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61. 发明授权

US08524910B2 Pyridyl derivatives as CFTR modulators 有权
标题翻译：吡啶衍生物作为CFTR调节剂
公开(公告)号：US08524910B2
公开(公告)日：2013-09-03
申请号：US13533326
申请日：2012-06-26
申请人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
发明人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
IPC分类号： A61K31/44 , C07D405/00
CPC分类号： C07D213/74 , C07D213/75 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to modulators of Formula I and the accompanying definitions herein of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases such as cystic fibrosis using such modulators.
摘要翻译：本发明涉及式I的调节剂以及ATP结合盒（“ABC”）转运蛋白或其片段（包括囊性纤维化跨膜电导调节剂（“CFTR”）及其组合物的随附定义。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病如囊性纤维化的方法。

62. 发明申请

US20130159529A1 MASTER DATA MANAGEMENT SYSTEM FOR MONITORING CLOUD COMPUTING 有权
标题翻译：用于监控云计算的主数据管理系统
公开(公告)号：US20130159529A1
公开(公告)日：2013-06-20
申请号：US13328170
申请日：2011-12-16
申请人： Kent Mitchell , Jason Heintz , Hollie McCurdy , Carroll Moon , Mark Miller , Brian Feck , Lou Nikodym , Vadi Ramalingam
发明人： Kent Mitchell , Jason Heintz , Hollie McCurdy , Carroll Moon , Mark Miller , Brian Feck , Lou Nikodym , Vadi Ramalingam
IPC分类号： G06F15/173
CPC分类号： G06F17/3007
摘要： An application provides cloud computing master data management. The application determines a rank associated with received server information from a server. The source rank is adjusted according to evaluation of server information against naming convention standards. The source rank is used in determining a category matching the server information. An assigned category includes instructions to configure assets of a server. The application assembles configuration information from the assigned category and provides the configuration information to the server.
摘要翻译：应用程序提供云计算主数据管理。应用程序确定与服务器接收到的服务器信息相关联的等级。根据服务器信息对命名约定标准的评估，调整源排名。源等级用于确定与服务器信息匹配的类别。分配的类别包括配置服务器资产的说明。应用程序从分配的类别中组合配置信息，并将配置信息提供给服务器。

63. 发明授权

US08106123B2 Modified resins for blown film 有权
标题翻译：用于吹塑薄膜的改性树脂
公开(公告)号：US08106123B2
公开(公告)日：2012-01-31
申请号：US12002560
申请日：2007-12-17
申请人： Rodolfo Mier , Mark Miller
发明人： Rodolfo Mier , Mark Miller
IPC分类号： C08L53/00 , C08K5/00
CPC分类号： C08L23/10 , C08J5/18 , C08J2323/10 , C08L23/06 , C08L23/16 , C08L2023/42 , C08L2205/02 , C08L2207/02 , C08L2666/02 , C08L2666/06
摘要： Processes for enhancing blown film processability and the blown films formed thereby are described herein. One embodiment of the processes generally includes providing a first propylene based heterophasic copolymer having a first melt flow rate, modifying the first propylene based heterophasic copolymer to form a second heterophasic polymer having a second melt flow rate, wherein the second melt flow rate is greater than the first melt flow rate, contacting the first heterophasic polymer, the second heterophasic copolymer or a combination thereof with a plurality of additives, wherein the plurality of additives include a nucleator, polyethylene and mineral oil to form a modified heterophasic copolymer and blowing the modified heterophasic polymer into a film.
摘要翻译：本文描述了用于提高吹塑薄膜加工性能的方法和由此形成的吹塑薄膜。该方法的一个实施方案通常包括提供具有第一熔体流动速率的第一丙烯基多相共聚物，修饰第一基于丙烯的多相共聚物以形成具有第二熔体流动速率的第二异相聚合物，其中第二熔体流动速率大于所述第一熔体流动速率，使所述第一多相聚合物，所述第二多相共聚物或其组合与多种添加剂接触，其中所述多种添加剂包括成核剂，聚乙烯和矿物油，以形成改性的多相共聚物，并将所述改性的异相聚合物成膜。

64. 发明授权

US07999113B2 Modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译：囊性纤维化跨膜电导调节剂的调节剂
公开(公告)号：US07999113B2
公开(公告)日：2011-08-16
申请号：US11503449
申请日：2006-08-11
申请人： Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人： Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号： A61K31/426 , C07D277/44
CPC分类号： C07D417/14 , A61K31/427
摘要： The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译：本发明涉及囊性纤维化跨膜电导调节剂（“CFTR”）的调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。

65. 发明授权

US07902325B2 Polypropylene having reduced residual metals 失效
标题翻译：聚丙烯具有减少的残余金属
公开(公告)号：US07902325B2
公开(公告)日：2011-03-08
申请号：US11473358
申请日：2006-06-22
申请人： Kenneth P. Blackmon , Mark C. Douglass , Kevin P. McGovern , Mark Miller , Joseph D. Thorman
发明人： Kenneth P. Blackmon , Mark C. Douglass , Kevin P. McGovern , Mark Miller , Joseph D. Thorman
IPC分类号： C08F6/02 , C08F110/06
CPC分类号： C08F110/06 , C08F6/02 , C08L23/10 , C08F2500/12 , C08L23/14
摘要： Polymerization processes are described herein. The polymerization processes generally include introducing a catalyst system to a reaction zone, introducing an olefin monomer to the reaction zone, contacting the olefin monomer with the catalyst system to form a polyolefin and contacting the polyolefin with a quench agent, wherein the quench agent is at least partially soluble in the olefin monomer.
摘要翻译：本文描述了聚合方法。聚合方法通常包括将催化剂体系引入反应区，将烯烃单体引入反应区，使烯烃单体与催化剂体系接触以形成聚烯烃并使聚烯烃与骤冷剂接触，其中骤冷剂处于最少部分溶于烯烃单体。

66. 发明申请

US20110047536A1 RUNTIME ACTIVATION AND VERSION SELECTION 有权
标题翻译：运行激活和版本选择
公开(公告)号：US20110047536A1
公开(公告)日：2011-02-24
申请号：US12545881
申请日：2009-08-24
申请人： Luiz F. Santos , Jesse D. Kaplan , David S. Mortenson , Richard E. Lander , Simon J. Hall , Mark Miller , Richard M. Byers , Ladislav Prosek , Sean Selitrennikoff
发明人： Luiz F. Santos , Jesse D. Kaplan , David S. Mortenson , Richard E. Lander , Simon J. Hall , Mark Miller , Richard M. Byers , Ladislav Prosek , Sean Selitrennikoff
IPC分类号： G06F9/44
CPC分类号： G06F8/71 , G06F9/44536
摘要： A runtime activation system uses a set of policies designed to provide a balance between backwards compatibility and ease of migrating existing (non side-by-side aware) applications to new runtime versions. The system chooses the runtime version to activate when an application runs or when a runtime application programming interface is invoked based on the set of policies. The system implements these policies by consulting compatibility data associated with the application indicating the intent of the author and level of side-by-side support provided by the application and/or global configuration data. Based on the compatibility data, the system chooses policies that are right in the most common cases, and easy to modify in less common cases. Thus, the runtime activation system allows applications to be flexibly configured to handle new runtime versions in a manner determined by the application author, a system administrator, or others.
摘要翻译：运行时激活系统使用一组策略，旨在提供向后兼容性和易于将现有（非并行感知）应用程序迁移到新运行时版本之间的平衡。系统选择运行时版本，以便在应用程序运行时或基于一组策略调用运行时应用程序编程接口时进行激活。该系统通过咨询与应用程序相关联的兼容性数据来实现这些策略，指示作者的意图以及由应用和/或全局配置数据提供的并行支持的级别。基于兼容性数据，系统选择最常见情况下正确的策略，在较不常见的情况下易于修改。因此，运行时激活系统允许应用程序被灵活地配置为以应用程序作者，系统管理员或其他人确定的方式处理新的运行时版本。

67. 发明申请

US20100329176A1 Rate adaptive modem 有权
标题翻译：速率自适应调制解调器
公开(公告)号：US20100329176A1
公开(公告)日：2010-12-30
申请号：US11882647
申请日：2007-08-03
申请人： Anil Agarwal , Mark Miller
发明人： Anil Agarwal , Mark Miller
IPC分类号： H04W40/00
CPC分类号： H04L1/0003 , H04L1/0009 , H04L1/0016
摘要： A communication system transmitting signals over a network using a transmission waveform in which a plurality of data packets are transmitted in a payload field of a transmission frame, the system includes a transmitter, which has a transmitting portion that sends information including user data in the data packets and a user data rate portion that dynamically changes the data rate of the user data to the highest rate possible for current link conditions by changing the waveform. The communication system also includes a receiver, which has a receiving portion that receives the information data packets and a reconfiguration portion that reconfigures the receiving portion based on the waveform parameters.
摘要翻译：一种通过网络使用传输波形传输信号的通信系统，其中在传输帧的有效载荷字段中发送多个数据分组，所述系统包括发射机，发射机具有发送包括数据中的用户数据的信息的发射部分分组和用户数据速率部分，其通过改变波形来动态地将用户数据的数据速率改变为可能的当前链路条件的最高速率。通信系统还包括接收机，其具有接收信息数据分组的接收部分和基于波形参数重新配置接收部分的重新配置部分。

68. 发明申请

US20100210638A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权
标题翻译： ATP结合蛋白转运蛋白的调节剂
公开(公告)号：US20100210638A1
公开(公告)日：2010-08-19
申请号：US12768894
申请日：2010-04-28
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/4418 , A61K31/4709 , A61P3/06 , A61P3/08 , A61P25/00 , A61P21/00 , A61P7/00
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

69. 发明授权

US07741321B2 Modulators of ATP-binding cassette transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US07741321B2
公开(公告)日：2010-06-22
申请号：US11594431
申请日：2006-11-08
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

70. 发明申请

US20100147138A1 FLASH MEMORY BASED STORED SAMPLE ELECTRONIC MUSIC SYNTHESIZER 有权
标题翻译：基于闪存存储的样品电子音乐合成器
公开(公告)号：US20100147138A1
公开(公告)日：2010-06-17
申请号：US12636275
申请日：2009-12-11
申请人： Howard Chamberlin , Timothy Thompson , Mark Miller , Sivaraman Natarajan
发明人： Howard Chamberlin , Timothy Thompson , Mark Miller , Sivaraman Natarajan
IPC分类号： G10H7/00
CPC分类号： G10H7/02 , G10H2230/031
摘要： A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity.
摘要翻译：基于闪存存储器的存储样本电子音乐合成器能够实现大量独立语音的电子再现，同时满足语音连续性，最小音符开始延迟和语音同步的严格要求。

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