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61. 发明申请

WO0155329A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155329A8
公开(公告)日：2001-09-07
申请号：PCT/US0101360
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C07K14/47 , C07K16/18 , C12N20060101 , C12N1/20 , C12N5/00 , C12N15/12 , C12N15/63 , C12P21/06 , C12Q1/68 , C12N
CPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C07K14/47 , C07K16/18 , C12N1/00 , C12N1/20 , C12N5/00 , C12N15/63 , C12P21/06 , C12Q1/68
摘要： The present invention relates to novel ovarian related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "ovarian antigens", and the use of such ovarian antigens for detecting disorders of the ovaries and/or breast, particularly the presence of ovarian and/or breast cancer and ovarian and/or breast cancer metastases. More specifically, isolated ovarian associated nucleic acid molecules are provided encoding novel ovarian associated polypeptides. Novel ovarian polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human ovarian associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the ovaries and/or breast, including ovarian and/or breast cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的卵巢相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“卵巢抗原”，以及使用这种卵巢抗原来检测卵巢和/或乳腺疾病，特别是卵巢和/ 或乳腺癌和卵巢和/或乳腺癌转移。更具体地，提供编码新的卵巢相关多肽的分离的卵巢相关核酸分子。提供结合这些多肽的新型卵巢多肽和抗体。还提供载体，宿主细胞，以及用于产生人卵巢相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与卵巢和/或乳腺相关的疾病（包括卵巢和/或乳腺癌）的诊断和治疗方法，以及用于治疗这些疾病的治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

62. 发明申请

WO0155318A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155318A8
公开(公告)日：2001-09-07
申请号：PCT/US0101332
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

63. 发明申请

WO0155316A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155316A8
公开(公告)日：2001-09-07
申请号：PCT/US0101328
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel prostate cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "prostate cancer antigens", and the use of such prostate cancer antigens for detecting disorders of the prostate, particularly the presence of prostate cancer and prostate cancer metastases. More specifically, isolated prostate cancer associated nucleic acid molecules are provided encoding novel prostate cancer associated polypeptides. Novel prostate cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human prostate cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the prostate, including prostate cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的前列腺癌相关多核苷酸和由本文统称为“前列腺癌抗原”的这些多核苷酸编码的多肽，以及这种前列腺癌抗原用于检测前列腺疾病，特别是前列腺癌和前列腺癌的存在癌症转移。更具体地说，提供了编码新型前列腺癌相关多肽的分离的前列腺癌相关核酸分子。提供了新的前列腺癌多肽和结合这些多肽的抗体。还提供了用于产生人前列腺癌相关多核苷酸和/或多肽的载体，宿主细胞以及重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与前列腺相关的病症（包括前列腺癌）的诊断和治疗方法，以及用于治疗这些病症的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

64. 发明申请

WO0155310A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155310A8
公开(公告)日：2001-09-07
申请号：PCT/US0101314
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders relates to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽相关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

65. 发明申请

WO0155204A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155204A8
公开(公告)日：2001-09-07
申请号：PCT/US0101336
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N5/10 , C12N5/16 , C12N15/63 , C12N15/64
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

66. 发明申请

WO0155202A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155202A8
公开(公告)日：2001-09-07
申请号：PCT/US0101325
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N5/10 , C12N5/16 , C12N15/63 , C12N15/64
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells,and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

67. 发明申请

WO0155322A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155322A2
公开(公告)日：2001-08-02
申请号：PCT/US0101341
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

68. 发明申请

WO9840483A3 28 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 28人类分泌蛋白
公开(公告)号：WO9840483A3
公开(公告)日：1998-11-19
申请号：PCT/US9804858
申请日：1998-03-12
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
发明人： RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K31/70 , A61K38/17 , C12N15/11 , C12N15/62 , C12Q1/48 , G01N33/53 , G01N33/60 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to 28 human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

69. 发明申请

WO0155313A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155313A3
公开(公告)日：2007-11-15
申请号：PCT/US0101323
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C12N15/00 , A61K38/00 , A61K48/00 , C07K1/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6424 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel excretory system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "excretory system antigens", and the use of such excretory system antigens for detecting disorders of the excretory system, particularly the presence of cancer of excretory system tissues and cancer metastases. More specifically, isolated excretory system associated nucleic acid molecules are provided encoding novel excretory system associated polypeptides. Novel excretory system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human excretory system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the excretory system, including cancer of excretory system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的排泄系统相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“排泄系统抗原”，以及这种排泄系统抗原用于检测排泄系统疾病，特别是排泄物癌症的存在系统组织和癌症转移。更具体地，提供了分离的排泄系统相关核酸分子，其编码新的排泄系统相关多肽。提供了与这些多肽结合的新型排泄系统多肽和抗体。还提供载体，宿主细胞，以及用于产生人排泄系统相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及可用于诊断，治疗，预防和/或预测与排泄系统相关的疾病，包括排泄系统组织的癌症以及治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

70. 发明申请

WO02077188A3 HUMAN SERINE/THREONINE KINASE 审中-公开
标题翻译：人类丝氨酸/丝氨酸激酶
公开(公告)号：WO02077188A3
公开(公告)日：2003-04-17
申请号：PCT/US0209239
申请日：2002-03-26
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M
发明人： ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： A61K38/00 , C07K14/47 , G01N33/53 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

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