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    • 62. 发明授权
    • Phosphonic diester derivatives
    • 膦酸二酯衍生物
    • US5527786A
    • 1996-06-18
    • US424345
    • 1995-04-19
    • Kazuyoshi MiyataYasuhisa KurogiYoshihiko TsudaKazuhiko TsutsumiTakeshi IwamotoChieko Naba
    • Kazuyoshi MiyataYasuhisa KurogiYoshihiko TsudaKazuhiko TsutsumiTakeshi IwamotoChieko Naba
    • C07F9/655A61K31/675A61K31/665C07F9/28
    • C07F9/65522
    • The present invention provides a phosphonic diester derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and they each represent a hydrogen atom, a lower alkyl group, a halogen atom, a cyano group, a hydroxyl group, or a lower alkoxy group optionally having a halogen atom, a phenyl group or a hydroxypiperidino group as a substituent; R.sup.4 represents a hydrogen atom, a lower alkoxy group, a halogen atom, or a lower alkyl group optionally having a halogen atom or a cyano group as a substituent; and R.sup.5 and R.sup.6 are the same or different and they each represent a hydrogen atom or a lower alkyl group.The derivative of the present invention has excellent hypolipidemic, vasodepressor and hypoglycemic activities and is useful as therapeutic and preventive agents for hyperlipidemic diseases, hypertension and diabetes.
    • PCT No.PCT / JP94 / 01307 Sec。 371日期1995年04月19日 102(e)1995年4月19日PCT PCT 1994年8月8日PCT公布。 出版物WO95 / 06051 日本3月2日公开本发明提供下式的膦酸二酯衍生物:其中R 1,R 2和R 3相同或不同,它们各自表示氢原子,低级烷基,卤素原子, 氰基,羟基或任选具有卤素原子的低级烷氧基,苯基或羟基哌啶子基作为取代基; R4表示氢原子,低级烷氧基,卤素原子或任选具有卤素原子或氰基作为取代基的低级烷基; R 5和R 6相同或不同,它们各自表示氢原子或低级烷基。 本发明的衍生物具有优异的降血脂,血管抑制剂和降血糖活性,可用作高脂血症和高血压病和糖尿病的治疗和预防剂。
    • 70. 发明授权
    • Method of changing width of slab in continuous casting
    • 连续铸造板坯宽度变化的方法
    • US4660617A
    • 1987-04-28
    • US783589
    • 1985-10-03
    • Kazuhiko TsutsumiWataru OhashiTakeyoshi NinomiyaMasami Temma
    • Kazuhiko TsutsumiWataru OhashiTakeyoshi NinomiyaMasami Temma
    • B22D11/16
    • B22D11/168
    • A width changing method in which the width of a slab under casting is changed by a movement of narrow face of a continuous casting mold by the operation of a horizontal driving device and a rotary driving device operable independently of the horizontal driving device. The period of width changing operation is divided into a forward taper changing period in which each narrow face is inclined toward the center of the mold and a rearward taper changing period in which each mold wall is inclined away from the center of the mold. The acceleration of the horizontal movement of each narrow face is determined by means of allowable shell deformation resistance as a parameter for each period. Also is determined the angular velocity of the rotary device or the difference in velocity between the upper and lower ends of the narrow face. The width changing operation is conducted while maintaining the acceleration and the angular velocity or the velocity difference at constant levels in respective periods.
    • 一种宽度改变方法,其中通过水平驱动装置的操作和独立于水平驱动装置可操作的旋转驱动装置,通过连续铸模的窄面的移动来改变铸造下的板坯的宽度。 宽度变化操作的周期被分为向前锥形变化期间,其中每个窄面朝向模具的中心倾斜,并且后向锥形变化期间,其中每个模具壁从模具的中心倾斜。 每个窄面的水平运动的加速度是通过允许的壳变形阻力作为每个周期的参数来确定的。 还确定了旋转装置的角速度或窄面的上端和下端之间的速度差。 在各个周期内将加速度和角速度或速度差维持在恒定水平的同时进行宽度改变操作。