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61. 发明授权

US5874285A Polynucleotide encoding a novel human nm23-like protein 失效
公开(公告)号：US5874285A
公开(公告)日：1999-02-23
申请号：US713825
申请日：1996-09-13
申请人： Olga Bandman , Phillip R. Hawkins
发明人： Olga Bandman , Phillip R. Hawkins
IPC分类号： A61K38/00 , C12N1/21 , C12N9/12 , C07H21/02 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/12 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.

62. 发明授权

US5869289A Human galectin homolog 失效
标题翻译：人半乳凝胶同源物
公开(公告)号：US5869289A
公开(公告)日：1999-02-09
申请号：US728521
申请日：1996-10-09
申请人： Phillip R. Hawkins , Olga Bandman
发明人： Phillip R. Hawkins , Olga Bandman
IPC分类号： C07K14/47 , C12N15/00 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/4726
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human galectin-8. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human galectin-8. The invention also provides for the production and use of substantially purified human galectin-8 in pharmaceutical compositions to increase immune responses. The invention also provides for the use of antisense molecules and antibodies in pharmaceutical compositions to decrease immune response. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding human galectin-8 and anti-human galectin-8 antibodies which specifically bind to human galectin-8.
摘要翻译：本发明提供鉴定和编码新型人半乳凝素-8的多核苷酸。本发明提供了包含编码人半乳凝素-8的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本纯化的人半乳凝素-8以增加免疫应答。本发明还提供在药物组合物中使用反义分子和抗体来降低免疫应答。本发明还描述了利用多核苷酸与编码人galectin-8和特异性结合人galectin-8的抗人galectin-8抗体的转录物和/或基因组DNA杂交的诊断测定法。

63. 发明授权

US5840544A DNA encoding rantes homolog from prostate 失效
标题翻译：编码前列腺同源物的DNA
公开(公告)号：US5840544A
公开(公告)日：1998-11-24
申请号：US633682
申请日：1996-04-17
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide PTEC (prostate expressed chemokine) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多肽PTEC（前列腺表达的趋化因子），该文库鉴定并编码新的人类同源物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

64. 发明授权

US5837493A Human galectins 失效
标题翻译：人类半乳凝素
公开(公告)号：US5837493A
公开(公告)日：1998-11-17
申请号：US788584
申请日：1997-01-23
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译：本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。

65. 发明授权

US06486300B1 Human nm23-like protein 失效
标题翻译：人类nm23样蛋白
公开(公告)号：US06486300B1
公开(公告)日：2002-11-26
申请号：US09460532
申请日：1999-12-13
申请人： Olga Bandman , Phillip R. Hawkins
发明人： Olga Bandman , Phillip R. Hawkins
IPC分类号： C07K1700
CPC分类号： C12N9/12 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人类nm23样蛋白（H-nm23）的多核苷酸。本发明提供了遗传工程改造的表达载体和宿主细胞，其包含编码H-nm23的核酸序列和用于产生蛋白质的方法。本发明还提供使用基本上纯化的H-nm23用于治疗与H-nm23表达相关的疾病。本发明还描述了利用包含与编码H-nm23的天然存在的序列和特异性结合蛋白的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

66. 发明授权

US06281333B1 Human galectin homolog 失效
标题翻译：人半乳凝胶同源物
公开(公告)号：US06281333B1
公开(公告)日：2001-08-28
申请号：US09212146
申请日：1998-12-15
申请人： Phillip R. Hawkins , Olga Bandman
发明人： Phillip R. Hawkins , Olga Bandman
IPC分类号： C07K100
CPC分类号： C07K14/4726
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human galectin-8. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human galectin-8. The invention also provides for the production and use of substantially purified human galectin-8 in pharmaceutical compositions to increase immune responses. The invention also provides for the use of antisense molecules and antibodies in pharmaceutical compositions to decrease immune response. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding human galectin-8 and anti-human galectin-8 antibodies which specifically bind to human galectin-8.
摘要翻译：本发明提供鉴定和编码新型人半乳凝素-8的多核苷酸。本发明提供了包含编码人半乳凝素-8的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本纯化的人半乳凝素-8以增加免疫应答。本发明还提供在药物组合物中使用反义分子和抗体来降低免疫应答。本发明还描述了利用多核苷酸与编码人galectin-8和特异性结合人galectin-8的抗人galectin-8抗体的转录物和/或基因组DNA杂交的诊断测定法。

67. 发明授权

US6087125A Polynucleotide encoding a novel human nm23-like protein 失效
标题翻译：编码新型人nm23样蛋白的多核苷酸
公开(公告)号：US6087125A
公开(公告)日：2000-07-11
申请号：US199842
申请日：1998-11-24
申请人： Olga Bandman , Phillip R. Hawkins
发明人： Olga Bandman , Phillip R. Hawkins
IPC分类号： A61K38/00 , C12N1/21 , C12N9/12 , C12N15/11 , C12N15/00 , C12N15/63
CPC分类号： C12N9/12 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人nm23样蛋白（H-nm23）的多核苷酸。本发明提供了遗传工程改造的表达载体和宿主细胞，其包含编码H-nm23的核酸序列和用于产生蛋白质的方法。本发明还提供使用基本纯化的H-nm23用于治疗与H-nm23表达相关的疾病。本发明还描述了利用包含与编码H-nm23的天然存在的序列和特异性结合蛋白的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

68. 发明授权

US06054290A Human vesicle binding protein 失效
标题翻译：人体囊泡结合蛋白
公开(公告)号：US06054290A
公开(公告)日：2000-04-25
申请号：US857213
申请日：1997-05-15
申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry
发明人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12N15/11 , C07H21/04 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human vesicle binding protein (MVBP) and polynucleotides which identify and encode MVBP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing MVBP and for treating or preventing disorders associated with expression of MVBP.
摘要翻译：本发明提供了人囊泡结合蛋白（MVBP）和识别和编码MVBP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了产生MVBP并用于治疗或预防与MVBP表达相关的病症的方法。

69. 发明授权

US5925521A Human serine carboxypeptidase 失效
公开(公告)号：US5925521A
公开(公告)日：1999-07-20
申请号：US828488
申请日：1997-03-31
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P39/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/57 , C12Q1/68 , C12N15/63
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.

70. 发明授权

US5840569A Human GTP-binding proteins 失效
标题翻译：人类GTP结合蛋白
公开(公告)号：US5840569A
公开(公告)日：1998-11-24
申请号：US766551
申请日：1996-12-12
申请人： Jennifer L. Hillman , Olga Bandman , Phillip R. Hawkins , Surya K. Goli
发明人： Jennifer L. Hillman , Olga Bandman , Phillip R. Hawkins , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides three novel GTP-binding proteins (designated individually as BND-1, BND-2, and BND-3, and collectively as BND) and polynucleotides which identify and encode BND. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding BND and a method for producing BND. The invention also provides for use of BND and agonists, antibodies, or antagonists specifically binding BND, in the prevention and treatment of diseases associated with expression of BND. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding BND for the treatment of diseases associated with the expression of BND. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding BND.
摘要翻译：本发明提供了三种新型GTP结合蛋白（分别命名为BND-1，BND-2和BND-3，共同称为BND）和识别和编码BND的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码BND的核酸序列和生产BND的方法。本发明还提供使用BND和特异性结合BND的激动剂，抗体或拮抗剂来预防和治疗与BND表达相关的疾病。另外，本发明提供反义分子用于编码BND的多核苷酸用于治疗与BND表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合BND的抗体的诊断测定法。

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