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61. 发明申请

US20120046564A1 METHODS AND SYSTEMS TO MONITOR AND IDENTIFY TRANSIENT ISCHEMIA 有权
标题翻译：监测和识别过渡期ISCHEMIA的方法和系统
公开(公告)号：US20120046564A1
公开(公告)日：2012-02-23
申请号：US12861573
申请日：2010-08-23
申请人： Steve Koh , Michael Yang , Ryan Rooke , Stuart Rosenberg , Wenbo Hou
发明人： Steve Koh , Michael Yang , Ryan Rooke , Stuart Rosenberg , Wenbo Hou
IPC分类号： A61B5/0402
CPC分类号： A61B5/0422 , A61B5/686 , A61B5/7282 , A61B2576/023 , A61N1/365 , A61N1/3702
摘要： A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The system and method record at least one of timing or segment shift information associated with the deviations in the segments of interest; and identify at least one of size, direction of development or rate of progression of an ischemia region based on the at least one of timing or segment shift information.
摘要翻译：提供了一种用于监测缺血发育的系统和方法。系统和方法识别非生理事件并且沿着多个感测向量获得心脏信号，其中至少一部分感测向量延伸到位于靠近左心室的电极。系统和方法监测沿着多个感测向量获得的心脏信号中的感兴趣区段，以识别感兴趣区段中的偏离基线。系统和方法记录与感兴趣的部分中的偏差相关联的定时或分段移位信息中的至少一个; 并且基于定时或段位移信息中的至少一个来识别缺血区域的大小，发育方向或进展速度中的至少一个。

62. 发明申请

US20120016253A1 Methods and Systems for Filtering Respiration Noise from Localization Data 有权
标题翻译：从定位数据过滤呼吸噪声的方法和系统
公开(公告)号：US20120016253A1
公开(公告)日：2012-01-19
申请号：US12835518
申请日：2010-07-13
申请人： Steve Koh , Stuart Rosenberg , Kyungmoo Ryu
发明人： Steve Koh , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61B5/08
CPC分类号： A61B5/063 , A61B5/113 , A61B5/721 , A61B90/36 , A61B2017/00053 , A61B2034/2048 , A61B2034/2051 , A61B2034/2053 , A61B2562/0219
摘要： A method of filtering respiration noise from a localization signal includes acquiring a localization signal from at least one position measurement sensor within a localization field and acquiring an acceleration signal for at least one localization field generator (e.g., a patch electrode). A displacement signal for the field generator is calculated, for example by integrating the acceleration signal twice, and transformed into the frequency domain in order to calculate a fractional power indicative of patient respiration. The fractional power can then be compared to a threshold value, and the localization signal can be filtered if the fractional power exceeds the threshold value. Alternatively, the acquired acceleration signal can be used to gate collection of data points from the localization signal.
摘要翻译：从定位信号过滤呼吸噪声的方法包括从定位场内的至少一个位置测量传感器获取定位信号，并获取至少一个定位场发生器（例如，贴片电极）的加速度信号。计算场发生器的位移信号，例如通过对加速度信号进行两次积分，并将其变换到频域以便计算指示患者呼吸的分数功率。然后可以将分数功率与阈值进行比较，如果分数功率超过阈值，则可以对定位信号进行滤波。或者，获取的加速度信号可以用于从定位信号门控收集数据点。

63. 发明申请

US20110118803A1 Cardiac Resynchronization Therapy Optimization Using Vector Measurements Obtained From Realtime Electrode Position Tracking 有权
标题翻译：使用从实时电极位置跟踪获得的矢量测量的心脏再同步治疗优化
公开(公告)号：US20110118803A1
公开(公告)日：2011-05-19
申请号：US12621397
申请日：2009-11-18
申请人： Wenbo Hou , Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Steve Koh , Thao Thu Nguyen , Kjell Norén , Michael Yang
发明人： Wenbo Hou , Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Steve Koh , Thao Thu Nguyen , Kjell Norén , Michael Yang
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0205 , A61B5/04011 , A61B5/0424 , A61B5/053 , A61B5/0538 , A61B5/063 , A61N1/3684 , A61N1/3686
摘要： An exemplary method includes selecting a first pair of electrodes to define a first vector and selecting a second pair of electrodes to define a second vector; acquiring position information during one or more cardiac cycles for the first and second pairs of electrodes wherein the acquiring comprises using each of the electrodes for measuring one or more electrical potentials in an electrical localization field established in the patient; and determining a dyssynchrony index by applying a cross-covariance technique to the position information for the first and the second vectors. Another method includes determining a phase shift based on the acquired position information for the first and the second vectors; and determining an interventricular delay based at least in part on the phase shift.
摘要翻译：一种示例性方法包括选择第一对电极以限定第一矢量并选择第二对电极以限定第二矢量; 在所述第一和第二对电极的一个或多个心动周期期间获取位置信息，其中所述获取包括使用每个所述电极来测量在所述患者中建立的电定位区域中的一个或多个电位; 以及通过将交叉协方差技术应用于所述第一和第二向量的位置信息来确定不同步索引。另一种方法包括基于所获取的第一和第二矢量的位置信息来确定相移; 以及至少部分地基于所述相移来确定心室间延迟。

64. 发明申请

US20090306732A1 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING ELECTROMECHANICAL DELAY FROM REALTIME ELECTRODE MOTION TRACKING 有权
标题翻译：使用电动延迟从实际电极运动跟踪的心脏再生治疗优化
公开(公告)号：US20090306732A1
公开(公告)日：2009-12-10
申请号：US12416771
申请日：2009-04-01
申请人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
发明人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Thu Nguyen , Michael Yang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61B5/1107 , A61B5/6876 , A61B2562/043 , A61N1/36514 , A61N1/36578 , A61N1/3684 , A61N1/37252
摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).
摘要翻译：示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械激活时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

65. 发明申请

US20050245854A1 Cervical brace 审中-公开
标题翻译：子宫颈大括号
公开(公告)号：US20050245854A1
公开(公告)日：2005-11-03
申请号：US11110121
申请日：2005-04-20
申请人： Eric Leuthardt , Dennis Rivet , Guy Genin , Stuart Rosenberg , Laura Seger , Elizabeth Tran
发明人： Eric Leuthardt , Dennis Rivet , Guy Genin , Stuart Rosenberg , Laura Seger , Elizabeth Tran
IPC分类号： A61F5/00 , A61F5/02 , A61F5/055
CPC分类号： A61F5/026 , A61F5/055
摘要： A cervical brace for restraining movement of a head and neck vertebra of a patient relative to at least one of a chest and an abdomen of the patient. The brace includes a mount sized and shaped for attachment to at least one of the chest and the abdomen of the patient and a support extending upward from the mount to a position in use adjacent a rearward surface of the head of the patient. The brace includes a loop sized and shaped for receiving the head of the patient cantilevered from the support. The support includes at least one joint for adjusting at least one of a pitch, a yaw and a roll of the loop relative to the mount.
摘要翻译：一种用于限制患者的头颈部颈部相对于患者的胸部和腹部中的至少一个的运动的子宫颈支架。支架包括尺寸和形状的安装件，用于附接到患者的胸部和腹部中的至少一个，以及从安装件向上延伸到使用中邻近患者头部的后表面的位置的支撑件。支架包括尺寸和形状适于接收从支撑件悬臂的患者的头部的环。该支撑件包括至少一个接头，用于相对于座架调整环路的俯仰，偏转和滚动中的至少一个。

66. 发明授权

US09002453B2 Devices, systems and methods to perform arrhythmia discrimination based on R-R interval stability corresponding to a plurality of ventricular regions 有权
标题翻译：基于对应于多个心室区域的R-R间期稳定性执行心律失常鉴别的装置，系统和方法
公开(公告)号：US09002453B2
公开(公告)日：2015-04-07
申请号：US13194732
申请日：2011-07-29
申请人： Allen J. Keel , Kyungmoo Ryu , Stuart Rosenberg
发明人： Allen J. Keel , Kyungmoo Ryu , Stuart Rosenberg
IPC分类号： A61N1/00 , A61B5/04 , A61B5/042 , A61B5/0452 , A61B5/0464 , A61N1/362 , A61N1/368 , A61B5/0456
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61N1/3627 , A61N1/3684 , A61N1/3686
摘要： Described herein are implantable systems and devices, and methods for use therewith, that can be used to perform arrhythmia discrimination. A plurality of different sensing vectors are used to obtain a plurality of different IEGMs, each of which is indicative of cardiac electrical activity at a different ventricular region. The plurality of different IEGMs can include, e.g., an IEGM indicative of cardiac electrical activity at a first region of the patient's left ventricular (LV) chamber and an IEGM indicative of cardiac electrical activity at a second region of the patient's LV chamber. Additionally, the plurality of different IEGMs can further include an IEGM indicative of cardiac electrical activity at a region of a patient's right ventricular (RV) chamber. For each of the IEGMs, there is a determination of a corresponding localized R-R interval stability metric indicative of the R-R interval stability at the corresponding ventricular region. This can include, e.g., determining, for each of the IEGMs, a plurality of R-R intervals corresponding to a plurality of consecutive cardiac cycles of the IEGM. For each IEGM, a measure of variation (e.g., standard deviation, range or variance, but not limited thereto) can then be determined for the plurality of R-R intervals to thereby determine the localized R-R interval stability metric for the IEGM. Arrhythmia discrimination is then performed using the plurality of determined localized R-R interval stability metrics.
摘要翻译：本文描述了可用于执行心律失常鉴别的可植入系统和装置及其使用方法。使用多个不同的感测向量来获得多个不同的IEGM，每个IEGM指示在不同心室区域处的心脏电活动。多个不同的IEGM可以包括例如指示患者左心室（LV）室的第一区域处的心脏电活动的IEGM和指示患者LV室的第二区域处的心脏电活动的IEGM。另外，多个不同的IEGM还可以包括指示患者右心室（RV）室的区域处的心脏电活动的IEGM。对于每个IEGM，存在确定相应的局部R-R间期稳定性度量，其指示相应心室区域处的R-R间期稳定性。这可以包括例如为每个IEGM确定对应于IEGM的多个连续心脏周期的多个R-R间隔。对于每个IEGM，然后可以为多个R-R间隔确定变化量（例如，标准偏差，范围或方差，但不限于此），从而确定IEGM的局部R-R间隔稳定性度量。然后使用多个确定的局部R-R间期稳定性度量进行心律失常鉴别。

67. 发明授权

US08682450B2 Systems and methods for controlling neurostimulation of acupuncture sites using an implantable cardiac rhythm management device 有权
标题翻译：使用植入式心律管理装置控制针刺部位神经刺激的系统和方法
公开(公告)号：US08682450B2
公开(公告)日：2014-03-25
申请号：US13563417
申请日：2012-07-31
申请人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
发明人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/042 , A61B5/0538 , A61B5/14532 , A61B5/4818 , A61B5/4836 , A61F7/00 , A61H39/002 , A61H39/06 , A61H2201/5002 , A61H2230/045 , A61H2230/305 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/3962 , A61N2/02
摘要： Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.
摘要翻译：技术提供用于与植入式心律管理（CRMD）系统一起使用，该系统被配备用于向患者的颈部，胸部或腹部前区域内的针灸位置递送神经刺激。检测与患者健康有关的参数，例如指示心律失常，心力衰竭和高血压的参数。

68. 发明授权

US08532774B1 Detection and reduction of phrenic nerve stimulation 有权
标题翻译：检测和减少膈神经刺激
公开(公告)号：US08532774B1
公开(公告)日：2013-09-10
申请号：US13545794
申请日：2012-07-10
申请人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
发明人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
IPC分类号： A61N1/37
CPC分类号： A61N1/36521 , A61B5/042 , A61B5/0538 , A61N1/3686 , A61N1/3702
摘要： The present invention provides methods for detecting phrenic nerve stimulation. A pacing module is instructed to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles and wherein the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. Impedance signals are measured in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle using at least one electrode configuration. At least one impedance signal is gathered from each time window, aggregated impedance signals are created using the impedance signals from the different time windows, and the aggregated impedance signals are analyzed to detect PNS.
摘要翻译：本发明提供了检测膈神经刺激的方法。指示起搏模块在左心室的不应期内输送具有预定脉搏幅度和/或宽度的起搏脉冲。起搏脉冲在多个心动周期期间重复递送，并且其中起搏脉冲相对于在不同心脏周期中的左心室的不应期的开始以不同的延迟递送。使用至少一个电极配置，在与左心室的不应期中的起搏脉冲的递送同步的时间窗口中测量阻抗信号。从每个时间窗口收集至少一个阻抗信号，使用来自不同时间窗口的阻抗信号创建聚合阻抗信号，并分析聚合阻抗信号以检测PNS。

69. 发明授权

US08412327B2 Cardiac resynchronization therapy optimization using vector measurements obtained from realtime electrode position tracking 有权
标题翻译：使用从实时电极位置跟踪获得的矢量测量的心脏再同步治疗优化
公开(公告)号：US08412327B2
公开(公告)日：2013-04-02
申请号：US12621397
申请日：2009-11-18
申请人： Wenbo Hou , Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Steve Koh , Thao Thu Nguyen , Kjell Noren , Michael Yang
发明人： Wenbo Hou , Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Steve Koh , Thao Thu Nguyen , Kjell Noren , Michael Yang
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0205 , A61B5/04011 , A61B5/0424 , A61B5/053 , A61B5/0538 , A61B5/063 , A61N1/3684 , A61N1/3686
摘要： An exemplary method includes selecting a first pair of electrodes to define a first vector and selecting a second pair of electrodes to define a second vector; acquiring position information during one or more cardiac cycles for the first and second pairs of electrodes wherein the acquiring comprises using each of the electrodes for measuring one or more electrical potentials in an electrical localization field established in the patient; and determining a dyssynchrony index by applying a cross-covariance technique to the position information for the first and the second vectors. Another method includes determining a phase shift based on the acquired position information for the first and the second vectors; and determining an interventricular delay based at least in part on the phase shift.
摘要翻译：一种示例性方法包括选择第一对电极以限定第一矢量并选择第二对电极以限定第二矢量; 在所述第一和第二对电极的一个或多个心动周期期间获取位置信息，其中所述获取包括使用每个所述电极来测量在所述患者中建立的电定位区域中的一个或多个电位; 以及通过将交叉协方差技术应用于所述第一和第二向量的位置信息来确定不同步索引。另一种方法包括基于所获取的第一和第二矢量的位置信息来确定相移; 以及至少部分地基于所述相移来确定心室间延迟。

70. 发明申请

US20130066222A1 SYSTEMS AND METHODS FOR DETECTING FAR-FIELD OVERSENSING BASED ON SIGNALS SENSED BY THE PROXIMAL ELECTRODE OF A MULTIPOLAR LV LEAD 有权
标题翻译：用于检测基于由多个LV引线的接近电极感测的信号的场地超声波的系统和方法
公开(公告)号：US20130066222A1
公开(公告)日：2013-03-14
申请号：US13230482
申请日：2011-09-12
申请人： Stuart Rosenberg , Tomas Svensson , Kjell Norén , Edward Karst , Kyungmoo Ryu
发明人： Stuart Rosenberg , Tomas Svensson , Kjell Norén , Edward Karst , Kyungmoo Ryu
IPC分类号： A61B5/0464 , A61N1/39 , A61B5/0452 , A61N1/365 , A61B5/0402 , A61B5/0456
CPC分类号： A61N1/3704 , A61B5/0464 , A61B5/0468 , A61B5/686 , A61N1/3627 , A61N1/3684
摘要： A device senses cardioelectrical signals using a right atrial (RA) lead, which might include far-field R-waves as well as near-field P-waves. The device concurrently senses events using a proximal electrode of an LV lead, which can sense both P-waves and R-waves as substantially near-field events. Suitable templates are then applied to the signals sensed via the proximal LV electrode to identify the origin of the signals (e.g. atrial vs. ventricular) so as to properly classify the corresponding events sensed in the RA as near-field or far-field events. In this manner, far-field oversensing is conveniently detected.
摘要翻译：一种装置使用右心房（RA）导联感测心电信号，其可能包括远场R波以及近场P波。该装置使用LV引线的近侧电极同时感测事件，其可以感测P波和R波作为基本近场事件。然后将合适的模板施加到经由近端LV电极感测的信号以识别信号的来源（例如心房与心室），以便将在RA中感测到的相应事件适当地分类为近场或远场事件。以这种方式，可以方便地检测远场超检测。

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