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61. 发明授权

US4179508A Sulfur-containing derivatives of 4,4-dimethyl-2H,4H-isoquinoline-1,3-dione, and anticonvulsant and antihyperlipidemic compositions thereof 失效
标题翻译： 4,4-二甲基-2H，4H-异喹啉-1,3-二酮的含硫衍生物及其抗惊厥和抗高脂血症组合物
公开(公告)号：US4179508A
公开(公告)日：1979-12-18
申请号：US925877
申请日：1978-07-18
申请人： Volkhard Austel , Eberhard Kutter , Wolfgang Eberlein , Joachim Heider , Joachim Kahling
发明人： Volkhard Austel , Eberhard Kutter , Wolfgang Eberlein , Joachim Heider , Joachim Kahling
IPC分类号： A61K31/47 , A61K31/472 , A61P3/06 , A61P25/08 , C07D217/24
CPC分类号： C07D217/24
摘要： Compounds of the formula ##STR1## wherein A is lower alkylene,R is lower alkyl, andn is 0, 1 or 2;the compounds are useful as anti-hyperlipidemics and anti-convulsants.
摘要翻译：其中A为低级亚烷基，R为低级烷基，n为0,1或2的式IMA化合物; 该化合物可用作抗高脂血症和抗惊厥药。

62. 发明授权

US4137318A N-(phenylalkylamino-alkyl)-dihydroisoquinolinones, pharmaceutical compositions and methods employing them 失效
标题翻译： N-（苯基烷基氨基 - 烷基） - 二氢异喹啉酮，药物组合物和采用它们的方法
公开(公告)号：US4137318A
公开(公告)日：1979-01-30
申请号：US826853
申请日：1977-08-22
申请人： Wolfgang Eberlein , Joachim Heider , Volkhard Austel , Jurgen Dammgen , Rudolf Kadatz
发明人： Wolfgang Eberlein , Joachim Heider , Volkhard Austel , Jurgen Dammgen , Rudolf Kadatz
IPC分类号： C07D209/44 , A61K31/47 , A61K31/472 , A61K31/55 , A61P9/00 , A61P9/12 , C07C217/04 , C07D217/06 , C07D217/24 , C07D217/26 , C07D223/16 , C07D491/056
CPC分类号： C07D223/16 , C07D217/24 , C07D217/26
摘要： Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.6, which may be identical to or different from each other, are each hydrogen or lower alkyl;R.sub.3 is lower alkoxy;R.sub.4 is lower alkoxy or, together with R.sub.3, methylenedioxy or ethylenedioxy;R.sub.5 is hydrogen, lower alkyl or benzyl;R.sub.7 is hydrogen or lower alkoxy;R.sub.8 is hydrogen, lower alkoxy or, together with R.sub.7, methylenedioxy or ethylenedioxy;M is 1 or 2; andN is 2 or 3;And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antihypertensives and heart rate reducers.
摘要翻译：式可以相同或不同的R 1，R 2和R 6各自为氢或低级烷基; R3是低级烷氧基; R4是低级烷氧基或与R3一起亚甲二氧基或亚乙二氧基; R5是氢，低级烷基或苄基; R7是氢或低级烷氧基; R8是氢，低级烷氧基或与R 7一起亚甲二氧基或亚乙二氧基; M IS 1 OR 2; 和N是2或3; 和非毒性，药理学上可接受的酸添加量。化合物及其盐可用作抗高血压药和心率降低剂。

63. 发明授权

US4087541A 2-(Aralkylaminoalkyl)phthalimidines 失效
标题翻译： 2-（芳烷基氨基烷基）苯二甲酰亚胺
公开(公告)号：US4087541A
公开(公告)日：1978-05-02
申请号：US793734
申请日：1977-05-04
申请人： Wolfgang Eberlein , Eberhard Kutter , Joachim Heider , Volkhard Austel , Rudolf Kadatz , Willi Diederen , Walter Kobinger , Christian Lillie , Jurgen Dammgen
发明人： Wolfgang Eberlein , Eberhard Kutter , Joachim Heider , Volkhard Austel , Rudolf Kadatz , Willi Diederen , Walter Kobinger , Christian Lillie , Jurgen Dammgen
IPC分类号： C07D209/46 , C07D209/48 , C07D275/06 , C07D491/056 , A61K31/40 , C07D405/12 , C07D491/04
CPC分类号： C07D209/48 , C07C309/00 , C07D209/46 , C07D275/06
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy.R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.
摘要翻译：其中R 1是氢，低级烷基或苯基，R 2是氢，氯或甲氧基，R 3是氢或甲氧基，R 2和R 3彼此是亚甲二氧基或亚乙二氧基，R 4和R 5各自是氢或低级烷基，R6是氢或低级烷氧基。

64. 发明授权

US4021558A 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents 失效
标题翻译： 1,3-二氧代-2- {8-（甲氧基苯乙基 - 氨基） - 烷基{9-4,4-二甲基 - 异喹啉及其盐作为降压剂
公开(公告)号：US4021558A
公开(公告)日：1977-05-03
申请号：US651568
申请日：1976-01-22
申请人： Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
发明人： Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
IPC分类号： C07D217/24 , A61K31/47
CPC分类号： C07D217/24 , Y10S514/821
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, methoxy or methylthio, R.sub.2 is hydrogen or methoxy,n is 2 or 3,R.sub.3 is hydrogen or methyl, andR.sub.4 and R.sub.5, which may be identical to or different from each other, are each hydrogen or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, sedatives, antiarrhythmics and bradycardiacs.
摘要翻译：其中R 1是氢，卤素，甲氧基或甲硫基，R 2是氢或甲氧基，N IS 2 OR 3，R 3是氢或甲基，R 4和R 5可以相同或相同，彼此不同，分别为氢或甲氧基，以及无毒的，药学上可接受的酸加成盐; 化合物和盐可用作低血糖，镇静剂，抗心律失常药物和心动过缓。

65. 发明授权

US07870656B2 Method for connecting two or more metal sheets or profile parts, especially of an automobile body segment, and said automobile body segment description 有权
标题翻译：用于连接两个或更多个金属板或型材部件，特别是汽车车身部件的方法以及所述汽车车身段描述
公开(公告)号：US07870656B2
公开(公告)日：2011-01-18
申请号：US10946138
申请日：2004-09-21
申请人： Wolfgang Eberlein
发明人： Wolfgang Eberlein
IPC分类号： B23P11/00 , B23P17/00
CPC分类号： B23K11/11 , B21J15/025 , B23K11/002 , B23K11/0066 , B23K11/02 , B23K11/06 , B23K2101/006 , B62D27/02 , F16B5/04 , F16B19/086 , Y10T29/49943 , Y10T29/49954 , Y10T29/49968 , Y10T29/5377
摘要： Method for connecting two or more metal sheets or profile parts, especially of an automobile body segment as well as said automobile body segment.A method is described for joining two or more metal sheets and/or profileparts of which typically one is a high strength steel with the following steps. a) mechanically joining in a force-locking or frictional manner the metal sheets or profile parts at one or more connecting sites and subsequently b) thermally joining the connecting sites by means of pressure welding. With the method according to the invention in particular in the motor vehicle sector automobile body segments can be produced which display qualitatively very high quality point weld joints.
摘要翻译：用于连接两个或更多个金属板或轮廓部分，特别是汽车车身段以及所述汽车车身段的方法。描述了用于连接两个或更多个金属片和/或轮廓部分的方法，其中通常一个是高强度钢，具有以下步骤。 a）在一个或多个连接部位以金属片或轮廓部件的力锁定或摩擦方式机械接合，随后b）通过压力焊接热连接连接部位。利用根据本发明的方法，特别是在机动车辆部件中，可以生产出显示质量上非常高质量的点焊接头的汽车车身部分。

66. 发明申请

US20100117400A1 COMPOSITE MADE OF TWO STEEL PLATES 有权
标题翻译：两块钢板的复合材料
公开(公告)号：US20100117400A1
公开(公告)日：2010-05-13
申请号：US12518137
申请日：2007-12-07
申请人： Wolfgang Eberlein
发明人： Wolfgang Eberlein
IPC分类号： B62D25/00 , C21D8/00 , C22C38/00
CPC分类号： B62D25/04 , B23K2101/006 , B23K2101/185 , B62D29/007 , C21D9/50
摘要： A composite is provided that includes, but is not limited to a first steel plate, which is welded via a weld seam to a second steel plate, in which the two steel plates and the weld seam bonding them are hardened and the composite has a broadening in the area of the weld seam. Furthermore, a B-column is provided for a motor vehicle body that includes, but is not limited to a reinforcement B-column, the reinforcement B-column including, but not limited to a first steel plate, which is welded via a weld seam to a second steel plate, and the two steel plates include, but are not limited to a heat-treated steel and are hardened like the weld seam bonding them, and the reinforcement B-column has a broadening in the area of the weld seam.
摘要翻译：提供了一种复合材料，其包括但不限于通过焊缝焊接到第二钢板的第一钢板，其中两个钢板和焊接它们的焊缝被硬化，并且复合材料具有加宽在焊缝区域。此外，为包括但不限于钢筋B柱的机动车体提供B柱，所述加固体B柱包括但不限于通过焊缝焊接的第一钢板第二钢板，并且两个钢板包括但不限于热处理钢，并且像焊接它们的焊缝一样被硬化，并且加强件B柱在焊缝的面积上变宽。

67. 发明申请

US20060183693A1 Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine 审中-公开
标题翻译：使用BIBN4096联合其他抗偏头痛药物治疗偏头痛
公开(公告)号：US20060183693A1
公开(公告)日：2006-08-17
申请号：US11276603
申请日：2006-03-07
申请人： Henri Doods , Wolfgang Eberlein , Klaus Rudolf
发明人： Henri Doods , Wolfgang Eberlein , Klaus Rudolf
IPC分类号： A61K38/04 , A61K31/517
CPC分类号： A61K31/422 , A61K31/4045 , A61K31/48 , A61K31/517 , A61K2300/00
摘要： A method of treatment or prevention of headache, migraine or cluster headaches, which method comprises co-administration of a therapeutically effective amount of the compound 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096BS] or a physiologically acceptable salt thereof and a therapeutically effective amount of a second active antimigraine drug, particularly sumatriptan, zolmitriptan or dihydroergotamin or a physiologically acceptable salt thereof, as well as to the corresponding pharmaceutical compositions and the preparation thereof.
摘要翻译：一种治疗或预防头痛，偏头痛或丛集性头痛的方法，该方法包括共同给予治疗有效量的化合物1- [N 2 - [3,5-二溴-N- [[4-（3,4-二氢-2（1H） - 恶唑啉-3-基）-1-哌啶基] - 羰基] -D-酪氨酰基] -L-赖氨酰基] -4-（4-吡啶基） - 哌嗪 [BIBN4096BS]或其生理上可接受的盐和治疗有效量的第二活性抗偏头痛药物，特别是舒马曲坦，佐米曲坦或二氢麦角胺或其生理学上可接受的盐，以及相应的药物组合物及其制备。

68. 发明授权

US5026699A Use of 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-ones substituted in the 11-position for treating bradycardia and bradyarrhythmia in human and veterinary medicine 失效
标题翻译：在11位取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4]苯并二氮杂-6-酮在人和兽医学中用于治疗心动过缓和缓慢性心律失常
公开(公告)号：US5026699A
公开(公告)日：1991-06-25
申请号：US367397
申请日：1989-06-15
申请人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
发明人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
IPC分类号： C07D471/04 , A61K31/55 , A61P1/00 , A61P9/04 , A61P9/06 , A61P11/00 , A61P13/02 , A61P15/00
CPC分类号： A61K31/55
摘要： 5,11-Dihydro-6H-pyrido[2,3-b][1,4]-benzo-diazepinones substituted in the 11-position corresponding to general formula I ##STR1## wherein R.sup.1 and R.sup.2 represent hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, A.sup.1 is a straight-chained or branched alkylene group with 1 to 5 carbon atoms, A.sup.2 is a methylene group or, if R.sup.1 is hydrogen and R.sup.2 is methyl, A.sup.2 may also be an ethylene group, and the physiologically acceptable acid addition salts thereof are suitable for treating bradycardia and bradyarrhythmia and spasm in the colon, bladder and bronchi.
摘要翻译：在对应于通式I（I）的11位上取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4] - 苯并二氮杂其中R 1和R 2表示氢原子或具有1至3个碳原子的烷基，A1是具有1至5个碳原子的直链或支链亚烷基，A2是亚甲基，或者如果R1是氢，R2是甲基，A2也可以是亚乙基，其生理上可接受的酸加成盐适用于治疗结肠，膀胱和支气管中的心动过缓和缓慢性心律失常和痉挛。

69. 发明授权

US4454128A 6.alpha.-Methoxy-penicillins 失效
标题翻译： 6α-甲氧基青霉素
公开(公告)号：US4454128A
公开(公告)日：1984-06-12
申请号：US410007
申请日：1982-08-20
申请人： Bernd Wetzel , Wolfgang Eberlein , Gunter Trummlitz , Eberhard Woitun , Roland Maier , Wolfang Reuter , Uwe Lechner , Hanns Goeth
发明人： Bernd Wetzel , Wolfgang Eberlein , Gunter Trummlitz , Eberhard Woitun , Roland Maier , Wolfang Reuter , Uwe Lechner , Hanns Goeth
IPC分类号： C07D499/68 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/00 , C07D499/21 , C07D499/64 , A61K31/635 , A61K31/505 , C07D499/54
CPC分类号： C07D499/00
摘要： Compounds of the formula ##STR1## wherein A is phenyl, p=hydroxy-phenyl, 2-thienyl or 3-thienyl; andR represents substituents of various types;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antibiotics.
摘要翻译：其中A是苯基，p =羟基 - 苯基，2-噻吩基或3-噻吩基的式IMA化合物; R代表各种类型的取代基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作抗生素。

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