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    • 65. 发明授权
    • Penam derivatives
    • Penam衍生物
    • US5637579A
    • 1997-06-10
    • US293865
    • 1994-08-22
    • Christian HubschwerlenHans RichterJean-Luc Specklin
    • Christian HubschwerlenHans RichterJean-Luc Specklin
    • A61K31/40A61K31/425A61K31/43A61K31/431A61K31/435A61K31/495A61K31/545A61P31/04A61P43/00C07D499/00C07D499/86C07D499/87C07D499/897
    • C07D499/00
    • The present invention discloses compounds having the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is --COR.sup.4, --CN, --CH.sub.2 R.sup.5, halogen, --CH.dbd.CHR.sup.6 or Q and the other is hydrogen or lower alkyl or both R.sup.1 and R.sup.2 together form a .gamma.-lactam ring,R.sup.3 is hydrogen, lower alkyl, aryl-alkyl, allyl or a residue which is cleavable in vivo,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino,R.sup.5 is hydroxy, --OCONHR.sup.7, --OCONH.sub.2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom,R.sup.6 is --CN or CHO,R.sup.7 is --COCH.sub.2 Cl,Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O andn is 0, 1 or 2,and the pharmaceutically compatible salts thereof.These compounds are good .beta.-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a .beta.-lactam antibiotic.
    • 本发明公开了具有下式的化合物,其中R 1和R 2之一是-COR 4,-CN,-CH 2 R 5,卤素,-CH = CHR 6或Q,另一个是氢或低级烷基,或者R 1和R 2一起 形成γ-内酰胺环,R3是氢,低级烷基,芳基 - 烷基,烯丙基或可在体内可切割的残基,R4是氢,低级烷基,低级烷氧基,苄氧基,氨基,低级烷基氨基或低级烷基 - 低级烷氧基氨基 R 5为羟基,-OCONHR 7,-OCONH 2或含有N,S和/或O且通过氮原子连接的五元或六元杂芳环,R 6为-CN或CHO,R 7为 - COCH 2 Cl,Q是含有N,S和/或O且n为0,1或2的五元或六元杂芳环及其药学上相容的盐。 这些化合物是良好的β-内酰胺酶抑制剂。 它们可用于预防或治疗细菌感染,任选与β-内酰胺抗生素一起使用。
    • 67. 发明授权
    • Apparatus for detecting forces directing the movement of a manipulating
instrument
    • 用于检测引导操纵器械运动的力的装置
    • US4298308A
    • 1981-11-03
    • US78280
    • 1979-09-24
    • Hans Richter
    • Hans Richter
    • B25J9/00B25J13/08G05B19/423G05B19/42
    • B25J13/085B25J9/0081G05B19/423G05B2219/37357
    • An apparatus attached to a motor driven manipulating instrument for detecting and identifying specific forces employed in moving the instrument along a predetermined spatial track. The apparatus includes a center portion rigidly attached to the manipulating instrument and a sleeve member surrounding the center portion. A plurality of separate, flexible blades join the sleeve and center portions to each other, with a separate transducer fixedly attached to each flexible blade and capable of detecting bending forces employed to move the sleeve and attached instrument. The transducers generate output signals indicative of the magnitude and direction of the forces, which signals are used for establishing a program for controlling the actuation of the various motors to allow the instrument to repeatedly execute the course set forth in the program.
    • 附接到马达驱动的操纵仪器上的装置,用于检测和识别沿预定的空间轨道移动仪器所采用的特定力。 该装置包括刚性地附接到操纵器具的中心部分和围绕中心部分的套筒部件。 多个单独的柔性叶片将套管和中心部分彼此连接,单独的换能器固定地附接到每个柔性叶片上并且能够检测用于移动套筒和附接的仪器的弯曲力。 换能器产生指示力的大小和方向的输出信号,该信号用于建立用于控制各种电机的致动的程序,以允许仪器重复执行程序中阐述的过程。
    • 68. 发明授权
    • Counter for measuring apparatus such as a water meter or the like
    • 计量器,如水表等
    • US3938737A
    • 1976-02-17
    • US545555
    • 1975-01-30
    • Hans Richter
    • Hans Richter
    • G01F15/07G06M1/04G06M1/14G06M1/26G07B15/00G06C25/02
    • G06M1/26G06M1/143
    • A counter for measuring apparatus such as a water meter or the like includes a first number wheel for a low decade; a drive shaft for driving the first number wheel; an additional number wheel for values of a lowest decade; a clutch coupling for coupling the additional number wheel to the drive shaft; and, a cam mechanism for aligning the number wheels. The cam mechanism includes a rotatable cam shaft for actuating a first pawl for engaging an alignment star of the first number wheel and an additional pawl for engaging an alignment star of the additional number wheel. The cam shaft is configured so as to first cause the additional pawl to engage the alignment star of the additional number wheel, and then, to cause the first pawl to engage the alignment star of the first number wheel when the cam shaft is rotated.
    • 用于诸如水表等的测量装置的计数器包括低十年的第一数字轮; 用于驱动第一数字轮的驱动轴; 额外的车轮,价值最低的十年; 离合器联接器,用于将附加数字轮连接到驱动轴; 以及用于对准数字轮的凸轮机构。 凸轮机构包括可旋转的凸轮轴,用于致动用于接合第一数字轮的对准星的第一棘爪和用于接合附加数字轮的对准星的附加棘爪。 凸轮轴构造成首先使附加棘爪接合附加数字轮的对准星,然后当凸轮轴旋转时使第一棘爪接合第一数字轮的对准星。
    • 70. 发明授权
    • Electric universal drive
    • 电动万能驱动
    • US08410662B2
    • 2013-04-02
    • US13068203
    • 2011-05-05
    • Hans Richter
    • Hans Richter
    • H01L41/08
    • H02N2/101F16D55/2245F16D65/54F16D2125/68H02N2/021
    • In a universal drive with a rotatable or linearly movable drive member and piezo actuators supported on a carrier for acting on a leg supported on the drive member and moving the leg in a high-frequency stepping sequence in a drive direction, wherein the carriers are jointly supported on a stator by a pretension member which biases them elastically toward the drive member via an elbow lever mechanism including a first elbow lever and at least a second elbow lever which are both connected to an actuator by a coupling member and this arrangement is such that, with the first elbow lever stretched, the second elbow lever is kinked and vice versa.
    • 在具有可旋转或可线性移动的驱动构件的通用驱动器和支撑在载体上的压电致动器用于作用在支撑在驱动构件上的腿上并以驱动方向的高频步进顺序移动腿,其中载体共同 通过预紧构件支撑在定子上,该预紧构件通过包括第一肘杆和至少第二肘杆的肘杆机构朝向驱动构件弹性地偏压,所述肘杆机构都通过联接构件连接到致动器,并且这种布置使得 第一肘杆拉伸,第二肘杆扭结,反之亦然。