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61. 发明授权

US08940738B2 Pyrimidone compounds 有权
标题翻译：嘧啶酮化合物
公开(公告)号：US08940738B2
公开(公告)日：2015-01-27
申请号：US13389504
申请日：2010-08-11
申请人： Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
发明人： Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
IPC分类号： A61K31/5377 , A61P25/28 , A61P9/10 , C07D413/04 , C07D401/04 , C07D413/14
CPC分类号： C07D413/04 , C07D401/04 , C07D413/14
摘要： A pyrimidone derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents hydrogen atom and Y represents hydroxyl group, or X represents fluorine atom and Y represents hydrogen atom; R1 represents a C1-6 alkyl group; R2 represents a morpholin-4-yl group which may be substituted, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译：由通式（I）表示的嘧啶酮衍生物或其药学上可接受的盐：其中X表示氢原子，Y表示羟基，或X表示氟原子，Y表示氢原子; R1表示C1-6烷基; R2表示可被取代的吗啉-4-基，其用于预防和/或治疗由tau蛋白激酶1多动症如神经变性疾病（例如阿尔茨海默病）引起的疾病。

62. 发明授权

US08581477B2 Piezoelectric film element using (Na,K,Li)NbO3 有权
标题翻译：使用（Na，K，Li）NbO 3的压电薄膜元件
公开(公告)号：US08581477B2
公开(公告)日：2013-11-12
申请号：US13018693
申请日：2011-02-01
申请人： Kazufumi Suenaga , Kenji Shibata , Kazutoshi Watanabe , Akira Nomoto
发明人： Kazufumi Suenaga , Kenji Shibata , Kazutoshi Watanabe , Akira Nomoto
IPC分类号： H01L41/047 , H01L41/187
CPC分类号： H01L41/187 , H01L41/0477 , H01L41/0805 , H01L41/094 , H01L41/1873 , H01L41/29 , H01L41/316
摘要： A piezoelectric film element is provided, which is capable of improving piezoelectric properties, having on a substrate at least a lower electrode, a lead-free piezoelectric film, and an upper electrode, wherein at least the lower electrode out of the lower electrode and the upper electrode has a crystal structure of a cubic crystal system, a tetragonal crystal system, an orthorhombic crystal system, a hexagonal crystal system, a monoclinic crystal system, a triclinic crystal system, a trigonal crystal system, or has a composition in which one of these crystals exists or two or more of them coexist, and crystal axes of the crystal structure are preferentially oriented to a specific axis smaller than or equal to two axes of these crystals, and a ratio c/a′ is set in a range of 0.992 or more and 0.999 or less, which is the ratio of a crystal lattice spacing c in a direction of a normal line to the substrate surface, with respect to a crystal lattice spacing a′ whose inclination angle from the substrate surface is in a range of 10° or more and 30° or less.
摘要翻译：提供一种能够改善压电性能的压电膜元件，其在基板上至少具有下电极，无铅压电膜和上电极，其中至少下电极中的下电极和上电极具有立方晶系，四方晶系，正交晶系，六方晶系，单斜晶系，三斜晶系，三
晶体系的晶体结构，或其组成为：这些晶体存在或其中的两种以上共存，并且晶体结构的晶轴优先取向小于或等于这些晶体的两个轴的特定轴，并且将比率c / a'设定在0.992的范围内以上且0.999以下，即与法线的方向相对于基板表面的晶格间距c的比例，相对于晶格间距a'，其倾斜角为基板表面的厚度在10°以上且30°以下的范围内。

63. 发明授权

US08334794B2 Input device and keyboard device having illumination function 失效
标题翻译：具有照明功能的输入装置和键盘装置
公开(公告)号：US08334794B2
公开(公告)日：2012-12-18
申请号：US12579903
申请日：2009-10-15
申请人： Kazutoshi Watanabe , Hideaki Nagakubo , Takenobu Kimura , Koichi Yamamoto , Katsuyuki Katayama , Naomi Sato , Naoya Akiyama , Shinichiro Kimura , Masahiro Ishida , Naoki Yamada , Keiji Takagi , Toshinobu Hosaka
发明人： Kazutoshi Watanabe , Hideaki Nagakubo , Takenobu Kimura , Koichi Yamamoto , Katsuyuki Katayama , Naomi Sato , Naoya Akiyama , Shinichiro Kimura , Masahiro Ishida , Naoki Yamada , Keiji Takagi , Toshinobu Hosaka
IPC分类号： H03M11/00
CPC分类号： G06F3/0202 , H01H13/83 , H01H2219/044 , H01H2219/056 , H01H2219/06 , H01H2219/062
摘要： An input device includes a plurality of manipulation portions; an input function portion manipulated by the manipulation portions to perform an input function; a light guiding sheet facing the rear side of the plurality of manipulation portions; and a light source applying light into the light guiding sheet, wherein a rear surface opposite to a front surface of the light guiding sheet facing the manipulation portions is provided with a plurality of concave portions which is depressed to the inside of the light guiding sheet, wherein each concave portion has a circular opening and an inner surface which is a smooth concave curve surface, and wherein light propagated through the inside of the light guiding sheet is reflected by the inner surface toward the inside of the light guiding sheet, and the light is applied from the front surface of the light guiding sheet to the manipulation portions.
摘要翻译：输入装置包括多个操作部分; 由操作部分操纵以输入功能的输入功能部分; 面向所述多个操作部的后侧的导光片; 以及向所述导光片施加光的光源，其中与所述导光片的面对所述操作部的前表面相对的后表面设置有多个凹陷部，所述凹部被压向所述导光片的内部，其特征在于，每个凹部具有圆形开口和内表面，该内表面是光滑的凹曲面，并且其中通过导光片的内部传播的光被内表面朝向导光片的内部反射，并且光从导光片的前表面施加到操作部。

64. 发明申请

US20120306314A1 PIEZOELECTRIC THIN FILM ELEMENT, AND PIEZOELECTRIC THIN FILM DEVICE 有权
标题翻译：压电薄膜元件和压电薄膜器件
公开(公告)号：US20120306314A1
公开(公告)日：2012-12-06
申请号：US13577405
申请日：2011-02-15
申请人： Kazufumi Suenaga , Kenji Shibata , Kazutoshi Watanabe , Akira Nomoto
发明人： Kazufumi Suenaga , Kenji Shibata , Kazutoshi Watanabe , Akira Nomoto
IPC分类号： H01L41/04
CPC分类号： H01L41/0805 , H01L41/1873 , H01L41/316
摘要： Disclosed are a piezoelectric thin film element and a piezoelectric thin film device which have improved piezoelectric properties and high performance and can be produced in improved yields. The piezoelectric thin film element (1) comprises: a substrate (10), and a piezoelectric thin film (40) which is arranged on the substrate (10), has at least one crystal structure represented by general formula (NaxKyLiz)NbO3 (0≦x≦1, 0≦y≦1, 0≦z≦0.2, x+y+z=1) and selected from the group consisting of pseudo-cubic crystal, a hexagonal crystal, and an orthorhombic crystal, and contains an inert gas element at a ratio of 80 ppm or less by mass.
摘要翻译：公开了一种压电薄膜元件和压电薄膜器件，其具有改进的压电性能和高性能，并且可以以提高的产率制造。压电薄膜元件（1）包括：基板（10）和布置在基板（10）上的压电薄膜（40），具有至少一个由通式（NaxKyLiz）NbO 3（0＆nlE）表示的晶体结构 ; x＆nlE; 1,0，nlE; y＆nlE; 1,0，nlE; z＆nlE; 0.2，x + y + z = 1），选自假立方晶体，六方晶体和正交晶体，气体元素的比例为80ppm以下。

65. 发明申请

US20120059165A1 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：用于合成药物代理的中间体化合物及其生产方法
公开(公告)号：US20120059165A1
公开(公告)日：2012-03-08
申请号：US13255748
申请日：2010-03-09
申请人： Rikizou Furuya , Hiroki Ozawa , Eiji Toyofuku , Shinichi Kusaka , Hiroshi Iwamura , Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
发明人： Rikizou Furuya , Hiroki Ozawa , Eiji Toyofuku , Shinichi Kusaka , Hiroshi Iwamura , Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
IPC分类号： C07D413/10 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14
摘要： A production method of an optically active 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110° C. to 140° C. in a reaction mixture comprising a Na2CO3, an organophosphorus compound, and a palladium catalyst in a polar aprotic solvent alone or combination of a polar aprotic solvent and other polar aprotic solvent or hydrocarbon solvent to give a cyanophenylmorpholine; 2) reacting the cyanophenylmorpholine with hydroxylamine or hydroxylamine hydrochloride at a temperature of from 10° C. to 40° C. in an aprotic polar solvent to give a hydroxylamine derivative; 3) reacting the hydroxylamine derivative with an acylation reagent selected from the group consisting of aliphatic acyl halides, aromatic acyl halides, aliphatic acyl anhydrides and aromatic anhydrides; and 4) keeping the mixture obtained after step 3) at a temperature of from 60° C. to 140° C. to give a 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine.
摘要翻译：提供了可用作合成药剂的中间体的光学活性2- {4-（5-取代 - 恶二唑基）苯基}吗啉的制备方法，该方法包括以下步骤1）至4）：1）在包含Na 2 CO 3，有机磷化合物和钯催化剂的反应混合物中，在单极极性非质子溶剂中使溴苯基吗啉与六氰基铁酸盐（II）或其水合物在110℃至140℃的温度下反应，或极性非质子溶剂和其他极性非质子溶剂或烃溶剂的组合，得到氰基苯基吗啉; 2）使氰基苯基吗啉与羟胺或羟胺盐酸盐在非质子极性溶剂中在10℃至40℃的温度下反应，得到羟胺衍生物; 3）使羟胺衍生物与选自脂族酰基卤，芳族酰基卤，脂族酰基酸酐和芳族酸酐的酰化试剂反应; 和4）将步骤3）后获得的混合物保持在60℃至140℃的温度下，得到2- {4-（5-取代 - 恶二唑基）苯基}吗啉。

66. 发明申请

US20110003988A1 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIM-IDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR 有权
标题翻译： 3-（（2S）-2-（4-（3-甲基-L，2,4-氧杂吖唑-5-基）苯基）吗啉）-6-（吡啶-4-基）吡啶 -4（3H） - 酮作为TA蛋白激酶抑制剂
公开(公告)号：US20110003988A1
公开(公告)日：2011-01-06
申请号：US12677161
申请日：2008-09-12
申请人： Daiki Sakai , Kazutoshi Watanabe
发明人： Daiki Sakai , Kazutoshi Watanabe
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐：用于预防和/或治疗由tau蛋白激酶1的异常活性（例如神经变性疾病（例如阿尔茨海默病））引起的疾病。

67. 发明申请

US20100096728A1 Nitride semiconductor sustrate and method of fabricating the same. 有权
标题翻译：氮化物半导体衬底及其制造方法。
公开(公告)号：US20100096728A1
公开(公告)日：2010-04-22
申请号：US12585109
申请日：2009-09-03
申请人： Kazutoshi Watanabe , Takehiro Yoshida
发明人： Kazutoshi Watanabe , Takehiro Yoshida
IPC分类号： H01L23/58 , B24B1/00 , B24B9/06
CPC分类号： B24B9/065
摘要： A nitride semiconductor substrate includes a front surface, a rear surface on an opposite side to the front surface, and a first edge portion including a chamfered edge on the front surface. A ratio of an average surface roughness of the front surface to an average surface roughness of the first edge portion is not more than 0.01. The substrate may include a second edge portion including a chamfered edge on the rear surface. A ratio of an average surface roughness of the rear surface to an average surface roughness of the second edge portion is not more than 0.01. The first edge portion has a visible light transmissivity not more than 0.2 times that of the front surface. The second edge portion has a visible light transmissivity not more than 0.2 times that of the rear surface.
摘要翻译：氮化物半导体衬底包括前表面，与前表面相反侧的后表面，以及在前表面上包括倒角边缘的第一边缘部分。前表面的平均表面粗糙度与第一边缘部分的平均表面粗糙度的比率不大于0.01。衬底可以包括在后表面上包括倒角边缘的第二边缘部分。后表面的平均表面粗糙度与第二边缘部分的平均表面粗糙度之比不大于0.01。第一边缘部分的可见光透射率不超过前表面的0.2倍。第二边缘部分的可见光透射率不超过背面的0.2倍。

68. 发明申请

US20090156804A1 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF 失效
标题翻译：用于合成药物代理的中间体化合物及其生产方法
公开(公告)号：US20090156804A1
公开(公告)日：2009-06-18
申请号：US11996205
申请日：2006-07-21
申请人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
发明人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
IPC分类号： C07D413/14 , C07C211/43 , C07D265/30 , C07D265/32 , C07D239/24
CPC分类号： C07D265/30 , C07D265/32
摘要： The present invention relates to a production method of an optically active morpholine compound represented by the formula 10, which includes the following steps: wherein each symbol is as defined in the specification.The present invention also relates to a production method of an compound represented by the formula 55, which includes the following steps: wherein each symbol is as defined in the specification.According to the production method of the present invention, an optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4′]bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method.
摘要翻译：本发明涉及由式10表示的光学活性吗啉化合物的制备方法，其包括以下步骤：其中每个符号如说明书中所定义。本发明还涉及由式55表示的化合物的制备方法，其包括以下步骤：其中每个符号如说明书中所定义。根据本发明的制备方法，光学活性2-芳基取代的吗啉化合物和3-氧代-3-（嘧啶-4-基）丙酸酯作为合成2-（2-芳基吗啉） -4-基）-1-甲基-1H- [4,4']二嘧啶基-6-酮，其具有tau蛋白激酶1抑制活性，可用作阿尔茨海默氏病等的治疗药物，可以以高通过工业上有利的方法得到。

69. 发明授权

US07427615B2 3-substituted-4-pyrimidone derivatives 有权
标题翻译： 3-取代-4-嘧啶酮衍生物
公开(公告)号：US07427615B2
公开(公告)日：2008-09-23
申请号：US10489606
申请日：2002-09-20
申请人： Fumiaki Uehara , Keiichi Aritomo , Aya Shoda , Shinsuke Hiki , Masahiro Okuyama , Yoshihiro Usui , Mitsuru Ooizumi , Kazutoshi Watanabe , Koichi Yamakoshi
发明人： Fumiaki Uehara , Keiichi Aritomo , Aya Shoda , Shinsuke Hiki , Masahiro Okuyama , Yoshihiro Usui , Mitsuru Ooizumi , Kazutoshi Watanabe , Koichi Yamakoshi
IPC分类号： C07D401/04 , C07D401/14 , A61K31/505
CPC分类号： C07D401/04 , C07D239/34 , C07D239/47 , C07D239/56 , C07D401/14 , C07D413/14
摘要： A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein R1 represents a C1-C12 alkyl group which may be substituted; R represents, for example, a group represented by the following formula (II): wherein R2 and R3 independently represent a hydrogen atom or a C1-C8 alkyl group; R4 represents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.
摘要翻译：由式（I）表示的嘧啶酮衍生物或其盐，或其溶剂合物或其水合物对tau蛋白激酶1具有抑制活性：其中R 1表示C 1〜可以被取代的C 1 -C 12烷基; R表示例如由下式（II）表示的基团：其中R 2和R 3独立地表示氢原子或C 1〜 C 1 -C 8烷基; R 4表示可以被取代的苯环，可以被取代的萘环，可以被取代的茚满环，可被取代的四氢萘环，或具有1个的任选取代的杂环至4个选自氧原子，硫原子和氮原子的杂原子，并且总共具有5至10个环构成原子。

70. 发明授权

US07404313B2 Scanning probe microscope 失效
标题翻译：扫描探针显微镜
公开(公告)号：US07404313B2
公开(公告)日：2008-07-29
申请号：US11374842
申请日：2006-03-14
申请人： Kazutoshi Watanabe
发明人： Kazutoshi Watanabe
IPC分类号： G01B5/28 , G01N13/16 , G01N13/20
CPC分类号： G01Q60/40 , G01Q20/04 , G01Q60/30
摘要： A scanning probe microscope has a self-detection type probe structure including a cantilever having an electrically conductive probe at a distal end thereof, a supporting part, and a piezoresistance element whose resistance value changes depending on the deflection of the cantilever. A detector applies a predetermined voltage to the piezoresistance element and detects the value of the current passing through the piezoresistance element to detect deflection of the cantilever. A sample table mounts a sample such that a surface of the sample confronts a tip of the probe, and a moving mechanism relatively moves the sample table and the probe tip in X, Y and Z directions. A controller controls the moving mechanism to maintain a fixed distance between the probe tip and the sample surface and measures the surface shape of the sample on the basis of the detection result of the detector. A predetermined voltage is applied between the probe and the sample surface, and a measuring part operates simultaneously with the detector and measures electrical property information caused by the applied voltage.
摘要翻译：扫描探针显微镜具有自检型探针结构，其包括在其远端具有导电探针的悬臂，支撑部和耐电阻值根据悬臂的偏转而变化的压阻元件。检测器将预定电压施加到压阻元件，并检测通过压阻元件的电流值，以检测悬臂的偏转。样品台安装样品，使得样品的表面面对探针的尖端，并且移动机构使样品台和探针尖端在X，Y和Z方向上相对移动。控制器控制移动机构以在探针尖端和样品表面之间保持固定的距离，并且基于检测器的检测结果测量样品的表面形状。在探针和样品表面之间施加预定的电压，并且测量部分与检测器同时操作并测量由所施加的电压引起的电特性信息。

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