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61. 发明申请

WO2005037326A2 UNIFIED SIMD PROCESSOR 审中-公开
标题翻译：统一SIMD处理器
公开(公告)号：WO2005037326A2
公开(公告)日：2005-04-28
申请号：PCT/GB2004004377
申请日：2004-10-13
申请人： CLEARSPEED TECHNOLOGY PLC , STUTTARD DAVID , WILLIAMS DAVID , PACKER JAMES , DAVIDSON COLIN , HICKEY NEIL , DAY TIMOTHY
发明人： STUTTARD DAVID , WILLIAMS DAVID , PACKER JAMES , DAVIDSON COLIN , HICKEY NEIL , DAY TIMOTHY
IPC分类号： G06F15/80 , A61K51/04 , A61K31/16 , A61P35/00
CPC分类号： G06F9/3887 , G06F9/3885
摘要： A data processor comprises a single control unit and an integral execution unit adapted to operate on both parallel and scalar data under the same instruction set. The execution unit comprises a SMO part comprising an array of processing elements adapted to operate on the parallel data and a scalar part adapted to operate on the scalar data. Substantially all the instructions are operable on the parallel and/or the scalar data. Preferably, both the scalar part and the SIMD part have a complete range of addressing modes that allow them to support: scalar variables pointing to data in scalar memory; scalar variables pointing to data in memory in the SIMD part of the execution unit; SHVM variables pointing to memory in the SIMD part of the execution unit; and SIMD variables pointing to data in scalar memory. The scalar part, the SIMD part, and I/O means are adapted to be operated in parallel by the same instruction stream.
摘要翻译：数据处理器包括单个控制单元和适于在相同指令集下的并行和标量数据上操作的整体执行单元。执行单元包括SMO部分，其包括适于对并行数据进行操作的处理元件阵列和适于对标量数据进行操作的标量部分。基本上所有的指令都可以在并行和/或标量数据上操作。优选地，标量部分和SIMD部分都具有允许它们支持的完整范围的寻址模式：指向标量存储器中的数据的标量变量; 标量变量指向执行单元的SIMD部分中的存储器中的数据; SHVM变量指向执行单元的SIMD部分中的存储器; 和SIMD变量指向标量存储器中的数据。标量部分，SIMD部分和I / O装置适于由相同的指令流并行操作。

62. 发明申请

WO02058679A2 ANTIANGIOGENIC COMPOUNDS AND AN ASSAY FOR INHIBITORS OF CELL INVASION 审中-公开
标题翻译：抗生素化合物和细胞侵入抑制剂的测定
公开(公告)号：WO02058679A2
公开(公告)日：2002-08-01
申请号：PCT/CA0200097
申请日：2002-01-25
申请人： UNIV BRITISH COLUMBIA , ROSKELLEY CALVIN , ANDERSEN RAYMOND , WILLIAMS DAVID , ROBERGE MICHEL , DEDHAR SHOUKAT , KARSAN ALY , MINCHINTON ANDREW
发明人： ROSKELLEY CALVIN , ANDERSEN RAYMOND , WILLIAMS DAVID , ROBERGE MICHEL , DEDHAR SHOUKAT , KARSAN ALY , MINCHINTON ANDREW
IPC分类号： G01N33/50 , A61K31/395 , A61K31/403 , A61K31/495 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/16 , A61P15/18 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D209/86 , C07D225/02 , C07D295/13 , G01N33/15 , G01N33/53 , A61K31/00
CPC分类号： C07D295/13 , A61K31/395 , A61K31/403 , C07D209/86 , C07D225/02
摘要： This invention provides the use of macrocyclic amines for inhibition of cellular invasion or angiogenesis. Compounds and pharmaceutical compositions of this invention are useful in the treatment of conditions characterized by cellular invasion or angiogenesis, including cancer. Compounds that may be used in this invention include the motuporamines.
摘要翻译：本发明提供了大环胺用于抑制细胞侵袭或血管发生的用途。本发明的化合物和药物组合物可用于治疗以细胞侵袭或血管生成为特征的病症，包括癌症。可用于本发明的化合物包括异丁胺。

63. 发明申请

WO0147301A3 DATA TRANSMISSION IN A CELLULAR COMMUNICATIONS SYSTEM 审中-公开
标题翻译：细胞通信系统中的数据传输
公开(公告)号：WO0147301A3
公开(公告)日：2001-11-29
申请号：PCT/EP0012726
申请日：2000-12-13
申请人： MOTOROLA LTD , ANDERSON NICHOLAS , KOTZIN MICHAEL , HOBSON PAOLA , WILLIAMS DAVID , CONNOR ERICK O , MCANDREW PATRICK , FREEMAN DAVID
发明人： ANDERSON NICHOLAS , KOTZIN MICHAEL , HOBSON PAOLA , WILLIAMS DAVID , O'CONNOR ERICK , MCANDREW PATRICK , FREEMAN DAVID
IPC分类号： H04W4/08 , H04W4/12 , H04Q7/32 , H04Q7/22
CPC分类号： H04W4/08 , H04W4/12
摘要： A method of transmitting data in a cellular communication system. The method includes receiving requests from a plurality of user stations, forming a request group consisting of those requests that specify a same item of data, and transmitting the same item of data by a common transmission resource. A transmitting step can be performed at a time determined according to a number of requests in the request group and/or transmission time criteria specified in the requests. Also described is a corresponding apparatus for transmitting data. Also described is a storage medium storing processor implantable instructions. The invention reduces the amount of transmission resource used.
摘要翻译：一种在蜂窝通信系统中发送数据的方法。该方法包括从多个用户站接收请求，形成由指定相同数据项的那些请求组成的请求组，以及通过公共传输资源发送相同的数据项。发送步骤可以根据在请求中指定的请求组中的请求数量和/或发送时间标准确定的时间执行。还描述了用于发送数据的相应装置。还描述了存储处理器可植入指令的存储介质。本发明减少所使用的传输资源的数量。

64. 发明申请

WO9923109A3 A METHOD FOR MAPPING THE ACTIVE SITES BOUND BY ENZYMES THAT COVALENTLY MODIFY SUBSTRATE MOLECULES 审中-公开
标题翻译：一种通过酶促共价修饰底物分子来定位有活性位点的方法
公开(公告)号：WO9923109A3
公开(公告)日：1999-07-08
申请号：PCT/GB9803259
申请日：1998-10-30
申请人： PEPTIDE THERAPEUTICS LTD , CLARK JONATHAN , LAMONT ALAN , WILLIAMS DAVID
发明人： CLARK JONATHAN , LAMONT ALAN , WILLIAMS DAVID
IPC分类号： C12Q1/48 , A61K38/00 , A61K38/55 , A61K45/00 , A61P43/00 , C07B61/00 , C07K1/04 , C12Q1/42 , A61K38/08 , G01N33/68
CPC分类号： C07K1/047 , A61K38/00
摘要： This invention provides for the active site mapping of enzymes which catalyse covalent modification including, but not limited to phosphorylation, acylation, dephosphorylation in which a fixed residue (known as the catalytic residue) such as a tyrosine, serine, threonine, histidine, aspartic acid residue or any other residue containing an appropriate side chain is modified. Mapping of protein kinases is exemplified. The method of the invention has an additional level of complexity over and above that of the self-deconvoluting libraries described in WO97/42216. This involves making a library of smaller libraries (referred to as subsets) where a fixed residue is moved stepwise through the sequence of amino acids or other groups (such as peptidomimetics). Using 5 subsets of libraries of peptides of 5 amino acids allows the mapping of a sequence of 9 amino acids. In general one could carry out the invention using n subsets of n-mer peptides so as to provide mapping data for the residues from -(n-1) to +(n-1) either side of the active site. Thus in general the length of the mapped sequence would be (2n)-1. In this invention there is no need to separate modified from unmodified sequences because of the self deconvoluting nature of the library. The assay screen produces a series of hits, the patterns of which reveal the unique sequences in each well. This enables a pattern of substrate preferences to be determined for any enzyme. The unique sequences obtained using this invention can be used to provide substrates for high throughput assays and provide detailed information about the active site to aid rational drug design. This invention can also be used as an inhibitor library to screen against known modifying enzymes where a known substrate exists and can be set up in an assay format.
摘要翻译：本发明提供催化共价修饰的酶的活性位点作图，包括但不限于磷酸化，酰化，去磷酸化，其中固定的残基（称为催化残基）如酪氨酸，丝氨酸，苏氨酸，组氨酸，天冬氨酸残基或含有适当侧链的任何其他残基被修饰。蛋白激酶的图谱是示例性的。本发明的方法比WO97 / 42216中描述的自去卷积文库具有更高的复杂程度。这涉及制作一个较小的文库（称为亚组）的库，其中固定的残基逐步移动通过氨基酸或其他基团（例如肽模拟物）的序列。使用5个氨基酸的肽库的5个亚组允许绘制9个氨基酸的序列。通常可以使用n个n聚体肽亚组来实施本发明，从而为从活性位点两侧的 - （n-1）至+（n-1）的残基提供映射数据。因此，通常映射序列的长度将是（2n）-1。在本发明中，由于文库的自去卷积性质，不需要将修饰与未修饰的序列分开。化验屏幕产生一系列命中，其中的模式显示每个孔中的独特序列。这使得可以为任何酶确定底物偏好的模式。使用本发明获得的独特序列可以用于提供用于高通量测定的底物并且提供关于活性位点的详细信息以帮助合理的药物设计。本发明也可以用作抑制剂文库筛选已知的修饰酶，其中已知的底物存在并且可以以测定形式建立。

65. 发明授权

US968621A Suspension-hook. 失效
公开(公告)号：US968621A
公开(公告)日：1910-08-30
申请号：US1910551573
申请日：1910-03-25
申请人： WILLIAMS DAVID
发明人： WILLIAMS DAVID
CPC分类号： B66C1/36 , Y10T24/45377

66. 发明授权

US958052A Pipe support and clamp. 失效
标题翻译：管道支撑和夹具。
公开(公告)号：US958052A
公开(公告)日：1910-05-17
申请号：US1909509986
申请日：1909-07-28
申请人： WILLIAMS DAVID
发明人： WILLIAMS DAVID
CPC分类号： F16C11/106 , F16B2/10 , F16B9/023 , F16L3/1033 , F16L3/11 , Y10T403/32311 , Y10T403/32795 , Y10T403/32803

67. 发明授权

US892345A Machine for polishing, cleansing, and rolling sheets or plates of tin. 失效
标题翻译：清洗机，清洗机，滚筒机或卷板机。
公开(公告)号：US892345A
公开(公告)日：1908-06-30
申请号：US1907389662
申请日：1907-08-22
申请人： DAVID S PYLE , GEORGE GREER , WILLIAMS DAVID
发明人： WILLIAMS DAVID
CPC分类号： B24B31/00

68. 发明授权

US1050370A Manufacture of chains. 失效
标题翻译：链条制造。
公开(公告)号：US1050370A
公开(公告)日：1913-01-14
申请号：US1911650291
申请日：1911-09-19
申请人： MCGLASHAN GEORGE COTTON , WILLIAMS DAVID
发明人： MCGLASHAN GEORGE COTTON , WILLIAMS DAVID
CPC分类号： B22D25/023 , Y10S76/03

69. 发明授权

US739370A Bat separating and folding machine. 失效
标题翻译： BAT分离和折叠机。
公开(公告)号：US739370A
公开(公告)日：1903-09-22
申请号：US1903146650
申请日：1903-03-07
申请人： WILLIAMS DAVID
发明人： WILLIAMS DAVID
CPC分类号： D04H1/74 , Y10T29/147

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