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61. 发明授权

US06734307B2 Oxazolidinone derivatives as antimicrobials 失效
标题翻译：恶唑烷酮衍生物作为抗微生物剂
公开(公告)号：US06734307B2
公开(公告)日：2004-05-11
申请号：US09906215
申请日：2001-07-16
申请人： Anita Mehta , Arora K. Sudershan , Biswajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
发明人： Anita Mehta , Arora K. Sudershan , Biswajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
IPC分类号： C07D41314
CPC分类号： C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

62. 发明申请

US20120004201A1 PHOSPHODIESTARASE INHIBITORS 审中-公开
标题翻译：磷酸酶抑制剂
公开(公告)号：US20120004201A1
公开(公告)日：2012-01-05
申请号：US13060832
申请日：2009-09-19
申请人： Sonali Rudra , Nidhi Gupta , Kakade Ganesh Chandrakant , Tarun Jain , Sreedhara Rao Voleti , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Kakade Ganesh Chandrakant , Tarun Jain , Sreedhara Rao Voleti , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/56 , C07D519/00 , A61K31/437 , A61P29/00 , A61P25/00 , A61P37/06 , A61P37/00 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/02 , A61P17/06 , A61P17/00 , A61P43/00 , A61P27/02 , A61P19/02 , A61P1/00 , A61P35/00 , A61P1/18 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

63. 发明授权

US07781460B2 Substituted indazoles as inhibitors of phosphodiesterase type-IV 失效
标题翻译：取代的吲唑作为IV型磷酸二酯酶的抑制剂
公开(公告)号：US07781460B2
公开(公告)日：2010-08-24
申请号：US12065819
申请日：2006-08-30
申请人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/443 , A61K31/416 , A61K31/422 , A61K31/427 , C07D413/04 , C07D271/06 , C07D271/10 , C07D261/04
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。

64. 发明授权

US07750735B1 Voltage-level translator 失效
标题翻译：电平转换器
公开(公告)号：US07750735B1
公开(公告)日：2010-07-06
申请号：US12171906
申请日：2008-07-11
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： H03F3/45
CPC分类号： H03F3/45183 , H03F2203/45244 , H03F2203/45466
摘要： A voltage-level translator includes an input node, a differential amplifier, first and second output transistors, and a constant current source. The input node receives an input signal. The differential amplifier produces a voltage swing at an amplifier node based at least in part on a difference between the input signal and a voltage supply. The first output transistor provides a substantially constant current to the output node. The voltage swing produced by the differential amplifier prevents forward biasing of the second output transistor. The constant current source provides a substantially constant current both to the differential amplifier and through the first output transistor. The translator outputs a first voltage in an output voltage range at the output node when the input signal is at a high voltage, and outputs a second voltage in the output voltage range at the output node when the input signal is at a low voltage.
摘要翻译：电压电平转换器包括输入节点，差分放大器，第一和第二输出晶体管以及恒流源。输入节点接收输入信号。差分放大器至少部分地基于输入信号和电压源之间的差异在放大器节点处产生电压摆幅。第一输出晶体管向输出节点提供基本恒定的电流。由差动放大器产生的电压摆动阻止了第二输出晶体管的正向偏置。恒流源向差分放大器和第一输出晶体管提供基本恒定的电流。当输入信号处于高电压时，转换器在输出节点的输出电压范围内输出第一电压，并且当输入信号处于低电压时，输出输出节点的输出电压范围内的第二电压。

65. 发明授权

US07747425B1 System and method for peak current modeling for an IC design 有权
标题翻译：用于IC设计的峰值电流建模的系统和方法
公开(公告)号：US07747425B1
公开(公告)日：2010-06-29
申请号：US11593729
申请日：2006-11-07
申请人： Vipin Kumar Tiwari , Manish Bhatia , Abhijit Ray
发明人： Vipin Kumar Tiwari , Manish Bhatia , Abhijit Ray
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： A peak current modeling method and system for modeling peak current demand of an integrated circuit (IC) block such as, e.g., a compilable memory instance. A current demand curve associated with the IC for a particular IC block event is obtained via simulation, for example. A defined time region associated with the particular IC block event is divided into multiple time segments, whereupon at least a first current value and a second current value for each time segment is obtained based on the current demand curve. Thereafter, the current demand curve is approximated, on a segment-by-segment basis, using a select approximate waveform depending on a relationship between the first and second current values.
摘要翻译：用于建模集成电路（IC）块的峰值电流需求的峰值电流建模方法和系统，例如可编译存储器实例。例如，通过模拟获得与特定IC块事件的IC相关联的电流需求曲线。与特定IC块事件相关联的定义的时间区域被划分为多个时间段，因此基于当前需求曲线获得每个时间段的至少第一当前值和第二电流值。此后，根据第一和第二电流值之间的关系，使用选择近似波形，逐段地逐次地近似当前需求曲线。

66. 发明申请

US20100099644A1 HPMA - DOCETAXEL OR GEMCITABINE CONJUGATES AND USES THEREFORE 有权
标题翻译： HPMA - DOCETAXEL或GEMCITABINE CONJUGATES及其用途
公开(公告)号：US20100099644A1
公开(公告)日：2010-04-22
申请号：US12575276
申请日：2009-10-07
申请人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
发明人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/551 , A61K47/58 , A61K47/64 , A61K47/65
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
摘要翻译：公开了通过将吉西他滨或多西他赛与诸如N-2-羟丙基甲基丙烯酰胺（HPMA）的水溶性聚合物缀合而形成的吉西他滨和多西紫杉醇的水溶性组合物。还公开了使用本发明的组合物治疗癌症的方法。

67. 发明授权

US07688111B1 Level-shifting circuit with bipolar junction transistor 有权
标题翻译：具有双极结型晶体管的电平移位电路
公开(公告)号：US07688111B1
公开(公告)日：2010-03-30
申请号：US12195725
申请日：2008-08-21
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： H03K19/082 , H03K19/0175
CPC分类号： H03K19/017509
摘要： A level-shifting circuit includes an input node, a first output transistor, a second output transistor, a pull-up transistor, and an output node. The input node receives an input signal. The first output transistor turns on when the input signal is at a first voltage level and couples an output node to a positive supply voltage when turned on. The second output transistor, a bipolar junction transistor (BJT), couples the output node to a negative supply voltage when turned on. The pull-up transistor turns on when the input signal is at a second voltage level and generates a voltage at a base terminal of the second output transistor that turns the second output transistor on. Additionally, the level-shifting circuit generates, at the output node, an output signal with a voltage swing that includes a positive voltage range and a negative voltage range.
摘要翻译：电平移动电路包括输入节点，第一输出晶体管，第二输出晶体管，上拉晶体管和输出节点。输入节点接收输入信号。当输入信号处于第一电压电平时，第一输出晶体管导通，并且当导通时将输出节点耦合到正电源电压。第二输出晶体管，双极结型晶体管（BJT）在导通时将输出节点耦合到负电源电压。当输入信号处于第二电压电平时，上拉晶体管导通，并在第二输出晶体管的基极端产生电压，使第二输出晶体管导通。此外，电平移动电路在输出节点产生具有包括正电压范围和负电压范围的电压摆幅的输出信号。

68. 发明申请

US20080207659A1 INHIBITORS OF PHOSPHODIESTERASE TYPE 4 审中-公开
标题翻译：磷酸二酯酶类型4的抑制剂
公开(公告)号：US20080207659A1
公开(公告)日：2008-08-28
申请号：US12031842
申请日：2008-02-15
申请人： Asit Kumar Chakraborti , Simi Sarin , Santosh Vijaykumar Rudrawar , Raj Kumar , Sunay Vijaykumar Chankeshwara , Abhijit Ray , Sunanda Ghosh Dastidar
发明人： Asit Kumar Chakraborti , Simi Sarin , Santosh Vijaykumar Rudrawar , Raj Kumar , Sunay Vijaykumar Chankeshwara , Abhijit Ray , Sunanda Ghosh Dastidar
IPC分类号： A61K31/506 , C07D239/20 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04
摘要： The present invention relates to inhibitors of phosphodiesterase (PDE) type 4.Compounds disclosed herein can be useful for treating, preventing, inhibiting or suppressing asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), AIDS, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis or other inflammatory diseases, especially in humans.Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as phosphodiesterase (PDE) type 4 inhibitors are provided.
摘要翻译：本发明涉及类型4的磷酸二酯酶（PDE）抑制剂。本文公开的化合物可用于治疗，预防，抑制或抑制哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性特发性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），艾滋病，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎或其他炎性疾病。提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）4型抑制剂的用途。

69. 发明申请

US20080114031A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20080114031A1
公开(公告)日：2008-05-15
申请号：US11692362
申请日：2007-03-28
申请人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
发明人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
IPC分类号： A61K31/4525 , A61K31/34 , A61P17/00 , A61P29/00 , A61P3/10 , A61P35/00 , A61P37/00 , A61P9/00 , C07D307/20 , C07D405/02 , C07D405/14 , C07D413/02
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥反应，炎症性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

70. 发明申请

US20080021080A1 5-LIPOXYGENASE INHIBITORS 失效
标题翻译： 5-LIPOXYGENASE抑制剂
公开(公告)号：US20080021080A1
公开(公告)日：2008-01-24
申请号：US11685892
申请日：2007-03-14
申请人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
发明人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
IPC分类号： A61K31/41 , A61P11/00 , C07D249/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.
摘要翻译：本发明涉及5-脂氧合酶抑制剂。本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性皮炎，过敏性鼻炎，其他炎性和自身免疫性疾病。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

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