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61. 发明授权

US07947015B2 Application of a therapeutic substance to a tissue location using an expandable medical device 有权
标题翻译：使用可扩张医疗装置将治疗物质施用于组织位置
公开(公告)号：US07947015B2
公开(公告)日：2011-05-24
申请号：US11804478
申请日：2007-05-18
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M37/00
CPC分类号： A61M25/1027 , A61L29/085 , A61L29/146 , A61L29/16 , A61L2300/22 , A61L2300/606 , A61M2025/1075 , A61M2025/1088 , C08L27/18
摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.
摘要翻译：应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。输送装置使用充气流体的压力膨胀。在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

62. 发明申请

US20100034867A1 DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
标题翻译：用于医疗设备的药物输送涂料和治疗血管损伤的方法
公开(公告)号：US20100034867A1
公开(公告)日：2010-02-11
申请号：US11919363
申请日：2006-04-28
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
IPC分类号： A61L27/54 , A61K31/436 , A61K38/13 , A61K47/12 , A61P9/00 , A61L29/16
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of medical devices coated with a therapeutic coating comprising a mTOR targeting compound and a calcineurin inhibitor, and methods of applying said coatings. In various aspects, the therapeutic coating comprises a bio-absorbable carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译：本发明提供涂覆有包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗性涂层的医疗器械的各种实施方案，以及施用所述涂层的方法。在各个方面，治疗性包衣包含至少部分由细胞吸收抑制剂和细胞摄取增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分。在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

63. 发明申请

US20090181937A1 CROSS-LINKED FATTY ACID-BASED BIOMATERIALS 有权
标题翻译：交联的基于脂肪酸的生物材料
公开(公告)号：US20090181937A1
公开(公告)日：2009-07-16
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/395 , A61P41/00
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

64. 发明申请

US20080109017A1 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

65. 外观设计

USD517897S1 Handle for chest drain bag 失效
标题翻译：胸部排液袋手柄
公开(公告)号：USD517897S1
公开(公告)日：2006-03-28
申请号：US29192612
申请日：2003-10-27
申请人： Nicholas Want , Theodore Karwoski , Steve A. Herweck
设计人： Nicholas Want , Theodore Karwoski , Steve A. Herweck

66. 发明授权

US06395208B1 Method of making an expandable fluoropolymer device 有权
标题翻译：制造可膨胀氟聚合物装置的方法
公开(公告)号：US06395208B1
公开(公告)日：2002-05-28
申请号：US09410329
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： B29C4904
CPC分类号： B29C55/24 , A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C47/0026 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device.
摘要翻译：一种制造径向可膨胀装置的方法，该装置具有由通常无弹性的膨胀的含氟聚合物材料构成的主体。当径向膨胀力从减小的直径，收缩构型施加到具有预定义和固定的增大直径的膨胀构型时，主体可展开。本体具有通常均匀材料的单一，单一结构，其特征在于扩展的氟聚合物材料如膨胀聚四氟乙烯（ePTFE）的无缝构造，并且优选通过挤出和膨胀方法构造。身体的特征还在于通过原纤维相互连接的节点的微结构，其中主体的基本上所有的节点大致垂直于身体的纵向轴线定向。身体的整体结构和垂直于身体的纵向轴线的节点的取向产生可预测和可靠地扩展到预定的，固定的最大直径的径向可扩张装置，其通常与用于径向的膨胀力无关展开设备。

67. 发明授权

US06358218B1 Fluid-recovery system with integrally molded components 失效
标题翻译：具有整体模制部件的流体回收系统
公开(公告)号：US06358218B1
公开(公告)日：2002-03-19
申请号：US09358944
申请日：1999-07-22
申请人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Thomas S. Cochran , Scott E. Corbeil , David R. Autote , Ralph L. Gillis
发明人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Thomas S. Cochran , Scott E. Corbeil , David R. Autote , Ralph L. Gillis
IPC分类号： A61B500
CPC分类号： A61M1/0013
摘要： The present invention relates to fluid recovery systems for collecting fluid from a patient. A fluid recovery system according to the teachings of the invention includes a housing having a collection chamber for collecting fluid from a patient, and further includes a plurality of components and/or structures that are integrally formed with the housing. Such integrally molded components can include valves for controlling fluid flow within the fluid recovery system and a tamper resistant disposal system.
摘要翻译：本发明涉及用于从患者收集流体的流体回收系统。根据本发明的教导的流体回收系统包括具有用于从患者收集流体的收集室的壳体，并且还包括与壳体一体形成的多个部件和/或结构。这种整体模制的部件可以包括用于控制流体回收系统内的流体流动的阀和防篡改处理系统。

68. 发明授权

US5925074A Vascular endoprosthesis and method 失效
公开(公告)号：US5925074A
公开(公告)日：1999-07-20
申请号：US759861
申请日：1996-12-03
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/82 , A61L31/04 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61L31/048 , A61F2/90 , A61F2/958
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

69. 发明授权

US5411550A Implantable prosthetic device for the delivery of a bioactive material 失效
标题翻译：用于输送生物活性材料的植入式假体装置
公开(公告)号：US5411550A
公开(公告)日：1995-05-02
申请号：US109103
申请日：1993-08-19
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/06 , A61L27/16 , A61L27/54 , A61L27/56 , A61F2/04
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/54 , A61F2250/0067 , A61L2300/602
摘要： An implantable prosthetic device for sustained release of a bioactive material into a fluid flow pathway of a patient comprises a body adapted for attachment to the fluid flow pathway. The body defines a primary lumen for accommodating fluid flow therethrough and at least one secondary lumen at least a portion of which is separated from the primary lumen by a wall sufficiently permeable to permit a bioactive material disposed in the lumen to diffuse through the wall and into the primary lumen. The bioactive material can be either a therapeutic or diagnostic agent. In a particular embodiment of the invention, the device comprises a tubular body consisting of stretched and/or expanded polytetrafluoroethylene and is adapted for attachment to a blood vessel of a patient.
摘要翻译：用于将生物活性材料持续释放到患者的流体流动路径中的可植入假体装置包括适于附接到流体流动路径的主体。主体限定用于容纳流体流动的主腔，以及至少一个第二内腔，其至少一部分与主腔分隔开足够透气的壁，以允许设置在内腔中的生物活性材料通过壁扩散并进入主管腔。生物活性物质可以是治疗剂或诊断剂。在本发明的一个具体实施方案中，该装置包括由拉伸和/或膨胀的聚四氟乙烯组成的管状体，并适于附着于患者的血管。

70. 发明授权

US5401262A Fluid recovery system 失效
标题翻译：流体回收系统
公开(公告)号：US5401262A
公开(公告)日：1995-03-28
申请号：US817582
申请日：1992-01-07
申请人： Theodore Karwoski , Steve A. Herweck , David Cross
发明人： Theodore Karwoski , Steve A. Herweck , David Cross
IPC分类号： A61M1/00
CPC分类号： A61M1/0013 , A61M1/0001 , A61M1/0015 , A61M1/0056 , A61M2205/59
摘要： A fluid collection vessel for drainage of body fluids includes a molded body with internal dividers constituting ports, baffles and subchambers, and a face plate that closes the body to form a suction-regulated multi-chamber vessel. The vessel has overpressure and underpressure protection, and cannot lose its fluid when tipped. The molded body incorporates novel valves and ports, and a wall structure enhances its utility for blood collection and monitoring. Dynamic fluid level is stabilized by diversion of fluid energy into a side chamber in the downstream region of the manometer column.
摘要翻译：用于排出体液的流体收集容器包括具有构成端口，挡板和副室的内部分隔件的模制体以及封闭主体以形成抽吸多腔室容器的面板。船舶具有超压和欠压保护，倾倒时不能失去流体。成型体结合了新颖的阀门和端口，壁结构增强了其对采血和监测的效用。动态流体液位通过将流体能量转移到压力计列的下游区域中的侧室来稳定。

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