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61. 发明授权

US08343325B2 Electrodialysis apparatus and electrodialysis method using the same 有权
标题翻译：电渗析装置及使用其的电渗析方法
公开(公告)号：US08343325B2
公开(公告)日：2013-01-01
申请号：US11737448
申请日：2007-04-19
申请人： Hun-joo Lee , Soo-suk Lee , Joon-ho Kim , Sung-ouk Jung , In-ho Lee
发明人： Hun-joo Lee , Soo-suk Lee , Joon-ho Kim , Sung-ouk Jung , In-ho Lee
IPC分类号： B01D61/44
CPC分类号： B01D61/422 , B01D2311/243 , B01D2313/02 , B01D2313/10 , B01D2313/26 , B01D2313/30 , B01D2313/50 , B01D2321/185
摘要： An electrodialysis apparatus includes a sample chamber including first and second dialysis membranes and filled with a sample between the first dialysis membrane and the second dialysis membrane, an anode chamber including an anode and filled with a first chamber solution between the anode and the first dialysis membrane, and a cathode chamber including a cathode and filled with a second chamber solution between the cathode and the second dialysis membrane. In particular, when a voltage is applied to the anode and the cathode, ionic materials of the sample move to the anode and cathode chambers.
摘要翻译：电渗透装置包括：样品室，包括第一和第二透析膜，并在第一透析膜和第二透析膜之间填充样品;阳极室，包括阳极，并在阳极和第一透析膜之间填充第一室溶液以及包括阴极并在阴极和第二透析膜之间填充有第二室溶液的阴极室。特别地，当向阳极和阴极施加电压时，样品的离子材料移动到阳极室和阴极室。

62. 发明申请

US20120329891A1 ION EXCHANGEABLE MIXTURE AND METHOD OF PRODUCING THE SAME 有权
标题翻译：离子交换混合物及其制造方法
公开(公告)号：US20120329891A1
公开(公告)日：2012-12-27
申请号：US13605503
申请日：2012-09-06
申请人： Hun-joo LEE , Ji-na Namgoong , Soo-suk Lee , Joon-ho Kim
发明人： Hun-joo LEE , Ji-na Namgoong , Soo-suk Lee , Joon-ho Kim
IPC分类号： B01J39/18
CPC分类号： C08J5/2218 , B01J39/20 , B01J41/14 , B01J47/016 , B01J47/12 , B01L3/5027 , C08J5/20
摘要： An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.
摘要翻译：含有由离子交换树脂，含有至少一种双丙烯酰胺和至少一种丙烯酰胺的丙烯酰胺混合物组成的聚合物的离子交换性混合物和通过使聚合物与丙烯酰胺混合物反应得到的共聚物及其制造方法被提供。通过使用离子交换性混合物制造的离子交换膜的电阻比常规的离子交换膜的电阻小得多，并且由于可离子交换膜带电而具有优异的选择性渗透性。离子交换膜可以在非常温和的生产条件下生产，因此可以非常容易地生产。此外，在水的溶剂中的交联反应期间，也可以将离子交换膜形成为膜，因此有利的是可离子交换膜可以自由地制成所需的尺寸，形状和形状。

63. 发明授权

US08263671B2 Ion exchangeable mixture and method of producing the same 有权
标题翻译：可离子交换混合物及其制备方法
公开(公告)号：US08263671B2
公开(公告)日：2012-09-11
申请号：US13086741
申请日：2011-04-14
申请人： Hun-joo Lee , Ji-na Namgoong , Soo-suk Lee , Joon-ho Kim
发明人： Hun-joo Lee , Ji-na Namgoong , Soo-suk Lee , Joon-ho Kim
IPC分类号： B01J49/00 , C08J5/20 , C01B31/16
CPC分类号： C08J5/2218 , B01J39/20 , B01J41/14 , B01J47/016 , B01J47/12 , B01L3/5027 , C08J5/20
摘要： An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.
摘要翻译：含有由离子交换树脂，含有至少一种双丙烯酰胺和至少一种丙烯酰胺的丙烯酰胺混合物组成的聚合物的离子交换性混合物和通过使聚合物与丙烯酰胺混合物反应得到的共聚物及其制造方法被提供。通过使用离子交换性混合物制造的离子交换膜的电阻比常规的离子交换膜的电阻小得多，并且由于可离子交换膜带电而具有优异的选择性渗透性。离子交换膜可以在非常温和的生产条件下生产，因此可以非常容易地生产。此外，在水的溶剂中的交联反应期间，也可以将离子交换膜形成为膜，因此有利的是可离子交换膜可以自由地制成所需的尺寸，形状和形状。

64. 发明授权

US07955842B2 Microfluidic device and method for concentrating sample containing cells or viruses and lysing cells or viruses, and method of producing the microfluidic device 有权
标题翻译：用于浓缩含有细胞或病毒的样品和裂解细胞或病毒的微流体装置和方法以及产生微流体装置的方法
公开(公告)号：US07955842B2
公开(公告)日：2011-06-07
申请号：US11670002
申请日：2007-02-01
申请人： Hun-joo Lee , Joon-ho Kim , Sung-young Jeong , Kyu-youn Hwang
发明人： Hun-joo Lee , Joon-ho Kim , Sung-young Jeong , Kyu-youn Hwang
IPC分类号： C12M1/42 , C12M1/33
CPC分类号： C12M47/02 , C12M47/06
摘要： A microfluidic device for concentrating a sample including cells or viruses and lysing the cells or viruses, the device including an anode chamber including an anode electrode, a cathode chamber including a cathode electrode and an ion exchange membrane separating the anode chamber and the cathode chamber. The cathode chamber includes a solid support therein. A method of producing the microfluidic device and a method of concentrating a sample including cells or viruses and lysing the cells or viruses therein using the microfluidic device.
摘要翻译：一种用于浓缩包含细胞或病毒的样品并裂解细胞或病毒的微流体装置，所述装置包括包括阳极电极的阳极室，包括阴极的阴极室和分离阳极室和阴极室的离子交换膜。阴极室包括固体支撑体。微流体装置的制造方法以及浓缩包含细胞或病毒的样品并使用微流体装置使细胞或病毒裂解的方法。

65. 发明授权

US07938945B2 Microfluidic device for electrochemically regulating pH of fluid and method of regulating pH of fluid using the microfluidic device 有权
标题翻译：用于电化学调节流体pH的微流体装置和使用微流体装置调节流体pH的方法
公开(公告)号：US07938945B2
公开(公告)日：2011-05-10
申请号：US11559196
申请日：2006-11-13
申请人： Hun-joo Lee , Joon-ho Kim , Kyu-youn Hwang
发明人： Hun-joo Lee , Joon-ho Kim , Kyu-youn Hwang
IPC分类号： C25B9/00
CPC分类号： G05D21/02
摘要： A microfluidic device includes; an ion exchange membrane, an anode chamber one side of which contacts a surface of the ion exchange membrane, wherein the anode chamber further includes a ladder-shaped anode and an anode support part, and a cathode chamber, one side of which contacts a surface of the ion exchange membrane opposite the anode chamber, wherein the cathode chamber further comprises a cathode, wherein the ladder-shaped anode is formed on a first surface of the anode support part, openings are formed in the anode support part which conform to the shape of the ladder-shaped anode, and a second surface of the anode support part which opposes the first surface of the anode contacts and supports the ion exchange membrane.
摘要翻译：微流体装置包括：离子交换膜，阳极室，其一面接触离子交换膜的表面，其中阳极室还包括梯形阳极和阳极支撑部分，阴极室的一侧接触表面所述阴极室还包括阴极，其中所述梯形阳极形成在所述阳极支撑部分的第一表面上，所述阳极支撑部分形成符合所述形状的阳极支撑部分的形状，并且与阳极的第一表面相对的阳极支撑部分的第二表面接触并支撑离子交换膜。

66. 发明授权

US07923551B2 Method of purifying RNA using kosmotropic salt 有权
标题翻译：使用去离子水纯化RNA的方法
公开(公告)号：US07923551B2
公开(公告)日：2011-04-12
申请号：US12110391
申请日：2008-04-28
申请人： Myo-yong Lee , Nam Huh , Joon-ho Kim
发明人： Myo-yong Lee , Nam Huh , Joon-ho Kim
IPC分类号： C07H21/00
CPC分类号： C07H21/02 , C12N15/1003 , C12N15/1006
摘要： The present invention provides a method of purifying RNA, including contacting a solid support with an acidic solution having a RNA-containing sample and a kosmotropic salt having a concentration of less than 1M, thereby binding the RNA to the solid support. According to the present invention, RNA is purified efficiently due to high RNA yield and low contamination by DNA. The present invention is particularly effective in purifying RNAs of 200 nucleotides or less.
摘要翻译：本发明提供了一种纯化RNA的方法，包括使固体支持物与具有含RNA样品的酸性溶液和浓度小于1M的感应性盐接触，从而将RNA与固体支持物结合。根据本发明，由于高RNA产量和低DNA污染，RNA被有效地纯化。本发明在纯化200个或更少核苷酸的RNA中特别有效。

67. 发明授权

US07803539B2 Method of isolating and purifying nucleic acids using immobilized hydrogel or PEG-hydrogel copolymer 失效
标题翻译：使用固定化水凝胶或PEG-水凝胶共聚物分离和纯化核酸的方法
公开(公告)号：US07803539B2
公开(公告)日：2010-09-28
申请号：US11297783
申请日：2005-12-07
申请人： Chang-eun Yoo , Joon-ho Kim , Kyu-youn Hwang , Hun-joo Lee , Hee-kyun Lim , Jun-hong Min
发明人： Chang-eun Yoo , Joon-ho Kim , Kyu-youn Hwang , Hun-joo Lee , Hee-kyun Lim , Jun-hong Min
IPC分类号： C12Q1/68 , C12M1/34 , C07H21/00
CPC分类号： C07H21/04
摘要： Provided is a method of isolating and purifying nucleic acids using an immobilized hydrogel or polyethylene glycol (PEG)-hydrogel copolymer. The method includes: immobilizing a functional group-containing hydrogel or PEG-hydrogel copolymer on a substrate; adding a mixed sample solution containing a salt and nucleic acids to the hydrogel- or PEG-hydrogel copolymer-immobilized substrate to bind the nucleic acids to the hydrogel or the PEG-hydrogel copolymer; washing the nucleic acid-bound hydrogel or PEG-hydrogel copolymer; and eluting the nucleic acids from the hydrogel or the PEG-hydrogel copolymer using an elution solvent. Therefore, binding and elution of nucleic acids can be performed even with no addition of a separate chemical substance, and an effect on a subsequent process such as PCR can be minimized. Furthermore, the amount and intensity for binding nucleic acids can be adjusted according to PEG concentration, and the presence of a hydrogel compound on a substrate enables patterning.
摘要翻译：提供了使用固定的水凝胶或聚乙二醇（PEG） - 水凝胶共聚物来分离和纯化核酸的方法。该方法包括：将含官能团的水凝胶或PEG-水凝胶共聚物固定在基材上; 将含有盐和核酸的混合样品溶液加入到水凝胶或PEG-水凝胶共聚物固定的底物中，以将核酸与水凝胶或PEG-水凝胶共聚物结合; 洗涤核酸结合的水凝胶或PEG-水凝胶共聚物; 并使用洗脱溶剂从水凝胶或PEG-水凝胶共聚物中洗脱核酸。因此，即使没有添加单独的化学物质也可以进行核酸的结合和洗脱，并且可以最小化对后续过程（例如PCR）的影响。此外，可以根据PEG浓度调节结合核酸的量和强度，并且在基材上存在水凝胶化合物能够进行图案化。

68. 发明申请

US20070068813A1 Microfluidic device for electrically regulating the pH of a fluid therein and method of regulating the pH of a fluid in a microfluidic device using the same 有权
标题翻译：用于电调节其中流体pH值的微流体装置及使用其调节微流体装置中的流体pH值的方法
公开(公告)号：US20070068813A1
公开(公告)日：2007-03-29
申请号：US11472182
申请日：2006-06-21
申请人： Jung-im Han , Joon-ho Kim
发明人： Jung-im Han , Joon-ho Kim
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G05D21/02
摘要： Provided is a microfluidic device for electrically regulating the pH of a fluid comprising: a first chamber comprising a first electrode; a second chamber comprising a second electrode; a third chamber comprising a third electrode, a metal ion exchange membrane between the first and second chambers; and a hydrogen ion exchange membrane between the first or second chamber and the third chamber.
摘要翻译：提供一种用于电流调节流体pH的微流体装置，包括：第一室，包括第一电极; 第二室，包括第二电极; 第三室，包括第三电极，在第一和第二室之间的金属离子交换膜; 以及在第一或第二室与第三室之间的氢离子交换膜。

69. 发明申请

US20060266650A1 Apparatus for regulating salt concentration using electrodialysis, lab-on-a-chip including the same, and method of regulating salt concentration using the apparatus 有权
标题翻译：使用电渗析法调节盐浓度的装置，包括该盐浓度的实验室的方法以及使用该装置调节盐浓度的方法
公开(公告)号：US20060266650A1
公开(公告)日：2006-11-30
申请号：US11440872
申请日：2006-05-25
申请人： Jung-im Han , Young-sun Lee , Joon-ho Kim
发明人： Jung-im Han , Young-sun Lee , Joon-ho Kim
IPC分类号： B01D61/42
CPC分类号： B01D61/422 , B01D61/46 , B01L3/5027 , G01N2001/4011
摘要： An apparatus for regulating salt concentration, a lab-on-a-chip including the same and a method of regulating salt concentration using the apparatus are provided. The apparatus includes: a reaction chamber that is defined by a cation exchange membrane and an anion exchange membrane and is selected from the group consisting of a biomolecule extraction chamber, an amplification chamber, a hybridization chamber, and a detection chamber; a first electrode chamber that is defined by the anion exchange membrane and a first electrode and includes an ion exchange medium; and a second electrode chamber that is defined by the cation exchange membrane and a second electrode and includes an ion exchange medium. Even without injecting solutions with different salt concentrations into the reaction chamber by operating pumps and valves for each operation stage, the salt concentration can be reversibly regulated in situ by adjusting the polarity, intensity and application time of a voltage.
摘要翻译：提供了一种调节盐浓度的装置，包括该盐浓度的实验室，以及使用该装置调节盐浓度的方法。该装置包括：由阳离子交换膜和阴离子交换膜限定的反应室，其选自生物分子提取室，扩增室，杂交室和检测室; 由阴离子交换膜和第一电极限定并包括离子交换介质的第一电极室; 以及由阳离子交换膜和第二电极限定并包括离子交换介质的第二电极室。即使在每个操作阶段通过操作泵和阀都不会将具有不同盐浓度的溶液注入反应室中，可以通过调节电压的极性，强度和施加时间来原位调节盐浓度。

70. 发明申请

US20060188906A1 Microfluidic chip for multiple bioassay and method of manufacturing the same 有权
标题翻译：微流控芯片用于多种生物测定及其制造方法
公开(公告)号：US20060188906A1
公开(公告)日：2006-08-24
申请号：US11335939
申请日：2006-01-20
申请人： Joon-ho Kim , Jun-hong Min , Kyung-hwan Park , Soo-suk Lee , Hyun-gyu Park
发明人： Joon-ho Kim , Jun-hong Min , Kyung-hwan Park , Soo-suk Lee , Hyun-gyu Park
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502707 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00632 , B01J2219/00644 , B01J2219/00657 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01L3/5025 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B82Y30/00
摘要： Provided are a microfluidic chip for multiple bioassay and a method of manufacturing the same. The method includes: forming microfluidic channels by coupling a channel structure having grooves for sample channels and probe channels in a bottom surface and a substrate; forming probe immobilization regions at intersections between the probe channels and the sample channels; and forming blocking walls in the probe channels before and after each of the probe immobilization regions to prevent mixing of target sample. Since the probes are immobilized in the microfluidic channels after the formation of the microfluidic channels, difficulty in connecting fluidic channels after the immobilization of probes on a substrate can be removed. In addition, a microfluidic platform for a multiple bioassay into which a plurality of samples can be simultaneously loaded can be formed.
摘要翻译：提供了用于多重生物测定的微流控芯片及其制造方法。该方法包括：通过在底表面和基底中耦合具有用于样品通道和探针通道的沟槽的通道结构来形成微流体通道; 在探针通道和样品通道之间的交叉处形成探针固定区域; 并且在每个探针固定区域之前和之后在探针通道中形成阻挡壁以防止靶样品混合。由于在形成微流体通道之后将探针固定在微流体通道中，因此可以除去在探针固定在基底上之后连接流体通道的困难。此外，可以形成用于多个生物测定的微流体平台，多个样品可以同时装载到该微生物测定中。

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