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61. 发明专利

CA2309558C SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS 未知
公开(公告)号：CA2309558C
公开(公告)日：2005-05-03
申请号：CA2309558
申请日：1998-11-18
申请人： SCHERING CORP
发明人： TING PAULINE C , SHIH NENG-YENG , ALAIMO CHERYL A , REICHARD GREGORY A , CARRUTHERS NICHOLAS I , LAVEY BRIAN J
IPC分类号： A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/451 , A61K31/452 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P1/08 , A61P11/00 , A61P11/06 , A61P11/14 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P43/00 , C07D211/24 , C07D211/34 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/76 , C07D211/94 , C07D401/12 , C07D401/14 , C07D417/14
摘要： Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R1 is H, methyl, ethyl, -CH2CN , - CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a) , (b), (c), (d) or (e); R4 is methyl or ethyl; and Z is substituted piperidinyl.

62. 发明专利

HK1066787A1 NK1 ANTAGONISTS NK1 未知
公开(公告)号：HK1066787A1
公开(公告)日：2005-04-01
申请号：HK04109823
申请日：2004-12-11
申请人： SCHERING CORP
发明人： WROBLESKI MICHELLE LACI , REICHARD GREGORY A , SHIH NENG-YANG , XIAO DONG
IPC分类号： A61K20060101 , A61K31/075 , A61K31/122 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/17 , A61K31/196 , A61K31/27 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/423 , A61K31/4453 , A61K31/498 , A61K31/5375 , A61K31/538 , A61K31/573 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P11/00 , A61P11/14 , A61P13/00 , A61P13/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P25/36 , A61P43/00 , C07C20060101 , C07C43/174 , C07C43/178 , C07C49/753 , C07C215/42 , C07C217/52 , C07C229/48 , C07C233/23 , C07C233/39 , C07C237/04 , C07C237/08 , C07C237/20 , C07C237/24 , C07C239/12 , C07C251/42 , C07C251/44 , C07C251/50 , C07C271/22 , C07C271/24 , C07C271/34 , C07C275/26 , C07D205/12 , C07D207/26 , C07D207/27 , C07D209/54 , C07D235/02 , C07D241/38 , C07D249/12 , C07D253/06 , C07D263/52 , C07D265/34 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/215 , C07D403/06 , C07J7/00
摘要： A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough:

63. 发明专利

BR0215158A 未知
公开(公告)号：BR0215158A
公开(公告)日：2004-10-19
申请号：BR0215158
申请日：2002-12-17
申请人： SCHERING CORP
发明人： PALIWAL SUNIL , REICHARD GREGORY A , WANG CHENG , XIAO DONG , TSUI HON-CHUNG , SHIH NENG-YANG , ARREDONDO JUAN D , WROBLESKI MICHELLE LACI , PALANI ANANDAN
IPC分类号： C07D491/107 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/4166 , A61K31/4178 , A61K31/4188 , A61K31/421 , A61K31/435 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/499 , A61K31/505 , A61K31/537 , A61K31/5377 , A61K31/664 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/14 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/02 , A61P29/00 , A61P31/18 , C07D207/14 , C07D207/26 , C07D207/50 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/34 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D498/10 , C07D513/10
摘要： A NK 1 antagonist having the formula (I), wherein Ar 1 and Ar 2 are optionally substituted phenyl or heteroaryl, X 1 is an ether, thio or imino linkage, R 4 and R 5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

64. 发明专利

AT277035T 未知
公开(公告)号：AT277035T
公开(公告)日：2004-10-15
申请号：AT99968048
申请日：1999-12-21
申请人： SCHERING CORP
发明人： REICHARD GREGORY A , SHIH NENG-YANG , WANG DASONG
IPC分类号： A61K31/454 , A61K31/496 , A61K31/513 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P3/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/10 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/24 , A61P27/02 , A61P29/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D417/14 , C07D401/00

65. 发明专利

MXPA04004477A ANTAGONISTAS DEL NEUROPEPTIDO NEUROQUININA-1(NK1). 未知
公开(公告)号：MXPA04004477A
公开(公告)日：2004-08-11
申请号：MXPA04004477
申请日：2002-11-12
申请人： SCHERING CORP
发明人： REICHARD GREGORY A
IPC分类号： C07D211/76 , A61K31/4015 , A61K31/4439 , A61K31/451 , A61K31/454 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/00 , A61P15/00 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P27/02 , A61P29/00 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/273 , C07D207/36 , C07D207/38 , C07D211/86 , C07D401/04 , C07D403/04 , A61K31/4025 , A61K31/44
摘要： Un antagonista NK1 que tiene la formula (I) con las variables definidas aqui, el cual es util para tratar una variedad de trastornos que incluyen tmesis, depresion, ansiedad y tos;(ver formula I)donde las variables son tal como se han definido en la especificacion; un compuesto representativo de la invencion es:(ver formula).

66. 发明专利

ES2202481T3 未知
公开(公告)号：ES2202481T3
公开(公告)日：2004-04-01
申请号：ES96936767
申请日：1996-10-28
申请人： SCHERING CORP
发明人： REICHARD GREGORY A , ASLANIAN ROBERT G
IPC分类号： A61K31/445 , A61K31/451 , A61P1/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P43/00 , C07D211/52
摘要： Aralkylamine derivatives of formula (I) and their salts are new: A1 = CH2R6, OR6, NR6R7, SOeR13, (CR6R7)qOR6, (CR6R7)qNR6R7 or (CR6R7)qSOeR13; q = 1-6; A2 = H; or A1+A2 = O, CR6R7, NOR6 or S; Q = R5-phenyl, R5-naphthyl, SR6, NR6R7, OR6 or R5-heteroaryl; T = H, R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl or R10-bridged cycloalkyl; b = 0-2; b1 = 1-2; X = a bond, CO, O, NR6, SOe, NR6CO, CONR6, OC(O)NR6, OC(S)NR6, NR6C(S)O, C(=NOR6), SO2NR6, NR6SO2, NR6CO2 or OC(O); R4, R5 = 1-3 of H, halo, OR6, OC(O)R6, OC(O)NR6R7, NR6R7, 1-6C alkyl, CF3, C2F5, COR6, CO2R6, CONR6R7, SOeR13, CN, OCF3, NR6CO2R16, NR6COR7, NR8CONR6R7, R15-phenyl, R15-benzyl, NO2, NR6SO2R13 or SO2NR6R7; or adjacent R4 substituents or adjacent R5 substituents can form OCH2O; or R4 = R15-heteroaryl; R6, R7, R8, R8a, R13 = H, 1-6C alkyl, 2-6C hydroxyalkyl, 1-6C alkoxy-1-6C alkyl, R15-phenyl or R15-benzyl or NR6R7 = 5-6 membered ring containing 1-2 of O, S and/or NR19; R9, R9a = R6 or OR6; provided that when R9 = OH, then X = a bond, CO, NR6CO or C(=NOR6); R10 = H or 1-6C alkyl; R15 = 1-3 of H, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, halo, CF3, C2F5, COR10, CO2R10, CON(R10)2, SOeR10, CN, N(R10)COR10, N(R10)CON(R10)2 or NO2; R16 = 1-6C alkyl, R15-phenyl or R15-benzyl; R19 = H, 1-6C alkyl, CON(R10)2, CO2R10, (CR8R9)fCO2R10 or (CR8R9)uC(O)N(R10)2; f = 1-6; u = 0-6; Z = a group of formula (a)-(c): g, j = 0-3; h, k = 1-4, provided that h +g = 1-7; J = (H, H), O, S, NR9 or NOR9; L, L1 = H, 1-6C alkyl, 1-6C alkenyl, CH2-cycloalkyl, R15-benzyl, R15-heteroaryl, COR6, (CH2)mOR6, (CH2)mNR6R7, (CH2)mCO2R6 or (CH2)mCONR6R7; m = 0-4; provided that when j = 0 then m = 1-4; R25 = H, 1-6C alkyl, CN, R15-phenyl or R15-benzyl; R26, R27 = H, 1-6C alkyl, R4-aryl or R4-heteroaryl or R26 = H, 1-6C alkyl, R4-aryl or R4-heteroaryl and R27 = COR6, CONR6R7, COR4-aryl, COR4-heteroaryl, SO2R13 or SO2R4-aryl; R28 = H, (CR6R19)tG or (CR6R7)vG2; t, v = 0-3; provided that when j = 0 then t = 1-3; R29 = H, 1-6C alkyl, C(R10)2SOeR6, R4-phenyl or R4-heteroaryl; G = H, R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl, OR6, NR7R6, COR6, CO2R6, CONR7R9, SOeR13, NR6CO2R16, NR6COR7, NR8CONR6R7, NR6SO2R13, SO2NR6R7, OC(O)R6, OC(O)NR6R7, C(=NOR8)NR6R7, C(=NR25)NR6R7, NR8C(=NR15)NR6R7, CN, C(O)NR6OR7 or C(O)N(R9)-(R4-heteroaryl), provided that when n = 1 and u = 0 or when R9 = OR6 then G is not OH or NR6R7 and G2 = R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl, COR6, CO2R16, SO2NR6R7 or CONR6R7. 15 Compounds (I) are specifically claimed e.g: N-(2-(3,4-dichlorophenyl)-3-hydroxy-4-(4-hydroxy-4-phenyl-1-piperidinyl)butyl)-N-methyl benzamide.

67. 发明专利

HU0301607A2 HETEROCYCLIC COMPOUND CONTAINING NITROGEN ATOMS HAVING SELECTIVE NEUROKININ ANATGONIST EFFECT PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：HU0301607A2
公开(公告)日：2003-12-29
申请号：HU0301607
申请日：2000-12-14
申请人： SCHERING CORP
发明人： BLYTHIN DAVID J , CHEN XIAO , PALIWAL SUNIL , PIWINSKI JOHN J , REICHARD GREGORY A , SHIH NENG-YANG , SHUE HO-JANE , XIAO DONG
IPC分类号： A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/433 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/04 , A61P1/08 , A61P1/14 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/10 , A61P15/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/28 , A61P29/00 , A61P31/04 , A61P37/08 , C07C45/71 , C07C217/46 , C07C217/48 , C07D211/58 , C07D233/14 , C07D233/16 , C07D233/22 , C07D233/30 , C07D233/32 , C07D233/34 , C07D233/40 , C07D233/42 , C07D233/46 , C07D233/48 , C07D233/78 , C07D239/10 , C07D263/24 , C07D285/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07F9/6506
摘要： Compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is -O-, -S-, -SO-, -SO2-, -NR -, -NCOR - or -NR SO2R ; (a) is selected from the group consisting of (b), (c), (d) and (e); X is -O-, -S- or -NR -; Y is =O, =S or =NR ; Y is H, C1-C6 alkyl, -NR R , -SCH3, R -aryl(CH2)n6-, R -heteroaryl-(CH2)n6-, -(CH2)n6-heterocycloalkyl, -(C1-C3)alkyl-NH-C(O)O(C1-C6)alkyl or -NHC(O)R ; R , R , R and R are H, alkyl, cycloalkyl, -CHF2, -CH2F or -CF3; or R and R , together with the carbon to which they are attached, form an alkylene ring; or R and R together are =O; R is R or -OH; and the remaining variables are as defined in the specification, methods of treating diseases susceptible to treatment with neurokinin antagonists with said compounds. Also disclosed are pharmaceutical compositions comprising an effective amount of a compound of claim 1, at least one pharmaceutically acceptable carrier, and in combination with an effective amount of a selective serotonin reuptake inhibitor.

68. 发明专利

AU2003220215A1 NK1 ANTAGONISTS 未知
公开(公告)号：AU2003220215A1
公开(公告)日：2003-09-29
申请号：AU2003220215
申请日：2003-03-12
申请人： SCHERING CORP
发明人： XIAO DONG , WROBLESKI MICHELLE LACI , REICHARD GREGORY A , SHIH NENG-YANG
IPC分类号： A61K31/075 , A61K31/122 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/17 , A61K31/196 , A61K31/27 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/423 , A61K31/4453 , A61K31/498 , A61K31/5375 , A61K31/538 , A61K31/573 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P11/00 , A61P11/14 , A61P13/00 , A61P13/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P25/36 , A61P43/00 , C07C43/174 , C07C43/178 , C07C49/753 , C07C215/42 , C07C217/52 , C07C229/48 , C07C233/23 , C07C233/39 , C07C237/04 , C07C237/08 , C07C237/20 , C07C237/24 , C07C239/12 , C07C251/42 , C07C251/44 , C07C251/50 , C07C271/22 , C07C271/24 , C07C271/34 , C07C275/26 , C07D205/12 , C07D207/26 , C07D207/27 , C07D209/54 , C07D235/02 , C07D241/38 , C07D249/12 , C07D253/06 , C07D263/52 , C07D265/34 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/215 , C07D403/06 , C07J7/00 , C07C237/10 , A61K31/13 , A61K31/195 , A61K31/197 , A61K31/416 , C07C251/38 , C07C251/36 , C07C217/54 , C07C237/14
摘要： A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough:

69. 发明专利

PE07622003A1 COMPUESTOS HETEROCICLICOS COMO ANTAGONISTAS NK1 未知
公开(公告)号：PE07622003A1
公开(公告)日：2003-09-05
申请号：PE0012002002
申请日：2002-12-12
申请人： SCHERING CORP
发明人： XIAO DONG , WROBLESKY MICHELLE LACI , TSUI HON-CHUNG , REICHARD GREGORY A , PALANI ANANDAN , ARREDONDO JUAN D , PALIWAL SUNIL , SHIH NENG-YANG , WANG CHENG
IPC分类号： C07D491/107 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/407 , A61K31/4166 , A61K31/4178 , A61K31/4188 , A61K31/421 , A61K31/435 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/499 , A61K31/505 , A61K31/537 , A61K31/5377 , A61K31/664 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/14 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/02 , A61P29/00 , A61P31/18 , C07D207/14 , C07D207/26 , C07D207/50 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/34 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D498/10 , C07D513/10
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： SE REFIERE A COMPUESTOS DE FORMULA I DONDE AR1 Y AR2 SON EL GRUPO a Y R17-HETEROARILO DONDE X1 ES -O-, -S-, -SO-, -SO2-, ENTRE OTROS; CUANDO X1 ES -SO- R1 Y R2 SON H, ALQUILO C1-C6, HIDROXI(ALQUILO C1-C3), CICLOALQUILO C3-C8, -CH2F, -CHF2, -CF3; R1 Y R2 JUNTO A C FORMAN UN ANILLO DE ALQUILENO DE C3-C6; R3 ES H, ALQUILO C1-C6, HIDROXI(ALQUILO C1-C3), ENTRE OTROS; R6 ES H, ALQUILO C1-C6, OH; R7 ES H, ALQUILO C1-C6; n2 ES 1-4; R4 Y R5 ES (CR28R29)n1-G; n1 ES 0-5 ; G ES H, -CF3, -CHF2, -CH2F, OH, ENTRE OTROS; R28 Y R29 SON H, ALQUILO C1-C2, ENTRE OTROS; R32 Y R33 SON H, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS DE FORMULA I, II ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DE FORMULA I SON ANTAGONISTAS DE LOS RECEPTORES DE NEUROQUININA Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS, INFLAMATORIAS

70. 发明专利

CA2470476A1 PYRROLIDINE AND PIPERIDINE DERIVATES AS NK1 ANTAGONISTS 未知
公开(公告)号：CA2470476A1
公开(公告)日：2003-06-26
申请号：CA2470476
申请日：2002-12-17
申请人： SCHERING CORP
发明人： PALANI ANANDAN , PALIWAL SUNIL , REICHARD GREGORY A , WANG CHENG , WROBLESKI MICHELLE LACI , TSUI HON-CHUNG , ARREDONDO JUAN D , SHIH NENG-YANG , XIAO DONG
IPC分类号： C07D491/107 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/4166 , A61K31/4178 , A61K31/4188 , A61K31/421 , A61K31/435 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/499 , A61K31/505 , A61K31/537 , A61K31/5377 , A61K31/664 , A61K45/00 , A61P1/00 , A61P1/08 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/14 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/02 , A61P29/00 , A61P31/18 , C07D207/14 , C07D207/26 , C07D207/50 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/34 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D498/10 , C07D513/10 , A61K31/407
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined i n the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

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