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61. 发明申请

US20070140986A1 Abrasive System for Oral Care Compositions 审中-公开
标题翻译：口腔护理组合物研磨系统
公开(公告)号：US20070140986A1
公开(公告)日：2007-06-21
申请号：US11614455
申请日：2006-12-21
申请人： Michael Prencipe , Sayed Ibrahim
发明人： Michael Prencipe , Sayed Ibrahim
IPC分类号： A61K8/18
CPC分类号： A61K8/18 , A61K8/25 , A61K8/347 , A61K2800/28 , A61K2800/412 , A61K2800/59 , A61K2800/5922 , A61Q11/00
摘要： Oral compositions comprising a first and a second abrasive are provided. The first abrasive preferably has an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions, and the second abrasive preferably has an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. A ratio of the first abrasive to the second abrasive ranges from about 1:1.6 to about 1.6:1, and the first and second abrasives are preferably present in the oral composition at an amount of about 13% to about 21% by weight, respectively. The pellicle cleaning ratio of the oral composition is greater than 100 and the radioactive dentin abrasiveness is preferably less than 200, and in certain embodiments, preferably less than about 175. Methods of using the oral compositions are also provided.
摘要翻译：提供包含第一和第二研磨剂的口腔组合物。第一研磨剂优选具有每100,000转大于约5毫克损失的艾因纳氏硬度，并且第二磨料优选具有每100,000转小于约5毫克损失的埃因纳氏硬度。第一研磨剂与第二研磨剂的比例为约1:1.6至1.6:1，第一和第二研磨剂分别以约13重量％至约21重量％的量存在于口腔组合物中。口腔组合物的防护薄膜清洁率大于100，并且放射性牙本质磨蚀性优选小于200，在某些实施方案中优选小于约175.还提供使用口腔组合物的方法。

62. 发明申请

US20060140879A1 Two phase toothpaste composition 有权
标题翻译：两相牙膏组成
公开(公告)号：US20060140879A1
公开(公告)日：2006-06-29
申请号：US11023968
申请日：2004-12-28
申请人： Linh Fruge , James Brown , Susan Herles , Kimberlee Panaligan , Evangelia Arvanitidou , Nebojsa Milanovich , Michael Prencipe
发明人： Linh Fruge , James Brown , Susan Herles , Kimberlee Panaligan , Evangelia Arvanitidou , Nebojsa Milanovich , Michael Prencipe
IPC分类号： A61K8/21
CPC分类号： A61K8/21 , A61K8/19 , A61K8/347 , A61K2800/88 , A61Q11/00
摘要： An oral care composition having a first phase of clinically efficacious 2,4,4′-trichloro 2′-hydroxydiphenyl ether admixed in a first orally acceptable aqueous vehicle, and a second phase having a stannous salt (such as stannous fluoride) admixed in a second orally acceptable aqueous vehicle. The second phase has no less than 10 molar percent of soluble stannous ion respective to a mathematical sum of moles of the soluble stannous ion and moles of the stannous salt in the second phase. In one embodiment, the two phases are provided in a dual-tube toothpaste oral care kit.
摘要翻译：一种口腔护理组合物，其具有混合在第一口服可接受的水性载体中的临床上有效的2,4,4'-三氯2'-羟基二苯醚的第一相，和在其中混合的具有亚锡盐（例如氟化亚锡）的第二相第二种口服可接受的水性载体。第二相具有不少于10摩尔％的可溶性亚锡离子，相对于第二相中可溶性亚锡离子的摩尔数和亚锡盐的摩尔数的数学和。在一个实施方案中，将两相设置在双管牙膏口腔护理套件中。

63. 发明申请

US20050170316A1 Toothbrush for detecting the presence of plaque 审中-公开
标题翻译：用于检测斑块存在的牙刷
公开(公告)号：US20050170316A1
公开(公告)日：2005-08-04
申请号：US10767573
申请日：2004-01-29
申请人： Bruce Russell , Robert Moskovich , Michael Prencipe , Diego Hoic
发明人： Bruce Russell , Robert Moskovich , Michael Prencipe , Diego Hoic
IPC分类号： A46B9/04 , A61B5/00 , A61C17/00 , A61C17/22 , A61C17/34 , A61C19/06 , A61N5/06
CPC分类号： A46B15/0002 , A46B15/0034 , A46B2200/1066 , A61B5/0088 , A61C17/22 , A61C17/3436 , A61C17/349 , A61C19/066
摘要： A dye is incorporated in a carrier. The dye has the characteristics of attaching itself to residual plaque on the tooth surface. The dye also has the characteristic of being activated by the presence of ultraviolet radiation to visually create a fluorescent effect that would indicate the presence of plaque remaining on the teeth. The carrier can be toothpaste or any other form of tooth applicator, such as a rinse or gum. The UV light source could be from a separate device or could be mounted in the toothbrush itself.
摘要翻译：将染料掺入载体中。该染料具有将自身附着在牙齿表面上的残留斑块的特征。该染料还具有被紫外线辐射活化的特征，以目测产生一种荧光效应，其表明残留在牙齿上的斑块的存在。载体可以是牙膏或任何其它形式的牙齿施用器，例如冲洗剂或牙龈。 UV光源可以来自单独的装置，也可以安装在牙刷本身中。

64. 发明授权

US06379654B1 Oral composition providing enhanced tooth stain removal 有权
标题翻译：口服组合物提供增强的牙齿清除
公开(公告)号：US06379654B1
公开(公告)日：2002-04-30
申请号：US09698453
申请日：2000-10-27
申请人： Petros Gebreselassie , Diego Hoic , James G. Masters , Michael Prencipe
发明人： Petros Gebreselassie , Diego Hoic , James G. Masters , Michael Prencipe
IPC分类号： A61K728
CPC分类号： A61Q11/00 , A61K8/25 , A61K8/66 , A61K38/4873
摘要： An abrasive dentifrice composition which effects enhanced tooth and stain removal which comprises an orally acceptable vehicle containing a combination of a low oil absorption silica abrasive having an oil absorption value of less than 100 cc/100 g silica and an proteolytic enzyme.
摘要翻译：一种具有增强的牙齿和污迹去除效果的研磨性洁齿剂组合物，其包含含有油吸收值小于100cc / 100g硅胶的低吸油性二氧化硅磨料与蛋白水解酶的组合的口腔可接受的载体。

65. 发明授权

US6110446A Dual component antiplaque and tooth whitening composition 有权
标题翻译：双组分抗牙斑和牙齿美白组合物
公开(公告)号：US6110446A
公开(公告)日：2000-08-29
申请号：US166025
申请日：1998-10-05
申请人： Michael Prencipe , Vincent O. Drago , Mike Wong , Barry D. Self , Malcolm Williams , John Afflitto
发明人： Michael Prencipe , Vincent O. Drago , Mike Wong , Barry D. Self , Malcolm Williams , John Afflitto
IPC分类号： A61K8/22 , A61K8/24 , A61K8/73 , A61K8/81 , A61Q11/00 , A61K7/16 , A61K7/20
CPC分类号： A61Q11/00 , A61K8/22 , A61K8/24 , A61K8/73 , A61K8/8147 , A61K2800/88
摘要： A dual component antiplaque and whitening dentifrice composition in which the first component is a paste composition containing an antibacterial agent such as Triclosan and the second component contains a peroxide compound such as hydrogen peroxide in a vehicle thickened with a combination of an inorganic thickeners and an organic thickener other than an alkylene oxide polymer wherein the antiplaque and whitening efficacy of the components is unimpaired when the components are physically separated prior to use and thereafter are mixed upon application to dental tissue.
摘要翻译：双组分抗菌和增白牙粉组合物，其中第一组分是含有抗菌剂如三氯生的糊组合物，第二组分在无机增稠剂和有机物的组合物中加入过氧化氢等过氧化物化合物除了环氧烷聚合物之外的增稠剂，其中当组分在使用之前物理分离时，组分的抗牙斑和增白功效不受损害，然后在施用于牙齿组织时混合。

66. 发明授权

US5639445A Dental material and method for applying preventative and therapeutic agents 失效
标题翻译：牙科材料和应用预防和治疗剂的方法
公开(公告)号：US5639445A
公开(公告)日：1997-06-17
申请号：US177900
申请日：1994-01-06
申请人： John Curtis , Salim Nathoo , Michael Prencipe
发明人： John Curtis , Salim Nathoo , Michael Prencipe
IPC分类号： A61C19/06 , A61K6/00 , A61K6/093 , A61K8/22 , A61K8/42 , A61K8/81 , A61K8/891 , A61Q11/00 , A61K6/08 , A61K31/74 , A61K33/40
CPC分类号： A61Q11/00 , A61C19/063 , A61C19/066 , A61K8/22 , A61K8/42 , A61K8/8176 , A61K8/891
摘要： A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.
摘要翻译：通过将生物活性成分分散在聚合物组合物中，由膨胀性硅氧烷聚合物组合物制备牙科用组合物。牙科组合物成形并压靠牙齿和牙龈表面，并使其保持在适当位置足以将活性成分释放到牙齿和牙龈的时间。膨胀的流变学特性使牙科组合物能够在牙龈瓣下推动以除去食物颗粒并处理牙龈线下面的牙齿和牙龈表面。该组合物具有足够的塑性，以便容易地从牙齿上除去，而没有破碎并附着在牙齿表面上。

67. 发明授权

US5310563A Dental material and method for applying preventative and therapeutic agents 失效
标题翻译：牙科材料和应用预防和治疗剂的方法
公开(公告)号：US5310563A
公开(公告)日：1994-05-10
申请号：US782700
申请日：1991-10-25
申请人： John Curtis , Salim Nahoo , Michael Prencipe
发明人： John Curtis , Salim Nahoo , Michael Prencipe
IPC分类号： A61C19/06 , A61K6/00 , A61K6/093 , A61K8/22 , A61K8/42 , A61K8/81 , A61K8/891 , A61Q11/00 , A61K6/08 , A61K31/74 , A61K33/40
CPC分类号： A61Q11/00 , A61C19/063 , A61C19/066 , A61K8/22 , A61K8/42 , A61K8/8176 , A61K8/891
摘要： A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.
摘要翻译：通过将生物活性成分分散在聚合物组合物中，由膨胀性硅氧烷聚合物组合物制备牙科用组合物。牙科组合物成形并压靠牙齿和牙龈表面，并使其保持在适当位置足以将活性成分释放到牙齿和牙龈的时间。膨胀的流变学特性使牙科组合物能够在牙龈瓣下推动以除去食物颗粒并处理牙龈线下面的牙齿和牙龈表面。该组合物具有足够的塑性，以便容易地从牙齿上除去，而没有破碎并附着在牙齿表面上。

68. 发明授权

US5300283A Viscoelastic dentifrice composition 失效
标题翻译：粘弹性洁牙剂组成
公开(公告)号：US5300283A
公开(公告)日：1994-04-05
申请号：US51319
申请日：1992-10-22
申请人： Michael Prencipe , Gary A. Durga
发明人： Michael Prencipe , Gary A. Durga
IPC分类号： A61K8/00 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/29 , A61K8/34 , A61K8/36 , A61K8/40 , A61K8/60 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/85 , A61K8/97 , A61Q5/06 , A61Q11/00 , A61Q19/00 , A61Q19/10 , A61K7/16 , A61K7/18
CPC分类号： A61Q11/00 , A61K8/8164
摘要： A toothpaste or dental gel composition containing an amount of a synthetic linearly viscoelastic cross-linked polymeric thickening agent, especially a cross-linked methyl vinyl ether/maleic anhydride copolymer, effective to render the composition linearly viscoelastic, and a method of promoting oral hygiene by applying an effective amount of the composition to dental surface.
摘要翻译：含有一定量的合成线性粘弹性交联聚合物增稠剂，特别是交联的甲基乙烯基醚/马来酸酐共聚物的牙膏或牙科凝胶组合物，有效使组合物线性粘弹性，以及通过以下方法促进口腔卫生：将有效量的组合物施用于牙齿表面。

69. 发明授权

US5000944A Zinc-containing oral products with reduced astringency 失效
标题翻译：含涩口味的含锌口服产品
公开(公告)号：US5000944A
公开(公告)日：1991-03-19
申请号：US364406
申请日：1989-06-09
申请人： Michael Prencipe , Shamsul K. Bakar
发明人： Michael Prencipe , Shamsul K. Bakar
IPC分类号： A61K8/24 , A61K8/27 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/27
摘要： A zinc-containing antitartar oral product substantially free of astringency, containing as the essential agent, a zinc/polyphosphate complex having at least about a 50% water solubility, formed by the reaction or interaction of a zinc compound with a potassium or sodium polyphosphate by dissolving a zinc salt in a polyphosphate solution such as pyrophosphate, tripolyphosphate, hexametaphosphate and combinations thereof.
摘要翻译：通过锌化合物与多磷酸钾或多磷酸钠的反应或相互作用而形成的含有至少约50％水溶性的锌/多磷酸盐络合物的基本上不含涩味的含锌抗口服制品将锌盐溶解在聚磷酸盐溶液如焦磷酸盐，三聚磷酸盐，六偏磷酸盐及其组合中。

70. 发明授权

US10278796B2 Oral care gel dispenser systems 有权
公开(公告)号：US10278796B2
公开(公告)日：2019-05-07
申请号：US14356810
申请日：2011-11-15
申请人： Elva Chen , Sharon Kennedy , Yelloji-Rao Mirajkar , Suzanne Jogun , Michael Prencipe
发明人： Elva Chen , Sharon Kennedy , Yelloji-Rao Mirajkar , Suzanne Jogun , Michael Prencipe
IPC分类号： A61C19/06 , A61K8/73 , A61K8/04 , A61Q11/00 , A46B11/00 , A61C17/02 , A61K49/00
摘要： The invention provides an oral care system comprising a gel in a pen dispenser, the dispenser comprising a chamber which permits dispensing of a measured amount of the gel, wherein the gel exhibits a Herschel-Bulkley yield stress of 10 to 230 dynes/cm2, a Herschel-Bulkley viscosity of 3 to 500 poise, and a Herschel-Bulkley rate index of 0.4 to 0.6, the specific viscosity permitting efficient application of the gel, as well as methods of using the same.

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