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61. 发明申请

US20100331903A1 HEART SOUND SENSING TO REDUCE INAPPROPRIATE TACHYARRHYTHMIA THERAPY 有权
标题翻译：心脏感觉减少不明显的TACHYARRHYTHMIA治疗
公开(公告)号：US20100331903A1
公开(公告)日：2010-12-30
申请号：US12495204
申请日：2009-06-30
申请人： Xusheng Zhang , David A. Anderson , Jeffrey M. Huston , Jeffrey M. Gillberg
发明人： Xusheng Zhang , David A. Anderson , Jeffrey M. Huston , Jeffrey M. Gillberg
IPC分类号： A61N1/39 , A61B5/02
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36528 , A61N1/36535
摘要： Techniques for detecting heart sounds to reduce inappropriate tachyarrhythmia therapy are described. In some examples, a medical device determines that a cardiac rhythm of the patient is treatable with a therapy, such as a defibrillation pulse, based on a cardiac electrogram (EGM). The medical device analyzes detected heart sounds, and withholds or allows the therapy based on the analysis of the heart sounds.
摘要翻译：描述了用于检测心音以减少不适当的快速性心律失常治疗的技术。在一些示例中，医疗装置通过基于心电图（EGM）的治疗，例如除颤脉冲来确定患者的心律是可治疗的。医疗器械分析检测到的心脏声音，并根据对心脏声音的分析，保留或允许进行治疗。

62. 发明申请

US20070239048A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的脑膜炎的方法和装置
公开(公告)号：US20070239048A1
公开(公告)日：2007-10-11
申请号：US11380802
申请日：2006-04-28
申请人： Raja Ghanem , Robert Stadler , Xusheng Zhang
发明人： Raja Ghanem , Robert Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, determining inflections of the sensed cardiac signals, generating a pulse amplitude threshold in response to the determined inflections, and determining whether the inflections are indicative of noise in response to the determined inflections and the generated pulse amplitude threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，确定感测的心脏信号的变形，响应于所确定的心脏信号产生脉冲幅度阈值并且确定所述变形是否响应于所确定的变形和产生的脉冲幅度阈值来指示噪声。

63. 发明授权

US09643014B2 System and method for pacing parameter optimization using heart sounds 有权
公开(公告)号：US09643014B2
公开(公告)日：2017-05-09
申请号：US13296605
申请日：2011-11-15
申请人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen
发明人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen
IPC分类号： A61N1/365 , A61N1/37 , A61N1/372 , A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/3686 , A61N1/3702 , A61N1/37247 , A61N1/37264
摘要： A medical device system and associated method predict a patient response to a cardiac therapy. The system includes for delivering cardiac pacing pulses to a patient's heart coupled to a cardiac sensing module and a cardiac pacing module for generating cardiac pacing pulses and controlling delivery of the pacing pulses at multiple pace parameter settings. An acoustical sensor obtains heart sound signals. A processor is enabled to receive the heart sound signals, derive a plurality of heart sound signal parameters from the heart sound signals, and determine a trend of each of the plurality of heart sound signal parameters with respect to the plurality of pace parameter settings. An external display is configured to present the trend of at least one heart sound parameter with respect to the plurality of pace parameter settings.

64. 发明申请

US20160291458A1 METHOD INTEGRATING TARGET OPTIMIZATION AND OPTICAL PROXIMITY CORRECTION 审中-公开
标题翻译：方法集成目标优化和光学近似校正
公开(公告)号：US20160291458A1
公开(公告)日：2016-10-06
申请号：US14753192
申请日：2015-06-29
申请人： Daquan He , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
发明人： Daquan He , Fang Wei , Jun Zhu , Yukun Lv , Xusheng Zhang
IPC分类号： G03F1/36 , G06F17/50
CPC分类号： G03F1/36
摘要： A method integrating target optimization and optical proximity correction including: fragmenting sides of a target pattern in the metal layer to form a plurality of fragments; simulating the target pattern and calculating image log slope of each fragment; calculating a target pattern optimal parameter for each fragment which is a product of three parameters including the image log slope, overlap ratio of the target pattern and a via pattern in a via layer, and critical dimension; optimizing the target pattern based on the target pattern optimal parameter; preforming optical proximity correction to the optimized target pattern; determining whether the corrected target pattern meets requirements; if yes, ending the target optimization and optical proximity correction; otherwise, using the corrected target pattern as a current target pattern and iterate from the step of simulating the target pattern and calculating image log slope of each fragment.
摘要翻译：一种集成目标优化和光学邻近校正的方法，包括：金属层中的目标图案的碎裂边以形成多个碎片; 模拟目标模式并计算每个片段的图像对数斜率; 计算每个片段的目标图案最优参数，该三个参数的乘积包括图像对数斜率，目标图案的重叠率和通孔层中的通孔图案以及临界尺寸; 基于目标模式优化参数优化目标模式; 对优化的目标图案进行光学邻近校正; 确定校正的目标模式是否满足要求; 如果是，结束目标优化和光学邻近校正; 否则，使用校正的目标图案作为当前目标图案，并且从模拟目标图案的步骤并且计算每个片段的图像对数斜率来迭代。

65. 发明授权

US08996101B2 Heart sound sensing to reduce inappropriate tachyarrhythmia therapy 有权
标题翻译：心音检测减少不适当的快速性心律失常治疗
公开(公告)号：US08996101B2
公开(公告)日：2015-03-31
申请号：US13457983
申请日：2012-04-27
申请人： Xusheng Zhang , Teresa A. Whitman , Paul J. DeGroot , Mark L. Brown , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Teresa A. Whitman , Paul J. DeGroot , Mark L. Brown , Jeffrey M. Gillberg
IPC分类号： A61B5/0464 , A61B5/00 , A61N1/365 , A61N1/362 , A61B5/046
CPC分类号： A61B5/7221 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/686 , A61B5/6869 , A61B5/7264 , A61B5/7285 , A61B7/00 , A61N1/3621 , A61N1/36514 , G06F19/00
摘要： A method and device for detecting a cardiac event that includes sensing cardiac electrical signals representative of electrical activity of a heart of a patient, detecting the cardiac event in response to the sensed cardiac signals, determining an indication of signal reliability corresponding to the sensed cardiac signals as being one of a reliable signal and a not reliable signal, and switching operation of the device between a first mode of determining whether the sensed signal is one of treatable and not treatable and a second mode of determining whether the sensed signal is one of treatable and not treatable in response to the determined indication of signal reliability.
摘要翻译：一种用于检测心脏事件的方法和装置，其包括感测表示患者心脏的电活动的心脏电信号，响应于感测到的心脏信号检测心脏事件，确定与所感测的心脏信号相对应的信号可靠度的指示作为可靠信号和不可靠信号之一，以及在确定感测信号是可治疗和不可治疗的第一模式之间的装置的切换操作以及确定感测信号是否是可治疗的信号之一的第二模式并且不能响应于所确定的信号可靠性指示而被处理。

66. 发明申请

US20130289640A1 HEART SOUND-BASED PACING VECTOR SELECTION SYSTEM AND METHOD 审中-公开
标题翻译：基于心音的PACING矢量选择系统和方法
公开(公告)号：US20130289640A1
公开(公告)日：2013-10-31
申请号：US13458009
申请日：2012-04-27
申请人： Xusheng Zhang , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Jeffrey M. Gillberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36578 , A61N1/3686
摘要： A system and method for generating a pacing vector selection table senses a heart sound signal generated by a heart sound sensor and representing sounds generated by the heart of the patient. A processor controls the sequential selection of a pacing electrode vectors from electrodes positioned along a heart chamber. Pacing pulses are delivered via the sequentially selected plurality of pacing electrode vectors. The processor receives the heart sound signal, determines a plurality of different pacing responses using the heart sound signal for each of the of pacing electrode vectors, and generates a pacing vector selection table listing the plurality of different pacing responses for each of the plurality of pacing electrode vectors.
摘要翻译：用于产生起搏矢量选择表的系统和方法感测由心音传感器产生的心音信号，并且表示由患者心脏产生的声音。处理器控制来自位于心室的电极的起搏电极向量的顺序选择。经由顺序选择的多个起搏电极载体递送起搏脉冲。处理器接收心音信号，使用针对起搏电极矢量中的每一个的心音信号来确定多个不同的起搏响应，并且生成起搏矢量选择表，其列出多个起搏响应中的每一个起搏响应电极向量。

67. 发明申请

US20120101393A1 SYSTEM AND METHOD FOR DERIVING RESPIRATION FROM INTRACARDIAC ELECTROGRAMS (EGM) OR ECG SIGNALS 有权
标题翻译：用于从内皮细胞电子（EGM）或ECG信号传导呼吸的系统和方法
公开(公告)号：US20120101393A1
公开(公告)日：2012-04-26
申请号：US12912217
申请日：2010-10-26
申请人： Xusheng Zhang , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Jeffrey M. Gillberg
IPC分类号： A61B5/0205
CPC分类号： A61B5/0452 , A61B5/0816 , A61B5/7239 , A61B5/7278 , A61B5/7282
摘要： A method and apparatus for monitoring respiration in a patient sense a cardiac electrical signal and detect signal peaks from the cardiac electrical signal. A peak amplitude waveform is generated from the signal peaks. a first derivative of the peak amplitude waveform is computed. Inspiration pulses are derived from the first derivative signal, and a respiration metric can be computed using the inspiration pulses derived from the cardiac electrical signal.
摘要翻译：用于监测患者呼吸的方法和装置感测心电信号并检测心电信号的信号峰值。从信号峰值产生峰值振幅波形。计算峰值幅度波形的一阶导数。启发脉冲从一阶导数信号导出，并且可以使用从心电信号导出的吸气脉冲来计算呼吸度量。

68. 发明申请

US20120101392A1 OPTIMIZATION OF ARRHYTHMIA DETECTION BASED ON PATIENT ACTIVITY 审中-公开
标题翻译：基于患者活动的ARRHYTHMIA检测优化
公开(公告)号：US20120101392A1
公开(公告)日：2012-04-26
申请号：US12912111
申请日：2010-10-26
申请人： Sourav K. Bhunia , Xusheng Zhang
发明人： Sourav K. Bhunia , Xusheng Zhang
IPC分类号： A61B5/0205
CPC分类号： A61N1/3621 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device is configured to perform a method for detecting cardiac events by sensing a patient activity signal and determining a patient activity trend in response to the activity signal. A cardiac event detection threshold is set in response to the patient activity trend. The device senses a cardiac signal and detects a cardiac event in response to the cardiac signal and the detection threshold.
摘要翻译：可植入医疗装置被配置为通过感测患者活动信号并且响应于活动信号确定患者活动趋势来执行用于检测心脏事件的方法。响应于患者活动趋势设置心脏事件检测阈值。该装置感测心脏信号，并根据心脏信号和检测阈值检测心脏事件。

69. 发明申请

US20070239050A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：US20070239050A1
公开(公告)日：2007-10-11
申请号：US11380830
申请日：2006-04-28
申请人： Raja Ghanem , Robert Stadler , Xusheng Zhang
发明人： Raja Ghanem , Robert Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

70. 发明申请

US20070239046A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：US20070239046A1
公开(公告)日：2007-10-11
申请号：US11380837
申请日：2006-04-28
申请人： Raja Ghanem , Robert Stadler , Xusheng Zhang
发明人： Raja Ghanem , Robert Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, and determining whether the sensing of cardiac signals along the first sensing vector and along the second sensing vector is corrupted by noise. If the cardiac signals sensed along both the first sensing vector and the second sensing vector are not corrupted by noise, a determination is made as to whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event. The determination of whether the cardiac signals sensed along the first sensing vector and along the second sensing vector are one of a first cardiac event and a second cardiac event is then confirmed.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括：感测来自形成第一感测向量和第二感测向量的多个电极的心脏信号，以及确定沿着第一感测向量并沿着第二感测的心脏信号的感测矢量被噪音破坏了。如果沿着第一感测向量和第二感测矢量两者感测的心脏信号不被噪声破坏，则确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二次心脏事件。然后确定沿着第一感测向量和沿着第二感测向量感测的心脏信号是否是第一心脏事件和第二心脏事件之一的确定。

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