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61. 发明申请

US20110151233A1 FABRIC INCLUDING POLYOLEFIN ELASTIC FIBER 审中-公开
标题翻译：织物包括聚烯烃弹性纤维
公开(公告)号：US20110151233A1
公开(公告)日：2011-06-23
申请号：US12969701
申请日：2010-12-16
申请人： Robert O. WALDBAUER, JR. , Young D. Nguyen , Hong Liu , James Michael Lambert
发明人： Robert O. WALDBAUER, JR. , Young D. Nguyen , Hong Liu , James Michael Lambert
IPC分类号： D02G3/02 , D02G3/00 , D01D5/08
摘要： An article comprising a yarn comprising an elastomeric propylene-based polymer composition; said polymer composition comprising at least one elastomeric propylene-based polymer, wherein said yarn has a draft greater than 200%; wherein said article is a fabric or a garment.
摘要翻译：一种制品，包括一种包含弹性体丙烯基聚合物组合物的纱线; 所述聚合物组合物包含至少一种基于丙烯的弹性体聚合物，其中所述纱线具有大于200％的牵伸力; 其中所述制品是织物或衣服。

62. 发明申请

US20110116093A1 SENSOR CHIP FOR BIOLOGICAL AND CHEMICAL SENSING 有权
标题翻译：传感器芯片生物和化学传感
公开(公告)号：US20110116093A1
公开(公告)日：2011-05-19
申请号：US12991070
申请日：2009-04-30
申请人： Hong Liu , Xiaodong Zhou
发明人： Hong Liu , Xiaodong Zhou
IPC分类号： G01N21/00 , G01N21/55
CPC分类号： G01N21/554 , G01N21/0303 , G01N2021/0346
摘要： A sensor chip comprising: a micro/nanofluidic channel; at least one nanostructure provided in said channel along an optical path for the transmission of a light beam; a light transparent element disposed along the optical path and arranged to allow transmission of light onto said nanostructure; and a non-transparent element surrounding at least a portion of said optical path to at least partially reduce light scatter from the optical path.
摘要翻译：一种传感器芯片，包括：微/纳流体通道; 沿着用于传输光束的光路的所述通道中设置的至少一个纳米结构; 光透明元件，沿着光路设置并布置成允许光透射到所述纳米结构上; 以及围绕所述光路的至少一部分的不透明元件，以至少部分地减少来自光路的光散射。

63. 发明申请

US20110065671A1 BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS 审中-公开
标题翻译：双相异构体衍生物及其作为GPR119调节剂的用途
公开(公告)号：US20110065671A1
公开(公告)日：2011-03-17
申请号：US12993363
申请日：2009-05-18
申请人： Joel M. Harris , Santhosh Francis , Bernard R. Neustadt , Craig D. Boyle , Hong Liu , Jinsong Hao , Andrew Starnford , Samuel Chackalamannil , William J. Greenlee
发明人： Joel M. Harris , Santhosh Francis , Bernard R. Neustadt , Craig D. Boyle , Hong Liu , Jinsong Hao , Andrew Starnford , Samuel Chackalamannil , William J. Greenlee
IPC分类号： A61K31/675 , C07D239/90 , A61K31/517 , C07D401/12 , A61K31/496 , C07F9/40 , C07D471/04 , A61K31/519 , C07D413/10 , A61K31/5377 , A61P3/00 , A61P9/00
CPC分类号： C07D239/90 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/12 , C07D471/04
摘要： The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bi-cyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient.
摘要翻译：本发明涉及式（I）的双环杂环衍生物，包含双环杂环衍生物的组合物，以及使用双环杂环衍生物治疗或预防肥胖，糖尿病，代谢紊乱，心血管疾病或病症相关的方法到患者的GPR1 19的活动。

64. 发明申请

US20100303009A1 METHOD AND SYSTEM FOR SELECTING ACCESS GATEWAY AND GATEWAY SELECTION EXECUTION NODE IN MOBILE PACKET DOMAIN 有权
标题翻译：在移动分组域中选择访问网关和网关选择执行节点的方法和系统
公开(公告)号：US20100303009A1
公开(公告)日：2010-12-02
申请号：US12681321
申请日：2008-10-20
申请人： Hong Liu
发明人： Hong Liu
IPC分类号： H04W40/00
CPC分类号： H04W48/17 , H04L29/12066 , H04L29/12188 , H04L61/1511 , H04L61/1588
摘要： A method and system for selecting a gateway and a gateway selection execution node in the mobile packet domain are disclosed. The method includes: encapsulating, by a gateway selection execution node upon reception of a bearer setup request transmitted from a User Equipment, an operator domain name corresponding to the bearer setup request into a DNS parse request when creating the DNS parse request, and transmitting the DNS parse request to a DNS server; parsing by the DNS server for obtaining the address of an access gateway; returning by the DNS server, to the gateway selection execution node, a DNS parse result containing the address information of the access gateway corresponding to the operator domain name; selecting by the gateway selection execution node according to the address information the access gateway corresponding to the operator domain name as the access gateway corresponding to the bearer setup request.
摘要翻译：公开了一种用于在移动分组域中选择网关和网关选择执行节点的方法和系统。该方法包括：在创建DNS解析请求时，由网关选择执行节点在接收到从用户设备发送的承载建立请求时，将与承载建立请求对应的运营商域名封装成DNS解析请求，并且发送 DNS解析请求到DNS服务器; 由DNS服务器解析获取接入网关的地址; 由DNS服务器返回到网关选择执行节点，包含对应于运营商域名的接入网关的地址信息的DNS解析结果; 由网关选择执行节点根据地址信息选择与运营商域名对应的接入网关作为对应于承载建立请求的接入网关。

65. 发明申请

US20100234225A1 Stable Mixtures of Microencapsulated and Non-Encapsulated Pesticides 有权
标题翻译：微胶囊化和非包封农药的稳定混合物
公开(公告)号：US20100234225A1
公开(公告)日：2010-09-16
申请号：US12279607
申请日：2007-02-21
申请人： Robin W. Dexter , Hong Liu
发明人： Robin W. Dexter , Hong Liu
IPC分类号： A01N43/707 , A01N43/34 , A01P13/00
CPC分类号： A01N25/04 , A01N25/28 , A01N25/30 , A01N43/80 , A01N39/02 , A01N43/707 , A01N47/30 , A01N2300/00
摘要： The present invention is directed to a composition comprising i) a microencapsulated pesticide, ii) a dispersant selected from the group consisting of a lignin, b) a lignosulfonate salt and c) a lignosulfonate salt combined with the sodium salt of substituted naphthalene sulfonate formaldehyde polymer, iii) a salt selected from the group consisting of magnesium sulfate, sodium chloride, sodium nitrate and calcium chloride, and iv) a non-encapsulated pesticide. The present invention is also directed to methods of making and using the compositions of the present invention.
摘要翻译：本发明涉及一种组合物，其包含i）微囊化农药，ii）选自木质素，b）木质素磺酸盐和c）与取代萘磺酸盐甲醛聚合物的钠盐组合的木质素磺酸盐的分散剂，iii）选自硫酸镁，氯化钠，硝酸钠和氯化钙的盐，和iv）未包封的农药。本发明还涉及制备和使用本发明组合物的方法。

66. 发明申请

US20100197739A1 Stable Suspension Concentrate Formulation for Water-Soluble Compounds 有权
标题翻译：水溶性化合物的稳定悬浮浓缩配方
公开(公告)号：US20100197739A1
公开(公告)日：2010-08-05
申请号：US12445905
申请日：2007-10-16
申请人： Robin W. Dexter , Hong Liu
发明人： Robin W. Dexter , Hong Liu
IPC分类号： A01N43/40 , A01P7/04
CPC分类号： A01N43/50 , A01N25/02 , A01N43/40 , A01N51/00 , A61K47/02 , A61K47/38 , A61L2400/06 , A01N25/04 , A01N59/02 , A01N59/06 , A01N2300/00
摘要： The present invention is directed to an insecticidal water based suspension concentrate formulation comprising a water-soluble insecticide selected from the group consisting of N-cyanomethyl-4-(trifluoromethyl)nicotinamide and (EZ)-1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidineamine and at least one water-soluble salt selected from the group consisting of magnesium sulfate (hydrated and anhydrous forms) and sodium sulfate, wherein the water-soluble insecticide is present in an insecticidally effective amount and methods of use.
摘要翻译：本发明涉及一种杀虫水基悬浮液浓缩物制剂，其包含选自N-氰基甲基-4-（三氟甲基）烟酰胺和（EZ）-1-（6-氯-3-吡啶基甲基）-N-硝基咪唑烷-2-基胺和至少一种选自硫酸镁（水合和无水形式）和硫酸钠的水溶性盐，其中水溶性杀虫剂以杀虫有效量存在，并且方法的使用。

67. 发明申请

US20100048541A1 SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION 审中-公开
标题翻译：作为ABETA蛋白质生产的抑制剂的替代的LACTAMS
公开(公告)号：US20100048541A1
公开(公告)日：2010-02-25
申请号：US12561420
申请日：2009-09-17
申请人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
发明人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
IPC分类号： A61K31/5513 , C07D243/24 , C07D401/04
CPC分类号： C07D223/12 , C07D223/18 , C07D243/12 , C07D243/24 , C07D401/04
摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
摘要翻译：本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ的生成，从而起到防止淀粉样蛋白的神经沉积的形成的作用。更具体地说，本发明涉及与阿尔茨海默病和唐氏综合征等淀粉样蛋白生成相关的神经障碍的治疗。

68. 发明授权

US07662860B2 3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US07662860B2
公开(公告)日：2010-02-16
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

69. 发明申请

US20100009992A1 AMPK MODULATORS 有权
标题翻译： AMPK调制器
公开(公告)号：US20100009992A1
公开(公告)日：2010-01-14
申请号：US12365671
申请日：2009-02-04
申请人： Neal C. Birnberg , Hong Liu , Qing Ping Weng , Haibo Shang , Pan Yin , Sharanappa B. Rajur , Hwa-Ok Kim , Paresh D. Salgaonkar , Norton P. Peet
发明人： Neal C. Birnberg , Hong Liu , Qing Ping Weng , Haibo Shang , Pan Yin , Sharanappa B. Rajur , Hwa-Ok Kim , Paresh D. Salgaonkar , Norton P. Peet
IPC分类号： A61K31/437 , A61K31/4985 , A61K31/4375 , A61K31/47 , A61K31/404 , C07D498/04 , C07D471/04 , C07D215/20 , C07D209/12 , A61P35/00 , A61P3/10 , A61P3/04
CPC分类号： C07D498/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/42 , C07D215/54 , C07D215/56 , C07D401/04 , C07D403/04 , C07D471/04
摘要： The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II): which are useful as AMPK modulators effective in treating diabetes, obesity and cancer in a subject.
摘要翻译：本发明涉及式（I）或（II）的化合物和药学上可接受的盐，酯和前药：其可用作对受试者中有效治疗糖尿病，肥胖和癌症的AMPK调节剂。

70. 发明申请

US20090247517A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 失效
标题翻译：化合物和组合物作为CANNABINOID受体1活性的抑制剂
公开(公告)号：US20090247517A1
公开(公告)日：2009-10-01
申请号：US11718016
申请日：2005-10-26
申请人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
发明人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
IPC分类号： A61K31/5377 , C07D487/02 , A61K31/519 , C07D471/02 , A61K31/437 , C07D473/30 , A61K31/522 , C07D413/14 , A61K31/496 , C07D413/02 , A61P3/04
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D498/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

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