专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US4755510A Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and use 失效
标题翻译：新型抗惊厥四氢-1,2,4-恶二嗪-5-衍生物和用途
公开(公告)号：US4755510A
公开(公告)日：1988-07-05
申请号：US786203
申请日：1985-10-10
申请人： Csilla Vezert nee Solyom , Laszlo rogdi , Lajos Kisfaludy , Laszlo Otvos , Zsuzsanna Tegyey , Helga Tudos nee Feuer , Eva Palosi , Sara Ronai nee Lukacs , Eszter Cholnoky , Laszlo Szporny
发明人： Csilla Vezert nee Solyom , Laszlo rogdi , Lajos Kisfaludy , Laszlo Otvos , Zsuzsanna Tegyey , Helga Tudos nee Feuer , Eva Palosi , Sara Ronai nee Lukacs , Eszter Cholnoky , Laszlo Szporny
IPC分类号： A61K31/535 , C07D273/04
CPC分类号： C07D273/04
摘要： The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings.The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.
摘要翻译：本发明涉及式（I）的新型光学活性或外消旋四氢-1,2,4-恶二嗪-5-硫酮衍生物（I）制备方法，包含所述化合物作为活性成分的药物组合物和方法用于哺乳动物，特别是人类的抗惊厥治疗。式I的化合物与二苯基乙内酰脲具有良好的活性，但其毒性低得多。

62. 发明授权

US4598080A Certain-2-methyl-6-{4-[1-phenyl-1-hydroxypropyl]-phenoxymethyl}pyridines which inhibit microsonal monoxygenase systems in liver 失效
标题翻译：在肝脏中抑制微血管单加氧酶系统的某些2-甲基-6- {4- [1-苯基-1-羟丙基] - 苯氧基甲基}吡啶
公开(公告)号：US4598080A
公开(公告)日：1986-07-01
申请号：US565831
申请日：1983-12-27
申请人： Edit Toth , Jozsef Torley , Eva Palosi , Szabolcs Szebereneyi , Laszlo Szporny , Sandor Gorog , Istvan Hajdu
发明人： Edit Toth , Jozsef Torley , Eva Palosi , Szabolcs Szebereneyi , Laszlo Szporny , Sandor Gorog , Istvan Hajdu
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P1/16 , A61P39/02 , A61P43/00 , C07D213/30
CPC分类号： C07D213/30
摘要： The invention relates to new pyridine derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,and acid addition and quaternary ammonium salts thereof.According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
摘要翻译：本发明涉及式（I）的新的吡啶衍生物：其中R 1和R 2独立地表示氢，卤素，三卤代甲基，具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基，以及酸加成物和季铵盐。根据本发明的另一方面，提供了这些化合物的制备方法。式（I）的化合物具有药理活性。特别地，它们抑制肝脏的微粒体单致原子酶系统。含有它们作为活性成分的药物组合物也在本发明的范围内。

63. 发明授权

US4508926A 4-Hydroxy-benzhydrols, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 4-羟基 - 二苯甲醛，其制备方法和含有它们的药物组合物
公开(公告)号：US4508926A
公开(公告)日：1985-04-02
申请号：US565840
申请日：1983-12-27
申请人： Edit Toth , Jozsef Torley , Gyorgy Fekete , Laszlo Szporny , Laszlo Vereczkey , Eva Palosi , Imre Klebovich , Pal Vittay , Sandor Gorog , Istvan Hajdu
发明人： Edit Toth , Jozsef Torley , Gyorgy Fekete , Laszlo Szporny , Laszlo Vereczkey , Eva Palosi , Imre Klebovich , Pal Vittay , Sandor Gorog , Istvan Hajdu
IPC分类号： C07C43/23 , A61K31/047 , A61K31/05 , A61K31/075 , A61P25/30 , C07C27/00 , C07C29/143 , C07C29/149 , C07C37/055 , C07C37/20 , C07C39/12 , C07C39/367 , C07C41/00 , C07C41/30 , C07C67/00 , C07C39/11
CPC分类号： C07C43/23 , C07C37/055 , C07C37/20 , C07C39/367
摘要： The invention relates to new 4-hydroxy-benzhydrols of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, with the proviso that if R.sub.1 is hydrogen, R.sub.2 is other than hydrogen or a 3-trifluoromethyl group, or if R.sub.1 is a 2-methyl group, R.sub.2 is other than a 5-methyl group.According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredients are also within the scope of the invention.
摘要翻译：本发明涉及式（I）的新的4-羟基 - 二苯甲醇：其中R 1和R 2独立地表示氢，卤素，三卤代甲基，具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基原子，条件是如果R1是氢，R2不是氢或3-三氟甲基，或者如果R1是2-甲基，则R2不是5-甲基。根据本发明的另一方面，提供了这些化合物的制备方法。式（I）的化合物具有药理活性。特别地，它们适用于治疗急性乙醇中毒。含有它们作为活性成分的药物组合物也在本发明的范围内。

64. 发明授权

US4406835A Tranquillo-sedative benzodiazepine derivatives 失效
标题翻译：镇静镇静苯并二氮杂衍生物
公开(公告)号：US4406835A
公开(公告)日：1983-09-27
申请号：US310420
申请日：1981-10-09
申请人： Julia Rohricht , Lajos Kisfaludy , Laszlo rogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
发明人： Julia Rohricht , Lajos Kisfaludy , Laszlo rogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/08 , A61P25/20 , C07D243/16 , C07D243/18 , C07D243/24 , C07D243/26
CPC分类号： C07D243/24 , C07D243/26
摘要： A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,R.sub.2 is hydrogen or methyl,R.sub.3 is --CONH.sub.2 or --CONHCH.sub.3, andR.sub.6 is phenyl or halophenyl.
摘要翻译：式（I）的镇静取代的1,3,4,5-四氢-2H- 1,4-benzodiazepine-2，其中R 1是卤素或硝基，R 2是氢或甲基，R 3 是-CONH 2或-CONHCH 3，R 6是苯基或卤代苯基。

65. 发明授权

US4342755A Tranquillo-sedative benzodiazepine derivatives 失效
标题翻译：镇静镇静苯并二氮杂衍生物
公开(公告)号：US4342755A
公开(公告)日：1982-08-03
申请号：US185512
申请日：1980-09-09
申请人： Julia Rohricht , Lajos Kisfaludy , Laszlo rogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
发明人： Julia Rohricht , Lajos Kisfaludy , Laszlo rogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/08 , A61P25/20 , C07D243/16 , C07D243/18 , C07D243/24 , C07D243/26
CPC分类号： C07D243/24 , C07D243/26
摘要： A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl,R.sub.3 is --CONH.sub.2, andR.sub.6 is phenyl or halophenyl.
摘要翻译：式（I）的镇静取代的1,3,4,5-四氢-2H- 1,4-benzodiazepine-2，其中R 1是卤素或硝基，R 2是氢或C 1至C 6 烷基，R 3是-CONH 2，R 6是苯基或卤代苯基。

66. 发明授权

US4094908A Alpha-substituted benzhydrol derivatives 失效
标题翻译： α-取代的二苯甲醇衍生物
公开(公告)号：US4094908A
公开(公告)日：1978-06-13
申请号：US722063
申请日：1976-09-09
申请人： Edit Toth , Jozsef Torley , Szabolcs Szeberenyi , Eva Palosi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
发明人： Edit Toth , Jozsef Torley , Szabolcs Szeberenyi , Eva Palosi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
IPC分类号： C07C33/34 , C07C39/21 , C07C65/01 , C07D295/135 , C07C93/08
CPC分类号： C07D295/135 , C07C255/00 , C07C33/34 , C07C39/21 , C07C65/01
摘要： The invention relates to new .alpha.-substituted benzhydrols and pharmaceutically acceptable acid addition salts or quaternary ammonium salts thereof with enzyme promoting or inhibiting effects;
摘要翻译：本发明涉及新的α-取代二苯甲醇及其药学上可接受的酸加成盐或季铵盐，具有促进或抑制酶的作用;

67. 发明授权

US4045433A 1,3,4,5-Tetrahydro-2H-1,4-benzodiazepin-2-ones 失效
标题翻译： 1,3,4,5-四氢-2H-1,4-苯并二氮杂-2-酮
公开(公告)号：US4045433A
公开(公告)日：1977-08-30
申请号：US580307
申请日：1975-05-23
申请人： Julia Rohricht , Lajos Kisfaludy , Laszlo Urogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
发明人： Julia Rohricht , Lajos Kisfaludy , Laszlo Urogdi , Eva Palosi , Szabolcs Szeberenyi , Laszlo Szporny
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/08 , A61P25/20 , C07D243/16 , C07D243/18 , C07D243/24 , C07D243/26
CPC分类号： C07D243/24 , C07D243/26
摘要： An N-substituted carbonyl tetrahydrobenzodiazepines having ethoxycarbonyl, formyl, carbamoyl or methyl carbamoyl as the N.sup.4 substituent.
摘要翻译：具有乙氧基羰基，甲酰基，氨基甲酰基或甲基氨基甲酰基作为N 4取代基的N-取代羰基四氢苯并二氮杂卓。

68. 发明授权

US4021421A Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物
公开(公告)号：US4021421A
公开(公告)日：1977-05-03
申请号：US589079
申请日：1975-06-23
申请人： Lajos Kisfaludy , Julianna Rohricht , Laszlo Urogdi , Szabolcs Szeberenyi , Eva Palosi , Laszlo Szporny
发明人： Lajos Kisfaludy , Julianna Rohricht , Laszlo Urogdi , Szabolcs Szeberenyi , Eva Palosi , Laszlo Szporny
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5513 , A61P3/00 , A61P25/20 , A61P39/02 , C07D243/16 , C07D243/18 , C07D243/24 , C07D243/26
CPC分类号： C07D243/24 , C07D243/26
摘要： New benzodiazepine derivatives of the formula (I), ##STR1## wherein R.sub.1 stands for halogen, trifluoromethyl, nitro or amino,R.sub.2 stands for hydrogen or alkyl, andR.sub.3 stands for nitroso, amino, alkylideneamino, substituted alkylideneamino, aralkylideneamino, substituted aralkylideneamino, acylamido or substituted acylamido.The new compounds possess remarkable enzyme-inducing effects and exert only moderate central nervous activities.
摘要翻译：式（I）的新的苯并二氮杂衍生物，其中R1代表卤素，三氟甲基，硝基或氨基，R2代表氢或烷基，R3代表亚硝基，氨基，亚烷基氨基，取代的亚烷基氨基，亚烷基氨基，取代的芳烷基氨基，酰氨基或取代的酰基酰氨基。

69. 发明授权

US4017507A 2,3-Dihydro-7-chlorothiazolo[3,2-a]benzimidazole and salt 失效
标题翻译： 2,3-二氢-7-氯噻唑并[8 3,2-a {9苯并咪唑和盐
公开(公告)号：US4017507A
公开(公告)日：1977-04-12
申请号：US637978
申请日：1975-12-05
申请人： Kalman Hideg , Olga Hankovszky , Eva Palosi , Gyorgy Hajos , Laszlo Szporny
发明人： Kalman Hideg , Olga Hankovszky , Eva Palosi , Gyorgy Hajos , Laszlo Szporny
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen. The reaction is carried out optionally in the presence of a base. The compounds of the general formula (I) can be converted into their acid addition salts.The compounds of the general formula (I) as well as their acid addition salts exert antipyretic and antiphlogistic activities, inhibit the reproduction of viruses, and exert a protecting effect against albumine shock.
摘要翻译：通式（I）的新型三环稠合咪唑衍生物，其中R1代表氢或羟基，N等于零或一，M等于零，一或二，A代表一个基团的通式（II），其中R 2表示氢或羟基，R 3表示氢或氨基，或Q和Z各自代表氮或a = C-基团，或A表示一个通式（III），其中R 4和R 5各自代表氢，甲基，氯或硝基，通过反应通用化合物（IV）化合物（IV）制备其中A和n各自具有与上述定义相同的含有通式（Ⅴ）的化合物，其中X代表卤素，R6代表氢，R7代表通式（Ⅵ）的基团，（CH2）mX VI。

70. 发明授权

US3989701A Diamine-benzophenones and a process for the preparation thereof 失效
标题翻译：二胺 - 二苯甲酮及其制备方法
公开(公告)号：US3989701A
公开(公告)日：1976-11-02
申请号：US485744
申请日：1974-07-03
申请人： Edit Toth , Jozsef Torley , Eva Palosi , Szaboles Szeberenyi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
发明人： Edit Toth , Jozsef Torley , Eva Palosi , Szaboles Szeberenyi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
IPC分类号： C07D295/10 , A61K31/135 , A61K31/165 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P25/24 , A61P25/26 , C07C67/00 , C07C213/00 , C07C225/22 , C07C231/00 , C07C231/02 , C07C233/43 , C07D207/06 , C07D233/56 , C07D233/61 , C07D295/135 , C07D295/00
CPC分类号： C07D295/135 , Y10S514/916
摘要： New compounds of the general formula (I) ##SPC1##whereinR.sub.1 and R.sub.2 each is a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form substituted or unsubstituted heterocyclic group with or without a further oxygen or nitrogen heteroatom, andR.sub.3 is hydrogen or an acyl group derived from a C.sub.1.sub.-18 carboxylic acid.The compounds are prepared by reducing the corresponding nitro compounds of the general formula (II) ##SPC2##and optionally acylating the obtained product.The compounds of the general formula (I) and their acid addition salts and quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess valuable antipyretic activity and a yohimbine lethality increasing effect characteristic of antidepressants.
摘要翻译：通式（I）的新化合物，其中R 1和R 2各自为饱和或不饱和的直链或支链烷基，芳烷基，饱和或不饱和环烷基或芳基，或者R1和R2与相邻的氮原子可以形成具有或不具有另外的氧或氮杂原子的取代或未取代的杂环基，并且R 3是氢或衍生自C 1-18羧酸的酰基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式