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61. 发明申请

WO2014140542A1 A DDA EXPERIMENT WITH REDUCED DATA PROCESSING 审中-公开
标题翻译：具有减少数据处理的DDA实验
公开(公告)号：WO2014140542A1
公开(公告)日：2014-09-18
申请号：PCT/GB2014/050697
申请日：2014-03-10
申请人： MICROMASS UK LIMITED
发明人： BROWN, Jeffery Mark , GILES, Kevin , GREEN, Martin Raymond , HOYES, John Brian , JONES, Christopher , MORRIS, Michael Raymond , PRINGLE, Steven Derek , RICHARDSON, Keith , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/005 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions; determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
摘要翻译：公开了一种质谱方法，包括：对多种不同类型的母体或前体离子进行测量扫描，其中所述测量扫描包括分析离子的离子迁移率和大量分析离子; 基于它们确定的离子迁移率和质荷比的组合来确定在测量扫描中分析的亲本或前体离子的电荷状态; 选择母体或前体离子进行碎裂或反应; 并且使所述选择的离子断裂或反应，其中基于所选离子的确定的电荷状态，所述断裂或反应条件选自多个不同的断裂或反应条件。

62. 发明申请

WO2014135862A1 SPATIALLY CORRELATED DYNAMIC FOCUSING 审中-公开
标题翻译：空间相关动态聚焦
公开(公告)号：WO2014135862A1
公开(公告)日：2014-09-12
申请号：PCT/GB2014/050638
申请日：2014-03-05
申请人： MICROMASS UK LIMITED
发明人： BROWN, Jeffery Mark , GREEN, Martin Raymond
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/403
摘要： A Time of Flight mass analyser is disclosed comprising one or more acceleration electrodes and a first device arranged and adapted to apply a DC voltage pulse to the one or more acceleration electrodes. The DC voltage pulse causes ions to be accelerated into a time of flight or drift region and the DC voltage pulse is applied, in use, to the one or more acceleration electrodes between a time Ti and a time T2. A second device is arranged and adapted to apply a single phase oscillating voltage to the one or more acceleration electrodes, wherein the single phase oscillating voltage undergoes multiple oscillations between the time T 1 and the time T 2 . The application of the DC voltage pulse and the single phase oscillating voltage to the one or more acceleration electrodes establishes an homogeneous electric field having a net force towards the time of flight or drift region.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个加速电极和布置并适于向一个或多个加速电极施加DC电压脉冲的第一装置。直流电压脉冲使得离子被加速到飞行时间或漂移区域，并且在使用时将直流电压脉冲施加到时间Ti和时间T2之间的一个或多个加速电极。第二装置被布置并适于将单相振荡电压施加到一个或多个加速电极，其中单相振荡电压在时间T1和时间T2之间经历多次振荡。将DC电压脉冲和单相振荡电压施加到一个或多个加速电极建立了均匀电场，其具有朝向飞行时间或漂移区域的净力。

63. 发明申请

WO2013171493A2 METHOD OF MS/MS MASS SPECTROMETRY 审中-公开
标题翻译： MS / MS质谱法的方法
公开(公告)号：WO2013171493A2
公开(公告)日：2013-11-21
申请号：PCT/GB2013/051259
申请日：2013-05-16
申请人： MICROMASS UK LIMITED
发明人： BROWN, Jeffery Mark , GREEN, Martin Raymond , PRINGLE, Steven Derek
IPC分类号： H01J49/00
CPC分类号： H01J49/0054 , H01J49/0031 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation ("ECD") at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.
摘要翻译：公开了一种质谱法，其包括在母体离子质量分析的第一模式和母体离子在大气压下进行电子俘获解离（“ECD”）的第二模式之间交替，以产生碎片离子，其中然后进行质量分析。基于它们被检测的时间，母体离子与它们的碎片离子相关联。这种方法使得母体离子与其碎片离子相关联，即使当在大气压下进行ECD断裂时。

64. 发明申请

WO2013140127A3 IMPROVED TIME OF FLIGHT QUANTITATION USING ALTERNATIVE CHARACTERISTIC IONS 审中-公开
公开(公告)号：WO2013140127A3
公开(公告)日：2013-09-26
申请号：PCT/GB2013/050553
申请日：2013-03-06
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond , JONES, Gareth Rhys , MORRIS, Michael Raymond , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00
摘要： A method of mass spectrometry is disclosed wherein the intensity of an analyte is determined by determining the intensity of first characteristic fragment ions when the intensity of the first characteristic fragment ions is within a first intensity range corresponding to the detection or unsaturated range of an ion detector. However, when the intensity of the first characteristic fragment ions is outside of the first intensity range so that the ion detector would saturate then the intensity of the analyte is determined by determining the intensity of second different characteristic fragment ions.

65. 发明申请

WO2013038212A1 ENCODING OF PRECURSOR ION BEAM TO AID PRODUCT ION ASSIGNMENT 审中-公开
标题翻译：编码前置离子束以帮助产品离子分配
公开(公告)号：WO2013038212A1
公开(公告)日：2013-03-21
申请号：PCT/GB2012/052293
申请日：2012-09-17
申请人： MICROMASS UK LIMITED
发明人： GILES, Kevin , GREEN, Martin Raymond , RICHARDSON, Keith , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/0045 , H01J49/14 , H01J49/26
摘要： A method of encoding a parent or precursor ion beam to aid product ion assignment is disclosed. According to an embodiment the energy of parent ions entering a collision cell 3 is progressively increased. Different species of parent ions fragment at different collision energies. Fragment ion intensity profiles are matched with parent ion intensity profiles to correlate fragment ions with corresponding parent ions.
摘要翻译：公开了编码母体或前体离子束以辅助产物离子分配的方法。根据实施例，进入碰撞池3的母体离子的能量逐渐增加。不同种类的亲本离子在不同碰撞能量下碎片。片段离子强度分布与母体离子强度分布匹配，以使碎片离子与相应的母体离子相关联。

66. 发明申请

WO2021069882A1 AUTOMATICALLY STANDARDISING SPECTROMETERS 审中-公开
公开(公告)号：WO2021069882A1
公开(公告)日：2021-04-15
申请号：PCT/GB2020/052468
申请日：2020-10-06
申请人： MICROMASS UK LIMITED
发明人： WILDGOOSE, Jason Lee , GREEN, Martin Raymond , RICHARDSON, Keith , KENNY, Daniel James , GORDON, David , WHYATT, Kate
IPC分类号： H01J49/00 , G01N27/62
摘要： A method of mass spectrometry is disclosed comprising: a step (10) of analysing a reference compound in a first mass spectrometer and outputting mass spectral data in response thereto; a step (20) of analysing the reference compound in a second, different mass spectrometer and outputting mass spectral data in response thereto; and a step (30) of automatically adjusting an operational parameter, duty cycle (e.g. duty cycle of data acquisition), or acquired spectral data of at least one mass spectrometer such that, for the same (given) consumption of reference compound by the spectrometer, the statistical precision of quantification (the number of detected ions) and/or of mass measurement (the mass resolution) by the mass spectrometer is substantially the same as that of the other mass spectrometer. A similar method of ion mobility spectrometry is disclosed.

67. 发明申请

WO2019158930A1 QUADRUPOLE DEVICES 审中-公开
公开(公告)号：WO2019158930A1
公开(公告)日：2019-08-22
申请号：PCT/GB2019/050404
申请日：2019-02-15
申请人： MICROMASS UK LIMITED
发明人： DAVID, Gordon , LANGRIDGE, David , GREEN, Martin Raymond , MOULDS, Richard , KENNY, Daniel J. , WORTHINGTON, Kenneth
IPC分类号： H01J49/42
摘要： A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X- band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device.

68. 发明申请

WO2018167487A1 MULTIPLEXING METHOD FOR SEPARATORS 审中-公开
公开(公告)号：WO2018167487A1
公开(公告)日：2018-09-20
申请号：PCT/GB2018/050653
申请日：2018-03-14
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond
IPC分类号： H01J49/00 , H01J49/40 , G01N27/62
摘要： The present disclosure provides a method comprising providing a sample to be analysed, separating successive populations of ions from said sample in a separator, wherein said populations of ions are introduced into said separator at regular intervals, and the intervals are timed such that at least some ions in a subsequent population of ions overlap ions in a preceding population of ions, varying one or more parameters of said separator such that different populations of ions experience different separation conditions, detecting ions from said populations of ions and obtaining a convolved data set, and de¬ convolving said convolved data set using the known variance of the parameters and outputting data corresponding to the successive populations of ions.

69. 发明申请

WO2018073594A1 ION SEPARATOR 审中-公开
公开(公告)号：WO2018073594A1
公开(公告)日：2018-04-26
申请号：PCT/GB2017/053165
申请日：2017-10-19
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond , RICHARDSON, Keith George
IPC分类号： H01J49/42 , G01N27/62
摘要： A method of separating ions is disclosed comprising: providing an ion separation device comprising a plurality of electrodes; providing a gas flow (5) so as to urge ions in a first direction along the device; applying voltages to said electrodes so that a plurality of travelling potentials (4) urge the ions in a second opposite direction; and varying at least one operational parameter of the travelling potentials (4) as a function of position along the device such that ions of different mobility or mass to charge ratio become trapped at different locations along the device.
摘要翻译：公开了一种分离离子的方法，包括：提供包括多个电极的离子分离装置; 提供气流（5）以沿着所述装置沿第一方向推动离子; 向所述电极施加电压，使得多个行进电位（4）在第二相反方向上推动离子; 并且根据沿装置的位置改变行进电位（4）的至少一个操作参数，使得具有不同迁移率或质荷比的离子被捕获在沿装置的不同位置处。

70. 发明申请

WO2018069735A1 GAS CHROMATOGRAPHY WITH VACUUM ULTRA-VIOLET DETECTOR AND MASS SPECTROMETER OR ION MOBILITY SPECTROMETER 审中-公开
标题翻译：真空超紫外检测器和质谱仪或离子迁移谱仪的气相色谱
公开(公告)号：WO2018069735A1
公开(公告)日：2018-04-19
申请号：PCT/GB2017/053122
申请日：2017-10-16
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond
IPC分类号： G01N30/74 , G01N30/72 , G01N21/05
摘要： Disclosed herein is an ion analysis instrument combining a chromatographic or other separation device for separating gaseous analyte material according to retention time with an ultra-violet ("UV") spectrometer or detector for obtaining ultra-violet spectral data of at least a portion of the analyte material separated in said chromatographic or other separation device and a mass and/or ion mobility spectrometer for obtaining mass and/or ion mobility spectral data of ions generated from at least a portion of the analyte material separated in said chromatographic or other separation device. This instrument is able to provide highly orthogonal multidimensional data sets.
摘要翻译：本文公开了结合色谱或其他分离装置的离子分析仪器，其用于根据保留时间用紫外（“UV”）光谱仪或检测器分离气态分析物材料以获得紫外线在所述色谱或其他分离装置和质量和/或离子迁移谱仪中分离的至少一部分分析物材料的光谱数据，用于获得由至少一部分分析物材料产生的离子的质量和/或离子迁移率光谱数据在所述色谱分离装置或其他分离装置中分离。该仪器能够提供高度正交的多维数据集。

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