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61. 发明专利

SG11201911653UA IMAGE SENSOR STRUCTURE 未知
公开(公告)号：SG11201911653UA
公开(公告)日：2020-01-30
申请号：SG11201911653U
申请日：2018-11-02
申请人： ILLUMINA INC
发明人： CAI XIUYU , AGAH ALI , FUNG TRACY H , DEHLINGER DIETRICH
IPC分类号： H01L27/146
摘要： An example image sensor structure (100) includes an image layer (108) with an array of light detectors (112) disposed therein. A device stack (126) is disposed over the image layer (108), with an array of light guides (130) disposed therein. Each light guide (130) is associated with at least one light detector of the array of light detectors (112). A passivation stack (104) is disposed over the device stack (126), comprising a passivation layer (142) and a chemical protection layer (144) disposed over the passivation layer (142), and preferably including a bottom surface (140) in direct contact with a top surface (132) of the light guides (130). An array of nanowells (120) is disposed in a top layer (144) of the passivation stack (104), with the contours of the nanowells (120) formed by a top layer (144) of the passivation stack (104). Each nanowell (120) is associated with a light guide (130). A crosstalk blocking metal structure (102/106) is disposed in the passivation stack (104), which reduces crosstalk within the passivation stack (104).

62. 发明专利

AU2018390335A1 Light detection devices with protective liner and methods related to same 未知
公开(公告)号：AU2018390335A1
公开(公告)日：2020-01-02
申请号：AU2018390335
申请日：2018-11-20
申请人： ILLUMINA INC
发明人： CAI XIUYU , PINTO JOSEPH FRANCIS , BAKER THOMAS A , FUNG TRACY HELEN
IPC分类号： H01L27/146
摘要： Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

63. 发明专利

CA3067424A1 TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME 未知
公开(公告)号：CA3067424A1
公开(公告)日：2019-06-27
申请号：CA3067424
申请日：2018-11-20
申请人： ILLUMINA INC
发明人： CAI XIUYU
IPC分类号： H01L27/146
摘要： Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

64. 发明专利

CL2018003752A1 Sensores que tienen circuitería de protección integrada 未知
公开(公告)号：CL2018003752A1
公开(公告)日：2019-04-12
申请号：CL2018003752
申请日：2018-12-21
申请人： ILLUMINA INC
发明人： FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , SAMIEE KEVAN , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N21/77 , G01N21/78 , G01N35/00
摘要： Un sensor de ejemplo incluye una celda de flujo, un dispositivo de detección y un controlador. La celda de flujo incluye una capa de pasivación que tiene superficies opuestas y un sitio de reacción en una primera de las superficies opuestas. La celda de flujo también incluye una tapa conectada de manera operativa a la capa de pasivación para definir parcialmente un canal de flujo entre la tapa y el sitio de reacción. El dispositivo de detección está en contacto con una segunda de las superficies opuestas de la capa de pasivación, e incluye una capa metálica incrustada que está aislada eléctricamente de otra circuitería de detección del dispositivo de detección. El controlador es para conectar a tierra la capa metálica incrustada; Sensores; Métodos.

65. 发明专利

LT3615922T JUTIKLIAI SU INTEGRUOTOMIS APSAUGOS GRANDINĖMIS 未知
公开(公告)号：LT3615922T
公开(公告)日：2022-10-25
申请号：LT18028265
申请日：2018-04-19
申请人： ILLUMINA INC
发明人： FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , SAMIEE KEVAN , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N33/543 , B01L3/00 , C12Q1/68 , C12Q1/6825 , G01N21/62 , G01N21/64 , G01N21/77

66. 发明专利

FI3615922T3 SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY 未知
公开(公告)号：FI3615922T3
公开(公告)日：2022-09-30
申请号：FI18791184
申请日：2018-04-19
申请人： ILLUMINA INC
发明人： FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , SAMIEE KEVAN , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N33/543 , B01L3/00 , C12Q1/68 , G01N21/62 , G01N21/64 , G01N21/77
摘要： An example sensor includes a detection device, including an optical waveguide, an optical sensor operatively associated with the optical waveguide and a device circuitry, including a reagent electrode, a first embedded metal layer electrically connected to the reagent electrode; and a second embedded metal layer electrically connected to the optical sensor wherein the first embedded metal layer is spaced from the second embedded metal layer by an electrically isolating gap, at least a portion of a passivation layer being in contact with the first embedded metal layer and an input region of the optical waveguide, the at least the portion of the passivation layer having a reaction site at least partially adjacent to the input region of the optical waveguide; and a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site, wherein the reagent electrode is positioned to be in contact with a reagent to be introduced into the flow channel. A method for performing a sensing operation of a sensor in response to a reaction at the reaction site involving at least some reaction component of the reagent and during the sensing operation, applying an electrical bias that renders the reagent electrode one of an anode or a cathode and the embedded metal layer the other of the cathode or the anode, thereby providing cathodic protection or anodic protection to the embedded metal layer, is also disclosed.

67. 发明专利

CA3067424C TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME 未知
公开(公告)号：CA3067424C
公开(公告)日：2022-08-02
申请号：CA3067424
申请日：2018-11-20
申请人： ILLUMINA INC
发明人： CAI XIUYU
IPC分类号： H01L27/146
摘要： Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

68. 发明专利

NZ759860A Structure and method to use active surface of a sensor 未知
公开(公告)号：NZ759860A
公开(公告)日：2022-07-01
申请号：NZ75986019
申请日：2019-01-29
申请人： ILLUMINA INC
发明人： TRAN HAI , LU DONGLAI , CAI XIUYU , FENG WENYI
IPC分类号： G01N21/17 , H01L27/146
摘要： Disclosed is an apparatus and method of forming, including a supporting structure, a sensor on the supporting structure, a pair of columns on the supporting structure at opposite sides of the sensor, the pair of columns having a column height relative to a top surface of the supporting structure, the column height being higher than a height of the active surface of the sensor relative to the top surface of the supporting structure, and a lidding layer on the pair of columns and over the active surface, the lidding layer being supported at opposite ends by the pair of columns. The active surface of the sensor, the lidding layer and the pair of columns form an opening above at least more than about half of the active surface of the sensor, and the supporting structure, the sensor, the lidding layer and the pair of columns together form a flow cell.

69. 发明专利

NZ759551A Two-filter light detection devices and methods related to same 未知
公开(公告)号：NZ759551A
公开(公告)日：2022-05-27
申请号：NZ75955118
申请日：2018-11-20
申请人： ILLUMINA INC
发明人： CAI XIUYU
IPC分类号： G01N21/64 , G02B5/20 , G02B6/293 , H01L27/146
摘要： Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

70. 发明专利

NZ759861A Image sensor structure 未知
公开(公告)号：NZ759861A
公开(公告)日：2021-11-26
申请号：NZ75986118
申请日：2018-11-02
申请人： ILLUMINA INC
发明人： CAI XIUYU , DEHLINGER DIETRICH , AGAH ALI , FUNG TRACY H
IPC分类号： H01L27/146 , G01J1/44 , G01N21/64
摘要： An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

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