专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO1997007202A1 NOVEL LIPOLYTIC ENZYMES 审中-公开
标题翻译：新型脂肪酶
公开(公告)号：WO1997007202A1
公开(公告)日：1997-02-27
申请号：PCT/DK1996000341
申请日：1996-08-12
申请人： NOVO NORDISK A/S , OKKELS, Jens, Sigurd , SVENDSEN, Allan , BORCH, Kim , THELLERSEN, Marianne , PATKAR, Shamkant, Anant , PETERSEN, Dorte, Aaby , ROYER, John, C. , KRETZSCHMAR, Titus
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C11D3/38627 , C12N9/20
摘要： Novel lipolytic enzymes are disclosed which are capable of removing substantial amounts of lard from a lard stained swatch in a one cycle wash. Preferred lipolytic enzymes are variants of the Humicola lanuginosa lipase which may be prepared by recombinant DNA techniques. The enzymes are advantageously used in detergent compositions.
摘要翻译：公开了新的脂肪分解酶，其能够在一次循环洗涤中从猪油染色的样本中除去大量的猪油。优选的脂肪分解酶是可通过重组DNA技术制备的Humicola lanuginosa脂肪酶的变体。酶有利地用于洗涤剂组合物中。

62. 发明申请

WO1997004078A1 A MODIFIED ENZYME WITH LIPOLYTIC ACTIVITY 审中-公开
标题翻译：具有脂质活性的改良酶
公开(公告)号：WO1997004078A1
公开(公告)日：1997-02-06
申请号：PCT/DK1996000321
申请日：1996-07-12
申请人： NOVO NORDISK A/S , FUGLSANG, Claus, Crone , OKKELS, Jens, Sigurd , PERTERSEN, Dorte, Aaby , PATKAR, Shamkant, Anant , THELLERSEN, Marianne , VIND, Jesper , HALKIER, Torben , JORGENSEN, Steen, Troels
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C12N9/20 , C11D3/38627
摘要： The invention relates to a modified enzyme with lipolytic activity recovered from a filamentous fungi or a bacteria having one or more peptide additions at the N-terminal and/or the C-terminal ends in comparison to the parent enzyme. Further, the invention relates to a DNA sequence encoding said modified enzyme, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said modified enzyme with lipolytic activity.
摘要翻译：本发明涉及从丝状真菌中回收的具有脂肪分解活性的修饰酶，或者与母体酶相比，在N末端和/或C末端具有一个或多个肽添加的细菌。此外，本发明涉及编码所述修饰酶的DNA序列，包含所述DNA序列的载体，携带所述DNA序列或所述载体的宿主细胞，以及产生具有脂肪分解活性的所述修饰酶的方法。

63. 发明申请

WO1997002753A1 CLEANING-IN-PLACE WITH A SOLUTION CONTAINING A PROTEASE AND A LIPASE 审中-公开
标题翻译：用含有蛋白酶和脂肪的溶液清洁
公开(公告)号：WO1997002753A1
公开(公告)日：1997-01-30
申请号：PCT/DK1996000301
申请日：1996-07-03
申请人： NOVO NORDISK A/S , OLSEN, Hans, Sejr
发明人： NOVO NORDISK A/S
IPC分类号： A23C07/02
CPC分类号： B08B9/032 , A23C7/02 , B01D65/02 , B01D2321/166 , B08B9/0323 , B08B9/08 , C11D3/38627 , C11D11/0041 , C12Y301/01003 , C12Y301/01004 , C12Y302/01001 , C12Y302/01004 , C12Y304/21004 , C12Y304/21014
摘要： A method of cleaning-in-place soiled process equipment comprising circulating a solution comprising a protease and a lipase for a sufficient period of time to permit action of the enzymes.
摘要翻译：一种现场清洁污染的工艺设备的方法，包括使包含蛋白酶和脂肪酶的溶液循环足够的时间以允许酶的作用。

64. 发明申请

WO1997002043A1 PREVENTION OF A DISEASE HAVING THE CHARACTERISTICS OF DIABETES 审中-公开
标题翻译：防止患有糖尿病特征的疾病
公开(公告)号：WO1997002043A1
公开(公告)日：1997-01-23
申请号：PCT/DK1996000297
申请日：1996-07-01
申请人： NOVO NORDISK A/S , DYRBERG, Thomas , WORSAAE, Anne
发明人： NOVO NORDISK A/S
IPC分类号： A61K38/28
CPC分类号： A61K38/28
摘要： Insulins and insulin analogues which are substantially devoid of hypoglycaemic effect can be used for preventing or delaying the onset of type 1 diabetes or for amelioration of an early stage thereof in a mammal at risk of developing said disease.
摘要翻译：基本上没有低血糖作用的胰岛素和胰岛素类似物可用于预防或延缓发生所述疾病风险的哺乳动物中1型糖尿病的发病或改善其早期阶段。

65. 发明申请

WO1997000871A1 TETRAHYDRO-BETACARBOLINE DERIVATIVES AND THEIR PREPARATION AND USE 审中-公开
标题翻译：四氢吡喃衍生物及其制备和使用
公开(公告)号：WO1997000871A1
公开(公告)日：1997-01-09
申请号：PCT/DK1996000258
申请日：1996-06-14
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo
发明人： NOVO NORDISK A/S
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Tetrahydro-betacarboline derivatives of formula (I), wherein R and R independently are hydrogen, alkyl, cycloalkyl, alkoxy, aralkyl, halogen, halogenalkyl, nitro, alkylthio; R , R and R independently are hydrogen, alkyl, alkenyl, or cycloalkyl; and R is (a), wherein A-B-C together with the benzene ring forms a five-membered heterocyclic ring comprising one or more N-, O- or S- atoms, and optionally substituted; and R and R independently are hydrogen, halogen, alkyl, alkenyl, nitro, CN, halogenalkyl or cycloalkyl, are useful in the treatment of disorders influenced by dysfunctions of the 5-HT2C receptors.
摘要翻译：式（I）的四氢 - betacarolineoline衍生物，其中R 1和R 2独立地是氢，烷基，环烷基，烷氧基，芳烷基，卤素，卤代烷基，硝基，烷硫基; R 3，R 5和R 6独立地是氢，烷基，链烯基或环烷基; 和R 4为（a），其中A-B-C与苯环一起形成包含一个或多个N，O-或S-原子并任选取代的五元杂环; R 7和R 8独立地为氢，卤素，烷基，烯基，硝基，CN，卤代烷基或环烷基，可用于治疗受5-HT 2C受体功能障碍影响的疾病。

66. 发明申请

WO1997000020A1 ENZYME-CONTAINING ORAL COMPOSITION FOR ANIMALS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：用于动物的含酶的口服组合物及其生产方法
公开(公告)号：WO1997000020A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001579
申请日：1996-06-11
申请人： NOVO NORDISK A/S , ITO, Shinobu , KAMACHI, Motoaki , SATO, Hajime
发明人： NOVO NORDISK A/S
IPC分类号： A23K01/165
CPC分类号： A23K20/189
摘要： An oral composition for animals which contains thermostable enzymes having a residual activity of 60 % or above after being heated at 80 DEG C for 20 seconds. It is useful as feed, food or drug that can be taken through the mouths of animals including humans, fish and birds and that are improved in functionality, nutritive value, storability, and in vivo digestibility.
摘要翻译：一种用于动物的口腔用组合物，其含有在80℃下加热20秒后具有60％或更高残留活性的热稳定酶。作为饲料，食品或药物，可以通过包括人类，鱼类和鸟类在内的动物的嘴巴进行，并且功能性，营养价值，保存性和体内消化率得到改善是有用的。

67. 发明申请

WO1996040792A1 MODIFICATION OF POLYPEPTIDES 审中-公开
标题翻译：多肽的改性
公开(公告)号：WO1996040792A1
公开(公告)日：1996-12-19
申请号：PCT/DK1996000250
申请日：1996-06-07
申请人： NOVO NORDISK A/S , OLSEN, Arne, Agerlin , BECK, Thomas, Christian
发明人： NOVO NORDISK A/S
IPC分类号： C07K17/08
CPC分类号： C12N11/08 , A61K8/64 , A61K47/60 , A61Q19/00 , C08F8/18 , C08F8/30 , C08G65/329
摘要： The invention relates to a process for producing polymer-polypeptide conjugates with reduced immunogenicity comprising the steps of: a) generating a polymer halogen formiate; and b) conjugating at least one polymer-halogen formiate to at least one attachment group on the polypeptide (Pep). The invention also relates to a polymer-polypeptide conjugate with reduced immunogenicity, an activated polymer for conjugating polypeptides (Pep), and the use of said process for reducing the immunogenicity of polypeptides used for pharmaceutical and/or industrial applications. Finally it is the object of the invention to provide the use of said polymer-polypeptide conjugate for a number of therapeutic and industrial purposes, such as the use in pharmaceuticals, personal care products and detergent compositions.
摘要翻译：本发明涉及具有降低的免疫原性的聚合物 - 多肽缀合物的制备方法，包括以下步骤：a）产生聚合物卤素甲酸酯; 和b）将至少一种聚合物 - 卤素甲酸酯与多肽（Pep）上的至少一个连接基团缀合。本发明还涉及具有降低的免疫原性的聚合物 - 多肽缀合物，用于缀合多肽的活化聚合物（Pep），以及用于降低用于制药和/或工业应用的多肽的免疫原性的所述方法的用途。最后，本发明的目的是提供所述聚合物 - 多肽缀合物在许多治疗和工业目的中的用途，例如在药物，个人护理产品和洗涤剂组合物中的用途。

68. 发明申请

WO1996036883A1 IMMUNOASSAY FOR GLUCAGON LIKE PROTEIN 1 (GLP-1) IN PLASMA 审中-公开
标题翻译：葡萄糖样蛋白1（GLP-1）在等离子体中的免疫
公开(公告)号：WO1996036883A1
公开(公告)日：1996-11-21
申请号：PCT/DK1996000212
申请日：1996-05-14
申请人： NOVO NORDISK A/S , PRIDAL, Lone , ANDERSEN, Lennart , LARSEN, Flemming Stig , OWENS, David
发明人： NOVO NORDISK A/S
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N2333/605
摘要： The invention relates to a sandwich immuno assay method which specifically measures the amount of biological active GLP-1 or pretreatment of the samples before measuring GLP-1 by an immuno assay.
摘要翻译：本发明涉及一种在通过免疫测定测量GLP-1之前特异性测量生物活性GLP-1量或样品预处理的夹心免疫测定方法。

69. 发明申请

WO1996031481A1 NOVEL HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新型杂环化合物
公开(公告)号：WO1996031481A1
公开(公告)日：1996-10-10
申请号：PCT/DK1996000141
申请日：1996-04-01
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , MADSEN, Peter , ANDERSEN, Knud, Erik , DÖRWALD, Florenzio, Zaragossa , JORGENSEN, Tine, Krogh , ANDERSEN, Henrik, Sune , HOHLWEG, Rolf , OLSEN, Uffe, Bang
IPC分类号： C07D223/28
CPC分类号： C07D223/28 , C07C229/56 , C07C2603/32 , C07D401/12
摘要： A compound of formula (I), in which Z is selected from (a), (b), (c) and (d). The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译：式（I）化合物，其中Z选自（a），（b），（c）和（d）。本发明涉及新的N-取代氨基酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床治疗其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用的疼痛，痛觉过敏和/或炎性病症。

70. 发明申请

WO1996031474A1 NOVEL HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新型杂环化合物
公开(公告)号：WO1996031474A1
公开(公告)日：1996-10-10
申请号：PCT/DK1996000151
申请日：1996-04-01
申请人： NOVO NORDISK A/S , ANDERSEN, Knud, Erik , OLSEN, Uffe Bang , ANDERSEN, Henrik, Sune , HOHLWEG, Rolf , JORGENSEN, Tine, Krogh , MADSEN, Peter , ZDENEK, Polivka , ALEXANDRA, Silhánková , KAREL, Sindelár
发明人： NOVO NORDISK A/S
IPC分类号： C07D211/62
CPC分类号： C07D265/30 , C07C2603/32 , C07D203/10 , C07D207/16 , C07D211/22 , C07D211/52 , C07D211/62 , C07D217/26 , C07D243/08 , C07D295/15 , C07D295/205
摘要： A compound of formula (I), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译：式（I）化合物，其中Z选自（a），（b），（c），（d），（e），（f），（g），（h）（j）和（k）。本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式