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61. 发明专利

JP2012071206A Control of electrical stimulation using heart rate variability 有权
标题翻译：使用心率变化控制电刺激
公开(公告)号：JP2012071206A
公开(公告)日：2012-04-12
申请号：JP2012009614
申请日：2012-01-20
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/368 , A61N1/38
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： PROBLEM TO BE SOLVED: To modulate the delivery of cardiac electrical therapies based on the changing needs and conditions of a patient.SOLUTION: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate the cardiac condition of a patient, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：要解决的问题：根据患者的不断变化的需要和状况来调节心脏电疗法的输送。解决方案：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的输送。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。版权所有（C）2012，JPO＆INPIT

62. 发明专利

JP2011120921A Advanced patient management for correlating data 审中-公开
标题翻译：相关数据的高级患者管理
公开(公告)号：JP2011120921A
公开(公告)日：2011-06-23
申请号：JP2011004415
申请日：2011-01-12
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： STAHMANN JEFFREY E , HATLESTAD JOHN , ZHU QINGSHENG
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/03 , A61B5/0464 , A61B5/08 , A61B5/083 , A61B5/16 , A61B7/00 , A61N1/08 , A61N1/37 , G06F19/00 , G06Q10/00 , G06Q50/00
CPC分类号： A61B5/02405 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/0464 , A61B5/0809 , A61B5/0816 , A61B5/0833 , A61B5/16 , A61B5/205 , A61B5/743 , A61B5/7435 , A61B5/7475 , A61B7/00 , A61B2560/0242 , A61B2560/0271
摘要： PROBLEM TO BE SOLVED: To provide a system, device, and method for identifying, displaying, and assisting in correlating health-related data. SOLUTION: One aspect is a programmable device having machine-practicable instructions for performing a method for use in correlating data to manage a patient's health. In various embodiments, data related to the patient's health are acquired. The acquired data include one or more trend-analyzed health-related parameters, and at least one of one or more predetermined health-related events and one or more health-related alerts. Correlations are identified. The one or more trend-analyzed health-related parameters and the at least one of the one or more predetermined health-related events and the one or more health-related alerts establish a causal relationship between the acquired data and the patient's health. Other aspects and embodiments are provided herein. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于识别，显示和辅助关联健康相关数据的系统，设备和方法。解决方案：一个方面是具有机器可行指令的可编程设备，用于执行用于关联数据以管理患者健康的方法。在各种实施例中，获取与患者健康有关的数据。所获取的数据包括一个或多个趋势分析的健康相关参数，以及一个或多个预定健康相关事件和一个或多个健康相关警报中的至少一个。确定相关性。一个或多个趋势分析的健康相关参数以及一个或多个预定健康相关事件和一个或多个健康相关警报中的至少一个建立所获取的数据与患者健康之间的因果关系。本文提供了其它方面和实施例。版权所有（C）2011，JPO＆INPIT

63. 发明专利

JP2011072843A Tachyarrhythmia detection and discrimination based on curvature parameter 审中-公开
标题翻译：基于曲线参数的TACHYARRHYTHMIA检测和辨别
公开(公告)号：JP2011072843A
公开(公告)日：2011-04-14
申请号：JP2011010291
申请日：2011-01-20
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： SWEENEY ROBERT J , RICCI CARLOS
IPC分类号： A61N1/08 , A61B5/0245 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/37 , A61N1/39 , G06K9/00
CPC分类号： G06K9/00523 , A61B5/0245 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61B5/7264 , A61N1/362 , A61N1/3962
摘要： PROBLEM TO BE SOLVED: To estimate a frequency of a sampled cardiac rhtym signal and to classify the rhythm.
SOLUTION: The received signal is sampled and transformed into a curvature series. A lobe in the curvature series corresponds to a characteristic point in the sampled series. Characteristic points are selected based on a time of a lobe in the curvature series and, in one embodiment, an amplitude of the signal at the time of the lobe. A frequency of the sampled series is estimated by autocorrelating a function of the series of the characteristic points. In one embodiment, the function is a time difference function. The rhythm is classified by plotting the timewise proximity of characteristic points derived from an atrial signal with characteristic points derived from a ventricular signal. Regions of the plot are associated with a particular rhythm, and the grouping of the data corresponds to the classification.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：估计采样心律信号的频率并对节律进行分类。解决方案：接收到的信号被采样并转换成曲率系列。曲率系列中的凸角对应于采样系列中的特征点。基于曲率序列中的波瓣的时间选择特征点，并且在一个实施例中，选择在波瓣时的信号的幅度。通过自相关一系列特征点的函数来估计采样序列的频率。在一个实施例中，该功能是时差功能。通过绘制从心房信号得到的特征点与从心室信号得到的特征点的时间接近，分类节律。情节的区域与特定的节奏相关联，数据的分组对应于分类。版权所有（C）2011，JPO＆INPIT

64. 发明专利

JP2010012285A Using implanted sensor for feedback control of implanted medical device 有权
标题翻译：使用植入式传感器进行植入式医疗装置的反馈控制
公开(公告)号：JP2010012285A
公开(公告)日：2010-01-21
申请号：JP2009205164
申请日：2009-09-04
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： SALO RODNEY , CHAVAN ABHI
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/3925
摘要： PROBLEM TO BE SOLVED: To provide a system for obtaining physiological data related to left ventricular end-diastolic pressure. SOLUTION: A system for administering a therapeutic treatment includes: a pressure sensor which is positioned in a pulmonary artery 22 and collects data which represents at least one of systolic pressure, diastolic pressure, pulse pressure, heart rate or pre-ejection period on the basis of pressure in the pulmonary artery; an implantable medical device 32 located remotely from the sensor; a control module 42 which is operatively coupled to the implantable medical device; and a communication means 46 for transmitting pressure data from the pressure sensor to the control module. In the system, the control module links at least one of systolic pressure, diastolic pressure, pulse pressure, heart rate or pre-ejection period to a pre-programmed value, and adjusts an operating parameter of the implantable medical device based on at least one relation of systolic pressure, diastolic pressure, pulse pressure, heart rate or pre-ejection period to the pre-programmed value, and this process is repeated until the relation is such that no adjustment is necessary. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于获得与左心室舒张末期压力相关的生理数据的系统。解决方案：用于施用治疗性治疗的系统包括：压力传感器，其位于肺动脉22中并且收集表示收缩压，舒张压，脉压，心率或预喷射周期中的至少一个的数据在肺动脉压力的基础上; 位于远离传感器的植入式医疗装置32; 可操作地耦合到可植入医疗装置的控制模块42; 以及用于将压力数据从压力传感器传送到控制模块的通信装置46。在所述系统中，所述控制模块将收缩压，舒张压，脉搏压力，心率或预喷射周期中的至少一个链接到预编程值，并且基于至少一个调节所述可植入医疗装置的操作参数收缩压，舒张压，脉压，心率或预喷射期间与预先编程的值的关系，重复该过程，直至不需要调整为止。版权所有（C）2010，JPO＆INPIT

65. 发明专利

JP2009178593A Method and apparatus for cell and electrical therapy of living tissue 审中-公开
标题翻译：细胞和生活组织电疗法的方法和装置
公开(公告)号：JP2009178593A
公开(公告)日：2009-08-13
申请号：JP2009122572
申请日：2009-05-20
申请人： Cardiac Pacemakers Inc , カーディアックペースメイカーズ, インコーポレイテッド
发明人： GIROUARD STEVEN D , SALO RODNEY W , KENKNIGHT BRUCE H
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368
摘要： PROBLEM TO BE SOLVED: To provide a method and an apparatus for improving effectiveness of cell therapy. SOLUTION: An electrical therapy system for heart tissues where exogenous cells are administered to at least a part of the heart tissues in cell therapy includes one or more catheter lead wires with electrodes and a pulse generator. The pulse generator includes an interface to connect to the one or more catheter lead wires, a controller capable of programming a plurality of pulse transmitting modes, and a sensitivity amplifying device for sensing electrical signals from the one or more catheter lead wires, and also includes a selectable pacing mode for giving therapeutic electrical stimuli to excite at least a part of the heart tissues, in advance, to which the exogenous cells are administered in the cell therapy. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种提高细胞治疗效果的方法和装置。解决方案：在细胞治疗中向心脏组织的至少一部分施用外源性细胞的心脏组织的电疗法包括具有电极和脉冲发生器的一个或多个导管引线。脉冲发生器包括连接到一个或多个导管引线的接口，能够编程多个脉冲发射模式的控制器和用于感测来自一个或多个导管引线的电信号的灵敏度放大装置，并且还包括可选择的起搏模式，用于给予治疗电刺激以激发至少一部分心脏组织，预先在细胞疗法中给予外源性细胞。版权所有（C）2009，JPO＆INPIT

66. 发明专利

JP2004105745A System and method for evaluating demand reference of induced defibrillation of device implanted without repeated induction of fibrillation 审中-公开
公开(公告)号：JP2004105745A
公开(公告)日：2004-04-08
申请号：JP2003351267
申请日：2003-10-09
申请人： Cardiac Pacemakers Inc , Duke Univ , カルディアックペースメーカーズインコーポレイテッド , デュークユニヴァーシティ
发明人： BACH JR STANLEY H , LANG DOUGLAS J , IDEKER RAYMOND E , WHARTON J MARCUS
IPC分类号： A61B5/0472 , A61B5/0402 , A61B5/0452 , A61N1/08 , A61N1/365 , A61N1/372 , A61N1/38 , A61N1/39
CPC分类号： A61N1/08 , A61N1/385 , A61N1/3943
摘要： PROBLEM TO BE SOLVED: To provide a system which determines an effective fibrillation energy released into an implanting fibrillation system without the repeated induction of the fibrillation in the heart of a patient. SOLUTION: The system herein disclosed determines the defibrillation threshold energy in the defibrillation induction structure by applying shocks to the heart until the heart undergoes the fibrillation state while lowering the energy level during the T wave period in the electrocardiogram. The lowest energy level of those examined that fail to make the heart undergo the fibrillation state is mutually related to the defibrillation threshold energy in the induction structure. COPYRIGHT: (C)2004,JPO

67. 发明专利

JPH0788199A RATE ADAPTABLE TYPE PACER WHICH USES VARIATION RELATED TO RESPIRATION IN VENTRICLE CAPACITY OR INTERNAL PRESSURE AS CONTROL PARAMETER 失效
公开(公告)号：JPH0788199A
公开(公告)日：1995-04-04
申请号：JP4153291
申请日：1991-03-07
申请人： CARDIAC PACEMAKERS INC
发明人： BURAIAN DEII PEDAASON , RODONII DABURIYU SARO
IPC分类号： A61N1/365
摘要： PURPOSE: To improve the safety and reliability by generating a rate control signal of a buried pacer by combining an interval of respiration, or the like with the other parameter taken out from an impedance signal to a time, in a proper rate control algorithm. CONSTITUTION: A pacer comprises a pulse generating means 18 for generating a pulse for stimulating a heart, and a sensing means including the electrodes 24, 26 attached to a catheter 12, for sensing the impedance in the blood in the selected one cardiac chamber. A time variable impedance signal in proportion to the impedance in the heart, is output from an impedance processing circuit 36 on the basis of the sensing signal, and the signal is added to a peak hold detector 40, to generate a signal in proportion to the cardiac output of the heart. Further the time variable impedance signal is added to a timing circuit 44 for the signal processing to output a signal relating to a time interval which is proportional to an ambient period, and this signal is used for adjusting the rate of the rate adaptive pacemaker.

68. 发明专利

JPH07542A MEDICAL TREATMENT DEVICE 失效
公开(公告)号：JPH07542A
公开(公告)日：1995-01-06
申请号：JP33653992
申请日：1992-11-04
申请人： CARDIAC PACEMAKERS INC
发明人： RODONII DABURIYU SARO , BURUUSU EI TOTSUKUMAN , MOOTON EMU MOUAA
IPC分类号： A61M5/172 , A61N1/36 , A61N1/362 , A61N1/365
摘要： PURPOSE: To provide an implantable monitor/stimulator monitoring and evaluating the parameters of the heart function including the strength and timing of cardiac contraction and automatically implementing the therapeutic mode selected by a doctor. CONSTITUTION: An impedance, an electrocardiogram, and a pressure measured value are evaluated, various cardiac parameters are calculated, and the calculated results are stored in a device and transmitted to an external monitor and a display for use by a doctor to select a therapeutic mode. A therapy is applied by the device itself or applied when a control signal is transmitted to a peripheral device. A cardiac function level is evaluated from the cardiac parameters such as ejection fraction, cardiac output, single work quantity, and pressure-volume relation, and the therapeutic mode is determined by the doctor. Various pacing types for the heart or skeletal muscles, medicine injection, an embedded type for monitoring by a central data system, and telemetry to an external device are included for the selection of the therapy.

69. 发明专利

JPH06339535A CONSTANT CHARGING PERIOD CIRCUIT TO CHARGE DEFIBRILLATION CAPACITOR OF HEART 失效
公开(公告)号：JPH06339535A
公开(公告)日：1994-12-13
申请号：JP29068993
申请日：1993-11-19
申请人： CARDIAC PACEMAKERS INC
发明人： JIYON MENKEN , POORU MONROO
IPC分类号： A61N1/37 , A61N1/39
摘要： PURPOSE: To charge a defibrillation capacitor at a regular time period without depending on battery voltage during substantial whole lifetime of the battery by using a charging technique of a control duty cycle. CONSTITUTION: An inverter circuit 14 and a transformer 16 are arranged between a battery 12 and capacitors C1, C2, the inverter 14 is driven by an inverter driving circuit 18 formed as one part of a low electric power hybrid circuit 20. The inverter 14 has a transistor switch repeatedly triggered to supply electric power from the battery 12 to the first side of the transformer 16, the second side of the transformer 16 is charged by the first side, and then the transformer 16 charges the capacitors C1, C2. The first side of the transformer 16 is controlled by each pulse of inverter driven signals, the second side supplies current to the defibrillation capacitors C1, C2 during an off half cycle of the driving signals, and the electric charge is increasingly established until a specified voltage.

70. 发明专利

JPH06238009A DDD PACEMAKER 失效
公开(公告)号：JPH06238009A
公开(公告)日：1994-08-30
申请号：JP13621293
申请日：1993-06-07
申请人： CARDIAC PACEMAKERS INC
发明人： ROBAATO JII HAUZAA , JIYURIO SHII SUPINERI
IPC分类号： A61N1/365 , A61N1/368
摘要： PURPOSE: To present a dual chamber cardiac pacemaker using a hysteresis presetting the A-V delay against paced ventricular pulse as most appropriate and normal conductive ventricular pulse as maximum. CONSTITUTION: The DDD pacemaker 34 has stimulating means 46, 48 to stimulate the ventricles 16, 18 of the heart 10 after specified A-V delay period as well as another means to adjust the A-V delay and improve detection accuracy of naturally occurring ventricular bipolar signals when they are detected at specified rate and switch onto more appropriate A-V delay period when the paced pulse is dominant. It is realized with the software run by a micro programmable controller equipped with the DDD pacemaker 34.

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