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61. 外观设计

USD716538S1 Heel of a shoe 有权
公开(公告)号：USD716538S1
公开(公告)日：2014-11-04
申请号：US29447815
申请日：2013-03-07
申请人： Yuan Wang
设计人： Yuan Wang

62. 发明申请

US20140054510A1 Y-TYPE OXOTITANIUM PHTHALOCYANINE NANOPARTICLES, PREPARATION, AND USE THEREOF 有权
标题翻译： Y型氧化亚铁烷基纳米粒子，其制备及其用途
公开(公告)号：US20140054510A1
公开(公告)日：2014-02-27
申请号：US14002938
申请日：2012-03-05
申请人： Yuan Wang , Dejian Liang , Wenlian Peng
发明人： Yuan Wang , Dejian Liang , Wenlian Peng
IPC分类号： G03G5/06
CPC分类号： G03G5/0662 , C09B67/0026 , G03G5/0596 , G03G5/0696 , Y10T428/2982
摘要： Oxotitanium phthalocyanine nanoparticles in the crystal form of phase-Y (Y-TiOPc) having particle diameters of 2˜4 nm, preparation, and applications thereof are disclosed. The preparation method comprises the following steps: mixing a concentrated sulfuric acid solution of TiOPc with water or dilute sulfuric acid, or water or dilute sulfuric acid with a surfactant dissolved therein, or an aqueous solution of a low molecular weight organic compound to form a suspension or hydrosol; adding into the resulting suspension or hydrosol chlorinated hydrocarbons to extract TiOPc into an organic phase, so as to form a colloidal solution of Y-TiOPc nanoparticles; and then, washing and drying the above nanoparticles to give rise to a powder of the Y-TiOPc nanoparticles. Such a nanoparticle powder can disperse in chlorinated hydrocarbons to form stable colloidal solutions, thereby providing an alternative approach for solving the problem of poor dispersibility for Y-type TiOPc.
摘要翻译：公开了具有粒径为2〜4nm的Y相（Y-TiOPc）晶体形式的氧钛钛酞菁纳米粒子，其制备及应用。该制备方法包括以下步骤：将TiOPc的浓硫酸溶液与水或稀硫酸或溶解有表面活性剂的水或稀硫酸或低分子量有机化合物的水溶液混合以形成悬浮液或水溶胶; 加入所得悬浮液或水溶液氯化烃中以将TiOPc萃取到有机相中，以形成Y-TiOPc纳米颗粒的胶体溶液; 然后洗涤和干燥上述纳米颗粒，得到Y-TiOPc纳米颗粒的粉末。这种纳米粒子粉末可以分散在氯化烃中以形成稳定的胶体溶液，从而为解决Y型TiOPc分散性差的问题提供了一种替代方法。

63. 发明申请

US20140020043A1 AUTOMATING AND/OR RECOMMENDING DATA SHARING COORDINATION AMONG APPLICATIONS IN MOBILE DEVICES 有权
标题翻译：在移动设备中应用的自动化和/或推荐数据共享协调
公开(公告)号：US20140020043A1
公开(公告)日：2014-01-16
申请号：US13545330
申请日：2012-07-10
申请人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Yuan Wang , Jing Min Xu , Jeaha Yang
发明人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Yuan Wang , Jing Min Xu , Jeaha Yang
IPC分类号： G06F9/46 , G06F21/00
CPC分类号： G06F9/544
摘要： Coordinating data sharing among applications in mobile devices, in one aspect, may include a shared data manager application on a mobile device that manages data trade requirements automatically of a plurality of mobile applications, and permission grants or denials to reads and writes of data managed by the shared data manager and used by the plurality of mobile applications.
摘要翻译：在一个方面，在移动设备中的应用之间协调数据共享可以包括在自动管理多个移动应用的数据交易需求的移动设备上的共享数据管理器应用，以及许可授予或拒绝读取和写入由共享数据管理器并由多个移动应用程序使用。

64. 发明申请

US20140018048A1 COORDINATING DATA SHARING AMONG APPLICATIONS IN MOBILE DEVICES 有权
标题翻译：协调移动设备应用中的数据共享
公开(公告)号：US20140018048A1
公开(公告)日：2014-01-16
申请号：US13545416
申请日：2012-07-10
申请人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Yuan Wang , Jing Min Xu , Jeaha Yang
发明人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Yuan Wang , Jing Min Xu , Jeaha Yang
IPC分类号： G06F21/24 , H04W4/00
CPC分类号： G06F21/6218 , G06F21/00 , G06F2221/2145 , H04W4/60
摘要： Coordinating data sharing among applications in mobile devices, in one aspect, may include a shared data manager application on a mobile device that manages data trade requirements of a plurality of mobile applications, and permission grants or denials to reads and writes of data managed by the shared data manager and used by the plurality of mobile applications.
摘要翻译：在一个方面，在移动设备中的应用之间协调数据共享可以包括在管理多个移动应用的数据交易要求的移动设备上的共享数据管理器应用，以及许可授予或拒绝读取和写入由共享数据管理器并被多个移动应用程序使用。

65. 发明申请

US20130011864A1 PHOTOLUMINESCENT NANOPARTICLE, PREPARATION, AND APPLICATION THEREOF 审中-公开
标题翻译：光致发光纳米颗粒，其制备和应用
公开(公告)号：US20130011864A1
公开(公告)日：2013-01-10
申请号：US13574511
申请日：2011-01-19
申请人： Yuan Wang , Guangsheng Shao , Rongcheng Han , Wen Yang , Yan Ma , Fumin Xue
发明人： Yuan Wang , Guangsheng Shao , Rongcheng Han , Wen Yang , Yan Ma , Fumin Xue
IPC分类号： G01N21/64 , C07F5/00 , B82Y15/00
CPC分类号： G01N33/52 , C07D403/14 , C07F5/003 , C09K11/06 , C09K2211/182 , G01N33/587 , G01N2458/40
摘要： Luminescent nanoparticles, preparation, and application thereof are disclosed. The luminescent nanoparticle consists of matrix, which is a macromolecular compound containing carboxyl group, and a rare-earth luminescent dye dispersed in the matrix. The preparation method of the luminescent nanoparticle comprises: dissolving the rare-earth complex luminescent dye and the macromolecular compound in organic solvent miscible with water, adding the solution into water, and forming the luminescent nanoparticle by coprecipitation-selfassembly process. The prepared luminescent nanoparticle has excellent long-wave excitational luminescent properties and good stability, and can be used in coupling the surface carboxyl group of a biomolecule. The biological probes based on such luminescent nanoparticles have wide application prospects on the aspects of high-sensitivity luminescent immunoassay, biological imaging and the like.
摘要翻译：公开了发光纳米颗粒，其制备和应用。发光纳米颗粒由分散在基质中的含有羧基的高分子化合物和稀土发光染料构成。发光纳米颗粒的制备方法包括：将稀土配合物发光染料和高分子化合物溶解在与水混溶的有机溶剂中，将溶液加入水中，并通过共沉淀 - 自组装过程形成发光纳米颗粒。制备的发光纳米颗粒具有优异的长波激发发光性能和良好的稳定性，可用于偶联生物分子的表面羧基。基于这种发光纳米颗粒的生物探针在高灵敏度发光免疫测定，生物成像等方面具有广泛的应用前景。

66. 发明申请

US20120303692A1 FEDERATION OF MASTER DATA MANAGEMENT SYSTEMS 失效
标题翻译：主数据管理系统的联合
公开(公告)号：US20120303692A1
公开(公告)日：2012-11-29
申请号：US13117321
申请日：2011-05-27
申请人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Xuan Liu , Bin Wang , Yuan Wang , Jing Min Xu , Jeaha Yang
发明人： Rangachari Anand , Stacy F. Hobson , Juhnyoung Lee , Xuan Liu , Bin Wang , Yuan Wang , Jing Min Xu , Jeaha Yang
IPC分类号： G06F15/16
CPC分类号： H04L67/1095 , H04L67/02 , H04W4/00
摘要： Federating master data management systems may include a network-aware adapter configured with a host master data management node. The network-aware adapter may establish one or more links with other master data management systems to allow the system to work together and leverage each other's data.
摘要翻译：联合主数据管理系统可以包括配置有主机主数据管理节点的网络感知适配器。网络感知适配器可以与其他主数据管理系统建立一个或多个链路，以允许系统一起工作并利用彼此的数据。

67. 发明申请

US20120076602A1 Transverse-Longitudinal Perpendicular Automatic Adjusting Apparatus 有权
标题翻译：横向纵向自动调节装置
公开(公告)号：US20120076602A1
公开(公告)日：2012-03-29
申请号：US13375211
申请日：2009-08-27
申请人： Haifeng Ni , Qi Lu , Yuan Wang
发明人： Haifeng Ni , Qi Lu , Yuan Wang
IPC分类号： B23Q1/01
CPC分类号： B23Q1/012
摘要： A transverse-longitudinal perpendicular automatic adjusting apparatus used for a cutting machine is disclosed. The automatic adjusting apparatus comprises a cross beam (8), a driving trolley (5), a driven trolley (7), a rotating shaft (1), a rolling bearing (2), a driving connecting plate (3) and a disc spring (4). The cross beam (8) is a drawn cross beam. The driving connecting plate (3) is connected to a bottom surface of the cross beam (8). A bottom surface of the cross beam is rigidly connected with a driven connecting plate (6), which is connected with the driven trolley (7). The apparatus ensures stable operation and is inexpensive. The apparatus is easy to adjust, install and manufacture.
摘要翻译：公开了一种用于切割机的横向纵向垂直自动调节装置。自动调节装置包括横梁（8），驱动手推车（5），从动手推车（7），旋转轴（1），滚动轴承（2），驱动连接板（3）和盘春天（4）。横梁（8）是拉伸横梁。驱动连接板（3）连接到横梁（8）的底面。横梁的底面与与驱动的手推车（7）连接的从动连接板（6）刚性连接。该装置确保稳定的操作并且便宜。该设备易于调整，安装和制造。

68. 发明申请

US20120067734A1 PHENOL CROSSLINK FOR SENSOR MEMBRANE 有权
标题翻译：用于传感器膜的PHENOL CROSSLINK
公开(公告)号：US20120067734A1
公开(公告)日：2012-03-22
申请号：US13107816
申请日：2011-05-13
申请人： Yuan Wang , Raeanne Gifford
发明人： Yuan Wang , Raeanne Gifford
IPC分类号： G01N27/26 , C12Q1/25 , C25D11/00 , C08G65/40
CPC分类号： B01D71/72 , A61B5/14532 , A61B2562/12 , B01D67/0006 , B01D2323/30 , C12Q1/003 , G01N27/3274 , G01N27/40
摘要： Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.
摘要翻译：本文的实施方案提供了一种膜，其是与一种或多种含有烯丙基的化合物交联的酚的产物。苯酚可以与含烯丙基的化合物电聚合以形成交联的聚合物。合适的含烯丙基化合物包括烯丙基苯酚，烯丙醇，烯丙胺和烯丙基氨基甲酰胺。膜可以具有一种类型的含烯丙基化合物，或者两种或更多种类型的化合物。如在分析物感测装置中使用的，由交联苯酚形成的膜可以提供改进的干扰排除，过氧化物反应，稳定性和/或耐溶剂性。

69. 发明申请

US20110293656A1 RECOMBINANT MVA CAPABLE OF EXPRESSING STRUCTURAL HCV ANTIGENS 审中-公开
标题翻译：表达结构性HCV抗原的重组MVA
公开(公告)号：US20110293656A1
公开(公告)日：2011-12-01
申请号：US13110471
申请日：2011-05-18
申请人： Gerd Sutter , Volker Erfle , Caroline Staib , Yuan Wang , Guangdi Li , Li-Xin Zhu
发明人： Gerd Sutter , Volker Erfle , Caroline Staib , Yuan Wang , Guangdi Li , Li-Xin Zhu
IPC分类号： A61K39/285 , C07H21/04 , C12N5/10 , A61P31/18 , A61P31/12 , C12N7/01 , A61K35/76 , C07H21/02
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C12N15/86 , C12N2710/24143 , C12N2770/24234 , C12N2770/24243
摘要： The invention relates to recombinant MVA which is capable of expressing structural HCV antigens, functional parts of said structural antigens or epitopes of said structural antigens. The invention further relates to a pharmaceutical composition, especially in the form of a vaccine and containing the recombinant MVA according to the invention, to eukaryotic cells that contain the inventive recombinant MVA and to various uses of the recombinant MVA, for example for producing recombinant structural proteins, for producing a pharmaceutical preparation that is suitable for the therapy and prophylaxis of HCV infections and diseases thereby caused. The invention further relates to methods for producing recombinant MVA and recombinant structural HCV polypeptides encoded by said recombinant MVA, and to DNA or RNA of said recombinant MVA.
摘要翻译：本发明涉及能够表达结构HCV抗原，所述结构抗原的功能部分或所述结构抗原表位的重组MVA。本发明进一步涉及一种药物组合物，特别是疫苗形式，并含有本发明的重组体MVA，其含有本发明的重组MVA的真核细胞以及重组MVA的各种用途，例如用于产生重组结构蛋白质，用于制备适于治疗和预防由此引起的HCV感染和疾病的药物制剂。本发明还涉及用于产生由所述重组MVA编码的重组MVA和重组结构HCV多肽以及所述重组MVA的DNA或RNA的方法。

70. 发明申请

US20110166201A1 MIRNAS AS THERAPEUTIC TARGETS IN CANCER 有权
标题翻译： MIRNAS作为癌症中的治疗目标
公开(公告)号：US20110166201A1
公开(公告)日：2011-07-07
申请号：US12996249
申请日：2009-06-05
申请人： Jingfang Ju , Bo Song , Yuan Wang
发明人： Jingfang Ju , Bo Song , Yuan Wang
IPC分类号： A61K31/7052 , C12N5/00 , C12Q1/68 , C07H21/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
摘要翻译：微RNA（miRNA）是一类非编码小RNA分子，通过与其靶mRNA的3'非翻译区（UTR）相互作用，在转录后水平调节基因表达。本发明涉及miR-192和miR-215的应用。这两种miRNA通过p53-miRNA电路影响细胞增殖，并与二氢叶酸还原酶（DHFR）和胸苷酸合酶（TS）相互作用。特别地，这些miRNA的上调减少细胞增殖。本发明涉及这一发现。例如，抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。此外，测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。因此，本发明涉及与miR-192和miR-215的表达的鉴定，表征和调节相关的组合物和方法。

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