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    • 62. 发明授权
    • Registration of three dimensional image data with patient in a projection imaging system
    • 在患者投影成像系统中注册三维图像数据
    • US07623736B2
    • 2009-11-24
    • US11429666
    • 2006-05-05
    • Raju R. Viswanathan
    • Raju R. Viswanathan
    • G06K9/00
    • G06T7/0012A61B6/032G06T5/50G06T7/33G06T2207/10072G06T2207/10116G06T2207/30048
    • A method for determining a translation of a three-dimensional pre-operative image data set to obtain a registration of the three-dimensional image data with a patient positioned in a projection imaging system. In one embodiment the user identifies an initial three-dimensional organ center from projections and extreme contour landmark points of the object on a set of projections. A set of contour points for the image object in each of a plurality of three-dimensional cross-section planes; is obtained and the points projecting nearest to the user-identified landmark points are selected. A three-dimensional grid having a predetermined number of intervals at a predetermined interval spacing centered at the user-identified organ center is defined. The three-dimensional image data contour points as centered onto each grid point are projected for evaluation and selection of the grid point leading to contour points projecting nearest to the user-identified landmark points. This selection leads to the iterative definition of a series of improved estimated three-dimensional organ centers, and associated translation vectors. Registration of a three dimensional image data to the patient positioned in a projection imaging system will allow, among other things, overlay of a visual representation of a pre-operative image object onto a projection image plane that can serve as a visual tool and a surgical navigation aid. In particular, the position and orientation of a medical device can be shown with respect to the three-dimensional image data and thus enable quicker, safer, and less invasive navigation of the medical device to and within an organ of interest.
    • 一种用于确定三维预处理图像数据集的平移以获得位于投影成像系统中的患者的三维图像数据的登记的方法。 在一个实施例中,用户从一组投影上的物体的投影和极端轮廓地标点识别初始三维器官中心。 在多个三维横截面中的每一个中的图像对象的一组轮廓点; 并且选择最靠近用户识别的地标点投影的点。 定义了以用户识别的器官中心为中心的预定间隔间隔的预定数量的间隔的三维网格。 投影在每个网格点上居中的三维图像数据轮廓点用于评估和选择网格点,导致最接近用户识别的地标点投影的轮廓点。 该选择导致一系列改进的估计三维器官中心和相关联的翻译矢量的迭代定义。 将三维图像数据注册到位于投影成像系统中的患者将允许除其他之外,将术前图像对象的视觉表示叠加到可用作视觉工具和手术的投影图像平面上 导航辅助 特别地,可以针对三维图像数据示出医疗装置的位置和取向,并且因此能使医疗装置更快,更安全,更少侵入性地导航到感兴趣的器官内和内部。
    • 70. 发明授权
    • Drug delivery and catheter systems, apparatus and processes
    • 药物输送和导管系统,装置和过程
    • US06464662B1
    • 2002-10-15
    • US09626059
    • 2000-07-26
    • Raghu RaghavanRaju R. ViswanathanTimothy Poston
    • Raghu RaghavanRaju R. ViswanathanTimothy Poston
    • A61M100
    • A61M25/007Y10S977/906
    • A class of customizable injection devices or delivery instruments whose basic form is a stiff tube with holes of user-selectable size at several user-selectable places is described. The use of this device includes a method of selection and construction of a particular device from such a class of devices for a particular treatment procedure using computer-assisted means. Thus, the user may make selections among available or creatable choices (such as selection of hole size, selection of hole location, number of holes, etc.), and a method can be practiced for making such user-selection serve the goals of delivery of materials such as drugs, cells, or of devices sufficiently small and numerous to be delivered in fluid suspension. The tube should be relatively stiff in the sense that it deflects by no more than an amount between 0° and 15° under the stresses of insertion and placement at the end of a catheter, and varies less than 5 or less than 10% per cent in cross-sectional area when so deflected to the maximum of about 15 degrees.
    • 描述了一类可定制的注射装置或输送装置,其基本形式是具有用户可选尺寸的孔的刚性管,其在几个用户可选择的位置。 该设备的使用包括使用计算机辅助装置从特定处理程序的这类设备中选择和构建特定设备的方法。 因此,用户可以在可用或可创建的选择之中进行选择(例如选择孔尺寸,孔位选择,孔数等),并且可以实施用于使这样的用户选择服务于递送目标的方法 的材料,例如药物,细胞或足够小和许多以流体悬浮液递送的装置。 管子应该是比较僵硬的,因为它在插入和放置在导管末端的应力下偏转不超过0°和15°之间的量,变化小于5或小于10% 在横截面积如此偏转到最大约15度时。