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    • 66. 发明授权
    • CE7-specific chimeric T cell receptor
    • CE7特异性嵌合T细胞受体
    • US07265209B2
    • 2007-09-04
    • US11477572
    • 2006-06-30
    • Michael Jensen
    • Michael Jensen
    • C12P21/08C07K16/00C12N5/06C12N5/08C12P21/04A61K39/395
    • C07K14/7051A61K48/00C07H21/04C07K2319/00C07K2319/02C07K2319/03C07K2319/30
    • Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the immune cell is a T cell and the cell surface protein is a single chain FvFc: ζ receptor where Fv designates the VH and VL chains of a single chain monoclonal antibody to CE7 linked by peptide, Fc represents a hinge-CH2-CH3 region of a human IgG1, and ζ represents the intracellular signaling domain of the zeta chain of human CD3. DNA constructs encoding a chimeric T-cell receptor and a method of making a redirected T cell expressing a chimeric T cell receptor by electroporation using naked DNA encoding the receptor are also disclosed.
    • 基因工程化的CE7特异性重定向免疫细胞,其表达具有细胞外结构域的细胞表面蛋白,所述胞外结构域包含对CE7特异性的受体,细胞内信号结构域和跨膜结构域,以及用于此类细胞用于CE7 +神经母细胞瘤的细胞免疫治疗的方法 被披露。 在一个实施方案中,免疫细胞是T细胞,细胞表面蛋白是单链FvFc:ζ受体,其中Fv表示一个或更多个的V H链和V L链 通过肽连接的CE7单链单克隆抗体代表人IgG的铰链-CH 2 H 2 C 3 H 3区域, SUB> 1,Zeta表示人CD3的zeta链的细胞内信号转导结构域。 还公开了编码嵌合T细胞受体的DNA构建体和通过使用编码受体的裸DNA通过电穿孔制备表达嵌合T细胞受体的重定向T细胞的方法。
    • 69. 发明申请
    • Dual antenna communication methods and systems
    • 双天线通信方法和系统
    • US20060093049A1
    • 2006-05-04
    • US11252443
    • 2005-10-18
    • Michael JensenMichael RiceNorman NelsonAdam Anderson
    • Michael JensenMichael RiceNorman NelsonAdam Anderson
    • H04L27/00
    • H04L1/0618
    • A dual antenna transmitter includes a diversity encoding module that receives a data stream and provides a pair of encoded data streams selected to cause generation of overlapping symbols that provide substantially constant signal power to a receiver when the first and second antennas are unobstructed from the receiver. The diversity encoding module may compensate for the state retention of standard modulators thereby enabling the implementation of the Alamouti transmit diversity scheme. A wireless receiver capable of receiving data transmitted from the aforementioned transmitter includes a metric extraction module that repetitively extracts a metric from a transmitted signal at a selected rate to provide a first and a second metric stream, the first metric stream comprising data that is time offset from data in the second metric stream, the time offset corresponding to a differential time delay to the receiver for symbols emitted from the transmitter antennas.
    • 双天线发射机包括分集编码模块,其接收数据流并提供一对编码数据流,所述编码数据流被选择为当所述第一和第二天线从所述接收机畅通时,向所述接收机提供基本恒定的信号功率的重叠符号的产生。 分集编码模块可以补偿标准调制器的状态保持,从而实现Alamouti发射分集方案。 能够接收从上述发射机发送的数据的无线接收机包括度量提取模块,其以所选择的速率从传输的信号重复提取度量,以提供第一和第二度量流,所述第一度量流包括时间偏移量的数据 从第二度量流中的数据,对应于从发射机天线发射的符号到接收机的差分时间延迟的时间偏移。