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1. 发明授权

US06947136B2 Multipass cavity for illumination and excitation of moving objects 有权
标题翻译：多光腔用于照明和激发移动物体
公开(公告)号：US06947136B2
公开(公告)日：2005-09-20
申请号：US10691292
申请日：2003-10-21
申请人： William E. Ortyn , David A. Basiji , Keith L. Frost , N. Robert McRuer
发明人： William E. Ortyn , David A. Basiji , Keith L. Frost , N. Robert McRuer
IPC分类号： G01J3/28 , G01N15/02 , G01N15/10 , G01N15/14 , G01N21/03 , G01N21/64 , G01N21/85 , G02B7/28 , G02B27/00 , G02B27/14 , G01N21/00
CPC分类号： G02B27/126 , G01J3/2803 , G01J3/2823 , G01N15/1434 , G01N15/147 , G01N21/031 , G01N21/6428 , G01N21/645 , G01N21/85 , G01N2015/0294 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G02B7/28
摘要： An illumination system for increasing a light signal from an object passing through a reflection cavity. The reflection cavity is defined by spaced-apart, opposed first and second surfaces disposed on opposite sides of a central volume. Preferably the first reflecting surface forms an acute angle with the second reflecting surface. A beam of light is directed into the reflection cavity so that light is reflected back and forth between the first and second surfaces a plurality of times, illuminating a different portion of the central volume with each pass until, having ranged over the central volume, the light exits the reflection cavity. The “recycling” of the light beam in this manner substantially improves the signal to noise ratio of a detection system used in conjunction with the reflection cavity by increasing an average illumination intensity in the central volume.
摘要翻译：一种用于增加来自穿过反射腔的物体的光信号的照明系统。反射空腔由设置在中心体积的相对侧上的间隔开的相对的第一和第二表面限定。优选地，第一反射表面与第二反射表面形成锐角。光束被引导到反射腔中，使得光在第一和第二表面之间多次反复地反射，每次通过照射中心体积的不同部分，直到超过中心体积，光离开反射腔。以这种方式“回收”光束通过增加中心体积中的平均照明强度，大大提高了与反射腔结合使用的检测系统的信噪比。

2. 发明授权

US06934408B2 Method and apparatus for reading reporter labeled beads 失效
标题翻译：阅读报道标记珠粒的方法和装置
公开(公告)号：US06934408B2
公开(公告)日：2005-08-23
申请号：US09976237
申请日：2001-10-12
申请人： Keith L. Frost , David A. Basiji , Richard A. Bauer , Rosalynde J. Finch , William E. Ortyn , David J. Perry
发明人： Keith L. Frost , David A. Basiji , Richard A. Bauer , Rosalynde J. Finch , William E. Ortyn , David J. Perry
IPC分类号： C12Q1/68 , C40B20/04 , C40B30/04 , C40B40/08 , C40B60/10 , G01N15/14 , G02B7/28 , G02B27/00 , G02B27/14 , G06K9/00
CPC分类号： G02B27/148 , C12Q1/6816 , C40B20/04 , C40B30/04 , C40B40/08 , C40B60/10 , G01N15/147 , G01N15/1475 , G01N2015/1447 , G01N2015/1472 , G01N2015/1479 , G01N2015/1497 , G02B7/28 , G02B27/0012 , G02B27/1013 , G02B27/126 , G02B27/144 , G02B27/145 , C12Q2563/179 , C12Q2563/155 , C12Q2563/107
摘要： Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed using a flow imaging system. Oligonucleotides and corresponding reporters are bound to the surfaces of a plurality of small beads such that different beads bear different oligo sequences. Each bead bears a unique optical signature comprising a predefined number of unique reporters, where each reporter comprises a predefined combination of different fluorochromes. The composite spectral signature in turn identifies the unique nucleotide sequence of its attached oligo chains. This optical signature is rapidly decoded using an imaging system to discriminate the different reporters attached to each bead in a flow in regard to color and spatial position on the bead.
摘要翻译：使用流动成像系统分析与编码的珠偶联的与扩增和标记的基因组DNA或核糖核酸（RNA）杂交的组合合成的脱氧核糖核酸（DNA）寡核苷酸。寡核苷酸和相应的报道结合到多个小珠的表面，使得不同的珠具有不同的寡核苷酸序列。每个珠具有唯一的光学特征，其包含预定数量的唯一记录器，其中每个报告者包含不同荧光染料的预定组合。复合光谱特征依次识别其连接的寡链的唯一核苷酸序列。使用成像系统快速解码该光学特征，以便鉴别珠子上颜色和空间位置的流动中附着于每个珠粒的不同报告者。

3. 发明授权

US06875973B2 Auto focus for a flow imaging system 有权
标题翻译：流量成像系统的自动对焦
公开(公告)号：US06875973B2
公开(公告)日：2005-04-05
申请号：US10822170
申请日：2004-04-09
申请人： William E. Ortyn , Michael J. Seo , David A. Basiji , Keith L. Frost , David J. Perry
发明人： William E. Ortyn , Michael J. Seo , David A. Basiji , Keith L. Frost , David J. Perry
IPC分类号： G01N15/10 , G01N15/14 , G02B27/00 , G06T7/20 , G02B27/40
CPC分类号： G06T7/20 , G01N15/1459 , G01N15/1463 , G01N2015/1018 , G01N2015/1443 , G01N2015/1447 , G01N2015/1452 , G01N2015/1497 , G02B27/0012 , G06K9/00134
摘要： A pair of optical gratings are used to modulate light from an object, and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.
摘要翻译：一对光栅被用于调制来自物体的光，并且来自任一光学的调制光用于确定物体的速度。每个光栅从参考焦点偏移相同的距离，一个光栅在正方向偏移，另一个光栅在负方向上偏移。可以处理响应于调制光产生的信号以确定主收集透镜应该移动的方向，以便改善成像系统对物体的焦点。透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

4. 发明授权

US06778263B2 Methods of calibrating an imaging system using calibration beads 有权
公开(公告)号：US06778263B2
公开(公告)日：2004-08-17
申请号：US10348193
申请日：2003-01-16
申请人： William E. Ortyn , David A. Basiji , Keith L. Frost , Brian E. Hall , Michael J. Seo
发明人： William E. Ortyn , David A. Basiji , Keith L. Frost , Brian E. Hall , Michael J. Seo
IPC分类号： G01P336
CPC分类号： G01N15/1012 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N2015/1018 , G01N2015/1025 , G01N2015/1075 , G01N2015/144 , G01N2015/1443 , G01N2015/1447 , G01N2015/1452 , G01N2015/1465 , G01N2015/1472 , G01N2015/1477 , G01N2015/1497 , G02B27/0012 , G06T7/20
摘要： When utilized in a flow imaging instrument, calibration beads provide a known data source that can be employed in various self-diagnostic, calibration and quality metric applications for the both the optical system of the flow imaging instrument, as well as the flow cell of the flow imaging instrument. Such data can be used to determine point spread functions associated with an imaging system, to determine a sensitivity of an imaging system, and to determine a focal point of the imaging system. Imagery collected from calibration beads can be used to determine core size and stability and TDI/flow speed synchronization. Calibration beads can be beneficially employed to enable stable system operation, even when very low sample concentration, or very small sample sizes are to be analyzed.

5. 发明授权

US06763149B2 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging 有权
标题翻译：用于校正多声道成像的串扰和空间分辨率的方法和装置
公开(公告)号：US06763149B2
公开(公告)日：2004-07-13
申请号：US10132059
申请日：2002-04-24
申请人： James K. Riley , Keith L. Frost
发明人： James K. Riley , Keith L. Frost
IPC分类号： G06K932
CPC分类号： G06K9/00503 , G01J3/28 , G01J3/2803 , G01J3/32 , G01J3/36 , G01N15/147 , G01N15/1475 , G06K9/00127 , G06T5/50 , G06T7/32 , G06T7/33 , G06T2207/10036
摘要： A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source. Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems.
摘要翻译：多通道成像系统为对象的每个视场生成图像集合。集合中的每个图像旨在包含来自对象的多个源中的一个源的信息。然而，由于串扰，来自第一源的信号的至少一部分出现在用于第二源的通道中。因为如果一个组合中的图像相对于彼此在空间上不对准，校正的精度将会降低，所以确定图像之间的空间偏移并且应用校正以基本上消除偏移。然后，确定对信号的校正，以从其它通道中的信号基本上减少对信道中的信号的贡献。信号处理可用于处理多个不同公开的成像系统中的每一个的输出信号。

6. 发明授权

US06580504B1 Multipass cavity for illumination and excitation of moving objects 有权
公开(公告)号：US06580504B1
公开(公告)日：2003-06-17
申请号：US09689172
申请日：2000-10-12
申请人： William E. Ortyn , David A. Basiji , Keith L. Frost , N. Robert McRuer
发明人： William E. Ortyn , David A. Basiji , Keith L. Frost , N. Robert McRuer
IPC分类号： G01N2100
CPC分类号： G06K9/00127 , G01J3/2803 , G01J3/2823 , G01N15/147 , G01N21/6428 , G01N21/6456 , G01N21/85 , G01N2015/0294 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G02B7/28 , G02B27/145 , G02B27/148
摘要： An illumination system for increasing a light signal from an object passing through a reflection cavity. The reflection cavity is disposed between spaced-apart, opposed first and second surfaces disposed on opposite sides of a moving stream of objects. A light collection system is disposed substantially orthogonal to a plane passing through the surfaces and the stream so as to collect light that is scattered from or emitted by the objects as they pass through a field of view disposed between the first and second surfaces. A beam of light from a laser source is directed through the stream of moving objects in a direction nearly orthogonal to the stream (but slightly inclined) and lying in the plane that extends through the surfaces and the stream. Due to the reflection angle and the distance between the stream and the first surface, the point at which the light reflected from the first surface intersects the stream on a second pass is displaced from where it passed though the stream on its initial pass. The light is reflected back and forth between the surfaces a plurality of times, illuminating a different portion of the field of view with each pass until, having ranged over the field of view, the light exits the reflection cavity. The “recycling” of the light beam in this manner substantially improves the SNR of the detection system by increasing an average illumination intensity experienced by the objects in the stream.

7. 发明授权

US5937103A Method and apparatus for alias free measurement of optical transfer function 失效
标题翻译：用于别名自由测量光学传递函数的方法和装置
公开(公告)号：US5937103A
公开(公告)日：1999-08-10
申请号：US788239
申请日：1997-01-25
申请人： Seho Oh , Keith L. Frost , Michael J. Seo , James K. Riley , Chih-Chau L. Kuan
发明人： Seho Oh , Keith L. Frost , Michael J. Seo , James K. Riley , Chih-Chau L. Kuan
IPC分类号： G01J9/02 , G06K7/14 , G06K9/36
CPC分类号： G06K7/14 , G01J9/02
摘要： Measurement of the optical transfer function of an optical system imaging a bar pattern. A one dimensional fast Fourier transform processes sampled image data from the bar pattern. A model of the system utilizes robust measurements of the period, duty cycle and center of each stripe in the pattern. A signal alias free optical transfer function is estimated from the plurality of one dimensional frequency representation of the signal. An idealized bar pattern synthesized from the measured parameters of period, duty cycle and the center of each stripe in the pattern generates an ideal optical transfer function. The noise reduced optical transfer function, OTF, is estimated from OTF of the signal and OTF of the synthesized bar pattern.
摘要翻译：测量条形图案的光学系统的光学传递函数。一维快速傅立叶变换处理来自条形图案的采样图像数据。该系统的模型利用对图案中每个条带的周期，占空比和中心的鲁棒测量。从信号的多个一维频率表示估计信号无别名的光学传递函数。从图案中的每个条纹的周期，占空比和中心的测量参数合成的理想条形图形产生理想的光学传递函数。通过信号的OTF和合成的条形图的OTF估计噪声降低的光传输函数OTF。

8. 发明授权

US5933519A Cytological slide scoring apparatus 失效
标题翻译：细胞学评分仪
公开(公告)号：US5933519A
公开(公告)日：1999-08-03
申请号：US867017
申请日：1997-06-03
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/62 , G06K9/68 , G06K9/70
CPC分类号： G06K9/00127 , G06K9/6253 , G06K9/685
摘要： The invention detects areas of interest at low magnification, locating possible abnormal cells or other cells of interest using image processing and statistical pattern recognition techniques. Next, at high magnification, the areas identified at low magnification are re-examined. The information from the low magnification and high magnification scans is collated and a determination is made about the slide--whether it is normal, abnormal, contains endocervical component, and so forth. The invention also provides a method and apparatus to train object feature and slide feature classifiers. The invention provides an automated cytology system that can process training slides for use in a feed back classifier development environment. The invention also can classify endocervical groups of cells.
摘要翻译：本发明使用图像处理和统计模式识别技术来检测低放大倍数的感兴趣区域，定位可能的异常细胞或感兴趣的其它细胞。接下来，在高放大倍数下，重新检查在低倍率下识别的区域。对来自低放大倍数和高倍率扫描的信息进行整理，并确定载玻片是否正常，异常，包含宫颈内部成分等。本发明还提供了一种训练对象特征和幻灯片特征分类器的方法和装置。本发明提供了一种自动细胞学系统，其可以处理用于反馈分类器开发环境中的训练幻灯片。本发明还可以分类宫颈癌细胞群。

9. 发明授权

US5883982A Astigmatism measurement apparatus and method based on a focal plane separation measurement 失效
标题翻译：基于焦平面分离测量的散光测量装置和方法
公开(公告)号：US5883982A
公开(公告)日：1999-03-16
申请号：US816837
申请日：1997-03-13
申请人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
发明人： James K. Riley , Keith L. Frost , William C. Lindow , Kim J. Hansen , Tuan Phan , James A. Stephanick
IPC分类号： G01B11/00 , G01M11/02 , G06T1/00 , G06K9/36
CPC分类号： G01M11/0264 , G01M11/0242
摘要： A computer receives image data from a star-shaped optical target in the object plane and calculates angle-dependent boundary sharpness. The horizontal, x-direction, amplitude derivative and the vertical, y-direction, amplitude derivative are computed over a portion of each star pattern image from a Z panning sequence. A microscope slide stage, carrying the target, is moved vertically from a level just below where the target is in focus to a level just above where the target is in focus. For each small increment of vertical motion, Z panning, an image of the star pattern is captured for analysis. Computations are performed on the differentiated images to search for evidence of elongation of the point spread function and variation with stage Z position of the angle of long axis of such an out-of-round point spread function. The presence of a distorted point spread function that varies along the optical axis indicates astigmatism.
摘要翻译：计算机从对象平面中的星形光学目标接收图像数据，并计算与角度相关的边界锐度。在Z平移序列的每个星型图像的一部分上计算水平，x方向，幅度导数和垂直，y方向，幅度导数。携带目标的显微镜载物台从目标对焦点正下方的水平垂直移动到目标对焦点正上方的水平位置。对于垂直运动的每个小增量，Z平移，捕获星形图案的图像用于分析。对差分图像进行计算，以搜索点扩散函数的伸长的证据以及这种外向点扩散函数的长轴角度的Z位置的变化。沿着光轴变化的失真点扩散函数的存在表示散光。

10. 发明授权

US5046827A Optical reconstruction filter for color mosaic displays 失效
标题翻译：彩色拼接显示器的光学重构滤波器
公开(公告)号：US5046827A
公开(公告)日：1991-09-10
申请号：US382514
申请日：1989-07-20
申请人： Keith L. Frost , Karen E. Jachimowicz , Michael J. Johnson
发明人： Keith L. Frost , Karen E. Jachimowicz , Michael J. Johnson
IPC分类号： G02B27/42 , G02B5/18 , G02B27/46 , G02F1/1335
CPC分类号： G02F1/133504 , G02B5/1842 , G02F2201/305
摘要： An optical reconstruction filter in the form of a phase diffraction grating (that is, a diffractive diffuser) placed between a flat panel liquid crystal color matrix display and a viewer to optically filter flat panel images and present a higher quality image to the viewer.

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