请日：2005-03-07
申请人： Timothy L. Wyant , Paul A. Raju , Aaron B. Kantor
发明人： Timothy L. Wyant , Paul A. Raju , Aaron B. Kantor
IPC分类号： G01N33/53 , G01N1/00
CPC分类号： G01N33/86 , G01N15/1468 , G01N15/1484 , G01N2015/0084 , G01N2015/1465 , G01N2015/1472 , G01N2015/1486 , Y10T436/108331 , Y10T436/24 , Y10T436/2525
摘要： The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry.
摘要翻译：样品中血小板表面蛋白的量可以通过将含有血小板的样品收集到含有血小板稳定组合物的收集管中，标记血小板表面蛋白并通过细胞计数进行检测来测量。

62. 发明申请

US20060228720A1 Method for imaging an array of microspheres 审中-公开
标题翻译：成像微球阵列的方法
公开(公告)号：US20060228720A1
公开(公告)日：2006-10-12
申请号：US11103765
申请日：2005-04-12
申请人： Martin Kaplan , Krishnan Chari , Samuel Chen , Douglas Vizard
发明人： Martin Kaplan , Krishnan Chari , Samuel Chen , Douglas Vizard
IPC分类号： C12Q1/68 , G01N33/53 , G06K9/00
CPC分类号： G01N15/1463 , G01N2015/1465
摘要： A method for imaging an array of microspheres. A light source, filter or combination of filters that isolate wavelength, or wavelength ranges, of light and a camera are used for detecting and quantifying the presence of biological probes that indicate the presence of specific chemical moieties within a biological system.
摘要翻译：一种用于对微球阵列进行成像的方法。用于隔离光和照相机的波长或波长范围的光源，滤光器或滤光器的组合用于检测和定量生物探针的存在，其指示生物系统内特定化学部分的存在。

63. 发明申请

US20050152593A1 Methods for altering one or more parameters of a measurement system 有权
标题翻译：用于改变测量系统的一个或多个参数的方法
公开(公告)号：US20050152593A1
公开(公告)日：2005-07-14
申请号：US11031905
申请日：2005-01-07
申请人： Edward Calvin
发明人： Edward Calvin
IPC分类号： G01N15/14 , G06K9/00 , G06K9/62
CPC分类号： G06K9/6262 , G01N15/1459 , G01N15/1463 , G01N2015/1465 , G01N2015/1497 , G06K9/00147 , G06K9/6228
摘要： Methods for altering one or more parameters of a measurement system are provided. One method includes analyzing a sample using the system to generate values from classification channels of the system for a population of particles in the sample. The method also includes identifying a region in a classification space in which the values for the populations are located. In addition, the method includes determining an optimized classification region for the population using one or more properties of the region. The optimized classification region contains a predetermined percentage of the values for the population. The optimized classification region is used for classification of particles in additional samples.
摘要翻译：提供了用于改变测量系统的一个或多个参数的方法。一种方法包括使用系统分析样品以从样品中的颗粒群体的系统的分类通道产生值。该方法还包括识别分类空间中的群体的值所位于的区域。此外，该方法包括使用区域的一个或多个属性来确定群体的优化分类区域。优化的分类区域包含对于群体的值的预定百分比。优化的分类区域用于附加样品中颗粒的分类。

64. 发明授权

US06778263B2 Methods of calibrating an imaging system using calibration beads 有权
公开(公告)号：US06778263B2
公开(公告)日：2004-08-17
申请号：US10348193
申请日：2003-01-16
申请人： William E. Ortyn , David A. Basiji , Keith L. Frost , Brian E. Hall , Michael J. Seo
发明人： William E. Ortyn , David A. Basiji , Keith L. Frost , Brian E. Hall , Michael J. Seo
IPC分类号： G01P336
CPC分类号： G01N15/1012 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N2015/1018 , G01N2015/1025 , G01N2015/1075 , G01N2015/144 , G01N2015/1443 , G01N2015/1447 , G01N2015/1452 , G01N2015/1465 , G01N2015/1472 , G01N2015/1477 , G01N2015/1497 , G02B27/0012 , G06T7/20
摘要： When utilized in a flow imaging instrument, calibration beads provide a known data source that can be employed in various self-diagnostic, calibration and quality metric applications for the both the optical system of the flow imaging instrument, as well as the flow cell of the flow imaging instrument. Such data can be used to determine point spread functions associated with an imaging system, to determine a sensitivity of an imaging system, and to determine a focal point of the imaging system. Imagery collected from calibration beads can be used to determine core size and stability and TDI/flow speed synchronization. Calibration beads can be beneficially employed to enable stable system operation, even when very low sample concentration, or very small sample sizes are to be analyzed.

65. 发明申请

US20030016897A1 Target analyte sensors utilizing microspheres 有权
标题翻译：使用微球的目标分析物传感器
公开(公告)号：US20030016897A1
公开(公告)日：2003-01-23
申请号：US09925292
申请日：2001-08-08
申请人： Trustees of Tufts College
发明人： David R. Walt , Karri L. Michael
IPC分类号： G02B006/26
CPC分类号： G01N33/54346 , B01J19/0046 , B01J2219/00317 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1456 , G01N15/1459 , G01N15/1468 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/543 , G01N2015/1438 , G01N2015/1465 , G01N2035/0097 , Y10S359/90 , Y10S435/808
摘要： A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.
摘要翻译：公开了一种基于微球的分析化学体系及其制备方法，其中携带生物活性剂的微球或颗粒可以随机或以有序的方式组合并分散在基质上以形成阵列，同时保持识别生物活性物质的位置的能力阵列内的代理和粒子，使用光学可询问的光学签名编码方案。可以使用各种各样的改性底物，其提供用于以随机或图案分布容纳微球体的离散或非离散位点。衬底可以由各种材料构成以形成二维或三维构型。在优选的实施方案中，采用改性的光纤束或阵列作为基底以产生高密度阵列。所公开的系统和方法具有检测目标分析物和筛选大型生物活性剂库的效用。

66. 发明授权

US5272354A Apparatus for imaging particles in a liquid flow 失效
标题翻译：用于在液体流中成像颗粒的装置
公开(公告)号：US5272354A
公开(公告)日：1993-12-21
申请号：US933737
申请日：1992-08-24
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01J1/44 , G01N15/14 , G01N21/17 , G01N33/49 , G01N15/06
CPC分类号： G01N15/1427 , G01N15/1459 , G01N15/1463 , G01J2001/4493 , G01N2015/1465 , G01N2015/1477
摘要： An apparatus for imaging and analyzing particle components in a sample liquid flow containing particle components such as blood and urine, or fine particles of organic high polymer in suspension or the like. A conventional particle imaging flow cytometer is combined with a light source such as a lamp with small coherence, and an image intensifier with gate function of high response, so that a clear particle image without a deflection or interference fringe is obtained. Thus, in the apparatus having the still imaging function, by using the image intensifier with a high speed gate function, even with a light source of a long luminous time such as a lamp, a clear still image of a particle flowing at high speed is obtained.

67. 发明授权

US5268966A Method of differentiating particles based upon a dynamically changing threshold 失效
标题翻译：基于动态变化的阈值来区分粒子的方法
公开(公告)号：US5268966A
公开(公告)日：1993-12-07
申请号：US769341
申请日：1991-10-01
申请人： Harvey L. Kasdan
发明人： Harvey L. Kasdan
IPC分类号： G01N15/14 , G06K9/00 , G01N33/48
CPC分类号： G06K9/00127 , G01N15/1463 , G01N2015/1465 , G01N2015/1477 , G01N2015/1497
摘要： A method of identifying a plurality of different types of particles in the field of view is disclosed. A first parameter is measured for each of the plurality of different particles. One of the type of particles is identified based upon the first parameter measured. Once the one type of particle is identified, a second parameter, different from the first parameter, is then measured for the one type of particle. The other types of particles in the field of view can be identified based upon the second parameter associated with the one type of particle which has been identified. In one example, color is first used to differentiate various different particles in the field of view and to identify one particular type of particle. Thereafter, a morphological parameter, such as size, associated with the one type of particle identified is measured. The measured morphological character associated with the one type of particle identified is used as a threshold to differentiate other particles in the field of view based upon the second morphological parameter. Similarly, a morphological characteristic can first be used to differentiate one type of particle. A second spectral parameter, such as color, can be measured for the one type of identified particle and can be used to differentiate other particles.
摘要翻译：公开了一种在视场中识别多种不同类型的粒子的方法。测量多个不同粒子中的每一个的第一参数。基于测量的第一个参数来识别颗粒类型之一。一旦识别出一种类型的粒子，则对于一种类型的粒子，测量与第一参数不同的第二参数。可以基于与已经鉴定的一种类型的颗粒相关联的第二参数来识别视野中的其它类型的颗粒。在一个示例中，颜色首先用于区分视场中的各种不同的颗粒并且识别一种特定类型的颗粒。此后，测量与识别的一种类型的颗粒相关联的形态学参数，例如尺寸。基于第二形态参数，将与所识别的一种类型的颗粒相关联的测量的形态特征用作阈值以区分视场中的其他颗粒。类似地，形态特征可以首先用于区分一种类型的颗粒。可以测量一种类型的识别的颗粒的第二光谱参数，例如颜色，并且可以用于区分其他颗粒。

69. 发明公开

EP2041563A4 ENUMERATION OF THROMBOCYTES 审中-公开
标题翻译：血小板计数
公开(公告)号：EP2041563A4
公开(公告)日：2013-09-18
申请号：EP07748312
申请日：2007-07-04
申请人： HEMOCUE AB
发明人： LINDBERG STELLAN
IPC分类号： G01N33/50 , B01L3/00 , G01N15/00 , G01N15/14 , G01N33/58
CPC分类号： G01N33/58 , B01L3/5027 , G01N15/1463 , G01N33/5044 , G01N2015/0069 , G01N2015/0084 , G01N2015/1465 , G01N2015/1486

70. 发明公开

EP2041563A1 ENUMERATION OF THROMBOCYTES 审中-公开
标题翻译： THROMBOZYTENZÄHLUNG
公开(公告)号：EP2041563A1
公开(公告)日：2009-04-01
申请号：EP07748312.1
申请日：2007-07-04
申请人： HemoCue AB
发明人： LINDBERG, Stellan
IPC分类号： G01N33/50 , G01N15/14
CPC分类号： G01N33/58 , B01L3/5027 , G01N15/1463 , G01N33/5044 , G01N2015/0069 , G01N2015/0084 , G01N2015/1465 , G01N2015/1486
摘要： A sample acquiring device for volumetric enumeration of thrombocytes in a blood sample comprises a measurement cavity for receiving a blood sample. The measurement cavity has a predetermined fixed thickness. The sample acquiring device further comprises a reagent, which is arranged in a dried form on a surface defining the measurement cavity. The reagent comprises a haemolysing agent for lysing red blood cells in the blood sample, and optionally a staining agent for selectively staining thrombocytes in the blood sample. A system comprises the sample acquiring device and a measurement apparatus. The measurement apparatus comprises a sample acquiring device holder, a light source, and an imaging system for acquiring a digital image of a magnification of the sample. The measurement apparatus further comprises an image analyser arranged to analyse the acquired digital image for determining the number of thrombocytes in the blood sample.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式