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61. 发明申请

WO2011114287A2 MOLECULAR MARKERS FOR URINARY TRACT INFECTIONS 审中-公开
标题翻译：泌尿系感染的分子标记
公开(公告)号：WO2011114287A2
公开(公告)日：2011-09-22
申请号：PCT/IB2011/051073
申请日：2011-03-15
申请人： UNIVERSITA' DI PISA , GIUNTA, Francesco , FORFORI, Francesco , SERI, Giada
发明人： GIUNTA, Francesco , FORFORI, Francesco , SERI, Giada
IPC分类号： G01N33/74 , G01N33/569
CPC分类号： G01N33/74 , G01N33/6893 , G01N2333/585 , G01N2800/348
摘要： The invention relates to an in vitro method for determining procalcitonin levels in plasma and urine as a diagnostic marker to identify patients with urinary tract infections, in vitro methods to perform said determination, a kit for the diagnosis of patients with urinary tract infections, and the usefulness of procalcitonin in the diagnosis urinary tract infections.
摘要翻译：本发明涉及一种用于测定血浆和尿中降钙素原水平的体外方法，作为鉴定尿路感染患者的诊断标记，进行所述测定的体外方法，用于诊断尿路感染患者的试剂盒，以及降钙素原在诊断尿路感染中的用途。

62. 发明申请

WO2009001290A2 A METHOD OF DETECTING AND SEPARATING SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) ISOFORMS IN A SAMPLE OF BIOLOGICAL FLUID AND THE ENZYME ISOFORMS THEREBY OBTAINED 审中-公开
标题翻译：一种在生物流体样品中检测和分离血清葡萄糖 - 谷氨酸转运酶（GGT）ISOFORMS的方法和获得的酶活性
公开(公告)号：WO2009001290A2
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052499
申请日：2008-06-24
申请人： UNIVERSITA' DI PISA , PAOLICCHI, Aldo , POMPELLA, Alfonso , FRANZINI, Maria , BARSACCHI, Renata , EMDIN, Michele , BRAMANTI, Emilia
发明人： PAOLICCHI, Aldo , POMPELLA, Alfonso , FRANZINI, Maria , BARSACCHI, Renata , EMDIN, Michele , BRAMANTI, Emilia
IPC分类号： C12Q1/48
CPC分类号： C12Q1/48
摘要： A method is described for detecting the gamma-glutamyl transferase enzyme isoforms (GGT, EC 2.3.2.2) in a sample of biological fluid, such as for example plasma or serum. The method comprises an HPLC separation step of the sample proteins based on the molecular size and a second step for detecting the GGT isoforms by post-column reaction with a GGT enzyme substrate capable of generating a detectable final product, preferably by spectrophotometric or fluorimetric means. The GGT isoforms can be separated by ultra-centrifugation, thereby obtaining three enzymatic isoforms characterised by molecular weights of approximately 2000, 940, and 140 KDa, respectively.
摘要翻译：描述了用于检测生物流体样品（例如血浆或血清）中的γ-谷氨酰转移酶同种型（GGT，EC 2.3.2.2）的方法。该方法包括基于分子大小的样品蛋白质的HPLC分离步骤，以及用于通过与能够产生可检测的最终产物的GGT酶底物进行柱后反应来检测GGT同种型的第二步骤，优选通过分光光度计或荧光测定方法。可以通过超离心分离GGT同种型，从而分别得到分子量分别为约2000,940和140KDa的三种酶同工型。

63. 发明申请

WO2008007210A2 NITROGENOUS N-SUBSTITUTED 4-SPIRO-HETEROCYCLIC 2, 2 -DIMETHYLCHROMANE DERIVATIVES 审中-公开
标题翻译： N-取代的4-取代的4-甲氧基-2-二甲基喹啉衍生物
公开(公告)号：WO2008007210A2
公开(公告)日：2008-01-17
申请号：PCT/IB2007/001957
申请日：2007-07-11
申请人： UNIVERSITA' DI PISA , BALSAMO, Aldo , CALDERONE, Vincenzo , RAPPOSELLI, Simona
发明人： BALSAMO, Aldo , CALDERONE, Vincenzo , RAPPOSELLI, Simona
IPC分类号： C07D498/10 , A61K31/537 , A61P9/14
CPC分类号： C07D498/10
摘要： A compound having the following general formula:(I) wherein - * represents a chiral center; - R0 is selected from the group comprised of : a carbonyl or thiocarbonyl group, an alkyl group (methylene, ethylene, or methylcarbonyl or methyl-thiocarbonyl group; - Y is selected from the group comprised of: a CH2 group, a C=O group, a C=S group, a C=NH group; - A is selected from the group comprised of: a -CONH- group, a - COO- group, a -CO- group, an alkyl group (C1-C3), alkylcarbonyl group, a carbonyl group, a thiocarbonyl group, an alkylthiocarbonyl group, a sulphonic group, an alkylsulphonic group; - R1 is selected from the group comprised of: a hydrogen atom, an alkyl group, (methyl, ethyl, propyl, isopropyl, butyl, iso-butyl or tert-butyl, an alkoxy group (methoxy, ethoxy, n-propyloxy, iso-propyloxy), an halide atom (F, Cl, Br, I), a trifluoromethyl group, a cyanide group, a nitro group, a hydroxy group, an amine group, an alkylamine group, an alkylamide (acetamide, trifluoroacetamide, propionamide) or alkylsulphonamide (methanesulphonamide, ethanesulphonamide) group. - -R2 is selected from the group comprised of: a hydrogen atom, an alkyl group with C1-C4 carbon atoms (methyl, ethyl, propyl, isopropyl, butyl, isobutyl or terbutyl), a carboxyl group, an alkoxy group (methoxy, ethoxy, n-propyloxy, iso-propyloxy), an halide atom (F, Cl, Br, I), a cyanide group, a nitro group, a trifluoromethyl group, a hydroxy group, a thioalkyl group (C1, C2, C3); an amine group of NR3R4 type where R3 and R4 can be indifferently a hydrogen atom, an alkyl, alkylsulphonic (methanesulphonic, ethanesulphonic), acyl (acetyl, propionyl), trifluoroalkyl group.
摘要翻译：具有以下通式的化合物：（I）其中 - *表示手性中心; - R 0选自羰基或硫代羰基，烷基（亚甲基，亚乙基或甲基羰基或甲基 - 硫代羰基）; -Y选自：CH 2基，C = O 基团，C = S基团，C = NH基团; -A选自-CONH-基团，-OCO-基团，-CO-基团，烷基（C1-C3），烷基羰基，羰基，硫代羰基，烷硫基羰基，磺酸基，烷基磺酸基; -R1选自氢原子，烷基，（甲基，乙基，丙基，异丙基），丁基，异丁基或叔丁基，烷氧基（甲氧基，乙氧基，正丙氧基，异丙氧基），卤素原子（F，Cl，Br，I），三氟甲基，氰基，硝基，羟基，胺基，烷基胺基，烷基酰胺（乙酰胺，三氟乙酰胺，丙酰胺）或烷基磺酰胺（甲磺酰胺，乙磺酰胺）基团-R 2 i （甲基，乙基，丙基，异丙基，丁基，异丁基或叔丁基）的羧基，烷氧基（甲氧基，乙氧基，n 丙氧基，异丙氧基），卤素原子（F，Cl，Br，I），氰化物基，硝基，三氟甲基，羟基，硫代烷基（C1，C2，C3）其中R 3和R 4可以是氢原子，烷基，烷基磺酸（甲磺酸，乙磺酸），酰基（乙酰基，丙酰基），三氟烷基的NR 3 R 4型胺基。

64. 发明申请

WO2007085463A1 PROCESS FOR MAKING NANOSTRUCTURED METAL CATALYSTS AND THEIR USE IN CATALYTIC REACTIONS. 审中-公开
标题翻译：制备纳米结构金属催化剂的方法及其在催化反应中的应用。
公开(公告)号：WO2007085463A1
公开(公告)日：2007-08-02
申请号：PCT/EP2007/000666
申请日：2007-01-26
申请人： UNIVERSITA DI PISA , SBRANA, Glauco , CARLINI, Carlo , RASPOLLI GALLETTI, Anna Maria , GIAIACOPI, Simone
发明人： SBRANA, Glauco , CARLINI, Carlo , RASPOLLI GALLETTI, Anna Maria , GIAIACOPI, Simone
IPC分类号： B01J37/08 , B01J37/16 , B22F9/18 , B22F9/20 , B22F9/24
CPC分类号： B01J37/16 , B01J21/04 , B01J21/18 , B01J23/38 , B01J23/42 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/52 , B01J23/70 , B01J35/0013 , B01J35/006 , B22F9/24 , B22F2998/00 , B22F2999/00 , B82Y40/00 , C07C5/03 , C07C5/11 , C07C29/141 , C07C45/512 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2523/50 , C07C13/18 , C07C13/20 , C07C49/403 , B22F1/0018 , B22F2203/13 , C07C33/22
摘要： The present invention relates to a new easy, cheap and reproducible process for preparing nanostructured metal catalysts and their use in catalytic reactions. One or more metal precursors are reduced by heating in the presence of a low boiling alcohol (employed as solvent or co-solvent) under an overpressure, eventually in the presence of a stabilizing agent. A support can be directly added in the reduction step or in a successive one. The obtained catalysts present good characteristics in terms of metal particles average diameter and dimensions distribution. The said catalysts can be advantageously employed in many peculiar catalytic reactions, such as the selective hydrogenation of organic substrates. In particular, these ruthenium nanocatalysts have shown higher performances respect to commercial ones in the selective hydrogenation of benzene to cyclohexene and of phenol to cyclohexanone.
摘要翻译：本发明涉及一种制备纳米结构金属催化剂的新型便宜且便宜且可重现的方法及其在催化反应中的应用。最终在稳定剂存在下，在低沸点醇（用作溶剂或共溶剂）的存在下，通过加热还原一种或多种金属前体。可以在还原步骤或连续的步骤中直接添加支持物。所获得的催化剂在金属颗粒平均直径和尺寸分布方面呈现良好的特性。所述催化剂可以有利地用于许多特殊的催化反应，例如有机底物的选择性氢化。特别地，这些钌纳米催化剂在苯选择性氢化成环己烯和苯酚至环己酮时，显示出较高的性能。

65. 发明申请

WO2004109817A2 ELECTROACTIVE POLYMER CONTRACTIBLE ACTUATOR 审中-公开
标题翻译：电动聚合物合同执行器
公开(公告)号：WO2004109817A2
公开(公告)日：2004-12-16
申请号：PCT/IB2004/001868
申请日：2004-06-09
申请人： UNIVERSITA DI PISA , CARPI, Federico , DE ROSSI, Michele
发明人： CARPI, Federico , DE ROSSI, Michele
IPC分类号： H01L41/00
CPC分类号： H01L41/45 , A61B2017/00398 , A61B2017/00871 , H01L41/0835 , H01L41/333 , H01L41/338
摘要： A electromechanical actuator for converting electric chanical energy or vice-versa comprising at and at least a second deformable electrode ric element that can be deformed located ectrodes in order to fill the space between two deformable electrodes (11 and 12) have ape extending as coils so that each coil of trode is alternated to a coil of the second in particular have helical shape. They can esilient material in which particles are conductive material and are arranged hat each coil of the first electrode (11) is a coil of the second electrode (12). Between coils of the electrodes (11 and 12) a ment (20) is located made of electro-active e of warping or deflecting. When a voltage to the couple of deformable electrodes (11) electrical field generated produces an inner uses the resilient material (20) to deform according to this voltage. Thus electric energy is converted in o mechanical energy when between said deformable el ctrodes a voltage generating an electrical field that causes the dielectric material to deform. Conversely me hanical energy is converted into electric energy when t e actuator is made of a material capable of generating electrical field and a deformation is applied. The actuator can be used also as sensor of deformation, s electric generator or as condenser at high specific capacity.
摘要翻译：一种用于将电能转换成机械能或反之亦然的机电致动器（1），包括至少第一和至少第二可变形电极（11和12）和电介质元件（20），所述电介质元件能够位于电极之间以填充线圈之间的空间。两个可变形电极（11和12）具有作为线圈延伸的曲线形状，使得第一电极的每个线圈被外部固定到第二电极的线圈，并且特别地具有螺旋形状。它们可以由弹性材料制成，其中导电材料的颗粒被整合并同轴布置，使得第一电极（11）的每个线圈交替到第二电极（12）的线圈。在电极（11和12）的线圈之间，定子（20）由翘曲或偏转的电活性e定位。当对一对可变形电极（11）的电压产生电场时，内部使用弹性材料（20）根据该电压而变形。因此，当所述可变形的电压产生导致电介质材料变形的电场的电压之间时，电能被以o机械能转换。相反，当执行器由能够产生电场并施加变形的材料制成时，机械能被转换为电能。致动器也可以用作变形传感器，发电机或具有高比容量的冷凝器。

66. 发明申请

WO2004054836A1 HYBRID DRIVE ASSEMBLY FOR A VEHICLE, IN PARTICULAR A SCOOTER 审中-公开
标题翻译：混合动力总成用于车辆，特别是电动车
公开(公告)号：WO2004054836A1
公开(公告)日：2004-07-01
申请号：PCT/EP2003/051022
申请日：2003-12-16
申请人： UNIVERSITA' DI PISA , PIAGGIO & C. S.P.A. , VITALE, Emilio , FRENDO, Francesco , ARNONE, Luigi , MARCACCI, Maurizio , RIGGIO, Giovanni
发明人： VITALE, Emilio , FRENDO, Francesco , ARNONE, Luigi , MARCACCI, Maurizio , RIGGIO, Giovanni
IPC分类号： B60K6/04
CPC分类号： B60K6/38 , B60K6/48 , B60K6/543 , B60L11/123 , B60L11/14 , B60L15/2054 , B60L2200/12 , B60L2240/507 , B60Y2200/126 , B62K2202/00 , B62M7/12 , Y02T10/6217 , Y02T10/6221 , Y02T10/645 , Y02T10/7077 , Y02T10/72 , Y02T10/7275 , Y10S903/903 , Y10T477/26
摘要： A hybrid drive assembly (1) for a vehicle having at least one drive wheel (2),the drive assembly including an internal combustion engine (3); a transmission unit (5) interposed between a drive shaft (4) of the internal combustion engine (3) and a propeller shaft (6) connected angularly to the drive wheel (2), and in turn including a continuously variable transmission (7) having a drive pulley (10) connected angularly to the drive shaft (4) and a driven pulley (11), and a centrifugal clutch (8) having a hub (20) connected to the driven pulley, and a driven bell (26) connected to the propeller shaft (6); and an electric machine (32) having a rotor (35) integral with the bell (26) of the centrifugal clutch (8) . The drive assembly (1) is controlled by a control unit (38), in response to a number of input signals (Ss, Sa, Sf), in a number of operating modes including an all-combustion propulsion mode, an all-electric propulsion mode, a first hybrid propulsion mode wherein the internal combustion engine (3) and the electric machine (32) are connected in series, and a second hybrid propulsion mode wherein the internal combustion engine (3) and the electric machine (32) are connected in parallel.
摘要翻译：一种用于具有至少一个驱动轮（2）的用于车辆的混合驱动组件（1），所述驱动组件包括内燃机（3）; 介于内燃机（3）的驱动轴（4）和与驱动轮（2）成角度地连接的传动轴（6）之间的传动单元（5），并且还包括无级变速器（7），具有与驱动轴（4）成角度地连接的驱动滑轮（10）和从动滑轮（11），以及具有连接到从动滑轮的轮毂（20）的离心式离合器（8）和从动滑轮（26）连接到传动轴（6）; 以及具有与所述离心式离合器（8）的所述钟形部（26）成一体的转子（35）的电机（32）。驱动组件（1）由控制单元（38）控制，响应于多个输入信号（Ss，Sa，Sf），在多种操作模式中包括全燃烧推进模式，全电动推进模式，其中内燃机（3）和电机（32）串联连接的第一混合推进模式和其中内燃机（3）和电机（32）是第二混合推进模式并联连接

67. 发明申请

WO2023007430A1 COMPOUNDS WITH A BENZO [A]CARBAZOLE STRUCTURE FOR USE IN THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASES 审中-公开
公开(公告)号：WO2023007430A1
公开(公告)日：2023-02-02
申请号：PCT/IB2022/057005
申请日：2022-07-28
申请人： UNIVERSITA' DI PISA
发明人： ROSSELLO, Armando , NENCETTI, Susanna , NUTI, Elisa , ORLANDINI, Elisabetta , MARTINI, Claudia , COSTA, Barbara , DANIELE, Simona , GIACOMELLI, Chiara , CICCONE, Lidia , CUFFARO, Doretta , COMAR, Manola
IPC分类号： A61K31/407 , A61K31/431 , A61K31/542 , A61K31/546 , A61K31/554 , A61K45/06 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P33/02
摘要： The invention relates to compounds of general formula (I): for use in the prevention and/or treatment of infectious diseases.

68. 发明申请

WO2022112965A1 METHOD IMPLEMENTED BY MEANS OF A COMPUTER FOR DETERMINING RETENTION TIMES AND CONCENTRATION VALUES OF ANALYTES IN A MIXTURE 审中-公开
公开(公告)号：WO2022112965A1
公开(公告)日：2022-06-02
申请号：PCT/IB2021/060924
申请日：2021-11-24
申请人： UNIVERSITA' DI PISA
发明人： CUCCHIARA, Federico , LUCI, Giacomo , DANESI, Romano , DI PAOLO, Antonello
IPC分类号： G01N30/86 , G01N30/64 , G01N30/74
摘要： A computer-implemented method for determining the retention times and concentration values of a plurality of analytes in a mixture in a chromatographic analysis process based on the elution of the analytes from a predetermined stationary retention phase to a predetermined eluent mobile phase, comprising: a. acquiring a plurality of values representative of a chromatogram or voltammogram comprising a series of peak curves; b. determining the retention time of respective analytes through the determination of a plurality of maximum points of said chromatogram or voltammogram, each associated with a respective peak curve; c. determining the inflection points of each peak curve associated with a determined maximum point; d. determining respective Gaussian interpolation curves of each portion of the peak curve comprised between the inflection points of each respective peak curve; e. determining a baseline of said chromatogram or voltammogram; f. determining the points of intersection of each Gaussian interpolation curve and the baseline; g. determining a deconvolution curve of each peak curve; and h. determining a concentration value of each analyte as the difference between the area subtended by the deconvolution curve and the area subtended by the baseline, included between the time values corresponding to the points of intersection of the respective Gaussian interpolation curve and the baseline.

69. 发明申请

WO2021094907A1 ELECTROMAGNETIC ACTUATOR WITH VARIABLE COMPLIANCE 审中-公开
公开(公告)号：WO2021094907A1
公开(公告)日：2021-05-20
申请号：PCT/IB2020/060554
申请日：2020-11-10
申请人： UNIVERSITA' DI PISA
发明人： RIZZO, Rocco , MUSOLINO, Antonino , BARMADA, Sami , CONSOLO, Valentina , CRISOSTOMI, Emanuele , FONTANA, Nunzia , SANI, Luca , TUCCI, Mauro
IPC分类号： H02K7/14 , H02K1/02 , H02K16/04 , H02K44/28 , H02K7/102 , F16D37/02 , F16F9/53 , H01F1/44
摘要： An electromagnetic actuator (1) is provided, comprising a motor shaft (2) defining an output axis (2a) of the motion of the actuator (1), a rotor (3) connected integrally to the motor shaft (2) and movable in response to the application of a first magnetic field, a first stator (4) configured to generate the first magnetic field in proportion to a first electrical signal so as to move the rotor (3) and including a first wall (40), a second stator (5) including a second wall (50) defining with the first wall (40) a chamber (45) including at least part of the rotor (3), and at least one magnetorheological fluid (6) housed in at least part of the chamber (45) and configured to oppose the motion of the rotor (3) in an inversely proportional way to its own compliance, in which the rotor (3) comprises a partition wall (30) configured to divide the chamber (45) into a first portion (45a) defined between the first wall (40) and the partition wall (30) and in a second portion (45b) defined between the wall (30) and the second wall (50), the wall (30) magnetically isolates the first portion (45a) and the second portion (45b), the magnetorheological fluid (6) is housed in the second portion (45b), and the second stator (5) is also configured to generate a second magnetic field in proportion to a second electrical signal in such a way as to vary, on command, the viscosity of said magnetorheological fluid (6) by implementing an actuator (1) with variable compliance.

70. 发明申请

WO2020152573A1 NANOTRANSDUCER-BASED GENOME EDITING SYSTEM 审中-公开
公开(公告)号：WO2020152573A1
公开(公告)日：2020-07-30
申请号：PCT/IB2020/050432
申请日：2020-01-21
申请人： UNIVERSITA' DI PISA , FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
发明人： RAFFA, Vittoria , LANDI, Elena , TANTUSSI, Francesco , DE ANGELIS, Francesco
IPC分类号： C12N15/10 , B82Y15/00 , G01N21/552 , G01N21/65 , B82Y5/00 , C12N15/102 , C12N2310/20
摘要： A non-naturally occurring or engineered genome editing system targeting a genomic target sequence in a target cell is described herein. The system of the invention comprises a macromolecular complex characterised in that it comprises a metallic nanoparticle capable of supporting a localized surface plasmon resonance, an inactive Cas nuclease enzyme, and a single-stranded guide RNA (g-RNA) molecule comprising a guide nucleotide sequence capable of hybridizing to a complementary region of the genomic target sequence. Irradiation of the target cell, which is transformed or transfected with the genome editing system of the invention, with a controlled wavelength electromagnetic radiation results in activation of the plasmonic nanoparticle as a localized heat source thanks to the excitation of the localized plasmon resonance of the nanoparticle and the generation of an amount of heat such as to cut the DNA molecule.

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