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61. 发明申请

US20100025250A1 Droplet Actuator Structures 审中-公开
标题翻译：液滴致动器结构
公开(公告)号：US20100025250A1
公开(公告)日：2010-02-04
申请号：US12529041
申请日：2008-03-03
申请人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
发明人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
IPC分类号： B41J2/045 , B03C9/00
CPC分类号： B01L3/502792 , B01L3/0241 , B01L3/50273 , B01L2200/06 , B01L2300/06 , B01L2400/0427 , B41J2/14
摘要： The objective of this research is to model and design a microfluidic system that uses electrostatic fields to induce movement of discrete droplets of solution. Of particular interest is movement of droplets of H2O for use in biological testing with lab-on a-chip and μTAS systems. Using computer modeling, the electric-fields for planar electrode configurations positioned on an insulating substrate are calculated for a hemispherical drop of H2O on the substrate at various positions. From these electric-fields the force on the drop is calculated. These models show that electrostatic actuation of droplets of H2O is possible. However, as the complexity of the model increases the properties of the system become less desirable and actuation may not be possible. Using microfabrication techniques, the modeled microfluidic systems have been built for testing using a Kapton substrate with copper electrodes. Hexadecenyltrichlorosilane (HTS), a self-assembled monolayer, and its oxidant have been studied and found capable of providing hydrophobic and hydrophilic surface coatings for the systems.
摘要翻译：本研究的目的是建立和设计一个使用静电场诱导离散液滴移动的微流体系统。特别令人感兴趣的是使用实验室上的芯片和muTAS系统用于生物测试的H 2 O滴。使用计算机建模，计算位于绝缘基板上的平面电极配置的电场，用于在不同位置的衬底上的半球形H 2 O的下降。从这些电场计算出液滴上的力。这些模型显示H2O的液滴的静电驱动是可能的。然而，随着模型的复杂性增加，系统的性能变得不太可取，并且致动可能是不可能的。使用微细加工技术，已经建立了用于使用具有铜电极的Kapton衬底进行测试的建模的微流体系统。已经研究了十六碳烯三氯硅烷（HTS），一种自组装单层及其氧化剂，能够为系统提供疏水和亲水的表面涂层。

62. 发明申请

US20090280476A1 Droplet-based affinity assay device and system 有权
标题翻译：基于液滴的亲和力测定装置和系统
公开(公告)号：US20090280476A1
公开(公告)日：2009-11-12
申请号：US11639822
申请日：2006-12-15
申请人： Vijay Srinivasan , Vamsee K. Pamula , Allen E. Eckhardt , Michael G. Pollack
发明人： Vijay Srinivasan , Vamsee K. Pamula , Allen E. Eckhardt , Michael G. Pollack
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： C12Q1/68 , B01L7/52 , B01L2300/0645 , B01L2300/1822 , B01L2300/1894 , B01L2400/0424 , B01L2400/0427 , C12Q1/6869 , G01N27/44791 , Y10T436/25 , C12Q2565/629 , C12Q2565/301 , C12Q2563/149
摘要： The present invention relates to a droplet-based affinity assay device and system. According to one embodiment, a droplet microactuator is provided and includes an antibody immobilized on a surface. According to another embodiment, a droplet microactuator is provided and includes a droplet on the droplet microactuator, the droplet comprising an antibody.
摘要翻译：本发明涉及一种基于液滴的亲和测定装置和系统。根据一个实施例，提供液滴微致动器并且包括固定在表面上的抗体。根据另一个实施例，提供液滴微致动器并且在液滴微致动器上包括液滴，所述液滴包含抗体。

63. 发明授权

US08872527B2 Capacitance detection in a droplet actuator 有权
标题翻译：液滴执行器中的电容检测
公开(公告)号：US08872527B2
公开(公告)日：2014-10-28
申请号：US12527208
申请日：2008-02-15
申请人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
发明人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
IPC分类号： G01R27/26 , G01N27/22
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502784 , B01L2200/0605 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2400/0427 , G01N27/22 , G01N27/223 , G01N27/227 , G01N2203/00 , G01V3/02
摘要： A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.
摘要翻译：一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，其包括：（i）基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。

64. 发明授权

US08845872B2 Sample processing droplet actuator, system and method 有权
标题翻译：样品处理液滴致动器，系统和方法
公开(公告)号：US08845872B2
公开(公告)日：2014-09-30
申请号：US13249425
申请日：2011-09-30
申请人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： G05D7/06 , C07K1/113 , C30B7/00 , C30B29/58
CPC分类号： B01L3/502784 , B01J19/0046 , B01J2219/00466 , B01J2219/00495 , B01J2219/00587 , B01J2219/00725 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0829 , B01L2300/0864 , B01L2300/0887 , B01L2300/0893 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07K1/1136 , C30B7/00 , C30B29/58 , Y10T436/2575
摘要： Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplets on a surface thereof; (b) a second plate mounted in a substantially parallel orientation with respect to the first plate providing an interior volume between the plates, the second plate including one or more stamping ports for transporting some portion or all of a droplet from the interior volume to an exterior location; (c) a port for introducing fluid into the interior volume between the plates; and (d) a path or network of reference electrodes corresponding to the path or network of control electrodes. Associated systems and methods including the stamping device are also provided.
摘要翻译：提供样品处理液滴致动器，系统和方法。根据一个实施例，提供了一种包括液滴微致动器的冲压装置，其包括：（a）包括用于在其表面上输送液滴的控制电极的路径或网络的第一板; （b）相对于第一板以基本上平行的方向安装的第二板，提供板之间的内部容积，第二板包括一个或多个冲压端口，用于将一些部分或全部液滴从内部容积输送到外部位置; （c）用于将流体引入板之间的内部容积的端口; 和（d）对应于控制电极的路径或网络的参考电极的路径或网络。还提供了包括冲压装置在内的相关系统和方法。

65. 发明授权

US08685754B2 Droplet actuator devices and methods for immunoassays and washing 有权
标题翻译：滴液致动器装置和免疫测定和洗涤方法
公开(公告)号：US08685754B2
公开(公告)日：2014-04-01
申请号：US12393534
申请日：2009-02-26
申请人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Richard B. Fair
发明人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Richard B. Fair
IPC分类号： G01N33/553
CPC分类号： G01N33/54333
摘要： Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead with a reduced concentration of a substance is provided and includes: (a) providing a super paramagnetic bead in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets. The set of droplets includes: (i) a droplet in contact with the super paramagnetic bead having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the super paramagnetic bead.
摘要翻译：提供液滴致动器装置和免疫测定和洗涤方法。根据一个实施方案，提供了一种提供与物质浓度降低的超顺磁珠的表面接触的液滴的方法，包括：（a）提供与包含起始浓度的液滴接触的超顺磁珠并开始物质的起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合液滴以产生一组液滴。一组液滴包括：（i）与超顺磁珠接触的液滴，其物质相对于起始浓度降低; 和（ii）从超顺磁珠分离的液滴。

66. 发明授权

US08685344B2 Surface assisted fluid loading and droplet dispensing 有权
标题翻译：表面辅助流体加载和液滴分配
公开(公告)号：US08685344B2
公开(公告)日：2014-04-01
申请号：US12523776
申请日：2008-01-22
申请人： Arjun Sudarsan , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Arjun Sudarsan , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： B01L3/00 , C02F1/48
CPC分类号： B01L3/0241 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427
摘要： The present invention relates to surface assisted fluid loading and droplet dispensing on a droplet micro actuator. A droplet actuator is provided and includes one or more electrodes configured for conducting one or more droplet operations on a droplet operations surface of the substrate. The droplet actuator further includes a wettable surface defining a path from a fluid reservoir into a locus which is sufficiently near to one or more of the electrodes that activation of the one or more electrodes results in a droplet operation. Methods and systems are also provided.
摘要翻译：本发明涉及液滴微型致动器上的表面辅助流体加载和液滴分配。提供液滴致动器并且包括一个或多个电极，其被配置用于在基板的液滴操作表面上进行一个或多个液滴操作。液滴致动器还包括可润湿表面，其限定从流体储存器到足以接近一个或多个电极的轨迹的路径，所述一个或多个电极的激活导致液滴操作。还提供了方法和系统。

67. 发明授权

US08613889B2 Droplet-based washing 有权
标题翻译：液滴洗涤
公开(公告)号：US08613889B2
公开(公告)日：2013-12-24
申请号：US11639531
申请日：2006-12-15
申请人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Richard B. Fair
发明人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Richard B. Fair
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01L3/502784 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , Y10T436/11 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention relates to droplet-based washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.
摘要翻译：本发明涉及液滴洗涤。根据一个实施方案，提供了一种提供与物质浓度降低的表面接触的液滴的方法，其中所述方法包括：（a）提供与液滴接触的表面，所述液滴包含起始浓度和起始浓度该物质并具有起始体积; （b）进行一个或多个液滴操作以将洗涤液滴与步骤（a）中提供的液滴合并以产生组合液滴; 和（c）进行一个或多个液滴操作以分开组合的液滴以产生一组液滴，所述液滴包括：（i）与所述物质接触的液滴相对于起始浓度具有降低的物质浓度; 和（ii）与表面分离的液滴。

68. 发明授权

US07998436B2 Multiwell droplet actuator, system and method 有权
标题翻译：多孔液滴致动器，系统和方法
公开(公告)号：US07998436B2
公开(公告)日：2011-08-16
申请号：US11839774
申请日：2007-08-16
申请人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： B01L3/00 , G01N1/00
CPC分类号： B01L3/502784 , B01J19/0046 , B01J2219/00466 , B01J2219/00495 , B01J2219/00587 , B01J2219/00725 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0829 , B01L2300/0864 , B01L2300/0887 , B01L2300/0893 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07K1/1136 , C30B7/00 , C30B29/58 , Y10T436/2575
摘要： Multiwell droplet actuators, systems and methods are provided. According to one embodiment, a substrate is provided and comprises: (a) one or more input ports for introduction of one or more reagents and/or samples; (b) a regular array of processing wells; and (c) a network of droplet transport pathways comprising pathways that provide direct or indirect droplet transport from each of the input ports to each of the one or more processing wells. Varying droplet actuators and systems related thereto are also provided.
摘要翻译：提供多孔液滴致动器，系统和方法。根据一个实施例，提供了一种衬底，其包括：（a）用于引入一种或多种试剂和/或样品的一个或多个输入端口; （b）一系列加工井; 和（c）液滴传输路径的网络，其包括提供从每个输入端口到所述一个或多个处理井中的每一个的直接或间接液滴传输的路径。还提供了与其相关的不同液滴致动器和系统。

69. 发明授权

US07901947B2 Droplet-based particle sorting 有权
标题翻译：基于液滴的颗粒分选
公开(公告)号：US07901947B2
公开(公告)日：2011-03-08
申请号：US11639566
申请日：2006-12-15
申请人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
发明人： Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： G01N1/10 , G01N1/00 , B01D57/02
CPC分类号： G01N27/447 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0427 , C12Q1/6806 , G01N15/1031 , G01N27/44717 , G01N27/44721 , G01N33/543 , G01N35/10 , G01N2015/0065 , G01N2015/0088 , G01N2015/1081 , G01N2035/1034 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/2575
摘要： The present invention relates to droplet-based particle sorting. According to one embodiment, a droplet microactuator is provided and includes: (a) a suspension of particles; and (b) electrodes arranged for conducting droplet operations using droplets comprising particles. A method of transporting a particle is also provided, wherein the method includes providing a droplet comprising the particle and transporting the droplet on a droplet microactuator.
摘要翻译：本发明涉及基于液滴的颗粒分选。根据一个实施例，提供了液滴微致动器，其包括：（a）颗粒悬浮液; 和（b）布置成使用包含颗粒的液滴进行液滴操作的电极。还提供了输送颗粒的方法，其中所述方法包括提供包含颗粒的液滴并将液滴输送到液滴微致动器上。

70. 发明授权

US07815871B2 Droplet microactuator system 有权
标题翻译：液滴微致动器系统
公开(公告)号：US07815871B2
公开(公告)日：2010-10-19
申请号：US11639664
申请日：2006-12-15
申请人： Vamsee K. Pamula , Vijay Srinivasan , Michael G. Pollack , Allen E. Eckhardt , Philip Y. Paik
发明人： Vamsee K. Pamula , Vijay Srinivasan , Michael G. Pollack , Allen E. Eckhardt , Philip Y. Paik
IPC分类号： B01J8/00 , G01N27/26
CPC分类号： B41J2/125 , B01L3/502792 , B01L2200/143 , B01L2200/147 , B01L2300/0645 , B01L2300/0654 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B41J2/17509 , G01N15/1484 , G01N2015/1006
摘要： The present invention relates to a droplet microactuator system. According to one embodiment, the droplet microactuator system includes: (a) a droplet microactuator configured to conduct droplet operations; (b) a magnetic field source arranged to immobilize magnetically responsive beads in a droplet during droplet operations; (c) a sensor configured in a sensing relationship with the droplet microactuator, such that the sensor is capable of sensing a signal from and/or a property of one or more droplets on the droplet microactuator; and (d) one or more processors electronically coupled to the droplet microactuator and programmed to control electrowetting-mediated droplet operations on the droplet actuator and process electronic signals from the sensor.
摘要翻译：液滴微致动器系统技术领域本发明涉及液滴微致动器系统。根据一个实施例，液滴微致动器系统包括：（a）构造成进行液滴操作的液滴微致动器; （b）磁场源，布置成在液滴操作期间将磁响应珠固定在液滴中; （c）配置成与液滴微致动器的感测关系的传感器，使得传感器能够感测来自液滴微致动器上的一个或多个液滴的信号和/或特性; 和（d）电子耦合到液滴微致动器的一个或多个处理器，并被编程为控制液滴致动器上的电润湿介导的液滴操作并处理来自传感器的电子信号。

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