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61. 发明授权

US08880041B2 Method and system for exchanging calling and called roles of communication terminals 有权
标题翻译：交换呼叫和通话终端角色的方法和系统
公开(公告)号：US08880041B2
公开(公告)日：2014-11-04
申请号：US13576441
申请日：2010-06-18
申请人： Jun Xie
发明人： Jun Xie
IPC分类号： H04M3/42
CPC分类号： H04M3/42195 , H04M15/08 , H04M15/09 , H04M15/10 , H04M15/8083
摘要： A method for exchanging calling and called roles of communication terminals is disclosed. The method includes: a virtual calling party initiating a service request, and sending service request information to a virtual called party; the virtual called party matching a characteristic field carried in received service request information with data in a self preset calling-called role exchange rule base, and if the characteristic field and data can be matched, initiating a corresponding callback service to the virtual calling party according to contents of matched items; and the virtual calling party receiving the corresponding callback service initiated by the virtual called party. A system for exchanging the calling and called roles of communication terminals is also disclosed. By the method and system of the invention, the exchange of calling and called roles between communication terminals of two parties can be implemented automatically, which improves user experience on communication terminal products.
摘要翻译：公开了一种用于交换通信终端的呼叫和被叫角色的方法。该方法包括：发起业务请求的虚拟主叫方，向虚拟被叫方发送业务请求信息; 虚拟被叫方将接收到的服务请求信息中携带的特征字段与自己预设的呼叫角色交换规则库中的数据进行匹配，如果特征字段和数据可以匹配，则根据虚拟主叫方发起相应的回呼业务匹配项目内容; 虚拟主叫方接收虚拟被叫方发起的对应回叫业务。还公开了用于交换通信终端的呼叫和被叫角色的系统。通过本发明的方法和系统，可以自动实现双方通信终端之间的呼叫和被叫角色的交换，从而提高通信终端产品的用户体验。

62. 发明申请

US20130281516A1 MULTICISTRONIC EXPRESSION CONSTRUCTS 有权
标题翻译：多媒体表达式结构
公开(公告)号：US20130281516A1
公开(公告)日：2013-10-24
申请号：US13642747
申请日：2011-04-22
申请人： Guangping Gao , Jun Xie
发明人： Guangping Gao , Jun Xie
IPC分类号： C12N15/113
CPC分类号： C12N15/86 , C12N7/00 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2750/14143 , C12N2750/14152 , C12N2830/205 , C12N2830/42
摘要： Some aspect of this invention provide nucleic acid constructs for transgene expression. Some aspects of this invention provide multicistronic nucleic acid constructs, for example, comprising an expression cassette encoding a hairpin RNA and a reporter expression cassette. Some aspects of this invention provide nucleic acid constructs comprising two or more self-complementary nucleic acid sequences, for example, hairpin RNA encoding nucleic acid sequences and AAV inverse terminal repeats. Methods for the use of the constructs in therapy and research are also provided.
摘要翻译：本发明的一些方面提供用于转基因表达的核酸构建体。本发明的一些方面提供了多顺反子核酸构建体，例如包含编码发夹RNA的表达盒和报告基因表达盒。本发明的一些方面提供了包含两个或多个自身互补核酸序列的核酸构建体，例如编码核酸序列的发夹RNA和AAV逆末端重复序列。还提供了在治疗和研究中使用构建体的方法。

63. 发明授权

US08323488B2 IC-processed polymer nano-liquid chromatoraphy system on-a-chip and method of making it 有权
标题翻译： IC加工聚合物纳米液体色谱体系及其制备方法
公开(公告)号：US08323488B2
公开(公告)日：2012-12-04
申请号：US13037192
申请日：2011-02-28
申请人： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
发明人： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
IPC分类号： B01D15/08 , B01D15/10 , B01D15/00
CPC分类号： H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
摘要翻译：根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。集成在色谱柱出口处的电化学/电导率传感器测量分离信号。自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

64. 发明申请

US20120214156A1 DEVICE INCLUDING A DISSOLVABLE STRUCTURE FOR FLOW CONTROL 审中-公开
标题翻译：包括用于流量控制的不溶性结构的装置
公开(公告)号：US20120214156A1
公开(公告)日：2012-08-23
申请号：US13403355
申请日：2012-02-23
申请人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
IPC分类号： C12Q1/68 , B01L3/02 , G01N1/38
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

65. 发明申请

US20120137379A1 NOVEL AAV'S AND USES THEREOF 有权
标题翻译：新款AAV及其用途
公开(公告)号：US20120137379A1
公开(公告)日：2012-05-31
申请号：US13322164
申请日：2010-04-23
申请人： Guangping Gao , Terence Flotte , Jun Xie
发明人： Guangping Gao , Terence Flotte , Jun Xie
IPC分类号： A01K67/027 , C07K14/075 , A61K38/16 , A61K48/00 , C07K2/00 , A61P11/00 , C12N5/10 , A61P21/00 , A61P9/00 , A61P1/16 , A61P1/18 , A61P25/00 , C07H21/00 , C12N7/01
CPC分类号： C07K14/005 , A61K31/7088 , A61K35/76 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145
摘要： The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
摘要翻译：本发明在某些方面涉及具有不同组织靶向能力的重组腺相关病毒。在一些方面，本发明涉及使用重组腺相关病毒的基因转移方法。在一些方面，本发明涉及分离的AAV衣壳蛋白和编码其的分离的核酸。

66. 发明授权

US08062611B2 Fluid processing device including composite material flow modulator 有权
标题翻译：流体处理装置包括复合材料流量调节器
公开(公告)号：US08062611B2
公开(公告)日：2011-11-22
申请号：US11252915
申请日：2005-10-18
申请人： Konrad Faulstich , Aldrich N. K. Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
发明人： Konrad Faulstich , Aldrich N. K. Lau , Debjyoti Banerjee , Umberto Ulmanella , Jun Xie
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.
摘要翻译：提供了一种流体处理装置，其包括衬底，形成在衬底中或衬底上的多个流体保持区域，以及至少部分地分离两个或更多个流体保持区域的屏障。屏障包括螯合材料和反应组分的混合物。反应组分可以是反应物，试剂，催化剂，引发剂，助催化剂，辅因子，酶，盐或其组合中的至少一种。隔离材料可以是多孔材料，可溶解材料或两者。

67. 发明申请

US20110114206A1 Fluid Processing Device Including Size-Changing Barrier 有权
标题翻译：包括尺寸变化屏障的流体处理装置
公开(公告)号：US20110114206A1
公开(公告)日：2011-05-19
申请号：US12945793
申请日：2010-11-12
申请人： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
发明人： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
IPC分类号： F15D1/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
摘要翻译：提供了一种诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。例如，阻挡层可以包含壳聚糖材料。

68. 发明申请

US20080171134A1 INTEGRATED CAPACITIVE MICROFLUIDIC SENSORS METHOD AND APPARATUS 有权
标题翻译：集成电容式微流体传感器方法和装置
公开(公告)号：US20080171134A1
公开(公告)日：2008-07-17
申请号：US11830581
申请日：2007-07-30
申请人： Jun Xie , Jason Shih , Yu-Chong Tai
发明人： Jun Xie , Jason Shih , Yu-Chong Tai
IPC分类号： C23C16/04 , C23C16/00 , H01G7/00 , G01L9/12
CPC分类号： G01N27/226 , B81B7/02 , B81B2201/0292 , B81B2201/058 , G01L9/0042 , G01L9/0072
摘要： A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.
摘要翻译：用于电容感测的微流体装置和方法。该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和所述第二电容器电极至少在所述腔区域内引起电场。基于聚合物的膜包括聚合物。

69. 发明授权

US07297640B2 Method for reducing argon diffusion from high density plasma films 有权
标题翻译：降低高密度等离子体膜的氩扩散的方法
公开(公告)号：US07297640B2
公开(公告)日：2007-11-20
申请号：US11034952
申请日：2005-01-13
申请人： Jun Xie , Hoon Lian Yap , Chuin Boon Yeap , Weoi San Lok
发明人： Jun Xie , Hoon Lian Yap , Chuin Boon Yeap , Weoi San Lok
IPC分类号： H01L21/31
CPC分类号： H01L21/76801 , C23C16/045 , C23C16/401 , C23C16/45523 , H01L21/02164 , H01L21/02274 , H01L21/31612 , H01L21/31629 , H01L21/76837
摘要： A two-step high density plasma-CVD process is described wherein the argon content in the film is controlled by using two different argon concentrations in the argon/silane/oxygen gas mixture used for generating the high density plasma. The first step deposition uses high argon concentration and low sputter etch-to-deposition (E/D) ratio. High E/D ratio maintains the gap openings without necking. In the second step, a lower argon concentration and lower E/D ratio are used. Since observed metal defects are caused by argon diffusion in the top 200-300 nm of the HDP-CVD film, by controlling argon concentration in the top part of the film (i.e. second step deposition) to a low value, a reduced number of metal defects are achieved.
摘要翻译：描述了两步高密度等离子体CVD工艺，其中通过在用于产生高密度等离子体的氩/硅烷/氧气混合物中使用两种不同的氩浓度来控制膜中的氩含量。第一步沉积使用高氩浓度和低溅射蚀刻至沉积（E / D）比。高E / D比保持间隙开口没有颈缩。在第二步中，使用较低的氩浓度和较低的E / D比。由于观察到的金属缺陷是通过在HDP-CVD膜的顶部200-300nm的氩扩散引起的，通过将膜顶部的氩浓度（即第二级沉积）控制到低值，减少数量的金属实现了缺陷。

70. 发明申请

US20070102293A1 Electrochemical flow cell, an assembly of and a method of fabrication of the same 审中-公开
标题翻译：电化学流通池，其组装及其制造方法
公开(公告)号：US20070102293A1
公开(公告)日：2007-05-10
申请号：US11517123
申请日：2006-09-06
申请人： Yu-Chong Tai , Jun Xie , Darron Young
发明人： Yu-Chong Tai , Jun Xie , Darron Young
IPC分类号： G01N27/26
CPC分类号： G01N27/403 , G01N30/64
摘要： An electrochemical flow cell comprises a substrate having an insulated surface, a polymer gasket integrally disposed on the surface, and a top cover disposed on the gasket. The components define a fluidic channel when assembled. An electrode(s) on the substrate surface provides for electrochemical detection of analytes in the fluid flowing over the electrode in the fluidic channel. The electrode(s) can be also integrated to the substrate. The assembly can be packaged. The flow cell inexpensive, versatile, and disposable. Small dimensions can facilitate good sensitivity and selectivity. Applications include environmental, life sciences, pharmaceuticals, and proteomics. The cell can be adapted for both detector and electrospray ionization applications.
摘要翻译：电化学流动池包括具有绝缘表面的基底，整体设置在表面上的聚合物垫片和设置在垫圈上的顶盖。组件在组装时定义流体通道。衬底表面上的电极提供了在流体通道中电极上流动的流体中的分析物的电化学检测。电极也可以与衬底集成。组装可以包装。流通池廉价，通用，一次性。小尺寸可以促进良好的灵敏度和选择性。应用包括环境，生命科学，药物和蛋白质组学。电池可以适用于检测器和电喷雾电离应用。

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