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61. 发明授权

US07264702B1 Total analyte quantitation 有权
标题翻译：总分析物定量
公开(公告)号：US07264702B1
公开(公告)日：2007-09-04
申请号：US10702115
申请日：2003-11-05
申请人： Calvin Y. H. Chow
发明人： Calvin Y. H. Chow
IPC分类号： G01N27/447
CPC分类号： G01N30/62 , G01N27/44717 , G01N30/8631 , G01N2030/625 , G01N2030/324
摘要： Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individual analyte to quantitate the total analyte amount. Separate measurements of the total analyte sample are also used to determine total analyte concentration.
摘要翻译：提供了确定总分析物浓度和量的方法，特别是与分析物分离结合。微流体装置用于分离分析物混合物并检测各个分析物。对每个单独的分析物求和信号区域，以量化总分析物的量。总分析物样品的单独测量也用于测定总分析物浓度。

62. 发明授权

US06986837B2 Microfluidic controller and detector system with self-calibration 有权
公开(公告)号：US06986837B2
公开(公告)日：2006-01-17
申请号：US10215885
申请日：2002-08-09
申请人： Calvin Y. H. Chow , Morten J. Jensen , Colin B. Kennedy , Michael M. Lacy , Robert E. Nagle
发明人： Calvin Y. H. Chow , Morten J. Jensen , Colin B. Kennedy , Michael M. Lacy , Robert E. Nagle
IPC分类号： G01N27/453
CPC分类号： G01N27/44721 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/148 , B01L2400/0415 , G01N27/44791
摘要： A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.

63. 发明授权

US06857449B1 Multi-layer microfluidic devices 有权
标题翻译：多层微流体装置
公开(公告)号：US06857449B1
公开(公告)日：2005-02-22
申请号：US10675567
申请日：2003-09-30
申请人： Calvin Y. H. Chow
发明人： Calvin Y. H. Chow
IPC分类号： B01J19/00 , B01L3/00 , B81B1/00 , C40B60/14 , F15C1/06
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00587 , B01J2219/00702 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B81B1/004 , B81B2201/0214 , B81B2201/058 , C40B60/14 , Y10T137/2224 , Y10T137/8242 , Y10T137/8326
摘要： The present invention provides multi-layer microfluidic systems, by providing additional substrate layers, e.g., third, fourth, fifth and more substrate layers, mated with the typically described first and second layers. Microfabricated elements, e.g., grooves, wells and the like, are manufactured into the surfaces between the various substrate layers. These microfabricated elements define the various microfluidic aspects or structures of the overall device, e.g., channels, chambers and the like. In preferred aspects, a separate microscale channel network is provided between each of the substrate layers.
摘要翻译：本发明通过提供与通常描述的第一和第二层配合的附加衬底层，例如第三，第四，第五和更多衬底层来提供多层微流体系统。诸如凹槽，井等的微细元件被制造成各种基底层之间的表面。这些微制造元件限定了整个装置的各种微流体方面或结构，例如通道，室等。在优选的方面，在每个基底层之间提供单独的微细通道网络。

64. 发明授权

US06787088B2 Controlled fluid transport in microfabricated polymeric substrates 有权
标题翻译：微管制聚合物基质中的受控流体输送
公开(公告)号：US06787088B2
公开(公告)日：2004-09-07
申请号：US10316571
申请日：2002-12-10
申请人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc J. Bousse
发明人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc J. Bousse
IPC分类号： B29C4516
CPC分类号： B01L3/502707 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L3/50273 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , G01N27/44791 , Y10S366/03 , Y10T29/49229 , Y10T137/2224
摘要： Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
摘要翻译：提供微流控器件用于化学和生物化学分析，合成和检测的性能。本发明的装置将精确的流体控制系统与微制造的聚合物基底结合在一起，以提供精确，低成本的小型化分析装置，其在化学，生物化学，生物技术，分子生物学和许多其它领域中具有广泛的应用。

65. 发明授权

US06733645B1 Total analyte quantitation 有权
标题翻译：总分析物定量
公开(公告)号：US06733645B1
公开(公告)日：2004-05-11
申请号：US09835085
申请日：2001-04-12
申请人： Calvin Y. H. Chow
发明人： Calvin Y. H. Chow
IPC分类号： G01N27447
CPC分类号： G01N30/62 , G01N27/44717 , G01N30/8631 , G01N2030/625 , G01N2030/324
摘要： Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individual analyte to quantitate the total analyte amount. Separate measurements of the total analyte sample are also used to determine total analyte concentration.
摘要翻译：提供了确定总分析物浓度和量的方法，特别是与分析物分离结合。微流体装置用于分离分析物混合物并检测各个分析物。对每个单独的分析物求和信号区域，以量化总分析物的量。总分析物样品的单独测量也用于测定总分析物浓度。

66. 发明授权

US06503757B1 Analytical system and method 有权
标题翻译：分析系统和方法
公开(公告)号：US06503757B1
公开(公告)日：2003-01-07
申请号：US09976132
申请日：2001-10-12
申请人： Calvin Y. H. Chow
发明人： Calvin Y. H. Chow
IPC分类号： G01N3500
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/143 , B01L2300/0645 , B01L2300/0654 , B01L2400/0415 , G01N2035/00326 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： An analytical or preparatory microfluidic system is disclosed which generally comprises a base unit comprising a first adapter interface array; a first adapter plate selected from a set of a plurality of different adapter plates, wherein the first adapter plate comprises a base unit interface array that is complementary to the first adapter interface array, and a first substrate interface array, wherein the first adapter plate is removably coupled to the base unit such that energy passes from the base unit to the adapter plate through the first adapter and base unit interface arrays. The system further comprises a first microfluidic substrate selected from a set of a plurality of different microfluidic substrates, the first microfluidic substrate comprising a plurality of mesoscale channels disposed therein and a second adapter interface array, wherein the second adapter interface array is complementary to the first substrate interface array. The first microfluidic substrate is mounted against the first adapter plate, and coupled to the adapter plate such that energy passes from the adapter plate to the microfluidic substrate through the second adapter and first substrate interface arrays. Methods of configuring a microfluidic system as described above to perform analytical and biological analyses and preparatory procedures are also disclosed.
摘要翻译：公开了一种分析或预备微流体系统，其通常包括基本单元，其包括第一适配器接口阵列; 第一适配器板，其选自一组不同的适配器板，其中所述第一适配器板包括与所述第一适配器接口阵列互补的基本单元接口阵列和第一基板接口阵列，其中所述第一适配器板是可拆卸地联接到基座单元，使得能量通过第一适配器和基座单元接口阵列从基座单元传递到适配器板。该系统还包括选自一组多个不同的微流体衬底的第一微流体衬底，第一微流体衬底包括设置在其中的多个中尺度通道和第二适配器接口阵列，其中第二适配器接口阵列与第一微流体衬底互补基板界面阵列。第一微流体衬底被安装在第一适配器板上并且耦合到适配器板，使得能量通过第二适配器和第一衬底接口阵列从适配器板传递到微流体衬底。还公开了如上所述构造微流体系统以进行分析和生物分析和准备程序的方法。

67. 发明授权

US06409900B1 Controlled fluid transport in microfabricated polymeric substrates 有权
标题翻译：微管制聚合物基质中的受控流体输送
公开(公告)号：US06409900B1
公开(公告)日：2002-06-25
申请号：US09664847
申请日：2000-09-19
申请人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc Bousse
发明人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc Bousse
IPC分类号： B44C122
CPC分类号： B01L3/502707 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L3/50273 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , G01N27/44791 , Y10S366/03 , Y10T29/49229 , Y10T137/2224
摘要： Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
摘要翻译：提供微流控器件用于化学和生物化学分析，合成和检测的性能。本发明的装置将精确的流体控制系统与微制造的聚合物基底结合在一起，以提供精确，低成本的小型化分析装置，其在化学，生物化学，生物技术，分子生物学和许多其它领域中具有广泛的应用。

68. 发明授权

US5885470A Controlled fluid transport in microfabricated polymeric substrates 失效
公开(公告)号：US5885470A
公开(公告)日：1999-03-23
申请号：US843212
申请日：1997-04-14
申请人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc Bousse
发明人： John Wallace Parce , Michael R. Knapp , Calvin Y. H. Chow , Luc Bousse
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447 , B44C1/22
CPC分类号： B01L3/502707 , B01J19/0093 , B01L3/50273 , G01N27/44791 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , Y10S366/03 , Y10T137/2224 , Y10T29/49229
摘要： Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.

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