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    • 61. 发明授权
    • Twin head for electronic still camera and a method for making the same
    • 电子静物照相机的双头和其制作方法
    • US4713709A
    • 1987-12-15
    • US760796
    • 1985-07-31
    • Isao YasudaYorinobu YoshisatoHideki YoshikawaKazuhiko Taketa
    • Isao YasudaYorinobu YoshisatoHideki YoshikawaKazuhiko Taketa
    • G11B5/127G11B5/147G11B5/29G11B5/255
    • G11B5/1475G11B5/29Y10T29/49048Y10T29/49057Y10T29/49792
    • A twin head for use in an electronic still camera includes a shield plate, first and second head chips bonded on opposite sides of the shield plate, and first and second reinforcing core members further bonded on first and second head chips, respectively. Each of the first and second head chip members has an elongated face that faces a recording medium and a magnetic gap defined at an intermediate portion of the elongated face. The length Wh of the elongated face is between 0.3 millimeter and 1 millimeter. Each of the first and second reinforcing core members has a coil wound thereon. The first and second head chip members, the shield plate, and the first and second reinforcing core members are bonded together such that the elongated faces of the first and second head chip members are in flush with each other and that the magnetic gaps of the first and second head chip members are aligned to each other.
    • 用于电子静物照相机的双头头包括屏蔽板,粘合在屏蔽板的相对侧上的第一和第二头部芯片,以及分别进一步结合在第一和第二头部芯片上的第一和第二加强芯部件。 第一和第二头部芯片构件中的每一个具有面对记录介质的细长面和限定在细长面的中间部分的磁隙。 细长面的长度Wh在0.3毫米至1毫米之间。 第一和第二加强芯构件中的每一个都具有卷绕在其上的线圈。 第一和第二头部芯片部件,屏蔽板以及第一和第二加强芯部件被结合在一起,使得第一和第二头部芯片部件的细长表面彼此齐平,并且第一和第二加强芯部件的磁隙 并且第二头部芯片构件彼此对准。
    • 62. 发明授权
    • Scaffold-free self-organized 3D synthetic tissue
    • 无支架的自组织3D合成组织
    • US09370606B2
    • 2016-06-21
    • US11676172
    • 2007-02-16
    • Norimasa NakamuraHideki YoshikawaWataru Ando
    • Norimasa NakamuraHideki YoshikawaWataru Ando
    • C12N5/00A61L27/36A61L27/38C07K14/78C12N5/077A61K35/12
    • A61L27/3633A61K35/12A61L27/3843C07K14/78C12N5/0655
    • The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue. The present invention also provides a method for producing an implantable synthetic tissue which does not require a plurality of monolayer cell sheets assembled to form a three-dimensionally structured synthetic tissue. The present invention is characterized by richness in adhesion molecules, nonnecessity of additional fixation at an implantation site, and good biological integration.
    • 本发明可用于没有支架的实际植入手术。 本发明提供可通过培养产生并具有高水平分化能力的合成组织或复合物。 本发明还提供了使用替换和覆盖来修复和/或再生组织的治疗和药物。 通过在特定培养条件下培养细胞,使得培养基含有细胞外基质合成促进剂,细胞被组织并容易从培养皿中分离。 本发明是通过发现这种现象来实现的。 此外,可以通过以悬浮方式培养组织来调节组织的自收缩。 因此,可以调节组织的三维形状。 本发明还提供了一种用于生产可植入的合成组织的方法,其不需要组装成多个单层细胞片以形成三维结构的合成组织。 本发明的特征在于粘附分子的丰富性,植入部位的附加固定的不必要性以及良好的生物整合性。
    • 64. 发明授权
    • Ultrasonic diagnostic device and ultrasonic image display method
    • 超声波诊断装置和超声波图像显示方法
    • US09131923B2
    • 2015-09-15
    • US13810524
    • 2011-07-28
    • Hideki Yoshikawa
    • Hideki Yoshikawa
    • A61B8/00A61B8/08A61B8/06A61B8/14
    • A61B8/5207A61B8/06A61B8/0891A61B8/14A61B8/461A61B8/463A61B8/465A61B8/481A61B8/5223
    • An ultrasonic diagnostic device and image display method display an inflow time map representing relative differences in blood flow dynamics such as inflow of a contrast agent, including extracting a vessel and constructing a noise-less inflow time map, and, in the comparison of differences in color between the constructed inflow time map and the past inflow time map, unifying the color of regions as a base. A TIC analysis unit calculates a parameter (tα) indicating an inflow starting time of a contrast agent and a difference of brightness ΔI due to the contrast agent using image data in a range designated by an image detection unit. A first pixel selection unit extracts a pixel and removes a non-contrast-enhanced region. An image construction unit constructs an inflow time map colored according to tα, and a second pixel selection unit extracts a vessel using a histogram based on ΔI.
    • 超声波诊断装置和图像显示方法显示表示血流动力学的相对差异的流入时间图,例如造影剂的流入,包括提取血管并构建无噪声流入时间图,并且在比较差异 构建的流入时间图与过去流入时间图之间的颜色,将区域的颜色统一为基础。 TIC分析单元计算指示造影剂的流入开始时间的参数(tα)和由图像检测单元指定的范围内的使用图像数据的造影剂引起的亮度差Dgr; I的差异。 第一像素选择单元提取像素并去除非对比度增强区域。 图像构造单元构造根据tα着色的流入时间图,第二像素选择单元使用基于&Dgr; I的直方图提取容器。
    • 66. 发明授权
    • X-ray convergence element and X-ray irradiation device
    • X射线会聚元件和X射线照射装置
    • US08416921B2
    • 2013-04-09
    • US12280136
    • 2007-02-08
    • Hiromoto NakazawaHideki YoshikawaAurel-Mihai VlaicuKenichi OboriShintaro KomataniSumito Ohzawa
    • Hiromoto NakazawaHideki YoshikawaAurel-Mihai VlaicuKenichi OboriShintaro KomataniSumito Ohzawa
    • G21K1/06
    • G21K1/06G21K2201/064
    • An X-ray convergence element and an X-ray irradiation device including the X-ray convergence element are provided. The X-ray convergence element can extend a working distance from an exit-side opening end thereof to a specimen, and can perform analysis of the specimen with rough surface, a fluorescent X-ray analysis, and a X-ray diffraction analysis, regardless of a size of the specimen. An X-ray blocking member 23 is provided with three supporting members 233 for supporting the X-ray blocking member 23, which extend from an annular member 232 having approximately the same diameter as a diameter of an entrance-side opening end (outer diameter of a capillary 20) toward the center of the X-ray blocking member 23 to fix the annular member 232 to the capillary 20. The annular member 232, the supporting members 233, and the X-ray blocking member 23 are integrally formed of a metal that shields X-rays, such as tantalum, tungsten, or molybdenum. A dimension of the X-ray blocking member 23 in the axial direction (thickness) is set to be sufficient for blocking X-rays.
    • 提供了包括X射线会聚元件的X射线会聚元件和X射线照射装置。 X射线会聚元件可以将其出口侧开口端的工作距离延伸到试样,并且可以进行具有粗糙表面,荧光X射线分析和X射线衍射分析的样品的分析 的样本大小。 X射线阻挡构件23设置有用于支撑X射线阻挡构件23的三个支撑构件233,其从具有与入口侧开口端的直径大致相同直径的环形构件232延伸(外径 毛细管20)朝向X射线阻挡构件23的中心,以将环形构件232固定到毛细管20.环形构件232,支撑构件233和X射线阻挡构件23由金属 屏蔽X射线,如钽,钨或钼。 X射线阻挡构件23的轴向(厚度)的尺寸被设定为足以阻挡X射线。
    • 68. 发明申请
    • X-RAY CONVERGENCE ELEMENT AND X-RAY IRRADIATION DEVICE
    • X射线融合元件和X射线辐照器件
    • US20100226477A1
    • 2010-09-09
    • US12280136
    • 2007-02-08
    • Hiromoto NakazawaHideki YoshikawaAurel-Mihai VlaicuKenichi OboriShintaro KomataniSumito Ohzawa
    • Hiromoto NakazawaHideki YoshikawaAurel-Mihai VlaicuKenichi OboriShintaro KomataniSumito Ohzawa
    • G21K5/00G21K1/02
    • G21K1/06G21K2201/064
    • An X-ray convergence element and an X-ray irradiation device including the X-ray convergence element are provided. The X-ray convergence element can extend a working distance from an exit-side opening end thereof to a specimen, and can perform analysis of the specimen with rough surface, a fluorescent X-ray analysis, and a X-ray diffraction analysis, regardless of a size of the specimen. An X-ray blocking member 23 is provided with three supporting members 233 for supporting the X-ray blocking member 23, which extend from an annular member 232 having approximately the same diameter as a diameter of an entrance-side opening end (outer diameter of a capillary 20) toward the center of the X-ray blocking member 23 to fix the annular member 232 to the capillary 20. The annular member 232, the supporting members 233, and the X-ray blocking member 23 are integrally formed of a metal that shields X-rays, such as tantalum, tungsten, or molybdenum. A dimension of the X-ray blocking member 23 in the axial direction (thickness) is set to be sufficient for blocking X-rays.
    • 提供了包括X射线会聚元件的X射线会聚元件和X射线照射装置。 X射线会聚元件可以将其出口侧开口端的工作距离延伸到试样,并且可以进行具有粗糙表面,荧光X射线分析和X射线衍射分析的样品的分析 的样本大小。 X射线阻挡构件23设置有用于支撑X射线阻挡构件23的三个支撑构件233,其从具有与入口侧开口端的直径大致相同直径的环形构件232延伸(外径 毛细管20)朝向X射线阻挡构件23的中心,以将环形构件232固定到毛细管20.环形构件232,支撑构件233和X射线阻挡构件23由金属 屏蔽X射线,如钽,钨或钼。 X射线阻挡构件23的轴向(厚度)的尺寸被设定为足以阻挡X射线。
    • 70. 发明授权
    • Staple type oligonucleotide and drug comprising the same
    • 短链型寡核苷酸和包含其的药物
    • US07595301B2
    • 2009-09-29
    • US10568226
    • 2004-09-29
    • Yasuo KunugizaNaruya TomitaHideo HashimotoHideki YoshikawaRyuichi Morishita
    • Yasuo KunugizaNaruya TomitaHideo HashimotoHideki YoshikawaRyuichi Morishita
    • A61K48/00A61K31/70C07H21/02C07H21/04
    • A61K31/713C12N15/111C12N2310/11C12N2310/14C12N2310/53C12N2320/51
    • Conventional oligonucleotides are opened at both ends and thereby unstable. Their stability against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
    • 常规寡核苷酸在两端开放,从而不稳定。 它们对分解代谢酶的稳定性通过硫代磷酸酯修饰而增加,但是这种硫代磷酸酯会引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说,它提供含有与活性成分相同的主要寡核苷酸和药物。 具体来说,它提供转录因子抑制剂,反义寡核苷酸和siRNA。 更具体地说,它提供用于预防,治疗或改善炎症,自身免疫性疾病,中枢性疾病,缺血性疾病中的再灌注损伤,器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说,它提供预防,治疗或改善关节炎,皮炎,肾炎,肝炎,肾衰竭,膀胱炎,前列腺炎,尿道炎,溃疡性结肠炎,克罗恩病,慢性类风湿性关节炎,骨关节炎,特应性皮炎,接触性皮炎,牛皮癣,皮肤 溃疡或褥疮。