专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明专利

JPS6357533A SUSTAINED RELEASE BASE 失效
公开(公告)号：JPS6357533A
公开(公告)日：1988-03-12
申请号：JP20110686
申请日：1986-08-26
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , FUKUZAKI HIRONOBU
IPC分类号： A61K47/34 , A61K47/00 , A61K47/44
摘要： PURPOSE:To obtain a sustained release base readily controlling prolongation of release amount, release time, etc., providing drugs with improved sustained release characteristics, consisting of an aluminum salt selected from aluminum salts of polylactide, polyglycolide and polycondensation product of the polylactide and the polyglycolide. CONSTITUTION:Agents such as polylactide or polyglycolide having 50-15,000 average molecular weight or polycondensation product of the polylactide and the polyglycolide and any of various inorganic salts are blended in a molten state under heating at >=150 deg.C. The blend is reacted with an aluminum salt of higher fatty acid, an aluminum alcoholate or anhydrous aluminum chloride to give the aimed substance. In the operation, the polylactide, the polyglycolide or the polycondensation product is required to convert into an aluminum salt thereof. Improved sustained release characteristics are shown by using both the aluminum salt and a higher alcohol, higher fatty acid ester or paraffin.

62. 发明专利

JPS5448883A PRODUCTION OF ACRYLAMIDE POLYMER 失效
公开(公告)号：JPS5448883A
公开(公告)日：1979-04-17
申请号：JP11505677
申请日：1977-09-24
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , SHINPO SHIYOUZOU
IPC分类号： C08F2/00 , C08F2/44 , C08F4/00 , C08F4/04 , C08F20/56
摘要： PURPOSE:To obtain an acrylamide polymer suitable for a soil conditioner, a coagulant for water treatment, a thickening agent, etc., having a molecular weight, improved water-solubility and coagulating effect, by polymerizing acrylamide monomers in the presence of a carbamic acid compound using an azo catalyst. CONSTITUTION:A) Preferably a 5-30 per cent aqueous solution of acrylamide or its mixture with comonomers (e.g. acrylic acid, etc.), is prepared. B) A water- soluble azo catalyst (e.g. 4,4'-azobis-4-cyano-valeric acid, etc.), preferably 0.005-0.1 wt.% based on the monomers is added to the aqueous solution thus obtained. C) A compound of carbamic acid (e.g. ammonium carbamate) in an amount of 0.01-1 wt.% based on the monomers is added to the resulting solution, which is polymerized preferably at 15-45 deg.C to give the desired acrylamide copolymer.

63. 发明专利

JP2003199817A ARTIFICIAL DURA MATER 审中-公开
公开(公告)号：JP2003199817A
公开(公告)日：2003-07-15
申请号：JP2002246647
申请日：2002-08-27
申请人： KAWASUMI LAB INC , TAKI CHEMICAL
发明人： ONO KIKURO , TAKAKUDA KAZUO , TOMINAGA TSUTOMU , SHIRAHAMA KENSHO , YUZUBA TOSHIYASU , OKADA TAKAO , IMAMURA YUKARI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide the artificial dura mater generating no leakage of a liquid from the needle hole around suturing yarn and capable of taking a suturing span at the time of operation widely as compared with the conventional artificial dura mater. SOLUTION: The artificial dura mater is constituted by laminating two or more layers comprising a biodegradable polymer and at least one layer is constituted of a water leak preventing layer (3). The water leak preventing layer (3) is constituted of a high viscosity biodegradable polymer (a) with a viscosity of 5,000-500,000 Pas and a biodegradable polymer (b) swollen in the presence of water. The Young's modulus of the whole of this artificial dura mater is 2-40 MPa. COPYRIGHT: (C)2003,JPO

64. 发明专利

JP2002167428A VITAL MATERIAL 失效
公开(公告)号：JP2002167428A
公开(公告)日：2002-06-11
申请号：JP2000367390
申请日：2000-12-01
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , IMAMURA YUKARI
IPC分类号： A61L17/00 , A61L24/00 , A61L27/00 , A61L33/10 , C08G63/00 , C08L101/16
摘要： PROBLEM TO BE SOLVED: To obtain a vital material with suitable strength and decomposability in a living body which does not cause a foreign matter reaction with living materials in the living body and does not inhibit the tissue restoration by a medicine. SOLUTION: The material comprises a copolymer obtained by reacting an acrylic polymer and/or a methacrylic polymer with a lactone based compound and/or a hydroxy carboxylic acid based compound.

65. 发明专利

JP2001054564A VITAL MATERIAL 失效
公开(公告)号：JP2001054564A
公开(公告)日：2001-02-27
申请号：JP23034899
申请日：1999-08-17
申请人： NAT INST RES INORGANIC MAT , KAWASUMI LAB INC , TAKI CHEMICAL
发明人： TANAKA JUNZO , KIKUCHI MASANORI , MIYAMOTO KIMIHIRO , SUWA SHUJI , ICHIKAWA SHUNJI , YOKOYAMA ETSURO , AKINO SOICHI , OKADA TAKAO , IMAMURA YUKARI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To obtain a material which has excellent biocompatibility and is effective for reproduction of the tissue having adequate strength and degradation rate by forming a vital material containing calcium phosphate and a lactic acid/glycolic acid/εcaprolatone copolymer. SOLUTION: The vital material is formed of the structure in which the calcium phosphate is coordinated with the carbonyl group of the lactic acid/ glycolic acid/ε-caprolatone copolymer and, therefore, adjusts the in-vivo degradability and vital tissue derivability of the calcium phosphate, thereby greatly accelerating the vital tissue derivability. While the shapes of the vital tissue to be rebuilt are intricate in general, various kinds of the materials from flexibility to high strength are molded by adjusting the tissue and molecular weight of the lactic acid/glycolic acid/εcaprolatone copolymer and, therefore, the vital material is not deformed by the oppression of the tissue and the fixation in tight contact with the tissue is possible. Also, the adjustment to the decomposition rate suitable for the damage of application parts is possible and, therefore, the rapid tissue restoration is made possible without the hindrance of the reproduction of the vital tissue.

66. 发明专利

JPH0940766A METHOD FOR REMOVING CATALYST FROM LACTIC ACID POLYMER 失效
公开(公告)号：JPH0940766A
公开(公告)日：1997-02-10
申请号：JP20997495
申请日：1995-07-25
申请人： TAKI CHEMICAL
发明人： NAGAOKA YOICHI , MIKI SHUICHI , OKADA TAKAO
IPC分类号： C08G63/08 , C08G63/90 , C08G63/91
摘要： PROBLEM TO BE SOLVED: To remove a catalyst from a high-molecular weight lactic acid polymer to thereby obtain a lactic acid polymer having high safety and scarcely undergoing thermal decomposition and thermal deterioration, by treating the polymer by immersing in a solution comprising a mixture of a specified organic solvent and an organic acid. SOLUTION: A lactic acid polymer having a viscosity-average molecular weight of at least 100,000 is treated by immersing in a solution comprising a mixture of an organic solvent and an organic acid. Satisfactory organic solvents used comprise those which are miscible with the acid and do not dissolve the polymer, and the examples thereof include esters such as methyl and ethyl acetates, ketones such as acetone and methyl ethyl ketone, and alcohols such as methanol and ethanol, among which ethyl acetate and actone are preferable in particular. Examples of the acid to be mixed with the organic solvent include monofunctional or polyfunctional organic acids, such as lactic, acetic and citric acids, among which lactic acid is preferable in particular. It is desirable that the weight ratio of the organic solvent to the organic acid in the mixture is (50 to 95):(50 to 5). The immersion time is about 5-24hr.

67. 发明专利

JPH0513963B2 失效
公开(公告)号：JPH0513963B2
公开(公告)日：1993-02-23
申请号：JP16465585
申请日：1985-07-24
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , FUKUZAKI HIRONOBU
IPC分类号： C08G63/00 , C08G63/06 , C08G63/82 , C08G63/85 , C08G63/87

68. 发明专利

JPH0428020B2 失效
公开(公告)号：JPH0428020B2
公开(公告)日：1992-05-13
申请号：JP5433586
申请日：1986-03-11
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , FUKUZAKI HIRONOBU
IPC分类号： B01J20/26 , A01N25/10 , A61K47/00 , A61K47/34 , C08J9/00 , C08K5/09 , C08L1/00 , C08L27/00 , C08L67/00 , C08L67/04 , C08L71/00 , C08L71/02

69. 发明专利

JPH0415207B2 失效
公开(公告)号：JPH0415207B2
公开(公告)日：1992-03-17
申请号：JP20110686
申请日：1986-08-26
申请人： TAKI CHEMICAL
发明人： OKADA TAKAO , FUKUZAKI HIRONOBU
IPC分类号： A61K47/34 , A61K47/00 , A61K47/44

70. 发明专利

JPH02203861A LIVING BODY MATERIAL 失效
公开(公告)号：JPH02203861A
公开(公告)日：1990-08-13
申请号：JP2305289
申请日：1989-01-31
申请人： TAKI CHEMICAL , TAKAOKA KUNIO
发明人： TAKAOKA KUNIO , OKADA TAKAO
IPC分类号： A61L27/00
摘要： PURPOSE:To obtain a material having biodegradation property and excellent in bone forming ability by using, as a support body of a bone forming factor, a gradually releasing base agent obtained by reacting a polymer or copolymer of lactic acid and/or glycolic acid with polyethylene glycol. CONSTITUTION:The polymer or copolymer of lactic acid and/or glycolic acid is obtained by direct dehydrating condensation polymerization of lactic acid and glycolic acid under reduced pressure, and those having a number average molecular weight of 300-10000 are used. As polyethylene glycol, those having a number average molecular weight ranging about 150-10000 are used, and the polymer or copolymer of lactic acid and/or glycolic acid and polyethylene glycol are used in a ratio such that the equivalent ratio of the latter ranges from 0.3 to 5.0. The polymer or copolymer of lactic acid and/or glycolic acid is heated and melted at 100-250 deg.C which is the softening temperature, polyethylene glycol is added to conduct the reaction, and the resulting gradually releasing base agent is used as the support body of a bone forming factor. Consequently, the speed of bone formation and the speed of degradation absorption of the base agent can be easily regulated, and a material excellent in bone forming ability can be obtained.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式