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61. 发明授权

US06505072B1 Implantable electronic stimulator having isolation transformer input to telemetry circuits 有权
标题翻译：具有隔离变压器输入到遥测电路的可植入电子刺激器
公开(公告)号：US06505072B1
公开(公告)日：2003-01-07
申请号：US09714337
申请日：2000-11-16
申请人： William J. Linder , Mark D. Amundson
发明人： William J. Linder , Mark D. Amundson
IPC分类号： A61N108
CPC分类号： A61N1/37211 , A61N1/3752 , Y10S128/903
摘要： An implantable medical device for applying electrical stimulating pulses to body tissue in which the device includes a hermetically sealed metal housing that contains the stimulating pulse delivery circuitry as well as a telemetry transmitter and telemetry receiver and where the metal housing serves as a return electrode. An isolation transformer is operatively coupled between an antenna/coil used to receive and transmit information from and to an external programmer device and the telemetry receiver and telemetry transmitter within the implanted device. The isolation transformer effectively precludes high voltage stimulating pulses from causing damage to the telemetry circuit components.
摘要翻译：一种用于向身体组织施加电刺激脉冲的可植入医疗装置，其中所述装置包括密封金属壳体，所述金属壳体包含刺激脉冲输送电路以及遥测发射器和遥测接收器，并且金属壳体用作返回电极。隔离变压器可操作地耦合在用于从外部编程器装置接收和发送信息的天线/线圈与植入装置内的遥测接收器和遥测发射器之间。隔离变压器有效地排除了高压刺激脉冲对遥测电路部件的损坏。

62. 发明授权

US06456256B1 Circumferential antenna for an implantable medical device 有权
标题翻译：可植入医疗器械的圆周天线
公开(公告)号：US06456256B1
公开(公告)日：2002-09-24
申请号：US09921653
申请日：2001-08-03
申请人： Mark D. Amundson , Jeffrey A. Von Arx , William J. Linder , Prashant Rawat , William R. Mass
发明人： Mark D. Amundson , Jeffrey A. Von Arx , William J. Linder , Prashant Rawat , William R. Mass
IPC分类号： H01Q140
CPC分类号： H01Q1/22 , A61N1/37229 , Y10S128/903
摘要： An apparatus and method for enabling far-field radio-frequency communications with an implantable medical device in which an antenna is embedded within a dielectric around the periphery of the device. Such a circumferential antenna saves space while still permitting far-field telemetry over a desired range of frequencies.
摘要翻译：一种用于实现与可植入医疗装置的远场射频通信的装置和方法，其中天线嵌入设备外围的电介质周围。这种周向天线节省了空间，同时仍然允许在期望的频率范围上进行远场遥测。

63. 发明授权

US06198123B1 Shielded integrated circuit capacitor connected to a lateral transistor 失效
标题翻译：屏蔽集成电路电容器
公开(公告)号：US06198123B1
公开(公告)日：2001-03-06
申请号：US08924456
申请日：1997-08-29
申请人： William J. Linder , Robert S. Harguth
发明人： William J. Linder , Robert S. Harguth
IPC分类号： H01G428
CPC分类号： H01L28/40
摘要： An integrated circuit (IC) capacitor offers reduced sensitivity to parasitic capacitance, reduced-size, and increased noise immunity, such as for use in digital-to-analog converters (DACs), analog-to-digital converters (ADCs), switched-capacitor filters, and other IC circuits. The capacitor includes a first polysilicon layer, a superjacent second polysilicon layer separated from the first polysilicon layer by an insulator, and an overlying metal layer separated from the second polysilicon layer by an insulator. The metal layer provides a shield that is connected to a known voltage, or to the first polysilicon layer. When connected to the first polysilicon layer, the overlying metal layer also provides additional parallel capacitance, thereby reducing the integrated circuit area of the capacitor. In one example, the overlying metal layer is a second metal layer that is also used, together with a first metal layer, for interconnecting IC components.
摘要翻译：集成电路（IC）电容器对寄生电容的灵敏度降低，尺寸减小，抗噪声能力增强，例如用于数/模转换器（DAC），模/数转换器（ADC）电容滤波器和其他IC电路。电容器包括第一多晶硅层，通过绝缘体与第一多晶硅层分离的相邻的第二多晶硅层，以及通过绝缘体与第二多晶硅层分离的上覆金属层。金属层提供连接到已知电压的屏蔽，或者连接到第一多晶硅层。当连接到第一多晶硅层时，上覆金属层还提供额外的并联电容，从而减小电容器的集成电路面积。在一个示例中，上覆金属层是第二金属层，其也与第一金属层一起用于互连IC部件。

64. 发明授权

US5699014A Linear amplifier 失效
标题翻译：线性放大器
公开(公告)号：US5699014A
公开(公告)日：1997-12-16
申请号：US627403
申请日：1996-04-04
申请人： Paul A. Haefner , William J. Linder
发明人： Paul A. Haefner , William J. Linder
IPC分类号： H03F1/32 , H03F3/45
CPC分类号： H03F1/3211 , H03F1/3205 , H03F2200/162 , H03F2200/372
摘要： A low-noise, low-power complementary metal-oxide-semiconductor (CMOS) integrated circuit common source differential amplifier is disclosed which is capable of amplifying low amplitude cardiac signals such as those produced by atrial depolarization of the heart. The amplifier has a pair of large area p-channel input field-effect transistors (FETs) biased in weak inversion. The amplifier also has active load FETs biased in the nonsaturation (linear) region by means of a varying gate terminal voltage applied by a dynamic bias circuit. The gate terminal voltage is varied to match the temperature dependence of the output conductance of the load FETs to the temperature dependence of the transconductance of the input FETs. The gate terminal voltage also sets a dc bias point which uses the nonlinearity in the load FET output conductance to cancel nonlinearity in the input FET transconductance.
摘要翻译：公开了一种低噪声，低功率互补金属氧化物半导体（CMOS）集成电路公共源差分放大器，其能够放大低振幅心脏信号，例如通过心脏去极化产生的心脏信号。放大器具有一对在弱反相中偏置的大面积p沟道输入场效应晶体管（FET）。放大器还通过由动态偏置电路施加的变化的栅极端子电压而在非饱和（线性）区域中偏置有有源负载FET。栅极端子电压变化以匹配负载FET的输出电导的温度依赖性与输入FET的跨导的温度依赖性。栅极端子电压还设置直流偏置点，其使用负载FET输出电导中的非线性来消除输入FET跨导中的非线性。

65. 发明授权

US4768019A Analog-to-digital converter 失效
标题翻译：模数转换器
公开(公告)号：US4768019A
公开(公告)日：1988-08-30
申请号：US101109
申请日：1987-09-25
申请人： William J. Linder
发明人： William J. Linder
IPC分类号： H03M1/08 , H03M1/00 , H03M1/50
CPC分类号： H03M1/52 , H03M1/123
摘要： An integrating analog-to-digital converter having an operational amplifier serving as an integrator and as a comparator.

66. 发明授权

US4543540A Phase locked loop with limited phase correction when in locked condition 失效
标题翻译：锁定环在锁定状态下进行有限的相位校正
公开(公告)号：US4543540A
公开(公告)日：1985-09-24
申请号：US487941
申请日：1983-04-25
申请人： William J. Linder
发明人： William J. Linder
IPC分类号： H03L7/191 , H03L7/00
CPC分类号： H03L7/191 , Y10S331/02
摘要： A phase locked loop provides limited phase correction when in lock in order to minimize the effects of noise in the periodic input signal to which the loop is locked. The phase locked loop includes a voltage controlled oscillator (VCO), a timing generation divider, a phase detector, a lock detector and an oscillator control circuit. The phase detector provides an output based upon the phase difference between rising edges of the input signal and a loop synthesized signal which is derived by the divider from an oscillator output signal. A window signal, which begins slightly before and ends slightly after an anticipated rising edge of the input signal, is also derived from the oscillator output signal. The lock detector provides a lock detect signal which indicates whether the loop is in lock. The oscillator control circuit provides an oscillator control voltage based upon the phase detector output signal, the window signal, and the lock detect signal. When the loop is in lock, changes to the oscillator control voltage based on the phase detector output are limited by the window signal. When the loop out of lock, full corrections to the oscillator control voltage based upon the phase detector output signal are permitted, so that the loop can rapidly regain the phase locked condition.
摘要翻译：锁相环在锁定时提供有限的相位校正，以便最小化环路锁定的周期性输入信号中噪声的影响。锁相环包括压控振荡器（VCO），定时产生分频器，相位检测器，锁定检测器和振荡器控制电路。相位检测器基于输入信号的上升沿之间的相位差和由分频器从振荡器输出信号导出的回路合成信号提供输出。在输入信号的预期上升沿之后稍微开始并稍微结束的窗口信号也从振荡器输出信号导出。锁定检测器提供一个锁定检测信号，指示环路是否处于锁定状态。振荡器控制电路基于相位检测器输出信号，窗口信号和锁定检测信号提供振荡器控制电压。当环路锁定时，基于相位检测器输出的振荡器控制电压的改变受到窗口信号的限制。当环路锁定时，允许基于相位检测器输出信号对振荡器控制电压的全面校正，使得环路可以快速恢复锁相状态。

67. 发明授权

US09555252B2 Systems for providing neural markers for sensed autonomic nervous system activity 有权
标题翻译：用于提供感觉到的自主神经系统活动的神经标记物的系统
公开(公告)号：US09555252B2
公开(公告)日：2017-01-31
申请号：US12612494
申请日：2009-11-04
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/37 , A61B5/04 , A61N1/36 , A61N1/362 , A61N1/372 , A61B5/00
CPC分类号： A61N1/37 , A61B5/04001 , A61B5/4035 , A61B5/4047 , A61B5/4052 , A61B5/726 , A61N1/36135 , A61N1/3627 , A61N1/3702 , A61N1/37217 , A61N1/37235
摘要： In various method embodiments, a neural activity signal is sensed, a feature from the sensed neural activity signal is extracted, and a neural marker for the extracted feature is created. The neural marker includes information regarding the extracted feature. Various device embodiments comprise a port to receive a neural activity signal, and a feature extractor adapted to receive and process the neural activity signal to produce a neural marker that includes information for the neural activity signal. Various device embodiments comprise a display, a memory adapted to store a neural marker associated with a sensed neural activity signal, and a controller adapted to communicate with the memory and the display to provide a representation of the neural marker on the display.
摘要翻译：在各种方法实施例中，感测神经活动信号，提取来自所感测的神经活动信号的特征，并且创建用于提取的特征的神经标记。神经标记包括关于提取的特征的信息。各种装置实施例包括用于接收神经活动信号的端口，以及适于接收和处理所述神经活动信号以产生神经标记的特征提取器，所述神经标记包括所述神经活动信号的信息。各种设备实施例包括显示器，适于存储与感测的神经活动信号相关联的神经标记的存储器，以及适于与存储器和显示器通信以提供显示器上的神经标记的表示的控制器。

68. 发明授权

US08855784B2 Implantable medical device including controllably isolated housing 有权
标题翻译：可植入医疗设备，包括可控制的隔离住房
公开(公告)号：US08855784B2
公开(公告)日：2014-10-07
申请号：US12977141
申请日：2010-12-23
申请人： Michael J. Lyden , William J. Linder
发明人： Michael J. Lyden , William J. Linder
IPC分类号： A61N1/00 , A61N1/02 , A61N1/375 , A61N1/37 , A61N1/39 , A61N1/36
CPC分类号： A61N1/025 , A61N1/3605 , A61N1/3718 , A61N1/3758 , A61N1/3956
摘要： An implantable medical device or some other ambulatory medical device, such as a pacer, defibrillator, or other cardiac rhythm management device can include an electrical energy delivery circuit, such as including an integrated circuit comprising a first electrostimulation output terminal, a can terminal, and a switch control output. The ambulatory or implantable device can include at least two switches in series, each including a respective substrate electrically separate from the integrated circuit, and from each other, the switches configured to controllably isolate a conductive housing of the implantable medical device from the can terminal of the integrated circuit, such as in response to the switch control output.
摘要翻译：可植入医疗装置或其他一些其他动态医疗装置，例如起搏器，除颤器或其他心律管理装置可以包括电能传递电路，例如包括集成电路，其包括第一电刺激输出端子，罐端子和开关控制输出。移动或可植入装置可以包括至少两个串联的开关，每个开关均包括与集成电路电气分离的相应基板，并且彼此之间，被配置为可控制地将可植入医疗装置的导电壳体与集成电路，如响应开关控制输出。

69. 发明授权

US08831718B2 Neural stimulation system to prevent simultaneous energy discharges 有权
标题翻译：神经刺激系统防止同时释放能量
公开(公告)号：US08831718B2
公开(公告)日：2014-09-09
申请号：US13007739
申请日：2011-01-17
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/18 , A61N1/39 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/3962
摘要： Various aspects of the present subject matter relate to a system. Various embodiments of the system comprise at least one port to connect to at least one lead with at least one electrode, at least one stimulator circuit and at least one controller. The at least one stimulator circuit is connected to the at least one port and is adapted to deliver neural stimulation to a neural stimulation target using the at least one electrode. The at least one controller is adapted to determine when another energy discharge other than the neural stimulation to the neural stimulation target is occurring and to prevent delivery of the neural stimulation simultaneously with the other energy discharge. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及系统。系统的各种实施例包括至少一个端口，以连接至少一个引线与至少一个电极，至少一个刺激器电路和至少一个控制器。所述至少一个刺激器电路连接到所述至少一个端口，并且适于使用所述至少一个电极将神经刺激递送到神经刺激靶。所述至少一个控制器适于确定何时发生除了对神经刺激靶的神经刺激以外的其他能量放电，并且防止神经刺激与另一能量放电同时传送。本文提供了其它方面和实施例。

70. 发明授权

US08489187B2 Defibrillation shock output circuit 有权
标题翻译：除颤电击输出电路
公开(公告)号：US08489187B2
公开(公告)日：2013-07-16
申请号：US13368882
申请日：2012-02-08
申请人： William J. Linder , Hari Sree
发明人： William J. Linder , Hari Sree
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： This document discusses, among other things, techniques for generating and delivering a high voltage defibrillation shock using an implantable cardiac rhythm management device. An output energy delivery bridge can be programmed to provide desired shock vectors or polarities. A bootstrapped fully solid-state switch control voltage generation circuit is described. Automatic polarity or vector reconfiguration embodiments are described, such as in response to an unsuccessful attempt to convert the heart to a normal rhythm.
摘要翻译：本文件尤其涉及使用可植入式心律管理装置产生和递送高压除颤电击的技术。输出能量输送桥可以被编程以提供期望的震动矢量或极性。描述了自举完全固态开关控制电压产生电路。描述了自动极性或向量重新配置实施例，例如响应于将心脏转换成正常节奏的不成功的尝试。

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