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61. 发明授权

US08716438B2 Matricryptic ECM peptides for tissue reconstruction 有权
标题翻译： Matricryptic ECM肽用于组织重建
公开(公告)号：US08716438B2
公开(公告)日：2014-05-06
申请号：US13500398
申请日：2010-10-08
申请人： Vineet Agrawal , Stephen F. Badylak , Scott Alan Johnson , Stephen Tottey
发明人： Vineet Agrawal , Stephen F. Badylak , Scott Alan Johnson , Stephen Tottey
IPC分类号： A61K38/08 , A61K38/10 , A61K38/04 , C07K7/06 , C07K7/08 , C07K7/00 , A61P17/02 , A61K38/00
CPC分类号： C07K14/78 , A61K35/22 , A61K38/00
摘要： Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
摘要翻译：本文提供了用于祖细胞的化学引诱物多肽化合物和包含该化合物的组合物和药物产品。将祖细胞吸引到患者中或患者的位置的方法也与生长和修复骨的方法一起提供。

62. 发明授权

US08535719B2 Biohybrid elastomeric scaffolds and methods of use thereof 有权
标题翻译：生物混合弹性体支架及其使用方法
公开(公告)号：US08535719B2
公开(公告)日：2013-09-17
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
IPC分类号： A61K9/70
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译：本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。

63. 发明申请

US20130202563A1 DECELLULARIZED ADIPOSE CELL GROWTH SCAFFOLD 有权
标题翻译：细胞生长的细胞生长SCAFFOLD
公开(公告)号：US20130202563A1
公开(公告)日：2013-08-08
申请号：US13515661
申请日：2010-12-20
申请人： Stephen F. Badylak , Bryan N. Brown , John M. Freund , J. Peter Rubin
发明人： Stephen F. Badylak , Bryan N. Brown , John M. Freund , J. Peter Rubin
IPC分类号： A61K35/12
CPC分类号： A61K35/35 , A61L26/0057 , A61L26/0076 , A61L27/3804 , A61L27/60 , C07K14/78 , C12N5/0068 , C12N5/0667 , C12N2533/90
摘要： Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
摘要翻译：本文提供了从脂肪组织制备细胞生长支架的方法，具有低脂质含量的细胞生长支架和使用细胞生长支架的方法。

64. 发明申请

US20130058991A1 MATRICRYPTIC ECM PEPTIDES FOR TISSUE RECONSTRUCTION 有权
标题翻译：用于组织重建的MATRICRYPTIC ECM肽
公开(公告)号：US20130058991A1
公开(公告)日：2013-03-07
申请号：US13500398
申请日：2010-10-08
申请人： Vineet Agrawal , Stephen F. Badylak , Scott Alan Johnson , Stephen Tottey
发明人： Vineet Agrawal , Stephen F. Badylak , Scott Alan Johnson , Stephen Tottey
IPC分类号： A61K38/10 , C07K7/06 , A61K9/70 , A61P19/00 , C07K7/08 , A61K38/08
CPC分类号： C07K14/78 , A61K35/22 , A61K38/00
摘要： Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
摘要翻译：本文提供了用于祖细胞的化学引诱物多肽化合物和包含该化合物的组合物和药物产品。将祖细胞吸引到患者中或患者的位置的方法也与生长和修复骨的方法一起提供。

65. 发明授权

US08003131B2 Biomaterial derived from vertebrate liver tissue 有权
标题翻译：衍生自脊椎动物肝组织的生物材料
公开(公告)号：US08003131B2
公开(公告)日：2011-08-23
申请号：US12349254
申请日：2009-01-06
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A61K35/407
CPC分类号： A61K35/407 , A61K35/12 , C12N5/0068 , C12N2533/90
摘要： A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
摘要翻译：描述了包含肝基底膜的组织移植组合物。移植组合物可以植入以代替或诱导损伤或患病组织的修复。

66. 发明申请

US20110165126A1 Enhanced Submucosal Tissue Graft Constructs 审中-公开
标题翻译：增强黏膜下组织移植构造
公开(公告)号：US20110165126A1
公开(公告)日：2011-07-07
申请号：US12852897
申请日：2010-08-09
申请人： Stephen F. Badylak , Kristina Lindberg , George B. Boder , Sherry Voytik-Harbin
发明人： Stephen F. Badylak , Kristina Lindberg , George B. Boder , Sherry Voytik-Harbin
IPC分类号： A61K35/12 , A61P17/02 , A61P43/00
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译：描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。

67. 发明授权

US07795022B2 Vascularization enhanced graft constructs 有权
标题翻译：血管化增强移植物构建体
公开(公告)号：US07795022B2
公开(公告)日：2010-09-14
申请号：US10428355
申请日：2003-05-02
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A61K35/407 , A61K35/12 , C12N5/08
CPC分类号： A61L27/3886 , A61K35/34 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3826 , A61L27/383
摘要： A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.
摘要翻译：提供了用于修复患病或受损组织的组织移植物构建体。组织移植物构建体包含选自肝基底膜和其提取物及其水解物的基质组合物，以及来自脊椎动物非粘膜下层源的加工胶原，加入的内皮细胞和至少一种另外预选的外源细胞群，其增强在授权中启动类似船只的结构。预选的细胞群可以是非角化角化角化细胞或角化细胞上皮细胞群或选自成纤维细胞，平滑肌细胞，骨骼肌细胞，心肌细胞，多潜能祖细胞，周细胞，成骨细胞和任何其它合适的细胞类型，优选基于待修复的组织选择。还提供了用于增强这些组织移植物构建体体内血管形成和制备这些移植物构建体的方法。

68. 发明申请

US20100222882A1 JOINT BIOSCAFFOLDS 有权
标题翻译：联合BIOSCAFFOLDS
公开(公告)号：US20100222882A1
公开(公告)日：2010-09-02
申请号：US12714195
申请日：2010-02-26
申请人： Stephen F. Badylak , Bryan N. Brown , William L. Chung
发明人： Stephen F. Badylak , Bryan N. Brown , William L. Chung
IPC分类号： A61F2/30
CPC分类号： A61F2/3099 , A61F2/30756 , A61F2/30942 , A61F2002/30062 , A61F2002/30069 , A61F2002/30113 , A61F2002/30125 , A61F2002/30574 , A61F2002/30576 , A61F2002/30581 , A61F2002/30588 , A61F2002/30754 , A61F2002/30766 , A61F2002/3092 , A61F2210/0004 , A61F2230/0006 , A61F2230/0008 , A61L27/14 , A61L27/3633 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L89/00
摘要： Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
摘要翻译：本文提供了组合物和医疗装置，特别是能够修复和替代软骨型半月板的可生物降解的支架。本文还提供了使用支架治疗退行性组织病症的方法。在某些实施方案中，这种支架可以促进颞下颌关节（TMJ）半月板的组织再生。

69. 发明申请

US20100119579A1 DECELLULARIZED LIVER FOR REPAIR OF TISSUE AND TREATMENT OF ORGAN DEFICIENCY 审中-公开
标题翻译：用于修复组织和治疗组织缺陷的细菌肝脏
公开(公告)号：US20100119579A1
公开(公告)日：2010-05-13
申请号：US12687546
申请日：2010-01-14
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A61K9/00 , C12N5/00 , A61K35/12 , A61P43/00
CPC分类号： A61L27/3834 , A61L27/3604 , A61L27/3641 , A61L27/3683 , A61L27/3804 , A61L27/3839
摘要： The present invention provides a liver-derived devitalized mammalian parenchymatous tissue composition which includes an interstitial structure of connective tissue which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.
摘要翻译：本发明提供一种肝衍生的失活的哺乳动物实质组织组合物，其包括可用作组织修复或再生的支架的结缔组织的间质结构。失活的哺乳动物实质组织组合物可进一步包括组织的基底膜。

70. 发明申请

US20080268019A1 Biohybrid elastomeric scaffolds and methods of use thereof 有权
标题翻译：生物混合弹性体支架及其使用方法
公开(公告)号：US20080268019A1
公开(公告)日：2008-10-30
申请号：US11825540
申请日：2007-07-06
申请人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
发明人： Stephen F. Badylak , Donald O. Freytes , Thomas W. Gilbert , Jianjun Guan , John Stankus , William R. Wagner
IPC分类号： A61L27/54 , A61L27/58 , A61P17/02 , A61P43/00
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3804 , A61L27/58
摘要： Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
摘要翻译：本文提供了包含合成聚合物组分和生物聚合物组分的生物混合弹性体支架。支架可以制造成具有许多不同的形式，其非限制性实例包括非织造纤维网或多孔复合材料。还提供了在伤口愈合和组织再生中使用生物混合弹性体支架的方法。

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