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61. 发明授权

US08471138B2 Musical instrument with one sided thin film capacitive touch sensors 有权
公开(公告)号：US08471138B2
公开(公告)日：2013-06-25
申请号：US13163401
申请日：2011-06-17
申请人： Michael Wallace , Philip T. Odom
发明人： Michael Wallace , Philip T. Odom
IPC分类号： G10H3/10
CPC分类号： G10H3/10 , G10H1/0551 , G10H1/32 , G10H1/342 , G10H3/00 , G10H2220/161 , G10H2230/135
摘要： Touch sensitive musical instruments are described herein including embodiments having: one-sided capacitive touch sensors with conductive ground planes, one-sided capacitive touch sensors with air gaps, one-sided capacitive touch sensors with separating material, and/or one-sided capacitive touch sensors including a combination of conductive ground planes, air gaps, and/or separating material. Embodiments of touch sensitive musical instruments simulating string instruments such as guitars are described.

62. 发明申请

US20110201012A1 METHODS AND COMPOSITIONS FOR DIAGNOSING EPITHELIAL CELL CANCER 审中-公开
标题翻译：用于诊断上皮细胞癌的方法和组合物
公开(公告)号：US20110201012A1
公开(公告)日：2011-08-18
申请号：US12907370
申请日：2010-10-19
申请人： MICHAEL MITAS , David J. Cole , William E. Gillanders , Michael Wallace
发明人： MICHAEL MITAS , David J. Cole , William E. Gillanders , Michael Wallace
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.
摘要翻译：提供了一种用于检测上皮癌转移的方法，包括在非原代组织中检测KS1 / 4核酸的过表达，或检测非小细胞组织过表达KS1 / 4和PIP核酸的组合， KS1 / 4，PIP和mam核酸或KS1 / 4和lunx核酸的PIP和mam的核酸的KS1 / 4和mam的核酸，KS1 / 4的核酸的过表达或KS1 / 4，PIP和mam核酸或核酸的核酸的PIP和mam的核酸的KS1 / 4和mam的核酸的KS1 / 4和PIP的核酸的组合的过表达或核酸 KS1 / 4的酸和非原发性组织中的lunx与上皮癌的转移相关。

63. 发明申请

US20080058724A1 METHOD AND SYSTEM FOR DELIVERING AN IMPLANT UTILIZING A LUMEN REDUCING MEMBER 审中-公开
标题翻译：用于递送使用减少会员的植入物的方法和系统
公开(公告)号：US20080058724A1
公开(公告)日：2008-03-06
申请号：US11934603
申请日：2007-11-02
申请人： Michael Wallace
发明人： Michael Wallace
IPC分类号： A61M25/088
CPC分类号： A61F2/966 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B2017/12063 , A61F2/95
摘要： Method and system for inserting an implant, such as vaso-occlusive device, an embolic containment device, or a stent into a vascular space to a vascular site in a body utilizing a lumen-reducing catheter. The method and system can be used to treat aneurysm, tumors and other vascular malformations. A guide is inserted into the vascular space. First and second catheters are inserted into the vascular space along the guide. The first or delivery catheter defines a first cavity, and the second or lumen-reducing catheter defines a second, smaller cavity. The second catheter is inserted within the first catheter. In one embodiment, an implant is advanced together with the first and second catheters to a vascular site. In an alternative embodiment, after the first and second catheters are positioned, the guide and the second catheter are removed from the first cavity, and an implant is inserted through the first cavity. With these configurations, radial movement of the guide is restricted to the smaller, second cavity rather than the larger, first cavity.
摘要翻译：用于使用内腔减少导管将诸如血管闭塞装置，栓塞容纳装置或支架的植入物插入血管空间的体内的方法和系统。该方法和系统可用于治疗动脉瘤，肿瘤和其他血管畸形。导管插入血管空间。第一和第二导管沿引导件插入血管空间。第一或输送导管限定第一腔，并且第二或内腔减少导管限定第二较小的腔。第二导管插入第一导管内。在一个实施例中，植入物与第一和第二导管一起前进到血管部位。在替代实施例中，在定位第一和第二导管之后，引导件和第二导管从第一腔体移除，并且植入物插入通过第一腔体。利用这些构造，引导件的径向移动限于较小的第二腔而不是较大的第一空腔。

64. 发明申请

US20070249611A1 DIPEPTIDYL PEPTIDASE INHIBITORS 失效
标题翻译： DIPEPTIDYL PEPTIDASE抑制剂
公开(公告)号：US20070249611A1
公开(公告)日：2007-10-25
申请号：US11691709
申请日：2007-03-27
申请人： Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
IPC分类号： A61K31/498 , A61K31/4745 , A61K31/4704 , C07D487/02
CPC分类号： C07D217/24 , C07D215/227 , C07D215/233 , C07D237/28 , C07D237/32 , C07D239/74 , C07D239/80 , C07D239/88 , C07D239/96 , C07D241/42 , C07D241/44
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含下式化合物：其中取代基如本文所定义。

65. 发明申请

US20070129238A1 Polymerization catalyst system using n-butylmethyldimethoxysilane for preparation of polypropylene film grade resins 失效
标题翻译：使用正丁基甲基二甲氧基硅烷制备聚丙烯薄膜级树脂的聚合催化剂体系
公开(公告)号：US20070129238A1
公开(公告)日：2007-06-07
申请号：US11700273
申请日：2007-01-31
申请人： Kenneth Blackmon , David Rauscher , Michael Wallace
发明人： Kenneth Blackmon , David Rauscher , Michael Wallace
IPC分类号： B01J31/00 , C08F4/44
CPC分类号： C08F4/6465 , B01J31/0212 , B01J2231/12 , C08F110/06 , Y02P20/52 , C08F2500/15 , C08F2500/26
摘要： It has been discovered that using n-butylmethyldimethoxysilane (BMDS) as an external electron donor for Ziegler-Natta catalysts can provide a catalyst system that may prepare polypropylene films with improved properties. The catalyst systems of the invention provide for controlled chain defects/defect distribution and thus a regulated microtacticity. Consequently, the curve of storage modulus (G′) v. temperature is shifted such that the film achieves the same storage modulus at a lower temperature enabling faster throughput of polypropylene film through a high-speed tenter.
摘要翻译：已经发现，使用正丁基甲基二甲氧基硅烷（BMDS）作为齐格勒 - 纳塔催化剂的外部电子给体可提供可制备具有改进性能的聚丙烯膜的催化剂体系。本发明的催化剂体系提供受控的链缺陷/缺陷分布，从而提供调节的微量活性。因此，储能模量（G'）v温度的曲线偏移，使得薄膜在较低温度下实现相同的储能模量，从而能够通过高速拉幅机获得更高的聚丙烯薄膜的生产量。

66. 发明申请

US20060259110A1 Collapsible/Expandable Tubular Electrode Leads 有权
标题翻译：可折叠/可扩展管状电极引线
公开(公告)号：US20060259110A1
公开(公告)日：2006-11-16
申请号：US11459618
申请日：2006-07-24
申请人： Michael Wallace , Robert Garabedian
发明人： Michael Wallace , Robert Garabedian
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

67. 发明申请

US20050283183A1 Expanding vaso-occlusive device 有权
标题翻译：扩张血管闭塞装置
公开(公告)号：US20050283183A1
公开(公告)日：2005-12-22
申请号：US10873982
申请日：2004-06-21
申请人： Tri Tran , Michael Wallace , Brent Gerberding , Like Que , Jimmy Dao , Thach Cao
发明人： Tri Tran , Michael Wallace , Brent Gerberding , Like Que , Jimmy Dao , Thach Cao
IPC分类号： A61B17/12 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063
摘要： This is a device for occluding a space within the body. In particular, the device comprises an expandable member, an inner member and one or more stop elements. The devices may be placed in a desired site within a mammal to facilitate the formation of an occlusion.
摘要翻译：这是一个用于遮挡体内空间的装置。特别地，该装置包括可扩张构件，内部构件和一个或多个止挡元件。装置可以放置在哺乳动物内的期望的位置以便于形成闭塞。

68. 发明申请

US20050272765A1 Dipeptidyl peptidase inhibitors 有权
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US20050272765A1
公开(公告)日：2005-12-08
申请号：US11145579
申请日：2005-06-03
申请人： Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen Gwaltney , Michael Wallace , Zhiyuan Zhang
IPC分类号： A61K31/4184 , A61K31/4192 , A61K31/4745 , A61P3/10 , C07C255/58 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D235/26 , C07D249/18 , C07D401/04 , C07D471/02
CPC分类号： C07D235/06 , C07C255/58 , C07D235/08 , C07D235/12 , C07D235/18 , C07D235/26 , C07D249/18 , C07D401/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含下式化合物：其中取代基如本文所定义。

69. 发明申请

US20050203600A1 Collapsible/expandable tubular electrode leads 审中-公开
标题翻译：可折叠/可扩展管状电极引线
公开(公告)号：US20050203600A1
公开(公告)日：2005-09-15
申请号：US10799295
申请日：2004-03-12
申请人： Michael Wallace , Robert Garabedian
发明人： Michael Wallace , Robert Garabedian
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. In the preferred embodiment, the tubular membrane has a non-circular cross-sectional shape. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。在优选实施例中，管状膜具有非圆形横截面形状。弹簧层构造成将绝缘膜推动成扩展的几何形状。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

70. 发明申请

US20050192619A1 Vaso-occlusive coils with non-overlapping sections 失效
标题翻译：具有非重叠部分的血管闭塞线圈
公开(公告)号：US20050192619A1
公开(公告)日：2005-09-01
申请号：US10791092
申请日：2004-03-01
申请人： Clifford Teoh , Michael Wallace
发明人： Clifford Teoh , Michael Wallace
IPC分类号： A61B17/12 , A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12145 , A61B2017/00526
摘要： A vaso-occlusive implant has a primary helical-coil shape that defines a primary axis and a three-dimensional secondary shape. The secondary shape includes a substantially helical section and a second section having a plurality of non-overlapping loops or loop sections. Each loop defines a plane that is oriented at an angle from about 30-150 degrees relative to a plane defined by an immediately preceding or immediately succeeding loop along the primary axis. The coil sections or loops can be generally circular loops or other smooth shapes.
摘要翻译：血管闭塞植入体具有限定主轴线和三维二次形状的初级螺旋线圈形状。次级形状包括基本上螺旋的部分和具有多个非重叠环或环部分的第二部分。每个环限定了相对于由紧邻的前一个或紧随其后的环沿主轴定义的平面以大约30-150度的角度定向的平面。线圈段或环可以是大体圆环或其它平滑形状。

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