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61. 发明申请

US20050278823A1 Emergency anti-hypothermia system and highly portable, inflatable emergency vest therefor 有权
标题翻译：紧急抗低温系统和高度便携，充气的紧急背心
公开(公告)号：US20050278823A1
公开(公告)日：2005-12-22
申请号：US11068267
申请日：2005-02-28
申请人： Ian Bruce
发明人： Ian Bruce
IPC分类号： A41D1/04 , A41D13/002
CPC分类号： A41D13/002 , A41D2400/14
摘要： An emergency anti-hypothermia system has a thermally insulating vest that is sufficiently portable to be carried for emergency use in a pocket, purse, backpack, compartment of a vehicle, ski pole or other location. The vest provides thermal insulation by being made with thermally insulating air impervious material that also provides for its inflation. The inflating air also provides insulation as, preferably, does thermal radiation reflective material on inwardly facing surfaces of the vest, preferably inwardly facing surfaces of outer layers of inflated chambers about the vest, the multiplicity of the chambers about the vest reducing convection heat transfer therewithin. The vest thus preferably provides thermal insulation by anti-conduction, anti-radiation and anti-convection in a highly portable system.
摘要翻译：紧急抗低温系统具有足够便携的绝热背心，以便在口袋，钱包，背包，车辆的车厢，滑雪杆或其他位置的紧急情况下携带。背心通过采用绝热不透气材料制成绝热材料，同时也提供充气。充气空气还提供绝缘，优选地，在背心的向内的表面的内侧表面上，优选地，围绕背心的充气室外层的表面，优选地面向内的表面，围绕背心的多个室减少对流传热。因此，背心优选地通过在高度便携式系统中的抗传导，抗辐射和抗对流来提供热绝缘。

62. 发明申请

US20050233360A1 Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes 审中-公开
公开(公告)号：US20050233360A1
公开(公告)日：2005-10-20
申请号：US11083210
申请日：2005-03-16
申请人： Martin Davies , Ian Bruce , Andreas Wolter
发明人： Martin Davies , Ian Bruce , Andreas Wolter
IPC分类号： C07H21/00 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6818 , C07H21/00 , C12Q1/686 , C12Q2565/107 , C12Q2565/1015 , C12Q2563/173 , C12Q2525/313 , C12Q2527/119 , C12Q2525/113 , C12Q2561/113
摘要： The invention comprises novel methods and strategies to detect and/or quantify nucleic acid analytes. The methods involve nucleic acid probes with covalently conjugated dyes, which are attached either at adjacent nucleotides or at the same nucleotide of the probe and novel linker molecules to attach the dyes to the probes. The nucleic acid probes generate a fluorescent signal upon hybridization to complementary nucleic acids based on the interaction of one of the attached dyes, which is either an intercalator or a DNA groove binder, with the formed double stranded DNA. The methods can be applied to a variety of applications including homogeneous assays, real-time PCR monitoring, transcription assays, expression analysis on nucleic acid microarrays and other microarray applications such as genotyping (SNP analysis). The methods further include pH-sensitive nucleic acid probes that provide switchable fluorescence signals that are triggered by a change in the pH of the medium.

63. 发明授权

US5126461A Process for opening cyclopropane rings 失效
标题翻译：打开环丙烷环的方法
公开(公告)号：US5126461A
公开(公告)日：1992-06-30
申请号：US612667
申请日：1990-11-14
申请人： Mark S. Baird , Ian Bruce
发明人： Mark S. Baird , Ian Bruce
IPC分类号： C07C43/215 , C07C43/225 , C07D333/08 , C07D333/12 , C07D333/28
CPC分类号： C07C43/215 , C07C43/225 , C07D333/08 , C07D333/12 , C07D333/28 , C07C2101/02 , C07C2102/08
摘要： Process for ring opening compounds of the formula ##STR1## in which R.sup.1 is heteroaryl or aryl, R.sup.2 is a leaving group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently selected from hydrogen, alkyl, aralkyl, aryl, heteroaryl and alkenyl, provided that at least one of the groups R.sup.3 to R.sup.6 is other than hydrogen, by breaking the bond joining the carbon atom attached to R.sup.3 and the carbon atom attached to R.sup.6 in organic solution using silica, giving useful diene or allyl derivatives, certain of which are novel.

64. 发明授权

US10004732B2 Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors 有权
公开(公告)号：US10004732B2
公开(公告)日：2018-06-26
申请号：US15303868
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/497 , A61K31/5377 , C07D403/04
CPC分类号： A61K31/497 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

65. 发明授权

US09492951B2 Ophthalmic device molds formed from water-soluble vinyl alcohol copolymer, ophthalmic devices molded therein, and related methods 有权
标题翻译：由水溶性乙烯醇共聚物形成的眼科装置模具，其中模制眼科装置及相关方法
公开(公告)号：US09492951B2
公开(公告)日：2016-11-15
申请号：US13810313
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： B29D11/00 , G02B1/04 , B29C33/40 , B29C45/26 , B29L11/00
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Ophthalmic device molds made from at least one water-soluble vinyl alcohol copolymer, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, packaged ophthalmic devices present in a solution comprising the at least one water-soluble vinyl alcohol copolymer, and related methods are described. The methods of manufacturing ophthalmic devices can use wet demolding processes, or wet delensing processes or both wet demolding and wet delensing processes involving dissolving the molds in water or an aqueous solution.
摘要翻译：由至少一种水溶性乙烯醇共聚物制成的眼科装置模具，眼部装置如眼部插入物和隐形眼镜，并且包括使用这些模具形成的硅氧水凝胶装置，包含眼用装置，其包含至少一种水溶性乙烯基醇共聚物和相关方法。制造眼科装置的方法可以使用湿脱模方法或湿脱胶方法，或者湿法脱模和湿脱胶方法，包括将模具溶解在水或水溶液中。

66. 发明授权

US09278489B2 Ophthalmic device molds and related methods 有权
标题翻译：眼科装置模具及相关方法
公开(公告)号：US09278489B2
公开(公告)日：2016-03-08
申请号：US13810911
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： B29D11/00 , B29C33/40 , G02B1/04
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Ophthalmic device molds made from a first portion of a molding surface formed from a first polymer and a second portion of the molding surface formed from a second polymer are described. When combined, the first portion and the second portion of the molding surface form an entire molding surface suitable for molding an entire surface, such as an anterior surface or a posterior surface of an ophthalmic device. Methods of manufacturing ophthalmic devices using these molds, including contact lenses, are also described.
摘要翻译：描述由第一聚合物形成的模制表面的第一部分和由第二聚合物形成的模制表面的第二部分制成的眼科装置模具。当组合时，模制表面的第一部分和第二部分形成适合于模制整个表面（例如眼科装置的前表面或后表面）的整个模制表面。还描述了使用这些模具制造眼科装置的方法，包括隐形眼镜。

67. 发明授权

US08979261B2 Silicone hydrogel ophthalmic devices molded in vinyl alcohol copolymer molds and related methods 有权
标题翻译：在乙烯醇共聚物模具中成型的硅酮水凝胶眼科装置及相关方法
公开(公告)号：US08979261B2
公开(公告)日：2015-03-17
申请号：US13810679
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： B29D11/00 , G02B1/04 , B29C33/40
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Silicone hydrogel ophthalmic devices, such as ocular inserts and contact lenses, formed in direct contact with molds comprising at least one vinyl alcohol copolymer and related methods are described. The at least one vinyl alcohol copolymer of the molds is a vinyl alcohol copolymer other than an ethylene-vinyl alcohol copolymer. The methods of manufacturing ophthalmic devices can use dry or wet demolding processes, or dry or wet delensing processes.
摘要翻译：描述了与包含至少一种乙烯醇共聚物的模具直接接触形成的硅胶水凝胶眼用装置，例如眼部插入物和隐形眼镜。模具的至少一种乙烯醇共聚物是乙烯 - 乙烯醇共聚物以外的乙烯醇共聚物。制造眼科装置的方法可以使用干式或湿式脱模方法，或干法或湿法脱胶方法。

68. 发明申请

US20130169926A1 Ophthalmic Device Molds Formed From Highly Amorphous Vinyl Alcohol Polymer, Ophthalmic Devices Molded Therein, And Related Methods 有权
标题翻译：由高度无定形乙烯醇聚合物形成的眼科装置模具及其制造的眼科装置及相关方法
公开(公告)号：US20130169926A1
公开(公告)日：2013-07-04
申请号：US13810325
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： G02C7/04 , B29D11/00
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Ophthalmic device molds made from at least one highly amorphous vinyl alcohol polymer, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, and related methods are described. The methods of manufacturing ophthalmic devices can use dry or wet demolding processes, or dry or wet delensing processes.
摘要翻译：描述了由至少一种高度无定形乙烯醇聚合物制成的眼科装置模具，眼科装置如眼部插入件和隐形眼镜，并且包括使用这些模具形成的硅酮水凝胶装置及相关方法。制造眼科装置的方法可以使用干式或湿式脱模方法，或干法或湿法脱胶方法。

69. 发明申请

US20130162943A1 Ophthalmic Device Molds Formed From Vinyl Alcohol Copolymer, Ophthalmic Devices Molded Therein, And Related Methods 有权
标题翻译：由乙烯基醇共聚物，其中成型的眼科装置形成的眼科装置模具及相关方法
公开(公告)号：US20130162943A1
公开(公告)日：2013-06-27
申请号：US13810907
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Ophthalmic device molds made from at least one vinyl alcohol copolymer and having a static sessile drop contact angle of less than 70 degrees, ophthalmic devices such as ocular inserts and contact lenses and including silicone hydrogel devices formed using these molds, and related methods are described. The methods of manufacturing ophthalmic devices can use dry or wet demolding processes, or dry or wet delensing processes.
摘要翻译：描述了由至少一种乙烯醇共聚物制成的具有小于70度的静态固着落接触角的眼科装置模具，眼科装置如眼部插入物和隐形眼镜，并且包括使用这些模具形成的硅酮水凝胶装置及相关方法。制造眼科装置的方法可以使用干式或湿式脱模方法，或干法或湿法脱胶方法。

70. 发明申请

US20130162942A1 Polar Thermoplastic Ophthalmic Lens Molds, Ophthalmic Lenses Molded Therein, And Related Methods 有权
标题翻译：极地热塑性眼科镜片模具，其中模制的眼科镜片及相关方法
公开(公告)号：US20130162942A1
公开(公告)日：2013-06-27
申请号：US13704869
申请日：2011-07-08
申请人： Lee Darren Norris , Edyta S. Bialek , Sarah L. Almond , David Robert Morsley , A.K.M. Shahab Siddiqui , Richard C. Rogers , Ian Bruce , Benjamin S. Sheader
发明人： Lee Darren Norris , Edyta S. Bialek , Sarah L. Almond , David Robert Morsley , A.K.M. Shahab Siddiqui , Richard C. Rogers , Ian Bruce , Benjamin S. Sheader
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： B29D11/00442 , B29D11/00 , B29D11/00038 , B29D11/00057 , B29D11/00067 , B29D11/00115 , B29D11/0048 , G02B1/043
摘要： Ophthalmic lens molds made from one or more thermoplastic polymers with average polarities from about 1% to about 7%, ophthalmic lenses including silicone hydrogel contact lenses molded using these less polar thermoplastic polymers, and related methods are described. When the molds are used to cast mold silicone hydrogel contact lenses, the resulting polymerized lens bodies have ophthalmically acceptably wettable surfaces.
摘要翻译：描述了由一种或多种平均极性为约1％至约7％的热塑性聚合物制成的眼镜片模具，包括使用这些极性较小的热塑性聚合物模制的硅酮水凝胶隐形眼镜的眼镜片及相关方法。当模具用于铸造硅胶水凝胶隐形眼镜时，所得到的聚合镜片体具有眼科可接受的可润湿表面。

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