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    • 62. 发明授权
    • Laboratory scale milling process
    • 实验室规模铣削加工
    • US06814319B2
    • 2004-11-09
    • US10007515
    • 2001-12-05
    • Royal J. Haskell
    • Royal J. Haskell
    • B02C1912
    • A61K9/146A61K9/14A61K9/145B02C17/005B02C17/163B02C17/20G09B5/14G09B9/08
    • There is provided a process for reducing particle size of a drug, the process comprising (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 &mgr;m; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
    • 提供了一种减少药物粒径的方法,该方法包括(a)将约10g或更少的药物分散在合适体积的液体分散介质中以形成悬浮液的步骤; (b)将容器研磨介质,用于搅拌和悬浮液的可磁化活化装置结合在一起的步骤; (c)磁力激活用于搅拌的装置以使悬浮液的研磨达到不大于约1μm的重均粒径的步骤; 和(d)将磨碎的悬浮液与研磨介质和可磁激活的装置分离以进行搅拌的步骤。
    • 67. 发明申请
    • MAGNETIC MILL
    • 磁铁厂
    • WO2014065681A1
    • 2014-05-01
    • PCT/PL2013/050023
    • 2013-10-14
    • PRESTO SP. Z O.O.
    • KOWALCZUK, Karol
    • B02C17/00B02C17/04B02C17/18
    • B02C17/005B02C17/04B02C17/18
    • A cylindrical working chamber (4) with ferromagnetic milling elements (5) is situated inside a body (1). Between magnets (2) and an outer side surface of the cylindrical working chamber (4) there is rotatably set an inner covering pipe (6) introduced into the rotary motion by means of a driving unit (10), said pipe being made of a magnetically insulating material, and having on its circumference longitudinal cut-outs (7) in order to guide magnetic field into the cylindrical working chamber (4). An additional covering pipe (8) made of a magnetically insulating material is engaged with the inner covering pipe (6), the additional covering pipe (8) having longitudinal cut-outs (9) coincident with at least some of longitudinal cut-outs (7) in the inner covering pipe (6). Moreover, the additional covering pipe (8) has an additional driving unit (12) designed to move angularly stepwise the additional covering pipe (8) in relation to the inner covering pipe (6).
    • 具有铁磁铣削元件(5)的圆柱形工作室(4)位于主体(1)的内部。 在磁体(2)和圆筒形工作室(4)的外侧表面之间,通过驱动单元(10)可旋转地设置引入旋转运动的内覆盖管(6),所述管由 磁绝缘材料,并且在其圆周上具有纵向切口(7),以便将磁场引导到圆柱形工作室(4)中。 由绝缘材料制成的另外的覆盖管(8)与内覆盖管(6)接合,具有纵向切口(9)的附加覆盖管(8)与至少一些纵向切口( 7)在内覆盖管(6)中。 此外,附加的覆盖管道(8)具有附加的驱动单元(12),该驱动单元设计成相对于内部覆盖管道(6)成角度地逐渐地移动附加的覆盖管道(8)。
    • 68. 发明申请
    • MAGNETIC MILL
    • 磁铁厂
    • WO2014065680A1
    • 2014-05-01
    • PCT/PL2013/050020
    • 2013-09-06
    • PRESTO SP. Z O.O.
    • KOWALCZUK, Karol
    • B02C17/00B02C17/04B02C17/18
    • B02C17/005B02C17/04B02C17/18
    • A cylindrical working chamber (4) with ferromagnetic milling elements (5) is situated inside a body (1). Between magnets (2) and an outer side surface of the cylindrical working chamber (4) there is rotatably set an inner covering pipe (6) introduced into the rotary motion by means of a driving unit (10), said pipe being made of a magnetically insulating material, and having on its circumference longitudinal cut- outs (7) in order to guide magnetic field into the cylindrical working chamber (4). An additional covering pipe (8) made of a magnetically insulating material is fastened on supports outside the inner covering pipe (6), the additional covering pipe (8) having longitudinal cut-outs (7) coincident with at least some of longitudinal cut-outs (7) in the inner covering pipe (6).
    • 具有铁磁铣削元件(5)的圆柱形工作室(4)位于主体(1)的内部。 在磁体(2)和圆筒形工作室(4)的外侧表面之间,通过驱动单元(10)可旋转地设置引入旋转运动的内覆盖管(6),所述管道由 磁绝缘材料,并且在其圆周上具有纵向切口(7),以便将磁场引导到圆柱形工作室(4)中。 由绝缘材料制成的另外的覆盖管(8)被紧固在内覆盖管(6)外部的支撑件上,具有纵向切口(7)的附加覆盖管(8)与至少一些纵向切口 (7)在内盖管(6)中。