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61. 发明申请

US20060149080A1 Process for preparing optically active cyclic amines 有权
标题翻译：光学活性环胺的制备方法
公开(公告)号：US20060149080A1
公开(公告)日：2006-07-06
申请号：US11320121
申请日：2005-12-28
申请人： Hansjorg Dietrich , Mark Ford , Thomas Muller , Jose Lassaletta Simon , Abel Ros Lao , Antonio Magriz Tascon
发明人： Hansjorg Dietrich , Mark Ford , Thomas Muller , Jose Lassaletta Simon , Abel Ros Lao , Antonio Magriz Tascon
IPC分类号： A61K31/405 , C07D209/02 , C07D403/02
CPC分类号： C07C231/18 , C07B2200/07 , C07C209/52 , C07C209/62 , C07C211/35 , C07C211/40 , C07C211/42 , C07C233/65
摘要： Optically active cyclic amines of the formula (I) or salts thereof in which A, R0, R are each as defined in claim 1, and R0 and A, or R and A, or R0 and R may also form rings, where R and the NH—R0 group on the two ring carbon atoms marked with an asterisk (*) in each case are arranged in cis arrangement to one another and the stereochemical configuration on these carbon atoms is different from the racemic configuration, can be prepared effectively by a process, which comprises converting an imine (a racemic imine) of the formula (II) in which A, R0 and R are each as defined in formula (I), in the presence of hydrogen or a hydrogen donor and a nonenzymatic catalyst which comprises a catalytically active optically active complex of one or more transition metals from the group of ruthenium, rhodium, palladium, iridium, osmium, platinum, iron, nickel and samarium with organic ligands, to the compound of the formula (I).
摘要翻译：式（I）的光学活性环胺或其盐，其中A，R 0，R 2各自如权利要求1所定义，R 0和A，或 R和A或R 0和R也可以形成环，其中在带有星号（*）的两个环碳原子上的R和NH-R 0 O基团在每种情况下彼此以顺序排列并且这些碳原子上的立体化学构型不同于外消旋构型，可以通过包括将式（II）的亚胺（外消旋亚胺）其中A，R 0和R 2各自如式（I）中所定义，在氢或氢供体和非酶催化剂的存在下，其包含一种或多种催化活性的光学活性复合物将钌，铑，钯，铱，锇，铂，铁，镍和钐与有机配体的过渡金属转化为式（I）的化合物。

62. 发明申请

US20050136511A1 GABA B receptors 审中-公开
标题翻译： GABA B受体
公开(公告)号：US20050136511A1
公开(公告)日：2005-06-23
申请号：US10867147
申请日：2004-06-14
申请人： Klaus Raming , Mario Mezler , Thomas Muller
发明人： Klaus Raming , Mario Mezler , Thomas Muller
IPC分类号： C12N15/09 , A01N63/00 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12R1/91 , C07H21/04
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The invention relates to polypeptides which exert the biological activity of GABA B receptors, and to nucleic acids which encode these polypeptides, and in particular to their use for finding active compounds for crop protection.
摘要翻译：本发明涉及发挥GABA B受体的生物学活性的多肽，以及编码这些多肽的核酸，特别是其用于发现作物保护活性化合物的用途。

63. 发明申请

US20050109009A1 Chain link for conveying chain of a machine of the tobacco-processing industry 失效
标题翻译：用于输送烟草加工业机器链条的链条
公开(公告)号：US20050109009A1
公开(公告)日：2005-05-26
申请号：US10994419
申请日：2004-11-23
申请人： Thomas Muller , Jan Stellmacher
发明人： Thomas Muller , Jan Stellmacher
IPC分类号： A24C5/39 , B65G17/08 , B65G17/38 , F16G13/06
CPC分类号： B65G17/086 , B65G2201/02
摘要： A chain link for a conveying chain of a machine of the tobacco-processing industry, in particular a storage device for a rod-shaped tobacco product, includes holding means for a hinge pin and a hinge pin bearing for connecting the chain link to adjacent chain links, and a carrying surface for carrying a tobacco product, which carrying surface is arranged substantially parallel to the hinge plane defined by the hinge axes. The chain link is designed laterally for cooperation with a deflection plate of the machine which rotates about a substantially vertical axis. During cooperation with the deflection plate the chain link is designed to pivot about a longitudinal pivot axis parallel to the longitudinal axis. The chain link has a guide element which cooperates with the deflection plate and which is designed in such a way that a pivot movement of the chain link about the longitudinal pivot axis is counteracted by a frictional force exerted by the deflection plate on the guide element. On the side of the carrying surface the chain link is designed to cooperate with a round deflection roller of the machine, which rotates about a substantially horizontal axis, wherein contact of the chain link with the deflection roller lies in the region of one of the hinge axes.
摘要翻译：用于烟草加工工业机器的输送链的链节，特别是用于棒状烟草制品的储存装置，包括用于将链节连接到相邻链条的铰链销和铰链销轴承的保持装置连接件和用于承载烟草制品的承载表面，所述承载表面基本上平行于由铰链轴限定的铰链平面布置。链节是横向设计的，用于与围绕基本垂直的轴线旋转的机器的偏转板协作。在与偏转板协作期间，链节被设计成围绕平行于纵向轴线的纵向枢转轴线枢转。链节具有与偏转板协作的引导元件，其被设计成使得链节围绕纵向枢转轴线的枢转运动被偏转板施加在引导元件上的摩擦力抵消。在承载表面的侧面上，链节被设计成与机器的圆偏转辊配合，该滚子围绕基本上水平的轴线旋转，其中链节与偏转辊的接触位于铰链之一的区域中轴。

64. 发明申请

US20050054625A1 Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors 审中-公开
标题翻译：使用HSP90抑制剂与核输出抑制剂组合治疗疾病的方法
公开(公告)号：US20050054625A1
公开(公告)日：2005-03-10
申请号：US10856703
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/35
CPC分类号： A61K31/33 , A61K31/35
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a nuclear export inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a nuclear export inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a nuclear export inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a nuclear export inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法涉及施用HSP90抑制剂和核出口抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用一种核出口抑制剂的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一剂HSP90抑制剂治疗受试者，随后用一定剂量的核输出抑制剂治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一定剂量的核输出抑制剂治疗受试者，随后用一定剂量的HSP90抑制剂治疗。

65. 发明申请

US20050026893A1 Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants 审中-公开
标题翻译：使用HSP90抑制剂与免疫抑制剂组合治疗疾病的方法
公开(公告)号：US20050026893A1
公开(公告)日：2005-02-03
申请号：US10857166
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/395 , A61K31/40 , A61K31/4745
CPC分类号： A61K45/06
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an immunosuppressant, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an immunosuppressant in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an immunosuppressant. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an immunosuppressant and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和免疫抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用免疫抑制剂的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一定剂量的HSP90抑制剂处理受试者，随后用一定剂量的免疫抑制剂处理。在本发明的另一方面，提供了一种治疗癌症的方法，其中受试者首先用免疫抑制剂的剂量治疗，随后用一定剂量的HSP90抑制剂治疗。

66. 发明授权

US5827849A Cyclic dericatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：循环衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5827849A
公开(公告)日：1998-10-27
申请号：US768365
申请日：1996-12-17
申请人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
发明人： F. Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Brian Guth , Thomas Muller , Johannes Weisenberger
IPC分类号： C07D403/02 , A61K31/395 , A61K31/41 , A61K31/47 , A61K31/4725 , A61K31/55 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07F9/6558 , A61K31/415
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的环状衍生物，其中Ra，Rb，X和Y如权利要求1所定义，互变异构体，立体异构体包括其混合物及其盐，特别是其生理上可接受的盐其具有有价值的药理学性质，优选聚集抑制作用的有机或无机酸或碱，含有该化合物的药物组合物及其制备方法。

67. 发明授权

US5791134A Winding device and method for wrapping a product being processed in cable technology 失效
标题翻译：用电缆技术缠绕正在加工的产品的卷绕装置和方法
公开(公告)号：US5791134A
公开(公告)日：1998-08-11
申请号：US793582
申请日：1997-02-28
申请人： Reiner Schneider , Thomas Muller , Horst Knoch , Martin Loczenski , Reiner Luthardt , Gunther Kessel
发明人： Reiner Schneider , Thomas Muller , Horst Knoch , Martin Loczenski , Reiner Luthardt , Gunther Kessel
IPC分类号： B65H59/38 , B65H59/40 , G01L5/10 , G02B6/44 , D02G3/36
CPC分类号： G01L5/108 , B65H57/20 , B65H59/384 , B65H59/40 , G01L5/10 , G02B6/4457 , B65H2701/31
摘要： A method and device for winding an elongated element onto a cable product comprises a probe for measuring the tensile stress of the elongated element as it moves from a supply coil to a point for winding the element onto the cable product.
摘要翻译： PCT No.PCT / DE95 / 00460 Sec。 371日期1997年2月28日 102（e）日期1997年2月28日PCT提交1995年4月5日PCT公布。出版物WO96 / 07878 日本1996年3月14日用于将细长元件缠绕到电缆产品上的方法和装置包括用于测量细长元件在从供给线圈移动到将元件缠绕到电缆产品上的点时的拉伸应力的探针。

68. 发明授权

US5736559A Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：联苯衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5736559A
公开(公告)日：1998-04-07
申请号：US691107
申请日：1996-08-01
申请人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Thomas Muller , Wolfgang Eisert , Johannes Weisenberger
发明人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Gunter Linz , Thomas Muller , Wolfgang Eisert , Johannes Weisenberger
IPC分类号： C07C211/44 , A61K38/00 , C07C211/48 , C07C211/50 , C07C211/53 , C07C233/65 , C07C237/36 , C07C237/38 , C07C243/22 , C07C255/54 , C07C255/56 , C07C255/57 , C07C255/58 , C07C255/59 , C07C255/60 , C07C257/18 , C07C271/64 , C07C275/28 , C07C275/32 , C07C275/38 , C07C275/42 , C07C279/18 , C07C307/10 , C07C309/11 , C07C311/04 , C07C311/06 , C07C311/08 , C07C311/11 , C07C311/16 , C07C311/19 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/44 , C07C317/46 , C07C321/24 , C07C323/60 , C07C323/62 , C07D207/08 , C07D207/26 , C07D211/34 , C07D211/60 , C07D211/62 , C07D211/70 , C07D257/04 , C07D295/192 , C07F9/40 , C07K5/06 , A61K31/445 , A61K31/40 , A61K31/495 , C07D211/06 , C07D295/185
CPC分类号： C07D295/192 , C07C237/36 , C07C237/38 , C07C243/22 , C07C255/56 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/18 , C07C271/64 , C07C275/42 , C07C307/10 , C07C309/11 , C07C311/04 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/60 , C07C323/62 , C07D211/34 , C07D211/60 , C07D211/62 , C07D211/70 , C07K5/06026 , A61K38/00 , C07C2101/14
摘要： The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的联苯衍生物，其中A至E和X如权利要求1所定义，其立体异构体包括它们的混合物及其盐，特别是其与无机或有机物的生理上可接受的盐酸或碱，其具有有价值的性质，优选聚集抑制作用，含有这些化合物的药物组合物及其制备方法。

69. 发明授权

US5364622A Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel 失效
标题翻译：通过应用组织纤溶酶原激活剂和羟乙基纤维素水凝胶防止器官和器官部分粘连的方法
公开(公告)号：US5364622A
公开(公告)日：1994-11-15
申请号：US196764
申请日：1993-10-13
申请人： Helmut Franz , Thomas Muller , Wolfgang Eisert
发明人： Helmut Franz , Thomas Muller , Wolfgang Eisert
IPC分类号： A61K38/49 , A61K47/38 , A61K37/547
CPC分类号： A61K47/38 , A61K38/49 , A61K9/0014
摘要： A method for the prevention of adhesions to body organs and parts of organs caused by therapeutic intervention by applying a pharmaceutical composition of tissue plasminogen activator and an aqueous hydroxyethylcellulose hydrogel.
摘要翻译：一种通过应用组织纤溶酶原激活剂和羟乙基纤维素水凝胶的药物组合物来预防由治疗干预引起的对身体器官和器官部分的粘连的方法。

70. 发明授权

US5300708A Process for the catalytic hydrogenation of organic compounds in the gas phase 失效
标题翻译：气相中有机化合物的催化氢化方法
公开(公告)号：US5300708A
公开(公告)日：1994-04-05
申请号：US81682
申请日：1993-06-23
申请人： Wolfgang Hofs , Thomas Muller
发明人： Wolfgang Hofs , Thomas Muller
IPC分类号： C07B31/00 , B01J10/00 , B01J12/00 , C07B41/02 , C07B61/00 , C07C29/141 , C07C31/02 , C07C31/18 , F28F9/22 , C07C31/20 , F16F1/34
CPC分类号： B01J12/00 , B01J10/005 , C07C29/141 , F28F9/22
摘要： A process for the catalytic hydrogenation of organic compounds in the gas phase. The reaction product-containing circulating gas leaving the hydrogenation reactor is compressed without prior cooling, and is then used to heat the starting materials in a superheater to the reaction temperature. The circulating gas stream is further cooled in a hot-gas heat exchanger by cold reactants in a counter-current manner; as a result, substantially all the reaction product condenses out leaving recycle gas. After addition of fresh gas and starting material, the recycle gas is returned via a purification column to the hydrogenation reactor.
摘要翻译：气相中有机化合物催化氢化的方法。离开氢化反应器的含反应产物的循环气体在没有预先冷却的情况下被压缩，然后用于将过热器中的原料加热至反应温度。循环气流在热气换热器中通过冷反应物以逆流方式进一步冷却; 结果，基本上所有的反应产物都会凝结出来，留下循环气体。加入新鲜气体和原料后，再循环气经净化塔返回到氢化反应器中。

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