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61. 发明申请

US20080026473A1 Analyte sensors and methods for making and using them 有权
标题翻译：分析物传感器和制造和使用它们的方法
公开(公告)号：US20080026473A1
公开(公告)日：2008-01-31
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
IPC分类号： G01N33/48 , A61B5/05 , C08G77/04
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。

62. 发明申请

US20070173712A1 Method of and system for stabilization of sensors 审中-公开
标题翻译：传感器稳定方法和系统
公开(公告)号：US20070173712A1
公开(公告)日：2007-07-26
申请号：US11322977
申请日：2005-12-30
申请人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
IPC分类号： A61B5/05 , G01D18/00 , A61B5/00
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry cases a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulator voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
摘要翻译：血糖感测系统包括传感器和传感器电子设备。传感器包括多个电极。传感器电子设备包括稳定电路。稳定电路将第一时间帧施加到电极中的一个施加第一电压，并且将第二电压施加到第二时间框架中的一个电极。稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节器电压，在第一时间帧向电极施加第一电压，并将第二电压施加到第二时间段的电极。

63. 发明授权

US07169600B2 Device for determining a glucose concentration in a tissue fluid 失效
标题翻译：用于测定组织液中葡萄糖浓度的装置
公开(公告)号：US07169600B2
公开(公告)日：2007-01-30
申请号：US10782290
申请日：2004-02-19
申请人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
发明人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
IPC分类号： C12M1/34
CPC分类号： A61B5/14865 , A61B5/14528 , A61B5/14532
摘要： The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.
摘要翻译：本发明涉及一种用于确定组织液中葡萄糖浓度的装置。在用于此目的的微透析技术中，含有灌注液的葡萄糖通过插入组织液中的微量透析探针在间歇递送脉冲中运输，并将在该过程中获得的透析液送至测量池以记录葡萄糖含量。为了即使在透析时间缩短的情况下也可以精确测定葡萄糖，建议根据命令变量，通过控制装置使灌注液中的葡萄糖的起始含量适应于组织液的葡萄糖含量源自测量单元的测量信号。当控制偏差可忽略时，灌注液中葡萄糖的瞬时起始含量可以被确定为组织液的葡萄糖含量的量度。

64. 发明授权

US06852500B1 Method for determining the concentration of glucose in a body fluid with glucose-containing perfusate 失效
标题翻译：用含葡萄糖的灌注液测定体液中葡萄糖浓度的方法
公开(公告)号：US06852500B1
公开(公告)日：2005-02-08
申请号：US09620038
申请日：2000-07-20
申请人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
发明人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
IPC分类号： G01N33/66 , A61B5/00 , G01N33/487 , C12Q1/54
CPC分类号： A61B5/14865 , A61B5/14528 , A61B5/14532
摘要： The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.
摘要翻译：本发明涉及一种用于确定体液中葡萄糖浓度的方法和装置。在用于此目的的微透析技术中，含有葡萄糖的灌注液通过插入到体液中的微量透析探针（10）以间歇递送脉冲的形式输送，并将在该过程中获得的透析液送至测量池（16）以记录葡萄糖含量。为了即使在透析时间缩短的情况下也能够精确地确定葡萄糖，建议通过控制装置（18,20）将灌注液中葡萄糖的起始含量与体液的葡萄糖含量相适应根据从测量单元（16）的测量信号导出的命令变量。当控制偏差可忽略时，可以将灌注液中葡萄糖的瞬时起始含量确定为体液葡萄糖含量的量度。

65. 发明授权

US10327677B2 Analyte sensors with a sensing surface having small sensing spots 有权
公开(公告)号：US10327677B2
公开(公告)日：2019-06-25
申请号：US13315034
申请日：2011-12-08
申请人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
发明人： Udo Hoss , Phu Le , Yi Wang , Frank David Fujimoto , Suyue Qian , Lam Tran
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1473 , C12Q1/00
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

66. 发明授权

US09795326B2 Continuous analyte measurement systems and systems and methods for implanting them 有权
公开(公告)号：US09795326B2
公开(公告)日：2017-10-24
申请号：US12842013
申请日：2010-07-22
申请人： Udo Hoss , John Charles Mazza , Phu Le
发明人： Udo Hoss , John Charles Mazza , Phu Le
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B2562/227
摘要： Low profile continuous analyte measurement systems and systems and methods for implantation within the skin of a patient are provided.

67. 发明授权

US09636450B2 Pump system modular components for delivering medication and analyte sensing at seperate insertion sites 有权
公开(公告)号：US09636450B2
公开(公告)日：2017-05-02
申请号：US12032593
申请日：2008-02-15
申请人： Udo Hoss , Gary A. Stafford
发明人： Udo Hoss , Gary A. Stafford
IPC分类号： A61M5/142 , A61M5/36 , A61M5/172 , A61M5/145
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/1723 , A61M5/365 , A61M2005/14268 , A61M2005/1726 , A61M2205/3561 , A61M2205/3592
摘要： Methods and systems for providing modular components in an integrated infusion device and analyte monitoring system where the components are independently replaceable are provided.

68. 发明申请

US20120138484A1 Analyte Sensors Comprising Thickeners, Enzyme Stabilizers and Osmium Boronates 审中-公开
标题翻译：分析物传感器，包括增稠剂，酶稳定剂和锇硼酸盐
公开(公告)号：US20120138484A1
公开(公告)日：2012-06-07
申请号：US13298020
申请日：2011-11-16
申请人： Balasubrahmanya S. Bommakanti , Udo Hoss , Gary Sandhu
发明人： Balasubrahmanya S. Bommakanti , Udo Hoss , Gary Sandhu
IPC分类号： G01N33/50 , B05D5/00 , G01N27/26
CPC分类号： C12Q1/006
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution and/or improved sensitivity and/or reduced sensitivity variation of the sensing layer by inclusion of a thickener and/or an enzyme stabilizer in the sensing layer. Embodiments of the present disclosure also relate to transition metal complexes having at least one pyridine boronic acid ligand are also described. Aspects of the disclosure include transition metal complexes chemically bonded to a polymer, such as a sensing layer polymer. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包含增稠剂和/或（例如，电化学分析物监测系统）具有改善的分布均匀性和/或改善的灵敏度和/或降低感测层的灵敏度变化酶稳定剂在感应层。还描述了本公开的实施方案涉及具有至少一个吡啶硼酸配体的过渡金属络合物。本公开的方面包括化学键合到聚合物上的过渡金属络合物，例如感测层聚合物。感测层设置在体内和/或体外分析物传感器的工作电极上，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

69. 发明申请

US20120004524A1 PROTRUDENT ANALYTE SENSOR 有权
标题翻译： PROTRUDENT分析仪传感器
公开(公告)号：US20120004524A1
公开(公告)日：2012-01-05
申请号：US13233338
申请日：2011-09-15
申请人： Nannette M. Van Antwerp , Udo Hoss
发明人： Nannette M. Van Antwerp , Udo Hoss
IPC分类号： A61B5/145
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.
摘要翻译：用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。可选地，传感器悬挂在静脉流动装置的内腔内。通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。或者，导电材料定位在静脉输液导管的外表面上。

70. 发明申请

US20110130988A1 METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS 审中-公开
公开(公告)号：US20110130988A1
公开(公告)日：2011-06-02
申请号：US13004677
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
IPC分类号： G06F19/00 , G01R27/28
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

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